Gene: AP3D1

8943
ADTD|HPS10|hBLVR
adaptor related protein complex 3 subunit delta 1
protein-coding
19p13.3
Ensembl:ENSG00000065000 MIM:607246 Vega:OTTHUMG00000180354 UniprotKB:O14617
NG_052886.2
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.272e-1 (AD)  7.692e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10413398chr19:2106697 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TAOK20.966
DHX300.963
GBA20.962
PPP6R20.961
DEF80.958
CLUH0.956
UBA10.955
CCAR20.955
GDI10.954
SCYL10.953

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.756
OR4F29-0.718
TFPI2-0.335
IL18RAP-0.323
CD48-0.322
MTRNR2L6-0.319
KLRB1-0.318
CXCR2-0.316
KCNJ15-0.316
MTRNR2L9-0.313

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of AP3D1 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AP3D1 mRNA"27188386
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of AP3D1 mRNA"21346803
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AP3D1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of AP3D1 mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of AP3D1 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of AP3D1 mRNA19770486
D001151ArsenicArsenic affects the expression of AP3D1 mRNA18414638
D001151ArsenicArsenic affects the methylation of AP3D1 gene25304211
D004958EstradiolEstradiol results in decreased expression of AP3D1 mRNA14681234
C044887beta-methylcholinebeta-methylcholine affects the expression of AP3D1 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of AP3D1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of AP3D1 mRNA26063408
C006780bisphenol Abisphenol A affects the expression of AP3D1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of AP3D1 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of AP3D1 mRNA15336504
C030583ceric oxideceric oxide analog results in decreased expression of AP3D1 mRNA24821434
D016572CyclosporineCyclosporine results in increased expression of AP3D1 mRNA20106945|2556210
D003976DiazinonDiazinon results in increased methylation of AP3D1 gene22964155
C000944dicrotophosdicrotophos results in increased expression of AP3D1 mRNA28302478
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of AP3D1 mRNA26924002
D004026DieldrinDieldrin results in decreased expression of AP3D1 mRNA23041725
D004178DiquatDiquat affects the expression of AP3D1 mRNA22814884
D018120FinasterideFinasteride results in increased expression of AP3D1 mRNA24136188
D005485FlutamideFlutamide results in decreased expression of AP3D1 mRNA21126777
D005839GentamicinsGentamicins results in increased expression of AP3D1 mRNA22061828
D007213IndomethacinIndomethacin results in decreased expression of AP3D1 mRNA28201806
C410337K 7174K 7174 results in increased expression of AP3D1 mRNA24086573
C008261lead acetatelead acetate affects the expression of AP3D1 mRNA21147602
C008261lead acetate[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of AP3D1 mRNA22839698
D008344Maneb[Paraquat co-treated with Maneb] results in decreased expression of AP3D1 mRNA18386188
D008727MethotrexateMethotrexate results in decreased expression of AP3D1 mRNA17400583
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of AP3D1 mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AP3D1 mRNA"27188386
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of AP3D1 mRNA"29244179
D009532NickelNickel results in decreased expression of AP3D1 mRNA24084258
D010269Paraquat[Paraquat co-treated with Maneb] results in decreased expression of AP3D1 mRNA18386188
C059514resveratrolresveratrol results in decreased expression of AP3D1 protein18089832
D013467SulindacSulindac results in increased expression of AP3D1 mRNA24136188
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AP3D1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of AP3D1 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of AP3D1 mRNA15644576
C009495titanium dioxidetitanium dioxide results in increased expression of AP3D1 mRNA23131501
C483909torcetrapibtorcetrapib results in increased expression of AP3D1 mRNA23228038
D014415TunicamycinTunicamycin results in increased expression of AP3D1 mRNA22378314
D014635Valproic AcidValproic Acid affects the expression of AP3D1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of AP3D1 mRNA23179753|2718838
D014635Valproic AcidValproic Acid affects the expression of AP3D1 mRNA17292431
C025643vinclozolinvinclozolin results in decreased expression of AP3D1 mRNA18042343|2303416
C017803zinc protoporphyrin[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of AP3D1 mRNA22839698

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005215transporter activity-TAS9303295  
GO ID GO Term Qualifier Evidence PubMed
GO:0006623protein targeting to vacuole-IBA21873635  
GO:0006726eye pigment biosynthetic process-TAS9303295  
GO:0006886intracellular protein transport-IBA21873635  
GO:0006886intracellular protein transport-IEA-  
GO:0006896Golgi to vacuole transport-IBA21873635  
GO:0008089anterograde axonal transport-ISS-  
GO:0016182synaptic vesicle budding from endosome-IBA21873635  
GO:0032438melanosome organization-IC22511774  
GO:0035646endosome to melanosome transport-IMP22511774  
GO:0048490anterograde synaptic vesicle transport-IBA21873635  
GO:0048490anterograde synaptic vesicle transport-ISS-  
GO:0048499synaptic vesicle membrane organization-IBA21873635  
GO:0061088regulation of sequestering of zinc ion-IMP17349999  
GO:0072657protein localization to membrane-IMP22511774  
GO:0098943neurotransmitter receptor transport, postsynaptic endosome to lysosome-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-IEA-  
GO:0005765lysosomal membrane-HDA17897319  
GO:0005794Golgi apparatus-TAS9151686  
GO:0010008endosome membrane-IBA21873635  
GO:0010008endosome membrane-IDA16162817  
GO:0016020membrane-HDA19946888  
GO:0030123AP-3 adaptor complex-IBA21873635  
GO:0030123AP-3 adaptor complex-IEA-  
GO:0043195terminal bouton-IBA21873635  
GO:0098830presynaptic endosome-IBA21873635  
GO:1904115axon cytoplasm-IEA-  
KEGG ID KEGG Term
hsa04142Lysosome
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal