Gene info: ID 8945

Gene: BTRC

GENE ID: 8945

Description: beta-transducin repeat containing E3 ubiquitin protein ligase

Gene type: protein-coding

Location: 10q24.32

dbXrefs: Ensembl:ENSG00000166167 MIM:603482 Vega:OTTHUMG00000018932 UniprotKB:Q9Y297

RefSeq: NG_009234.1

Retrived from: SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: ND

# Publications: 0

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.882e-1 (AD) 3.181e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs17760784	chr10:101396659 (GRCh38.p7)	G>C	nicotine dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MYH10	0.976
CELF2	0.973
ARHGEF9	0.97
KCNMA1	0.969
ATRN	0.968
RBFOX2	0.967
AMIGO1	0.966
NUDCD3	0.966
PPP2R5D	0.964
INPP4A	0.964

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.546
OR4F29	-0.494
HEY2	-0.492
CSAG1	-0.48
RAI14	-0.478
TFPI2	-0.472
MYL3	-0.464
CNN2	-0.458
YES1	-0.454
WWTR1	-0.445

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C003898	2-anisidine	2-anisidine results in increased expression of BTRC mRNA	28089782
C090942	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quinacrine results in decreased expression of BTRC protein]	28867437
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of BTRC mRNA	19770486
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of BTRC mRNA	26238291
D004958	Estradiol	[Estradiol co-treated with ESR1 protein] promotes the reaction [ESR1 protein binds to BTRC protein]	26990689
D004958	Estradiol	Estradiol inhibits the reaction [ESR1 protein promotes the reaction [BTRC protein binds to CTNNB1 protein]]	26990689
C543008	bis(4-hydroxyphenyl)sulfone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of BTRC mRNA	28628672
C006780	bisphenol A	bisphenol A affects the expression of BTRC mRNA	25181051
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of BTRC mRNA	20061341
D002220	Carbamazepine	Carbamazepine affects the expression of BTRC mRNA	25979313
C014347	decitabine	decitabine results in decreased expression of BTRC mRNA	27915011
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of BTRC mRNA	28628672
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of BTRC mRNA	17361019
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal results in increased expression of BTRC protein"	28548306
D004365	Drugs, Chinese Herbal	"PPP2CA protein affects the reaction [Drugs, Chinese Herbal results in increased expression of BTRC protein]"	28548306
C045651	epigallocatechin gallate	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of BTRC mRNA	22079256
D005947	Glucose	[INS protein co-treated with Glucose] results in decreased expression of BTRC mRNA	22634610
D006902	Hydroxymercuribenzoates	Hydroxymercuribenzoates results in decreased activity of [RBX1 protein binds to CUL1 protein binds to SKP1 protein binds to BTRC protein]	10748083
D006902	Hydroxymercuribenzoates	[Hydroxymercuribenzoates results in decreased activity of [RBX1 protein binds to CUL1 protein binds to SKP1 protein binds to BTRC protein]] which results in decreased ubiquitination of NFKBIA protein	10748083
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of BTRC mRNA	28628672
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of BTRC mRNA	25613284
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of BTRC mRNA	28628672
D007854	Lead	Lead results in decreased expression of BTRC mRNA	19921347
D008627	Mercuric Chloride	Mercuric Chloride results in decreased activity of [RBX1 protein binds to CUL1 protein binds to SKP1 protein binds to BTRC protein]	10748083
D008627	Mercuric Chloride	[Mercuric Chloride results in decreased activity of [RBX1 protein binds to CUL1 protein binds to SKP1 protein binds to BTRC protein]] which results in decreased ubiquitination of NFKBIA protein	10748083
D008727	Methotrexate	Methotrexate results in increased expression of BTRC mRNA	24449571
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of BTRC mRNA	28001369
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of BTRC mRNA	20061341
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of BTRC mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of BTRC mRNA"	25554681
C028007	nickel monoxide	nickel monoxide results in increased expression of BTRC mRNA	19167457
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in decreased expression of BTRC mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in decreased expression of BTRC mRNA	25729387
C027373	potassium chromate(VI)	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of BTRC mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of BTRC mRNA	22079256
D011374	Progesterone	Progesterone results in increased expression of BTRC mRNA	17170212
D011796	Quinacrine	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quinacrine results in decreased expression of BTRC protein]	28867437
D011796	Quinacrine	BTRC protein inhibits the reaction [Quinacrine results in increased expression of BAX protein]	28867437
D011796	Quinacrine	BTRC protein inhibits the reaction [Quinacrine results in increased expression of SP1 protein]	28867437
D011796	Quinacrine	FOXP3 protein affects the reaction [Quinacrine results in decreased expression of BTRC protein]	28867437
D011796	Quinacrine	MIR183 mRNA affects the reaction [Quinacrine results in decreased expression of BTRC protein]	28867437
D011796	Quinacrine	Quinacrine results in decreased expression of and results in decreased stability of BTRC mRNA	28867437
D011796	Quinacrine	Quinacrine results in decreased expression of BTRC protein	28867437
D012402	Rotenone	Rotenone results in decreased expression of BTRC mRNA	23186747
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of BTRC mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of BTRC mRNA	25975270
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of BTRC mRNA	22298810
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of BTRC mRNA	25613284
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in decreased expression of BTRC mRNA	25729387
D019772	Topotecan	Topotecan results in decreased expression of BTRC mRNA	25729387
C012589	trichostatin A	trichostatin A affects the expression of BTRC mRNA	28542535
D014635	Valproic Acid	Valproic Acid affects the expression of BTRC mRNA	25979313
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of BTRC gene	25560391

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004842	ubiquitin-protein transferase activity	-	EXP	11158290 14673179 19028597
GO:0004842	ubiquitin-protein transferase activity	contributes_to	IDA	15448698
GO:0004842	ubiquitin-protein transferase activity	-	TAS	-
GO:0005515	protein binding	-	IPI	9660940 9859996 10531035 10644755 11238952 12037680 12482991 12609982 12791267 12820959 12902344 14603323 15070733 15448698 15917222 16189514 16371461 16376880 16885022 17318178 17510365 18354482 18354483 18521620 18794143 18805092 19159283 19196987 19411070 19615732 19945379 19966869 20389281 20531388 20708156 21900206 21988832 22307056 22632967 24211253 24270572 24561623 25081058 25416956 25503564 25670079 25873176 26871637 27705803 29420262
GO:0008013	beta-catenin binding	-	IDA	12820959
GO:0016874	ligase activity	-	IEA	-
GO:0030515	snoRNA binding	-	IBA	21873635
GO:0045309	protein phosphorylated amino acid binding	-	IEA	-
GO:0046983	protein dimerization activity	-	IEA	-
GO:0061630	ubiquitin protein ligase activity	contributes_to	IDA	12820959

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000086	G2/M transition of mitotic cell cycle	-	TAS	-
GO:0000209	protein polyubiquitination	-	IDA	12820959
GO:0000209	protein polyubiquitination	-	IMP	12820959
GO:0000209	protein polyubiquitination	-	TAS	-
GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	-	IBA	21873635
GO:0006470	protein dephosphorylation	-	ISS	-
GO:0006511	ubiquitin-dependent protein catabolic process	-	IDA	15448698
GO:0007165	signal transduction	-	TAS	9990853
GO:0016032	viral process	-	IEA	-
GO:0016055	Wnt signaling pathway	-	TAS	-
GO:0016567	protein ubiquitination	-	IDA	16885022
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	-	ISS	21911472
GO:0031648	protein destabilization	-	IMP	16885022
GO:0033598	mammary gland epithelial cell proliferation	-	IEA	-
GO:0038061	NIK/NF-kappaB signaling	-	TAS	-
GO:0042752	regulation of circadian rhythm	-	IDA	15917222
GO:0042753	positive regulation of circadian rhythm	-	ISS	-
GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	-	IEA	-
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	-	IDA	15917222
GO:0043433	negative regulation of DNA-binding transcription factor activity	-	TAS	11001584
GO:0043687	post-translational protein modification	-	TAS	-
GO:0045862	positive regulation of proteolysis	-	IMP	16885022
GO:0045879	negative regulation of smoothened signaling pathway	-	TAS	11001584
GO:0045892	negative regulation of transcription, DNA-templated	-	IMP	19966869
GO:0045893	positive regulation of transcription, DNA-templated	-	ISS	-
GO:0048511	rhythmic process	-	IEA	-
GO:0051403	stress-activated MAPK cascade	-	TAS	-
GO:0051726	regulation of cell cycle	-	IEA	-
GO:0060444	branching involved in mammary gland duct morphogenesis	-	IEA	-
GO:0060828	regulation of canonical Wnt signaling pathway	-	IC	12820959
GO:0061136	regulation of proteasomal protein catabolic process	-	IEA	-
GO:0070498	interleukin-1-mediated signaling pathway	-	TAS	-
GO:0071407	cellular response to organic cyclic compound	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005654	nucleoplasm	-	TAS	-
GO:0005829	cytosol	-	TAS	-
GO:0019005	SCF ubiquitin ligase complex	-	IDA	12820959 19966869
GO:0032040	small-subunit processome	-	IBA	21873635
GO:0034388	Pwp2p-containing subcomplex of 90S preribosome	-	IBA	21873635

KEGG ID	KEGG Term
hsa04114	Oocyte meiosis
hsa04120	Ubiquitin mediated proteolysis
hsa04310	Wnt signaling pathway
hsa04340	Hedgehog signaling pathway
hsa04710	Circadian rhythm
hsa05131	Shigellosis

Reactome ID	Reactome Term	Evidence
R-HSA-1168372	Downstream signaling events of B Cell Receptor (BCR)	TAS
R-HSA-1169091	Activation of NF-kappaB in B cells	TAS
R-HSA-1170546	Prolactin receptor signaling	TAS
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-162582	Signal Transduction	IEA
R-HSA-162906	HIV Infection	TAS
R-HSA-162909	Host Interactions of HIV factors	TAS
R-HSA-1640170	Cell Cycle	TAS
R-HSA-1643685	Disease	TAS
R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade	TAS
R-HSA-166058	MyD88:Mal cascade initiated on plasma membrane	TAS
R-HSA-166166	MyD88-independent TLR4 cascade	TAS
R-HSA-168138	Toll Like Receptor 9 (TLR9) Cascade	TAS
R-HSA-168142	Toll Like Receptor 10 (TLR10) Cascade	TAS
R-HSA-168164	Toll Like Receptor 3 (TLR3) Cascade	TAS
R-HSA-168176	Toll Like Receptor 5 (TLR5) Cascade	TAS
R-HSA-168179	Toll Like Receptor TLR1:TLR2 Cascade	TAS
R-HSA-168181	Toll Like Receptor 7/8 (TLR7/8) Cascade	TAS
R-HSA-168188	Toll Like Receptor TLR6:TLR2 Cascade	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-168898	Toll-Like Receptors Cascades	TAS
R-HSA-174113	SCF-beta-TrCP mediated degradation of Emi1	TAS
R-HSA-174143	APC/C-mediated degradation of cell cycle proteins	TAS
R-HSA-176408	Regulation of APC/C activators between G1/S and early anaphase	TAS
R-HSA-180534	Vpu mediated degradation of CD4	TAS
R-HSA-181438	Toll Like Receptor 2 (TLR2) Cascade	TAS
R-HSA-195253	Degradation of beta-catenin by the destruction complex	TAS
R-HSA-195721	Signaling by WNT	TAS
R-HSA-201681	TCF dependent signaling in response to WNT	TAS
R-HSA-202403	TCR signaling	TAS
R-HSA-202424	Downstream TCR signaling	TAS
R-HSA-2454202	Fc epsilon receptor (FCERI) signaling	TAS
R-HSA-2565942	Regulation of PLK1 Activity at G2/M Transition	TAS
R-HSA-2871837	FCERI mediated NF-kB activation	TAS
R-HSA-3769402	Deactivation of the beta-catenin transactivating complex	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-400253	Circadian Clock	IEA
R-HSA-446652	Interleukin-1 family signaling	TAS
R-HSA-448424	Interleukin-17 signaling	TAS
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-450294	MAP kinase activation	TAS
R-HSA-453274	Mitotic G2-G2/M phases	TAS
R-HSA-453276	Regulation of mitotic cell cycle	TAS
R-HSA-5358351	Signaling by Hedgehog	TAS
R-HSA-5358351	Signaling by Hedgehog	IEA
R-HSA-5607761	Dectin-1 mediated noncanonical NF-kB signaling	TAS
R-HSA-5607764	CLEC7A (Dectin-1) signaling	TAS
R-HSA-5610780	Degradation of GLI1 by the proteasome	TAS
R-HSA-5610783	Degradation of GLI2 by the proteasome	IEA
R-HSA-5610785	GLI3 is processed to GLI3R by the proteasome	TAS
R-HSA-5610787	Hedgehog 'off' state	TAS
R-HSA-5610787	Hedgehog 'off' state	IEA
R-HSA-5621481	C-type lectin receptors (CLRs)	TAS
R-HSA-5663205	Infectious disease	TAS
R-HSA-5668541	TNFR2 non-canonical NF-kB pathway	TAS
R-HSA-5676590	NIK-->noncanonical NF-kB signaling	TAS
R-HSA-5684264	MAP3K8 (TPL2)-dependent MAPK1/3 activation	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-69275	G2/M Transition	TAS
R-HSA-69278	Cell Cycle, Mitotic	TAS
R-HSA-8951664	Neddylation	TAS
R-HSA-9020702	Interleukin-1 signaling	TAS
R-HSA-937061	TRIF(TICAM1)-mediated TLR4 signaling	TAS
R-HSA-975138	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	TAS
R-HSA-975155	MyD88 dependent cascade initiated on endosome	TAS
R-HSA-975871	MyD88 cascade initiated on plasma membrane	TAS
R-HSA-983168	Antigen processing: Ubiquitination & Proteasome degradation	TAS
R-HSA-983169	Class I MHC mediated antigen processing & presentation	TAS
R-HSA-983705	Signaling by the B Cell Receptor (BCR)	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal