Gene: CCND3

896
-
cyclin D3
protein-coding
6p21.1
Ensembl:ENSG00000112576 MIM:123834 Vega:OTTHUMG00000014690 UniprotKB:P30281
NG_041939.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.537e-2 (AD)  6.611e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HSF10.878
CLU0.878
SLC35A40.873
USP390.872
GNB20.868
POLDIP30.863
KDELR10.86
FYN0.86
TPD52L20.86
ADIPOR10.859

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.776
OR4F29-0.749
CETP-0.314
KRT73-0.251
GZMK-0.25
KLRB1-0.24
KRT72-0.24
MXRA5-0.23
LY9-0.227
KLRF1-0.226

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0449851',2'-dihydrorotenone"1',2'-dihydrorotenone results in decreased expression of CCND3 protein"24615755
C49562614-deoxy-11,12-didehydroandrographolide"14-deoxy-11,12-didehydroandrographolide results in decreased expression of CCND3 mRNA"22101062
C09724015-deoxy-delta(12,14)-prostaglandin J2"15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of CCND3 protein"15729575
C0364231-aminomethylphosphonic acid[1-aminomethylphosphonic acid co-treated with methoxyacetic acid] results in decreased expression of CCND3 protein26006246
C0364231-aminomethylphosphonic acid1-aminomethylphosphonic acid results in decreased expression of CCND3 protein23983455
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of CCND3 mRNA"20453058
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of CCND3 mRNA"25614096
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of CCND3 protein]12163013
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran affects the expression of CCND3 mRNA"18343893
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL2 protein results in increased expression of CCND3 mRNA]15778701
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL2 protein results in increased expression of CCND3 protein]15778701
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of CCND3 protein14757120
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one[Sirolimus co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [IL2 protein results in increased expression of CCND3 protein]15778701
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of CCND3 protein15601625
C1202752-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone results in decreased expression of CCND3 protein11468187
C4971012-hydroxy-9-cis-octadecenoic acid2-hydroxy-9-cis-octadecenoic acid results in decreased expression of CCND3 mRNA16027227
C4971012-hydroxy-9-cis-octadecenoic acid2-hydroxy-9-cis-octadecenoic acid results in decreased expression of CCND3 protein16027227
C0228302-methoxyestradiol2-methoxyestradiol results in decreased expression of CCND3 protein23967052
C0163923,3'-diindolylmethane"3,3'-diindolylmethane results in decreased expression of CCND3 protein"22514694
C4949143,5,3',4',5'-pentamethoxystilbene"3,5,3',4',5'-pentamethoxystilbene results in decreased expression of CCND3 protein"19916542
C0388644-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid"4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCND3 protein]"12421932
C0388644-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid"4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in decreased expression of CCND3 protein"16273314
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of CCND3 mRNA"18648102
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [CPG-oligonucleotide results in increased expression of CCND3 protein]17209053
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Tretinoin promotes the reaction [CPG-oligonucleotide results in increased expression of CCND3 protein]]17209053
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CCND3 mRNA"27188386
C5139355-((5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl)-N-(2-hydroxy-3-morpholin-4-ylpropyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide"5-((5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl)-N-(2-hydroxy-3-morpholin-4-ylpropyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide results in decreased expression of CCND3 mRNA"17537993
C5139355-((5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl)-N-(2-hydroxy-3-morpholin-4-ylpropyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide"5-((5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl)-N-(2-hydroxy-3-morpholin-4-ylpropyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide results in decreased expression of CCND3 protein"17537993
C5805985-OH-BDE-475-OH-BDE-47 results in increased expression of CCND3 mRNA26988655
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CCND3 mRNA"27188386
C5319376-O-angeloylenolin6-O-angeloylenolin results in decreased expression of CCND3 protein21192922
C1217077,3'-dihydroxy-4'-methoxyisoflavone"7,3'-dihydroxy-4'-methoxyisoflavone results in decreased expression of CCND3 mRNA"24455688
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of CCND3 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of CCND3 mRNA]17585979
C063261acetylleucyl-leucyl-norleucinalacetylleucyl-leucyl-norleucinal inhibits the reaction [Tretinoin results in increased degradation of and results in decreased expression of CCND3 protein]16024653
C058956acteosideacteoside results in decreased expression of CCND3 protein17634406
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CCND3 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of CCND3 gene27153756
C103303alitretinoinalitretinoin results in decreased expression of CCND3 protein16273314
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Tretinoin results in increased expression of CCND3 protein]"16920920
D000499AllylamineAllylamine results in increased expression of CCND3 mRNA15910882
D000643Ammonium ChlorideAmmonium Chloride results in increased expression of CCND3 protein16483693
D003913DextroamphetamineDextroamphetamine results in increased expression of CCND3 mRNA12558987
C023650anilineaniline results in increased expression of CCND3 mRNA21070798
C023650anilineaniline results in increased expression of CCND3 protein21070798
D001151Arsenic[silybin co-treated with Arsenic] results in decreased expression of CCND3 protein25868784
C006632arsenic trioxidearsenic trioxide results in decreased expression of CCND3 mRNA20458559
D001205Ascorbic AcidAscorbic Acid inhibits the reaction [chromium hexavalent ion results in decreased expression of CCND3 protein]21621607
D001241AspirinAspirin promotes the reaction [troglitazone results in decreased expression of CCND3 protein]19908241
D001241AspirinAspirin results in decreased expression of CCND3 mRNA14976132
D001241AspirinAspirin results in decreased expression of CCND3 protein19908241
D001241Aspirintroglitazone promotes the reaction [Aspirin results in decreased expression of CCND3 protein]19908241
D001280AtrazineAtrazine results in decreased expression of CCND3 mRNA22378314
D001285Atropine[Parathion co-treated with Atropine] results in increased expression of CCND3 mRNA17390078
D001554BenzeneTRP53 protein promotes the reaction [Benzene results in decreased expression of CCND3]15935813
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of CCND3 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CCND3 mRNA21632981
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CCND3 mRNA20061341
D004958EstradiolEstradiol affects the expression of CCND3 mRNA21826169|2257421
D004958EstradiolEstradiol results in increased expression of CCND3 mRNA15897899|1762232
D004958EstradiolIGF1R mutant form promotes the reaction [Estradiol results in increased expression of CCND3 mRNA]23094148
D004958EstradiolCycloheximide affects the reaction [Estradiol affects the expression of CCND3 mRNA]9094091
D004958EstradiolEstradiol affects the expression of CCND3 mRNA9094091
D004958EstradiolEstradiol results in increased expression of CCND3 mRNA11861973
D004958Estradiolfulvestrant inhibits the reaction [Estradiol affects the expression of CCND3 mRNA]9094091
D004958EstradiolTamoxifen inhibits the reaction [Estradiol affects the expression of CCND3 mRNA]9094091
D004958EstradiolEstradiol results in increased expression of CCND3 mRNA24236210
C006780bisphenol Abisphenol A affects the expression of CCND3 mRNA21826169
C006780bisphenol Abisphenol A results in increased expression of CCND3 protein23222814
C006780bisphenol ACurcumin inhibits the reaction [bisphenol A results in increased expression of CCND3 protein]23222814
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased expression of CCND3 mRNA18958704
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased expression of CCND3 mRNA17553608
C471992bosutinibbosutinib affects the localization of CCND3 protein17129604
C471992bosutinib[bosutinib co-treated with Imatinib Mesylate] affects the localization of CCND3 protein17129604
D0200011-Butanol1-Butanol inhibits the reaction [PDGFB protein results in decreased expression of CCND3 protein]15919668
D002083Butylated HydroxyanisoleButylated Hydroxyanisole results in decreased expression of CCND3 mRNA25086368
D020148Butyric AcidButyric Acid results in increased expression of CCND3 mRNA12800193
C584509C646 compoundC646 compound results in increased expression of CCND3 mRNA26191083
D002104CadmiumCadmium results in increased expression of CCND3 mRNA24236210
D002104Cadmiumfulvestrant inhibits the reaction [Cadmium results in increased expression of CCND3 mRNA]24236210
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of CCND3 mRNA18636176
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CCND3 mRNA24236210
D019256Cadmium Chloridefulvestrant inhibits the reaction [Cadmium Chloride results in increased expression of CCND3 mRNA]24236210
D002220CarbamazepineCarbamazepine affects the expression of CCND3 mRNA24752500
D002713Chlorine[Ozone co-treated with Chlorine] results in decreased expression of CCND3 mRNA18636392
D002737ChloropreneChloroprene results in increased expression of CCND3 mRNA23125180
D002746ChlorpromazineChlorpromazine analog results in decreased expression of CCND3 mRNA15924885
C074702chromium hexavalent ionAscorbic Acid inhibits the reaction [chromium hexavalent ion results in decreased expression of CCND3 protein]21621607
C074702chromium hexavalent ionchromium hexavalent ion results in decreased expression of CCND3 protein21621607
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of CCND3 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of CCND3 mRNA]17585979
D002994ClofibrateClofibrate results in increased expression of CCND3 mRNA12851107
D003024ClozapineClozapine results in increased expression of CCND3 mRNA15860345
C018021cobaltous chloridecobaltous chloride results in decreased expression of CCND3 mRNA19376846
D003042CocaineCocaine affects the expression of CCND3 mRNA20187946
D003300Copper[Thiosemicarbazones binds to Copper] which results in decreased expression of CCND3 protein20931265
C477330CP-654577CP-654577 results in decreased expression of CCND3 protein12907618
C539572CpG-ODN DSP30[CpG-ODN DSP30 co-treated with IL2 protein] results in increased expression of CCND3 protein17805332
C539572CpG-ODN DSP30teriflunomide inhibits the reaction [[CpG-ODN DSP30 co-treated with IL2 protein] results in increased expression of CCND3 protein]17805332
C408982CPG-oligonucleotide4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [CPG-oligonucleotide results in increased expression of CCND3 protein]17209053
C408982CPG-oligonucleotide4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Tretinoin promotes the reaction [CPG-oligonucleotide results in increased expression of CCND3 protein]]17209053
C408982CPG-oligonucleotideCPG-oligonucleotide results in increased expression of CCND3 protein17209053
C408982CPG-oligonucleotideRo 41-5253 inhibits the reaction [Tretinoin promotes the reaction [CPG-oligonucleotide results in increased expression of CCND3 protein]]17209053
C408982CPG-oligonucleotideTretinoin promotes the reaction [CPG-oligonucleotide results in increased expression of CCND3 protein]17209053
C408982CPG-oligonucleotide[Tretinoin results in increased secretion of IL10 protein] promotes the reaction [CPG-oligonucleotide results in increased expression of CCND3 protein]17209053
C408982CPG-oligonucleotideU 0126 inhibits the reaction [CPG-oligonucleotide results in increased expression of CCND3 protein]17209053
D003474CurcuminCurcumin inhibits the reaction [bisphenol A results in increased expression of CCND3 protein]23222814
D003474CurcuminCurcumin results in decreased expression of CCND3 protein23222814
D003513CycloheximideCycloheximide affects the expression of CCND3 mRNA9094091
D003513CycloheximideCycloheximide affects the reaction [Estradiol affects the expression of CCND3 mRNA]9094091
D003520CyclophosphamideCyclophosphamide results in decreased expression of CCND3 mRNA21041162
D016572CyclosporineCyclosporine results in decreased expression of CCND3 mRNA25562108
D003561CytarabineCytarabine results in decreased expression of CCND3 mRNA21198554
D000069439DasatinibDasatinib results in decreased expression of CCND3 protein16740687
D003630DaunorubicinDaunorubicin results in increased expression of CCND3 mRNA12656675
D003676DeferoxamineDeferoxamine results in decreased expression of CCND3 protein11468187
D003907DexamethasoneDexamethasone results in decreased expression of CCND3 mRNA21041162
C539263di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone"di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone affects the expression of CCND3 protein"21750178
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of CCND3 mRNA21266533
D003994BucladesineBucladesine results in increased expression of CCND3 protein16718685
D002945Cisplatin[Cisplatin co-treated with Quercetin] results in increased expression of CCND3 mRNA27514524
D002945CisplatinCisplatin results in increased expression of CCND3 mRNA27392435|2759478
D002945CisplatinCisplatin results in increased expression of CCND3 mRNA21151649
D004008DiclofenacDiclofenac affects the expression of CCND3 mRNA24752500
D004041Dietary FatsDietary Fats results in increased expression of CCND3 mRNA25016146
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of CCND3 mRNA21041162
D004317DoxorubicinDoxorubicin results in increased expression of CCND3 mRNA25896364
D004317Doxorubicin[zoledronic acid co-treated with Doxorubicin] results in decreased expression of CCND3 protein19789217
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in decreased expression of CCND3 protein"15456542
D004785Environmental PollutantsEnvironmental Pollutants affects the expression of CCND3 mRNA19118595
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of CCND3 mRNA12655031
C472787erucylphospho-N,N,N-trimethylpropylammonium"erucylphospho-N,N,N-trimethylpropylammonium results in decreased expression of CCND3"24987858
C472787erucylphospho-N,N,N-trimethylpropylammonium"RB1 mutant form inhibits the reaction [erucylphospho-N,N,N-trimethylpropylammonium results in decreased expression of CCND3]"24987858
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of CCND3 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CCND3 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CCND3 mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of CCND3 mRNA23649840
D000068338EverolimusEverolimus results in decreased expression of CCND3 protein16856892
C540355fenamidonefenamidone results in increased expression of CCND3 mRNA27029645
D005472FluorouracilCCND3 affects the susceptibility to Fluorouracil15067352
D005472FluorouracilCCND3 protein affects the susceptibility to Fluorouracil15548681|1838381
D005472FluorouracilFluorouracil results in increased expression of CCND3 mRNA16709241
D005473FluoxetineFluoxetine results in decreased expression of CCND3 mRNA21497159
D005485FlutamideFlutamide results in increased expression of CCND3 mRNA19299419
D005492Folic AcidFolic Acid results in decreased expression of CCND3 mRNA11723236
D005557FormaldehydeFormaldehyde results in increased expression of CCND3 mRNA23649840
C473894fujiflavone P40fujiflavone P40 results in decreased expression of CCND3 mRNA14656947
C070081fulvestrantfulvestrant inhibits the reaction [Estradiol affects the expression of CCND3 mRNA]9094091
C070081fulvestrantfulvestrant inhibits the reaction [Cadmium Chloride results in increased expression of CCND3 mRNA]24236210
C070081fulvestrantfulvestrant inhibits the reaction [Cadmium results in increased expression of CCND3 mRNA]24236210
D005664FurazolidoneFurazolidone results in increased expression of CCND3 mRNA23112108|2609581
D005664FurazolidoneFurazolidone results in increased expression of CCND3 protein23112108|2609581
D005664FurazolidoneGADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND3 mRNA]26095818
D005664FurazolidoneGADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND3 protein]26095818
D005664FurazolidoneSB 203580 inhibits the reaction [Furazolidone results in increased expression of CCND3 mRNA]23112108
D005664FurazolidoneSB 203580 inhibits the reaction [Furazolidone results in increased expression of CCND3 protein]23112108
C419708gefitinibgefitinib results in decreased expression of CCND3 protein16740687
D006220HaloperidolHaloperidol results in increased expression of CCND3 mRNA15860345
D006588HexanonesHexanones results in decreased expression of CCND3 protein14757120
C479128HS 1200HS 1200 results in decreased expression of CCND3 protein12969788
D006843Hydrocarbons, Chlorinated"Hydrocarbons, Chlorinated results in decreased expression of CCND3 protein"14757120
D006918HydroxyureaHydroxyurea results in increased expression of CCND3 protein11468187
D006997Hypochlorous AcidHypochlorous Acid results in decreased expression of CCND3 mRNA19376150
D000068877Imatinib Mesylate[Imatinib Mesylate co-treated with tetraarsenic tetrasulfide] results in decreased expression of CCND3 mRNA19208803
D000068877Imatinib MesylateImatinib Mesylate results in decreased expression of CCND3 mRNA19208803
D000068877Imatinib MesylateImatinib Mesylate results in decreased expression of CCND3 protein15100154
D000068877Imatinib Mesylate[bosutinib co-treated with Imatinib Mesylate] affects the localization of CCND3 protein17129604
D000068877Imatinib Mesylate[wortmannin co-treated with Imatinib Mesylate] affects the localization of CCND3 protein17129604
D000068877Imatinib MesylateImatinib Mesylate results in decreased expression of CCND3 mRNA21536647
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CCND3 mRNA25613284
C506002ircinin-1ircinin-1 results in decreased expression of CCND3 mRNA16163705
C506002ircinin-1ircinin-1 results in decreased expression of CCND3 protein16163705
D007545IsoproterenolIsoproterenol results in increased expression of CCND3 mRNA20003209
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CCND3 mRNA23086925|2708169
C059021kinamycin Fkinamycin F results in decreased expression of CCND3 mRNA20079721
C059021kinamycin Fkinamycin F results in decreased expression of CCND3 protein20079721
C095104LG 100268LG 100268 results in decreased expression of CCND3 protein15729575
D008148LovastatinLovastatin results in decreased expression of CCND3 protein10502407
C015330lycorinelycorine results in decreased expression of CCND3 mRNA23376478
D058185Magnetite NanoparticlesMagnetite Nanoparticles results in increased expression of CCND3 mRNA25532727
C013598methoxyacetic acid[1-aminomethylphosphonic acid co-treated with methoxyacetic acid] results in decreased expression of CCND3 protein26006246
C030667methylazoxymethanolmethylazoxymethanol results in increased expression of CCND3 mRNA17107856
C005219methyl cellosolvemethyl cellosolve affects the expression of CCND3 mRNA19643169
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of CCND3 mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CCND3 mRNA20061341
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CCND3 protein17760861
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of CCND3 mRNA23649840
D008770MethylnitrosoureaMethylnitrosourea results in increased expression of CCND3 protein18155124
D008777MethyltestosteroneMethyltestosterone results in increased expression of CCND3 mRNA29191790
C568376MT19c compoundMT19c compound results in decreased expression of CCND3 protein21803404
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CCND3 mRNA"15585362
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CCND3 mRNA"25554681
D019888NelfinavirNelfinavir results in decreased expression of CCND3 protein19106637
D009532NickelNickel results in increased expression of CCND3 mRNA24768652|2558310
D009534NiclosamideNiclosamide results in decreased expression of CCND3 mRNA22576131
D010126Ozone[Ozone co-treated with Chlorine] results in decreased expression of CCND3 mRNA18636392
C500026palbociclibpalbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of MEF2D protein]22094256
C500026palbociclibpalbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of RB1 protein]22094256
C500026palbociclibpalbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of RBL2 protein]22094256
C500026palbociclibpalbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of SENP3 protein]22094256
C500026palbociclibpalbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of ZEB1 protein]22094256
C500026palbociclibpalbociclib results in increased expression of CCND3 protein20473330
C500026palbociclib[CDKN2A gene mutant form results in increased expression of CCND3 protein] which results in increased susceptibility to palbociclib24098593
D010269ParaquatParaquat results in decreased expression of CCND3 mRNA17935786
D010278Parathion[Parathion co-treated with Atropine] results in increased expression of CCND3 mRNA17390078
D010278ParathionParathion results in increased expression of CCND3 mRNA17390078|1762232
D010424PentobarbitalPentobarbital results in decreased expression of CCND3 protein19346066
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of CCND3 mRNA18692542
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of CCND3 mRNA19162173
D010656Phenylephrine2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of CCND3 protein]12163013
D010656PhenylephrinePhenylephrine results in increased expression of CCND3 protein12163013
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CCND3 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of CCND3 mRNA26272509
D010852PicrotoxinPicrotoxin results in increased expression of CCND3 mRNA15170462
C060836pioglitazonepioglitazone results in decreased expression of CCND3 protein15729575
C006253pirinixic acidpirinixic acid results in increased expression of CCND3 mRNA18301758|1917653
C006253pirinixic acidpirinixic acid results in increased expression of CCND3 protein19176532
C006253pirinixic acidRXRA protein promotes the reaction [pirinixic acid results in increased expression of CCND3 mRNA]19176532
C006253pirinixic acidRXRA protein promotes the reaction [pirinixic acid results in increased expression of CCND3 protein]19176532
D010894PiroxicamPiroxicam results in decreased expression of CCND3 mRNA21858171
D011192Potassium DichromatePotassium Dichromate results in decreased expression of CCND3 mRNA26348139
D011374ProgesteroneProgesterone results in increased expression of CCND3 mRNA17170212
D011794Quercetin[Cisplatin co-treated with Quercetin] results in increased expression of CCND3 mRNA27514524
D011794QuercetinQuercetin results in decreased expression of CCND3 mRNA14715546
C059514resveratrolresveratrol results in decreased expression of CCND3 protein18089832
C059514resveratrolresveratrol results in decreased expression of CCND3 protein22104698
C084904Ro 41-5253Ro 41-5253 inhibits the reaction [Tretinoin promotes the reaction [CPG-oligonucleotide results in increased expression of CCND3 protein]]17209053
C089730rosiglitazonerosiglitazone results in decreased expression of CCND3 protein15729575
C085746rottlerin[sorafenib co-treated with rottlerin] results in decreased expression of CCND3 protein16959960
C093642SB 203580SB 203580 inhibits the reaction [Furazolidone results in increased expression of CCND3 mRNA]23112108
C093642SB 203580SB 203580 inhibits the reaction [Furazolidone results in increased expression of CCND3 protein]23112108
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of CCND3 mRNA25895662
C440975silybin[silybin co-treated with Arsenic] results in decreased expression of CCND3 protein25868784
D020123Sirolimus[Sirolimus co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [IL2 protein results in increased expression of CCND3 protein]15778701
D020123SirolimusSirolimus inhibits the reaction [IL2 protein results in increased expression of CCND3 mRNA]15778701
D020123SirolimusSirolimus results in decreased expression of CCND3 mRNA15882288
D020123SirolimusSirolimus results in decreased expression of CCND3 protein12393642|1507069
D020123SirolimusSirolimus results in decreased stability of CCND3 mRNA15882288
D020123SirolimusSirolimus inhibits the reaction [KITL protein results in increased expression of CCND3 protein]10849422
C017947sodium arsenitesodium arsenite results in increased expression of CCND3 mRNA20886546|2587980
C017947sodium arsenitesodium arsenite results in decreased expression of CCND3 mRNA11241755
C016104sodium bichromatesodium bichromate results in increased expression of CCND3 mRNA12325037
C471405sorafenib[sorafenib co-treated with rottlerin] results in decreased expression of CCND3 protein16959960
C471405sorafenibsorafenib results in decreased expression of CCND3 protein16959960|1900143
C016766sulforafansulforafan results in increased expression of CCND3 mRNA26833863
D013629TamoxifenTamoxifen affects the expression of CCND3 mRNA17555576
D013629TamoxifenTamoxifen inhibits the reaction [Estradiol affects the expression of CCND3 mRNA]9094091
C527525teriflunomideteriflunomide inhibits the reaction [[CpG-ODN DSP30 co-treated with IL2 protein] results in increased expression of CCND3 protein]17805332
C501413tesaglitazartesaglitazar results in increased expression of CCND3 mRNA21270424
C534735tetraarsenic tetrasulfide[Imatinib Mesylate co-treated with tetraarsenic tetrasulfide] results in decreased expression of CCND3 mRNA19208803
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of CCND3 mRNA26988606
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CCND3 mRNA18343893|2157046
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CCND3 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CCND3 mRNA21041162
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CCND3 mRNA15328365|1794274
D013755Tetradecanoylphorbol Acetate"4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCND3 protein]"12421932
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of CCND3 protein12421932
D013755Tetradecanoylphorbol AcetateTretinoin promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCND3 protein]12421932
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CCND3 mRNA25613284
D013882Thiosemicarbazones[Thiosemicarbazones binds to Copper] which results in decreased expression of CCND3 protein20931265
C475928THRX 165724THRX 165724 results in decreased expression of CCND3 mRNA17537993
C475928THRX 165724THRX 165724 results in decreased expression of CCND3 protein17537993
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of CCND3 mRNA20133372
D024505TocopherolsTocopherols results in decreased expression of CCND3 protein12504091
D014044TolbutamideTolbutamide results in increased expression of CCND3 protein16718685
D014118Toxins, Biological"Toxins, Biological affects the expression of CCND3 mRNA"19682533
D014212Tretinoin4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Tretinoin promotes the reaction [CPG-oligonucleotide results in increased expression of CCND3 protein]]17209053
D014212Tretinoinacetylleucyl-leucyl-norleucinal inhibits the reaction [Tretinoin results in increased degradation of and results in decreased expression of CCND3 protein]16024653
D014212Tretinoin"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Tretinoin results in increased expression of CCND3 protein]"16920920
D014212TretinoinRo 41-5253 inhibits the reaction [Tretinoin promotes the reaction [CPG-oligonucleotide results in increased expression of CCND3 protein]]17209053
D014212TretinoinTretinoin promotes the reaction [CPG-oligonucleotide results in increased expression of CCND3 protein]17209053
D014212TretinoinTretinoin promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCND3 protein]12421932
D014212TretinoinTretinoin results in decreased expression of CCND3 mRNA16024653
D014212TretinoinTretinoin results in increased degradation of and results in decreased expression of CCND3 protein16024653
D014212TretinoinTretinoin results in increased expression of CCND3 mRNA16920920
D014212TretinoinTretinoin results in increased expression of CCND3 protein16920920|2050731
D014212Tretinoin[Tretinoin results in increased secretion of IL10 protein] promotes the reaction [CPG-oligonucleotide results in increased expression of CCND3 protein]17209053
D014212TretinoinTretinoin results in decreased expression of CCND3 mRNA16604517
D014212TretinoinTretinoin inhibits the reaction [FGF2 protein results in increased expression of CCND3 mRNA]11675954
D014212TretinoinTretinoin results in decreased expression of CCND3 protein11675954
D014241TrichloroethylenePPARA protein inhibits the reaction [Trichloroethylene results in increased expression of CCND3 protein]15363585
D014241TrichloroethyleneTrichloroethylene results in increased expression of CCND3 mRNA15363585
C012589trichostatin Atrichostatin A results in increased expression of and results in increased stability of CCND3 protein15179185
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of CCND3 mRNA"26179874
C057693troglitazoneAspirin promotes the reaction [troglitazone results in decreased expression of CCND3 protein]19908241
C057693troglitazonetroglitazone promotes the reaction [Aspirin results in decreased expression of CCND3 protein]19908241
C057693troglitazonetroglitazone results in decreased expression of CCND3 protein15729575|1990824
C046243tryptanthrinetryptanthrine results in decreased expression of CCND3 protein23500671
C113580U 0126U 0126 inhibits the reaction [CPG-oligonucleotide results in increased expression of CCND3 protein]17209053
C113580U 0126U 0126 results in decreased expression of CCND3 protein14757120
D014520UrethaneUrethane results in increased expression of CCND3 mRNA28818685
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in decreased expression of CCND3 protein17461466
C005466ursolic acidursolic acid results in decreased expression of CCND3 protein24802810
C073339usnic acidusnic acid results in decreased expression of CCND3 protein27369375
D014635Valproic AcidValproic Acid results in decreased expression of CCND3 mRNA22580532
D014635Valproic AcidValproic Acid results in increased expression of CCND3 mRNA29154799
C025643vinclozolinvinclozolin affects the expression of CCND3 mRNA19015723
D014810Vitamin EVitamin E affects the expression of CCND3 mRNA15370891
C009687wortmanninwortmannin affects the localization of CCND3 protein17129604
C009687wortmannin[wortmannin co-treated with Imatinib Mesylate] affects the localization of CCND3 protein17129604
C009687wortmanninwortmannin inhibits the reaction [KITL protein results in increased expression of CCND3 protein]10849422
D015039ZiramZiram results in decreased expression of CCND3 mRNA28973382
C088658zoledronic acid[zoledronic acid co-treated with Doxorubicin] results in decreased expression of CCND3 protein19789217
C088658zoledronic acidzoledronic acid results in decreased expression of CCND3 protein19789217

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004672protein kinase activityCONTRIBUTES_TOIBA21873635  
GO:0004693cyclin-dependent protein serine/threonine kinase activity-IEA-  
GO:0005515protein binding-IPI9106657  9311810  11896535  14641107  15232106  15327989  
16189514  16721056  17517622  19237555  21516116  21988832  
23455922  23602568  25241761  25416956  25910212  26496610  
27107012  
GO:0016538cyclin-dependent protein serine/threonine kinase regulator activity-IBA21873635  
GO:0019901protein kinase binding-IBA21873635  
GO:0019901protein kinase binding-IPI8114739  
GO ID GO Term Qualifier Evidence PubMed
GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity-IBA21873635  
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0000278mitotic cell cycle-IBA21873635  
GO:0001934positive regulation of protein phosphorylation-IDA8114739  
GO:0007049cell cycle-IEA-  
GO:0007088regulation of mitotic nuclear division-IBA21873635  
GO:0007165signal transduction-IEA-  
GO:0008284positive regulation of cell proliferation-IBA21873635  
GO:0042098T cell proliferation-IEA-  
GO:0042127regulation of cell proliferation-IEA-  
GO:0045737positive regulation of cyclin-dependent protein serine/threonine kinase activity-IDA8114739  
GO:0045787positive regulation of cell cycle-IBA21873635  
GO:0046626regulation of insulin receptor signaling pathway-IEA-  
GO:0051301cell division-IEA-  
GO:1900087positive regulation of G1/S transition of mitotic cell cycle-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000307cyclin-dependent protein kinase holoenzyme complex-IBA21873635  
GO:0000307cyclin-dependent protein kinase holoenzyme complex-IDA8114739  
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IEA-  
GO:0016020membrane-IEA-  
KEGG ID KEGG Term
hsa04110Cell cycle
hsa04115p53 signaling pathway
hsa04310Wnt signaling pathway
hsa04510Focal adhesion
hsa04630Jak-STAT signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1640170Cell CycleTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-381340Transcriptional regulation of white adipocyte differentiationTAS
R-HSA-453279Mitotic G1-G1/S phasesTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5687128MAPK6/MAPK4 signalingTAS
R-HSA-69231Cyclin D associated events in G1TAS
R-HSA-69236G1 PhaseTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8878171Transcriptional regulation by RUNX1TAS
R-HSA-8934593Regulation of RUNX1 Expression and ActivityTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29133146Association of genetic polymorphisms with erythrocyte traits: Verification of SNPs reported in a previous GWAS in a Japanese population. (2018 Feb 5)Seiki TGene
28240520Roles of Signal Transducer Pathways in Investigation of Biopsies from Patients with Bladder Tumors (2017 Jan 1)Bayrak AAsian Pac J Cancer Prev
26318107SASH1, a new potential link between smoking and atherosclerosis. (2015 Oct)Weidmann HAtherosclerosis