Gene info: ID 8972

Gene: MGAM

GENE ID: 8972

Synonyms: MG|MGA

Description: maltase-glucoamylase

Gene type: protein-coding

Location: 7q34

dbXrefs: Ensembl:ENSG00000257335 MIM:154360 Vega:OTTHUMG00000158395 UniprotKB:O43451

RefSeq: NG_033954.1

Retrived from: SNP Mapped

SNPs: 3 ANCO-SNPs

Phenotype: ND|AD

# Publications: 0

Sherlock p-value : 3.396e-1 (AD) 1.928e-1 (ND) (Frontal_Cortex)

Pascal p-value : 3.553e-1 (AD) 6.740e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs4276595	chr7:142065905 (GRCh38.p7)	T>C	nicotine dependence	SNV(Single Nucleotide Variation)
rs2204607	chr7:142009894 (GRCh38.p7)	C>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs6947481	chr7:141993008 (GRCh38.p7)	T>G	nicotine dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CXCR1	0.77
FCGR3B	0.749
CXCR2	0.747
NFE2	0.739
VNN2	0.738
PROK2	0.722
S100A12	0.714
IL18RAP	0.709
MMP9	0.706
MMP25	0.703

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MAGIX	-0.499
CORT	-0.495
BCL11A	-0.481
NNAT	-0.479
MARCH4	-0.466
DLK2	-0.456
HAS1	-0.456
CDK5R2	-0.455
FBLN7	-0.453
SVOP	-0.452

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00284	Acarbose	Small Molecule	56180-94-0	Approved\|Investigational	Target
DB00491	Miglitol	Small Molecule	72432-03-2	Approved	Target
DB04878	Voglibose	Small Molecule	83480-29-9	Approved\|Investigational	Target
DB00284	Acarbose	Small Molecule	56180-94-0	Approved\|Investigational	Target
DB00747	Scopolamine	Small Molecule	51-34-3	Approved\|Investigational	Target
DB01050	Ibuprofen	Small Molecule	15687-27-1	Approved	Target
DB09213	Dexibuprofen	Small Molecule	51146-56-6	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of MGAM mRNA"	25614096
D020909	Acarbose	Acarbose results in decreased activity of MGAM protein	20349118
D020909	Acarbose	Acarbose results in decreased activity of MGAM protein	17585022
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of MGAM mRNA	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of MGAM mRNA	19770486
D000393	Air Pollutants	Air Pollutants analog results in decreased expression of MGAM mRNA	21757418
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of MGAM mRNA	24449571
C487081	belinostat	belinostat results in decreased expression of MGAM mRNA	27188386
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of MGAM mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of MGAM mRNA	22178795
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of MGAM mRNA	19770486
C006780	bisphenol A	bisphenol A results in increased expression of MGAM mRNA	29275510
C006780	bisphenol A	bisphenol A results in decreased expression of MGAM mRNA	26063408
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of MGAM mRNA	26472689
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of MGAM mRNA	26314618
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of MGAM mRNA	23741332
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of MGAM mRNA	27339419
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of MGAM mRNA	20938992
C074702	chromium hexavalent ion	chromium hexavalent ion affects the expression of MGAM mRNA	28472532
D002994	Clofibrate	Clofibrate results in decreased expression of MGAM mRNA	23811191
D002994	Clofibrate	Clofibrate results in decreased expression of MGAM mRNA	22300585
D016572	Cyclosporine	Cyclosporine results in decreased expression of MGAM mRNA	27989131
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of MGAM mRNA	21266533
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of MGAM mRNA	27392435
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate results in decreased expression of MGAM mRNA	26924002
C024629	dimethyl phthalate	dimethyl phthalate results in decreased expression of MGAM mRNA	26924002
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of MGAM mRNA	20938992
D005947	Glucose	[MGAM protein results in increased metabolism of maltodextrin] which results in increased abundance of Glucose	17585022
D005947	Glucose	[MGAM protein results in increased metabolism of Maltose] which results in increased abundance of Glucose	17585022
D017313	Fenretinide	Fenretinide results in increased expression of MGAM mRNA	28973697
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of MGAM mRNA	27392435
C544151	jinfukang	jinfukang results in decreased expression of MGAM mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of MGAM mRNA	27432991
C008315	maltodextrin	MGAM protein results in increased metabolism of maltodextrin	17585022
C008315	maltodextrin	[MGAM protein results in increased metabolism of maltodextrin] which results in increased abundance of Glucose	17585022
D008320	Maltose	MGAM protein results in increased metabolism of Maltose	17585022
D008320	Maltose	[MGAM protein results in increased metabolism of Maltose] which results in increased abundance of Glucose	17585022
C009819	maltotetraose	MGAM protein results in increased metabolism of maltotetraose	22803678
C009819	maltotetraose	nimbidiol inhibits the reaction [MGAM protein results in increased metabolism of maltotetraose]	22803678
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of MGAM mRNA	20938992
C517284	monomethyl phthalate	monomethyl phthalate results in decreased expression of MGAM mRNA	26924002
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of MGAM mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of MGAM mRNA"	25620056
C496111	nimbidiol	nimbidiol inhibits the reaction [MGAM protein results in increased metabolism of maltotetraose]	22803678
C496111	nimbidiol	nimbidiol results in decreased activity of MGAM protein	22803678
C572573	N-nitroso-tris-chloroethylurea	[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of MGAM mRNA	27935865
C572573	N-nitroso-tris-chloroethylurea	[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of MGAM mRNA	27935865
C060836	pioglitazone	[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of MGAM mRNA	27935865
C550268	ponkoranol	ponkoranol analog results in decreased activity of MGAM protein	20801033
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of MGAM mRNA	23608068
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of MGAM mRNA	28903501
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of MGAM mRNA	25895662
D013213	Starch	MGAM protein results in increased metabolism of Starch	17585022
D013452	Sulfonium Compounds	Sulfonium Compounds results in decreased activity of MGAM protein	17316580
C016766	sulforafan	sulforafan results in increased expression of MGAM mRNA	26833863
C009495	titanium dioxide	titanium dioxide results in increased expression of MGAM mRNA	23557971
D014520	Urethane	Urethane results in increased expression of MGAM mRNA	28818685
D014635	Valproic Acid	Valproic Acid results in decreased expression of MGAM mRNA	29154799
D014638	Vanadates	Vanadates results in increased expression of MGAM mRNA	22714537
D014640	Vancomycin	Vancomycin results in increased expression of MGAM mRNA	18930951
C581157	XL147	[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of MGAM mRNA	27935865

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003824	catalytic activity	-	TAS	9446624
GO:0004339	glucan 1,4-alpha-glucosidase activity	-	IEA	-
GO:0004558	alpha-1,4-glucosidase activity	-	TAS	-
GO:0016160	amylase activity	-	IEA	-
GO:0030246	carbohydrate binding	-	IEA	-
GO:0032450	maltose alpha-glucosidase activity	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000023	maltose metabolic process	-	IEA	-
GO:0005983	starch catabolic process	-	TAS	9446624
GO:0043312	neutrophil degranulation	-	TAS	-
GO:0044245	polysaccharide digestion	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005886	plasma membrane	-	TAS	-
GO:0016021	integral component of membrane	-	IEA	-
GO:0016324	apical plasma membrane	-	IEA	-
GO:0070062	extracellular exosome	-	HDA	23533145
GO:0070821	tertiary granule membrane	-	TAS	-
GO:0101003	ficolin-1-rich granule membrane	-	TAS	-

KEGG ID	KEGG Term
hsa00052	Galactose metabolism
hsa00500	Starch and sucrose metabolism
hsa01100	Metabolic pathways
hsa04973	Carbohydrate digestion and absorption

Reactome ID	Reactome Term	Evidence
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-189085	Digestion of dietary carbohydrate	TAS
R-HSA-6798695	Neutrophil degranulation	TAS
R-HSA-8935690	Digestion	TAS
R-HSA-8963743	Digestion and absorption	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal