Gene: MGAM

8972
MG|MGA
maltase-glucoamylase
protein-coding
7q34
Ensembl:ENSG00000257335 MIM:154360 Vega:OTTHUMG00000158395 UniprotKB:O43451
NG_033954.1
SNP Mapped
ND|AD
0   
3.396e-1 (AD)  1.928e-1 (ND)   (Frontal_Cortex)
3.553e-1 (AD)  6.740e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4276595chr7:142065905 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)
rs2204607chr7:142009894 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs6947481chr7:141993008 (GRCh38.p7)T>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CXCR10.77
FCGR3B0.749
CXCR20.747
NFE20.739
VNN20.738
PROK20.722
S100A120.714
IL18RAP0.709
MMP90.706
MMP250.703

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAGIX-0.499
CORT-0.495
BCL11A-0.481
NNAT-0.479
MARCH4-0.466
DLK2-0.456
HAS1-0.456
CDK5R2-0.455
FBLN7-0.453
SVOP-0.452

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00284AcarboseSmall Molecule56180-94-0Approved|InvestigationalTarget
DB00491MiglitolSmall Molecule72432-03-2ApprovedTarget
DB04878VogliboseSmall Molecule83480-29-9Approved|InvestigationalTarget
DB00284AcarboseSmall Molecule56180-94-0Approved|InvestigationalTarget
DB00747ScopolamineSmall Molecule51-34-3Approved|InvestigationalTarget
DB01050IbuprofenSmall Molecule15687-27-1ApprovedTarget
DB09213DexibuprofenSmall Molecule51146-56-6Approved|InvestigationalTarget
ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of MGAM mRNA"25614096
D020909AcarboseAcarbose results in decreased activity of MGAM protein20349118
D020909AcarboseAcarbose results in decreased activity of MGAM protein17585022
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MGAM mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of MGAM mRNA19770486
D000393Air PollutantsAir Pollutants analog results in decreased expression of MGAM mRNA21757418
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of MGAM mRNA24449571
C487081belinostatbelinostat results in decreased expression of MGAM mRNA27188386
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of MGAM mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MGAM mRNA22178795
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MGAM mRNA19770486
C006780bisphenol Abisphenol A results in increased expression of MGAM mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of MGAM mRNA26063408
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of MGAM mRNA26472689
D019256Cadmium ChlorideCadmium Chloride results in increased expression of MGAM mRNA26314618
D019256Cadmium ChlorideCadmium Chloride results in increased expression of MGAM mRNA23741332
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of MGAM mRNA27339419
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of MGAM mRNA20938992
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of MGAM mRNA28472532
D002994ClofibrateClofibrate results in decreased expression of MGAM mRNA23811191
D002994ClofibrateClofibrate results in decreased expression of MGAM mRNA22300585
D016572CyclosporineCyclosporine results in decreased expression of MGAM mRNA27989131
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of MGAM mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of MGAM mRNA27392435
C036042dicyclohexyl phthalatedicyclohexyl phthalate results in decreased expression of MGAM mRNA26924002
C024629dimethyl phthalatedimethyl phthalate results in decreased expression of MGAM mRNA26924002
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of MGAM mRNA20938992
D005947Glucose[MGAM protein results in increased metabolism of maltodextrin] which results in increased abundance of Glucose17585022
D005947Glucose[MGAM protein results in increased metabolism of Maltose] which results in increased abundance of Glucose17585022
D017313FenretinideFenretinide results in increased expression of MGAM mRNA28973697
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of MGAM mRNA27392435
C544151jinfukangjinfukang results in decreased expression of MGAM mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of MGAM mRNA27432991
C008315maltodextrinMGAM protein results in increased metabolism of maltodextrin17585022
C008315maltodextrin[MGAM protein results in increased metabolism of maltodextrin] which results in increased abundance of Glucose17585022
D008320MaltoseMGAM protein results in increased metabolism of Maltose17585022
D008320Maltose[MGAM protein results in increased metabolism of Maltose] which results in increased abundance of Glucose17585022
C009819maltotetraoseMGAM protein results in increased metabolism of maltotetraose22803678
C009819maltotetraosenimbidiol inhibits the reaction [MGAM protein results in increased metabolism of maltotetraose]22803678
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of MGAM mRNA20938992
C517284monomethyl phthalatemonomethyl phthalate results in decreased expression of MGAM mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of MGAM mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of MGAM mRNA"25620056
C496111nimbidiolnimbidiol inhibits the reaction [MGAM protein results in increased metabolism of maltotetraose]22803678
C496111nimbidiolnimbidiol results in decreased activity of MGAM protein22803678
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of MGAM mRNA27935865
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of MGAM mRNA27935865
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of MGAM mRNA27935865
C550268ponkoranolponkoranol analog results in decreased activity of MGAM protein20801033
D011192Potassium DichromatePotassium Dichromate results in increased expression of MGAM mRNA23608068
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of MGAM mRNA28903501
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of MGAM mRNA25895662
D013213StarchMGAM protein results in increased metabolism of Starch17585022
D013452Sulfonium CompoundsSulfonium Compounds results in decreased activity of MGAM protein17316580
C016766sulforafansulforafan results in increased expression of MGAM mRNA26833863
C009495titanium dioxidetitanium dioxide results in increased expression of MGAM mRNA23557971
D014520UrethaneUrethane results in increased expression of MGAM mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of MGAM mRNA29154799
D014638VanadatesVanadates results in increased expression of MGAM mRNA22714537
D014640VancomycinVancomycin results in increased expression of MGAM mRNA18930951
C581157XL147[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of MGAM mRNA27935865

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003824catalytic activity-TAS9446624  
GO:0004339glucan 1,4-alpha-glucosidase activity-IEA-  
GO:0004558alpha-1,4-glucosidase activity-TAS-  
GO:0016160amylase activity-IEA-  
GO:0030246carbohydrate binding-IEA-  
GO:0032450maltose alpha-glucosidase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000023maltose metabolic process-IEA-  
GO:0005983starch catabolic process-TAS9446624  
GO:0043312neutrophil degranulation-TAS-  
GO:0044245polysaccharide digestion-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
GO:0016324apical plasma membrane-IEA-  
GO:0070062extracellular exosome-HDA23533145  
GO:0070821tertiary granule membrane-TAS-  
GO:0101003ficolin-1-rich granule membrane-TAS-  
KEGG ID KEGG Term
hsa00052Galactose metabolism
hsa00500Starch and sucrose metabolism
hsa01100Metabolic pathways
hsa04973Carbohydrate digestion and absorption
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-189085Digestion of dietary carbohydrateTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-8935690DigestionTAS
R-HSA-8963743Digestion and absorptionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal