Gene: CHRNA6

8973
CHNRA6
cholinergic receptor nicotinic alpha 6 subunit
protein-coding
8p11.21
Ensembl:ENSG00000147434 MIM:606888 Vega:OTTHUMG00000165275 UniprotKB:Q15825
NC_000008.11
PubMed
0   ANCO-SNPs
CD|ND|AD
25   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.295e-1 (AD)  1.822e-4 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IGF10.797
RELN0.79
SP80.788
NDNF0.763
NPR30.736
SSTR40.732
PTHLH0.726
VIP0.725
SLC10A40.72
PDGFD0.718

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AQP1-0.494
KIF19-0.467
NRN1L-0.433
GNG8-0.43
ROM1-0.415
FAM107B-0.414
TGFB3-0.414
BCAS1-0.41
AZGP1-0.409
RHBDL2-0.407

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00184NicotineSmall Molecule54-11-5ApprovedTarget
DB00674GalantamineSmall Molecule357-70-0ApprovedTarget
DB00898EthanolSmall Molecule64-17-5ApprovedTarget
DB01273VareniclineSmall Molecule249296-44-4Approved|InvestigationalTarget
DB09028CytisineSmall Molecule485-35-8Approved|InvestigationalTarget
ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CHRNA6 mRNA"19114083
D000082AcetaminophenAcetaminophen results in decreased expression of CHRNA6 mRNA22230336
C098872alpha-conotoxin MIIalpha-conotoxin MII binds to and results in decreased activity of CHRNA6 protein19644040
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CHRNA6 mRNA16483693
C006632arsenic trioxidearsenic trioxide results in decreased expression of CHRNA6 mRNA27829220
C006632arsenic trioxidearsenic trioxide results in increased expression of CHRNA6 mRNA20458559
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CHRNA6 mRNA15034205
D004958EstradiolEstradiol affects the expression of CHRNA6 mRNA23557687
C006780bisphenol Abisphenol A affects the expression of CHRNA6 mRNA21786754|2355768
C006780bisphenol Abisphenol A results in decreased expression of CHRNA6 mRNA25181051
D004390ChlorpyrifosChlorpyrifos affects the expression of CHRNA6 mRNA18977431
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of CHRNA6 mRNA21266533
D004041Dietary FatsDietary Fats results in increased expression of CHRNA6 mRNA25016146
D004298DopamineNicotine inhibits the reaction [[CHRNA6 protein binds to CHRNB2 protein] which results in increased secretion of Dopamine]17227438
D004298Dopamine[pozanicline binds to and results in increased activity of [CHRNA6 protein binds to CHRNB2 protein]] which results in increased secretion of Dopamine19481067
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of CHRNA6 mRNA23649840
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of CHRNA6 gene16495775
D005557FormaldehydeFormaldehyde results in increased expression of CHRNA6 mRNA23649840
D005557FormaldehydeFormaldehyde results in decreased expression of CHRNA6 mRNA12679049
C039281furanfuran results in increased methylation of CHRNA6 gene22079235
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CHRNA6 mRNA21385734
D008743Methyl ParathionMethyl Parathion results in increased expression of CHRNA6 mRNA18977431
D008774MethylphenidateMethylphenidate results in decreased expression of CHRNA6 mRNA22470460
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CHRNA6 protein"19594327
C500085muraglitazarmuraglitazar results in decreased expression of CHRNA6 mRNA21515302
D009538NicotineNicotine results in decreased expression of CHRNA6 mRNA12628473
D009538NicotineCHRNA6 gene polymorphism affects the susceptibility to Nicotine10734154
D009538NicotineNicotine inhibits the reaction [[CHRNA6 protein binds to CHRNB2 protein] which results in increased secretion of Dopamine]17227438
D009538NicotineNicotine inhibits the reaction [Paraquat results in decreased expression of [CHRNA6 protein binds to CHRNB2 protein]]17227438
D010269ParaquatNicotine inhibits the reaction [Paraquat results in decreased expression of [CHRNA6 protein binds to CHRNB2 protein]]17227438
D010269ParaquatParaquat results in decreased expression of [CHRNA6 protein binds to CHRNB2 protein]17227438
D010269ParaquatParaquat affects the expression of CHRNA6 mRNA18198484
C108326pozanicline[CHRNA6 protein binds to CHRNB2 protein] which affects the susceptibility to pozanicline19481067
C108326pozaniclinepozanicline binds to and results in increased activity of [CHRNA6 protein binds to CHRNB2 protein]19481067
C108326pozanicline[pozanicline binds to and results in increased activity of [CHRNA6 protein binds to CHRNB2 protein]] which results in increased secretion of Dopamine19481067
C108326pozanicline[pozanicline binds to CHRNB2 protein] results in increased activity of [CHRNA6 protein binds to CHRNB2 protein]19481067
C089730rosiglitazonerosiglitazone results in decreased expression of CHRNA6 mRNA21515302
D012834SilverSilver results in increased expression of CHRNA6 mRNA27131904
C501413tesaglitazartesaglitazar results in decreased expression of CHRNA6 mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CHRNA6 mRNA15034205
C040533trimethyltin chloridetrimethyltin chloride results in decreased expression of CHRNA6 mRNA23000284
C057693troglitazonetroglitazone results in decreased expression of CHRNA6 mRNA21515302
D014635Valproic AcidValproic Acid results in decreased methylation of CHRNA6 gene29154799
D000068580VareniclineVarenicline binds to and results in increased activity of CHRNA6 protein16766716

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005230extracellular ligand-gated ion channel activityCONTRIBUTES_TOIBA21873635  
GO:0005515protein binding-IPI27344019  
GO:0015276ligand-gated ion channel activity-TAS-  
GO:0015464acetylcholine receptor activityCONTRIBUTES_TOIBA21873635  
GO:0015464acetylcholine receptor activity-TAS8906617  
GO:0042166acetylcholine bindingCONTRIBUTES_TOIBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-IBA21873635  
GO:0007165signal transduction-TAS8906617  
GO:0007268chemical synaptic transmission-IBA21873635  
GO:0007268chemical synaptic transmission-TAS8906617  
GO:0007271synaptic transmission, cholinergic-IBA21873635  
GO:0007274neuromuscular synaptic transmission-IBA21873635  
GO:0014059regulation of dopamine secretion-IEA-  
GO:0034220ion transmembrane transport-IBA21873635  
GO:0035094response to nicotine-IBA21873635  
GO:0042391regulation of membrane potential-IBA21873635  
GO:0050877nervous system process-IBA21873635  
GO:0051899membrane depolarization-IEA-  
GO:0060079excitatory postsynaptic potential-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005892acetylcholine-gated channel complex-IBA21873635  
GO:0030054cell junction-IEA-  
GO:0043005neuron projection-IBA21873635  
GO:0045202synapse-IBA21873635  
GO:0045211postsynaptic membrane-IEA-  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-181431Acetylcholine binding and downstream eventsTAS
R-HSA-622323Presynaptic nicotinic acetylcholine receptorsTAS
R-HSA-622327Postsynaptic nicotinic acetylcholine receptorsTAS
R-HSA-629594Highly calcium permeable postsynaptic nicotinic acetylcholine receptorsTAS
R-HSA-629597Highly calcium permeable nicotinic acetylcholine receptorsTAS
R-HSA-629602Activation of Nicotinic Acetylcholine ReceptorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28851948Significant association of the CHRNB3-CHRNA6 gene cluster with nicotine dependence in the Chinese Han population. (2017 Aug 29)Wen LSci Rep
24804708Functional characterization improves associations between rare non-synonymous variants in CHRNB4 and smoking behavior. (2014)Haller GPLoS One
24401102Multiple distinct CHRNB3-CHRNA6 variants are genetic risk factors for nicotine dependence in African Americans and European Americans. (2014 May)Culverhouse RCAddiction
24057674Rare missense variants in CHRNB3 and CHRNA3 are associated with risk of alcohol and cocaine dependence. (2014 Feb 1)Haller GHum Mol Genet
22042774Rare missense variants in CHRNB4 are associated with reduced risk of nicotine dependence. (2012 Feb 1)Haller GHum Mol Genet
24479813ANKS1B is a smoking-related molecular alteration in clear cell renal cell carcinoma. (2014 Jan 31)Eckel-Passow JEBMC Urol
23899432Nicotinic receptor gene variants interact with attention deficient hyperactive disorder symptoms to predict smoking trajectories from early adolescence to adulthood. (2013 Nov)Lee CTAddict Behav
24792900Combined effect between CHRNB3-CHRNA6 region gene variant (rs6474412) and smoking in psoriasis vulgaris severity. (2014 Jul 10)Zhu KJGene
21498873Associations of nicotine intake measures with CHRN genes in Finnish smokers. (2011 Aug)Keskitalo-Vuokko KNicotine Tob Res
27327258Crucial roles of the CHRNB3-CHRNA6 gene cluster on chromosome 8 in nicotine dependence: update and subjects for future research. (2016 Jun 21)Wen LTransl Psychiatry
24253422Significant associations of CHRNA2 and CHRNA6 with nicotine dependence in European American and African American populations. (2014 May)Wang SHum Genet
19698703Association of nAChR gene haplotypes with heavy alcohol use and body mass. (2009 Dec 11)Landgren SBrain Res
23811312Nicotinic acetylcholine receptors containing the alpha6 subunit contribute to ethanol activation of ventral tegmental area dopaminergic neurons. (2013 Oct 15)Liu LBiochem Pharmacol
25823894A genetic variant in CHRNB3-CHRNA6 increases risk of esophageal squamous cell carcinoma in Chinese populations. (2015 May)Song YCarcinogenesis
20854418CHRNB2 promoter region: association with subjective effects to nicotine and gene expression differences. (2011 Mar)Hoft NRGenes Brain Behav
26184988Effect of genetic variation in the nicotinic receptor genes on risk for posttraumatic stress disorder. (2015 Sep 30)Kimbrel NAPsychiatry Res
24119711The association between CHRN genetic variants and dizziness at first inhalation of cigarette smoke. (2014 Jan)Pedneault MAddict Behav
19564872Differential contribution of genetic variation in multiple brain nicotinic cholinergic receptors to nicotine dependence: recent progress and emerging open questions. (2009 Oct)Greenbaum LMol Psychiatry
25233467Role of nicotine dependence on the relationship between variants in the nicotinic receptor genes and risk of lung adenocarcinoma. (2014)Tseng TSPLoS One
24451080Molecular profiles of non-small cell lung cancers in cigarette smoking and never-smoking patients. (2013)Szymanowska-Narloch AAdv Med Sci
20584212Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans. (2010 Oct)Saccone NLGenes Brain Behav
19500157SNPs in CHRNA6 and CHRNB3 are associated with alcohol consumption in a nationally representative sample. (2009 Aug)Hoft NRGenes Brain Behav
21191315Genetic association of bipolar disorder with the beta(3) nicotinic receptor subunit gene. (2011 Apr)Hartz SMPsychiatr Genet
21831805[Human chromosome 8p11 (CHRNB3-CHRNA6) region gene polymorphisms and susceptibility to lung cancer in Chinese Han population]. (2011 Aug)Zhang XBYi Chuan
26283763Deep Sequencing of Three Loci Implicated in Large-Scale Genome-Wide Association Study Smoking Meta-Analyses. (2016 May)Clark SLNicotine Tob Res