Gene: P4HA2

8974
MYP25
prolyl 4-hydroxylase subunit alpha 2
protein-coding
5q31.1
Ensembl:ENSG00000072682 MIM:600608 Vega:OTTHUMG00000059647 UniprotKB:O15460
NG_052887.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.176e-1 (AD)  5.177e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CHORDC10.878
JMJD60.871
BANP0.847
FKBP40.825
STIP10.823
ZNF4730.796
DEDD20.786
CCDC1170.781
RCC10.779
TDRG10.775

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ALDH1L1-AS2-0.446
CCT6B-0.422
SOX3-0.403
HPDL-0.393
SNX22-0.393
HES5-0.39
PDE11A-0.371
TTC16-0.366
RMDN1-0.362
PON1-0.361

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00139Succinic acidSmall Molecule110-15-6Approved|NutraceuticalTarget
DB00172L-ProlineSmall Molecule147-85-3Approved|NutraceuticalTarget
ID Drug Name Action PubMed
C0252051,10-phenanthroline"1,10-phenanthroline results in increased expression of P4HA2 mRNA"19502547
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of P4HA2 mRNA28329830
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of P4HA2 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of P4HA2 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of P4HA2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of P4HA2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of P4HA2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of P4HA2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of P4HA2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of P4HA2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of P4HA2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of P4HA2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of P4HA2 mRNA22230336|2906747
D000082AcetaminophenAcetaminophen affects the expression of P4HA2 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of P4HA2 mRNA21641981
D001205Ascorbic AcidAscorbic Acid results in decreased expression of P4HA2 mRNA19197388
D001280AtrazineAtrazine results in increased expression of P4HA2 mRNA22378314
C547126AZM551248AZM551248 results in increased expression of P4HA2 mRNA22323515
D001507BeclomethasoneBeclomethasone results in increased expression of P4HA2 mRNA23656298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of P4HA2 mRNA22316170
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of P4HA2 mRNA19619570
D004958EstradiolEstradiol results in increased expression of P4HA2 mRNA19619570
C006780bisphenol Abisphenol A affects the expression of P4HA2 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of P4HA2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of P4HA2 gene28505145
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of P4HA2 mRNA26472689
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of P4HA2 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of P4HA2 mRNA27339419
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of P4HA2 mRNA20938992
D007464ClioquinolClioquinol results in decreased expression of P4HA2 mRNA19502547
C018021cobaltous chloridecobaltous chloride results in increased expression of P4HA2 mRNA19320972|1937684
C018021cobaltous chloridezinc chloride inhibits the reaction [cobaltous chloride results in increased expression of P4HA2 mRNA]22202117
C018021cobaltous chloridecobaltous chloride results in increased expression of P4HA2 mRNA24386269
D016572CyclosporineCyclosporine results in increased expression of P4HA2 mRNA20106945|2556210
D003561CytarabineCytarabine results in decreased expression of P4HA2 mRNA21198554
C014347decitabinedecitabine affects the expression of P4HA2 mRNA23300844
C014347decitabinedecitabine results in increased expression of P4HA2 mRNA19194470
D003907DexamethasoneDexamethasone results in decreased expression of P4HA2 mRNA25047013
D002945CisplatinCisplatin affects the expression of P4HA2 mRNA23300844
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of P4HA2 mRNA27392435
D002945CisplatinCisplatin results in increased expression of P4HA2 mRNA27392435
D002945CisplatinP4HA2 protein results in decreased susceptibility to Cisplatin16734730
D004008DiclofenacDiclofenac results in increased expression of P4HA2 mRNA17379860
D004041Dietary FatsDietary Fats results in decreased expression of P4HA2 mRNA18042831
C118739entinostatentinostat results in increased expression of P4HA2 mRNA26272509|2718838
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of P4HA2 mRNA"27188386
D000431EthanolEthanol results in increased expression of P4HA2 mRNA28986285
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of P4HA2 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of P4HA2 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of P4HA2 mRNA17942748
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of P4HA2 mRNA28329830
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of P4HA2 mRNA20938992
C492448ICG 001ICG 001 results in increased expression of P4HA2 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of P4HA2 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of P4HA2 mRNA27392435
C544151jinfukangjinfukang results in increased expression of P4HA2 mRNA27392435
D007854LeadLead affects the expression of P4HA2 mRNA28903495
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of P4HA2 mRNA"24972896
D008694Methamphetamine[Methamphetamine co-treated with SCH 23390] results in increased expression of P4HA2 mRNA19564919
D008694MethamphetamineMethamphetamine results in increased expression of P4HA2 mRNA19564919
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of P4HA2 mRNA20938992
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of P4HA2 mRNA"26251327
D008777MethyltestosteroneMethyltestosterone results in increased expression of P4HA2 mRNA29191790
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of P4HA2 mRNA"25554681
C022838nickel chlorideHIF1A affects the reaction [nickel chloride results in increased expression of P4HA2 mRNA]12426141|1272925
C022838nickel chloridenickel chloride results in increased expression of P4HA2 mRNA12426141|1272925
C022838nickel chloridenickel chloride affects the expression of P4HA2 mRNA22110744
C017557nickel subsulfidenickel subsulfide affects the expression of P4HA2 mRNA12729255
C029938nickel sulfatenickel sulfate results in increased expression of P4HA2 mRNA17382205
C558013NSC 689534NSC 689534 results in increased expression of P4HA2 mRNA20971185
C030110oxaliplatinoxaliplatin results in decreased expression of P4HA2 mRNA17762391
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of P4HA2 mRNA25729387
D010100OxygenHIF1A mutant form inhibits the reaction [Oxygen deficiency results in increased expression of P4HA2 mRNA]23423382
D010100OxygenOxygen deficiency results in increased expression of P4HA2 mRNA19502547|2342338
D010100OxygenHIF1A protein promotes the reaction [Oxygen deficiency results in increased expression of P4HA2 mRNA]20880076
D010100OxygenOxygen deficiency results in increased expression of P4HA2 mRNA20880076
D000073878Palm OilPalm Oil results in decreased expression of P4HA2 mRNA18042831
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of P4HA2 mRNA18593933
D010416PentachlorophenolPentachlorophenol results in increased expression of P4HA2 mRNA24642059
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of P4HA2 protein23427857
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of P4HA2 mRNA23427857
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of P4HA2 protein26879310
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of P4HA2 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of P4HA2 mRNA19482888
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of P4HA2 mRNA"27188386
D011192Potassium DichromatePotassium Dichromate results in increased expression of P4HA2 protein18563748
D011374ProgesteroneProgesterone results in decreased expression of P4HA2 mRNA23012394|2301818
D011374ProgesteroneProgesterone affects the expression of P4HA2 mRNA17251523
C045950propiconazolepropiconazole results in increased expression of P4HA2 mRNA21278054
C534628SCH 23390[Methamphetamine co-treated with SCH 23390] results in increased expression of P4HA2 mRNA19564919
C534628SCH 23390SCH 23390 results in increased expression of P4HA2 mRNA19564919
C009277sodium arsenatesodium arsenate results in decreased expression of P4HA2 mRNA23922661
C017947sodium arsenitesodium arsenite results in increased expression of P4HA2 mRNA24516582
D013629TamoxifenTamoxifen affects the expression of P4HA2 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of P4HA2 mRNA16443690
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of P4HA2 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of P4HA2 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of P4HA2 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of P4HA2 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of P4HA2 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of P4HA2 mRNA17942748|2756255
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of P4HA2 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of P4HA2 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of P4HA2 mRNA27760801
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of P4HA2 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of P4HA2 mRNA25729387
D014212TretinoinTretinoin results in increased expression of P4HA2 mRNA17138961
C011559tributyltintributyltin results in decreased expression of P4HA2 mRNA27614199
D014241TrichloroethyleneTrichloroethylene results in increased methylation of P4HA2 gene27618143
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of P4HA2 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of P4HA2 mRNA24935251|2627250
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of P4HA2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of P4HA2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of P4HA2 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of P4HA2 gene29154799
D014638VanadatesVanadates results in increased expression of P4HA2 mRNA22714537
D014640VancomycinVancomycin results in decreased expression of P4HA2 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of P4HA2 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of P4HA2 mRNA23034163
D002762CholecalciferolCholecalciferol results in increased expression of P4HA2 mRNA17170073
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of P4HA2 mRNA18593933
C016837zinc chloridezinc chloride inhibits the reaction [cobaltous chloride results in increased expression of P4HA2 mRNA]22202117
C088658zoledronic acidzoledronic acid results in increased expression of P4HA2 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004656procollagen-proline 4-dioxygenase activityCONTRIBUTES_TOIBA21873635  
GO:0004656procollagen-proline 4-dioxygenase activity-IEA-  
GO:0005506iron ion binding-IEA-  
GO:0009055electron transfer activity-TAS9211872  
GO:0016702oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen-IEA-  
GO:0031418L-ascorbic acid binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0018401peptidyl-proline hydroxylation to 4-hydroxy-L-proline-IBA21873635  
GO:0019511peptidyl-proline hydroxylation-IEA-  
GO:0022900electron transport chain-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005783endoplasmic reticulum-IBA21873635  
GO:0005783endoplasmic reticulum-IDA-  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0005829cytosol-IDA-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
hsa00330Arginine and proline metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1474290Collagen formationTAS
R-HSA-1650814Collagen biosynthesis and modifying enzymesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22797725Association analyses identify multiple new lung cancer susceptibility loci and their interactions with smoking in the Chinese population. (2012 Jul 15)Dong JNat Genet