Gene: NAV1

89796
POMFIL3|STEERIN1|UNC53H1
neuron navigator 1
protein-coding
1q32.1
Ensembl:ENSG00000134369 MIM:611628 Vega:OTTHUMG00000035766 UniprotKB:Q8NEY1
NG_053179.1
PubMed
OD|ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.457e-1 (AD)  1.587e-2 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg14780068chr1:201751846NAV1Gene body2.519e-4Alcohol use disorders26763658
cg00313914chr1:201618901NAV19.890e-8Alcohol consumption der day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SOGA10.872
ARID1A0.83
POGZ0.83
ANGEL10.82
SIDT20.819
CBFA2T20.818
STX160.815
MAU20.812
KSR10.811
TNRC6C0.811

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.555
OR4F29-0.5
NANOGNB-0.266
OR6C74-0.258
AGTR1-0.256
CLEC6A-0.248
PAGE4-0.243
KLRC2-0.24
IRX3-0.23
SIM1-0.226

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of NAV1 mRNA19933214
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of NAV1 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NAV1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NAV1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NAV1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NAV1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NAV1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NAV1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NAV1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NAV1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NAV1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NAV1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NAV1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NAV1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NAV1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NAV1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NAV1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NAV1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of NAV1 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of NAV1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of NAV1 mRNA28458013
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of NAV1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of NAV1 gene28458013
D016604Aflatoxin B1decitabine inhibits the reaction [Aflatoxin B1 results in decreased expression of NAV1 mRNA]28458013
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of NAV1 mRNA24449571
D001151ArsenicArsenic results in decreased expression of NAV1 mRNA19654921
C015001arsenitearsenite results in decreased expression of NAV1 mRNA23974009
C547126AZM551248AZM551248 results in increased expression of NAV1 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NAV1 mRNA20064835
D001564Benzo(a)pyrene[Soot co-treated with Benzo(a)pyrene] results in decreased expression of NAV1 protein modified form24464499
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of NAV1 mRNA]22228805
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of NAV1 mRNA28628672
C006780bisphenol Abisphenol A results in decreased methylation of NAV1 promoter27312807
C006780bisphenol Abisphenol A results in increased expression of NAV1 mRNA29097150
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of NAV1 mRNA28628672
C018475butyraldehydebutyraldehyde results in decreased expression of NAV1 mRNA26079696
C018021cobaltous chloridecobaltous chloride results in decreased expression of NAV1 mRNA19320972
D005576ColforsinColforsin results in decreased expression of NAV1 mRNA16751804
C014347decitabinedecitabine inhibits the reaction [Aflatoxin B1 results in decreased expression of NAV1 mRNA]28458013
D003907DexamethasoneDexamethasone results in decreased expression of NAV1 mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of NAV1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of NAV1 mRNA28628672
D003907DexamethasoneDexamethasone results in decreased expression of NAV1 mRNA22733784
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of NAV1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of NAV1 mRNA19561079|2739243
D004041Dietary FatsDietary Fats results in decreased expression of NAV1 mRNA18042831
D002117CalcitriolCalcitriol results in decreased expression of NAV1 mRNA16002434
C118739entinostatentinostat results in decreased expression of NAV1 mRNA26272509
C118739entinostatentinostat results in increased expression of NAV1 mRNA27188386
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NAV1 mRNA"27188386
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of NAV1 mRNA29097150
D017313FenretinideFenretinide results in decreased expression of NAV1 mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of NAV1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of NAV1 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NAV1 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of NAV1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of NAV1 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of NAV1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of NAV1 mRNA21889194
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of NAV1 mRNA21641980
C042720mercuric bromidemercuric bromide results in decreased expression of NAV1 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NAV1 mRNA"27188386
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of NAV1 mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of NAV1 mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NAV1 mRNA"27188386
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of NAV1 mRNA"26251327
D015741MetriboloneMetribolone results in decreased expression of NAV1 mRNA16751804
D009020MorphineMorphine results in decreased expression of NAV1 mRNA21178816
C523799MRK 003NAV1 results in increased susceptibility to MRK 00319903844
D009532NickelNickel results in increased expression of NAV1 mRNA25583101
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of NAV1 mRNA"21673326
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"PON1 protein affects the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of NAV1 mRNA]"21673326
D000073878Palm OilPalm Oil results in decreased expression of NAV1 mRNA18042831
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NAV1 mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of NAV1 mRNA26272509
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NAV1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of NAV1 mRNA26272509
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of NAV1 mRNA25895662
C009277sodium arsenatesodium arsenate results in increased expression of NAV1 mRNA21795629
C017947sodium arsenitesodium arsenite results in increased stability of NAV1 mRNA25493608
D053260Soot[Soot co-treated with Benzo(a)pyrene] results in decreased expression of NAV1 protein modified form24464499
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of NAV1 mRNA21641980
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NAV1 mRNA17555868
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NAV1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NAV1 mRNA19933214
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NAV1 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of NAV1 mRNA28111298
D014212TretinoinTretinoin results in decreased expression of NAV1 mRNA21934132
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NAV1 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of NAV1 mRNA24935251|2627250
C012589trichostatin Atrichostatin A results in increased expression of NAV1 mRNA24935251
C057693troglitazonetroglitazone results in increased expression of NAV1 mRNA19140230
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NAV1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of NAV1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of NAV1 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased expression of NAV1 mRNA24935251
D014638VanadatesVanadates results in increased expression of NAV1 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of NAV1 gene25560391
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NAV1 mRNA"27188386
C111237vorinostatvorinostat results in decreased expression of NAV1 mRNA26272509
C088658zoledronic acidzoledronic acid results in decreased expression of NAV1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0001578microtubule bundle formation-IBA21873635  
GO:0001578microtubule bundle formation-IEA-  
GO:0001764neuron migration-IBA21873635  
GO:0001764neuron migration-IEA-  
GO:0007399nervous system development-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
GO:0005874microtubule-IEA-  
GO:0015630microtubule cytoskeleton-IBA21873635  
GO:0043194axon initial segment-IBA21873635  
GO:0043194axon initial segment-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26005122[American Academy of Neurology, Washington, 18-25 April 2015]. (2015 Jun-Jul)Sibon IRev Neurol (Paris)
27530870Proarrhythmic mechanisms of the common anti-diarrheal medication loperamide: revelations from the opioid abuse epidemic. (2016 Oct)Kang JNaunyn Schmiedebergs Arch Pharmacol