Gene: NAV2

89797
HELAD1|POMFIL2|RAINB1|STEERIN2|UNC53H2
neuron navigator 2
protein-coding
11p15.1
Ensembl:ENSG00000166833 MIM:607026 Vega:OTTHUMG00000151837 UniprotKB:Q8IVL1
NG_030347.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.721e-1 (AD)  3.893e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1386449chr11:19466536 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg12535090chr11:20071677NAV25.000e-9Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARID1A0.817
ZBTB430.796
LRP10.783
ANKFY10.779
BCL90.778
MTMR30.772
ANO80.769
ZXDC0.765
PLEC0.764
SLITRK20.764

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.485
OR4F29-0.431
KLRC2-0.368
C17orf112-0.288
OR6C74-0.286
KLRC3-0.273
C19orf33-0.271
HMHB1-0.254
TSPAN8-0.243
SH2D1A-0.243

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NAV2 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NAV2 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NAV2 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NAV2 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NAV2 mRNA"25510870
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NAV2 mRNA"20816883
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NAV2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NAV2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NAV2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NAV2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of NAV2 mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of NAV2 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of NAV2 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of NAV2 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NAV2 mRNA16483693
D001151ArsenicArsenic affects the methylation of NAV2 gene25304211
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of NAV2 mRNA"25351596
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of NAV2 mRNA"18687144
D019324beta-Naphthoflavonebeta-Naphthoflavone results in decreased expression of NAV2 mRNA19737606
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NAV2 mRNA20064835|2010694
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of NAV2 mRNA"19150397|2038263
D004958EstradiolEGF protein promotes the reaction [Estradiol results in increased expression of NAV2 mRNA]24758408
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of NAV2 mRNA19619570
D004958EstradiolEstradiol promotes the reaction [ESR2 protein affects the expression of NAV2 mRNA]20404318
D004958EstradiolEstradiol results in increased expression of NAV2 mRNA19619570|2475840
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of NAV2 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of NAV2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of NAV2 gene28505145
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of NAV2 mRNA28628672
D019256Cadmium ChlorideCadmium Chloride results in increased expression of NAV2 mRNA25993096
D002737ChloropreneChloroprene results in decreased expression of NAV2 mRNA23125180
C018021cobaltous chloridecobaltous chloride results in decreased expression of NAV2 mRNA19376846
C018021cobaltous chloridecobaltous chloride results in decreased expression of NAV2 mRNA24386269
D019327Copper SulfateCopper Sulfate results in decreased expression of NAV2 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of NAV2 mRNA20106945|2556210
D003561CytarabineCytarabine results in decreased expression of NAV2 mRNA21198554
D003609DactinomycinDactinomycin inhibits the reaction [Tretinoin results in increased expression of NAV2 mRNA]16688769
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of NAV2 mRNA23914054
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of NAV2 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of NAV2 mRNA28628672
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of NAV2 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of NAV2 mRNA19561079|2739243
C000944dicrotophosdicrotophos results in increased expression of NAV2 mRNA28302478
D004041Dietary FatsDietary Fats results in increased expression of NAV2 mRNA25016146
D004237DiuronDiuron results in decreased expression of NAV2 mRNA21551480
C024565ethylene dichlorideethylene dichloride results in increased expression of NAV2 mRNA28189721
D005839GentamicinsGentamicins results in decreased expression of NAV2 mRNA22061828
D017313FenretinideFenretinide results in increased expression of NAV2 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of NAV2 mRNA20044591
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of NAV2 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of NAV2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of NAV2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of NAV2 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of NAV2 mRNA27392435
C045463leflunomideleflunomide results in increased expression of NAV2 mRNA28988120
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of NAV2 mRNA21641980
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of NAV2 mRNA23179753
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of NAV2 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of NAV2 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of NAV2 mRNA"25620056
D009532NickelNickel results in decreased expression of NAV2 mRNA25583101
C022838nickel chloridenickel chloride results in increased expression of NAV2 mRNA17312168
C028007nickel monoxidenickel monoxide results in increased expression of NAV2 mRNA19167457
C013935N,N-diethyl 4-phenylenediamine"NAV2 gene SNP affects the susceptibility to N,N-diethyl 4-phenylenediamine"25622337
C016030pantogabpantogab results in decreased expression of NAV2 mRNA17379144
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NAV2 mRNA"25510870
D010634PhenobarbitalPhenobarbital affects the expression of NAV2 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NAV2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of NAV2 mRNA26272509
D011192Potassium DichromatePotassium Dichromate results in decreased expression of NAV2 mRNA23608068
D011441PropylthiouracilPropylthiouracil results in decreased expression of NAV2 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of NAV2 mRNA21632981
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NAV2 mRNA19059307
D012643SeleniumSelenium results in decreased expression of NAV2 mRNA19244175
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of NAV2 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of NAV2 mRNA25351596
D012822Silicon DioxideSilicon Dioxide results in increased expression of NAV2 mRNA23221170
D012999SomanSoman results in increased expression of NAV2 mRNA19281266
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of NAV2 mRNA21641980
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in decreased expression of NAV2 mRNA19059307
D013629TamoxifenTamoxifen affects the expression of NAV2 mRNA20937368
D013629TamoxifenTamoxifen results in decreased expression of NAV2 mRNA25123088
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of NAV2 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NAV2 mRNA22298810|2257421
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NAV2 mRNA19619570|2010694
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of NAV2 mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of NAV2 mRNA20133372
D014212TretinoinDactinomycin inhibits the reaction [Tretinoin results in increased expression of NAV2 mRNA]16688769
D014212TretinoinTretinoin results in increased expression of NAV2 mRNA16688769|1743110
C012589trichostatin Atrichostatin A results in increased expression of NAV2 mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of NAV2 mRNA"26179874
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NAV2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of NAV2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of NAV2 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of NAV2 mRNA23179753|2627250
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of NAV2 gene25487561
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of NAV2 gene25560391
C111237vorinostatvorinostat results in decreased expression of NAV2 mRNA27188386
C088658zoledronic acidzoledronic acid results in decreased expression of NAV2 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004386helicase activity-IEA-  
GO:0005515protein binding-IPI16189514  25416956  
GO:0005524ATP binding-IEA-  
GO:0008201heparin binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0003025regulation of systemic arterial blood pressure by baroreceptor feedback-IEA-  
GO:0007399nervous system development-IBA21873635  
GO:0007605sensory perception of sound-IEA-  
GO:0007608sensory perception of smell-IEA-  
GO:0007626locomotory behavior-IEA-  
GO:0021554optic nerve development-IEA-  
GO:0021563glossopharyngeal nerve development-IEA-  
GO:0021564vagus nerve development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005614interstitial matrix-IEA-  
GO:0005654nucleoplasm-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal