Gene: CCNE1

898
CCNE|pCCNE1
cyclin E1
protein-coding
19q12
Ensembl:ENSG00000105173 MIM:123837 Vega:OTTHUMG00000177626 UniprotKB:P24864
NC_000019.10
PubMed|SNP Mapped
ND|AD
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.537e-2 (AD)  4.933e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3218065chr19:29821675 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC25A140.901
OSCP10.898
GLS20.894
GOT10.894
ACOT70.891
ACTL6B0.89
AP3B20.889
ZFYVE270.888
CACNA2D30.885
ENO20.885

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
REST-0.514
RAI14-0.506
YES1-0.501
CARD8-0.494
DISC1-0.478
TFPI2-0.477
WWTR1-0.474
HEY2-0.471
MYL3-0.471
EBF1-0.465

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5691071-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one"1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one results in decreased expression of CCNE1 mRNA"23826121
C0449851',2'-dihydrorotenone"1',2'-dihydrorotenone results in decreased expression of CCNE1 protein"24615755
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [CDK2 protein binds to CCNE1 protein]"20637255
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [CDK2 protein binds to CCNE1 protein binds to CDKN1A protein]"20637255
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [CDK2 protein binds to CCNE1 protein binds to CDKN1B protein]"20637255
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CCNE1 mRNA"22698814
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CCNE1 protein"12807759
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"Androstanols inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CCNE1 protein]"12807759
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CCNE1 mRNA]"22698814
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"Tetrachlorodibenzodioxin promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [CDK2 protein binds to CCNE1 protein]]"20637255
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"Tetrachlorodibenzodioxin promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [CDK2 protein binds to CCNE1 protein binds to CDKN1A protein]]"20637255
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"[Tetrachlorodibenzodioxin promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [CDK2 protein binds to CCNE1 protein binds to CDKN1A protein]]] which results in decreased activity of CDK2 protein"20637255
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"Tetrachlorodibenzodioxin promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [CDK2 protein binds to CCNE1 protein binds to CDKN1B protein]]"20637255
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"[Tetrachlorodibenzodioxin promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [CDK2 protein binds to CCNE1 protein binds to CDKN1B protein]]] which results in decreased activity of CDK2 protein"20637255
C09724015-deoxy-delta(12,14)-prostaglandin J2"15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of CCNE1 protein"15729575
C00202917alpha-ethynylestr-5(10)-ene-3alpha,17beta-diol"17alpha-ethynylestr-5(10)-ene-3alpha,17beta-diol results in decreased expression of CCNE1 protein"16019103
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine co-treated with U 0126] results in decreased expression of CCNE1 protein"22101421
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine results in decreased expression of CCNE1 protein"22101421
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CCNE1 mRNA"25510870
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CCNE1 mRNA"26988655
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased expression of CCNE1 protein]17273796
C4881852-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide"[2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [Cadmium Chloride results in increased expression of CCNE1 protein]"26385184
C4881852-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide"[2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [EGF protein results in increased expression of CCNE1 protein]"26385184
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CCNE1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CCNE1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CCNE1 mRNA"25510870
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of CCNE1 protein14757120
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Vanadates results in increased expression of CCNE1 protein]14971663
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of CCNE1 protein15601625
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CCNE1 mRNA"25510870
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of CCNE1 mRNA"21346803
C0369902-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"[flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCNE1 mRNA"23681119
C1202752-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone results in increased expression of CCNE1 protein11468187
C4971012-hydroxy-9-cis-octadecenoic acid2-hydroxy-9-cis-octadecenoic acid results in increased expression of CCNE1 mRNA16027227
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of CCNE1 mRNA"12734338
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of CCNE1 mRNA]"19467301
C4949143,5,3',4',5'-pentamethoxystilbene"3,5,3',4',5'-pentamethoxystilbene results in decreased expression of CCNE1 protein"19916542
C5810043-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile"3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile results in decreased expression of CCNE1 protein"28834734
C0388644-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid"4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCNE1 protein]"12421932
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CCNE1 mRNA"27188386
C5688624-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline"4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline results in increased expression of CCNE1 protein"24161432
C0415944-nonylphenol4-nonylphenol results in decreased expression of CCNE1 mRNA26804032
C5732335,7-dihydroxy-2-methyl-8-(4-(3-hydroxy-1-methyl)-piperidinyl)-4H-1-benzopyran-4-one"5,7-dihydroxy-2-methyl-8-(4-(3-hydroxy-1-methyl)-piperidinyl)-4H-1-benzopyran-4-one inhibits the reaction [[INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in increased expression of CCNE1 protein]"24646949
C5805985-OH-BDE-475-OH-BDE-47 results in increased expression of CCNE1 mRNA26988655
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CCNE1 mRNA"27188386
C5805996-OH-BDE-476-OH-BDE-47 results in increased expression of CCNE1 mRNA26988655
C5538177-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one"7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one results in decreased expression of CCNE1 mRNA"19936915
C0257249-methoxycamptothecin9-methoxycamptothecin results in increased expression of CCNE1 mRNA23369935
C072876A 771726A 771726 results in decreased expression of CCNE1 protein19174558
C072876A 771726A 771726 results in increased expression of CCNE1 protein12181422
C542662AC 93253AC 93253 results in decreased expression of CCNE1 mRNA25912555
D000082AcetaminophenAcetaminophen results in increased expression of CCNE1 mRNA22230336
C487680acetylbritannilatoneacetylbritannilatone analog results in decreased expression of CCNE1 protein27262408
D000111AcetylcysteineAcetylcysteine inhibits the reaction [bisphenol A results in decreased expression of CCNE1 protein]24909818
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Nitrofurazone results in increased expression of CCNE1 mRNA]15945272
D000143AcidsAcids results in increased expression of CCNE1 protein18512153
D000143Acidssorafenib inhibits the reaction [Acids results in increased expression of CCNE1 protein]18512153
D020106AcrylamideAcrylamide analog results in decreased expression of CCNE1 mRNA17317719
D020106AcrylamideAcrylamide analog results in decreased expression of CCNE1 protein17317719
D020106AcrylamideAcrylamide results in increased expression of CCNE1 mRNA28959563
C058956acteosideacteoside results in decreased expression of CCNE1 protein17634406
C016601afimoxifene[afimoxifene co-treated with lapatinib] promotes the reaction [CDKN1B protein binds to and results in decreased activity of [CCNE1 protein binds to CDK2 protein]]15665275
C016601afimoxifeneafimoxifene promotes the reaction [CDKN1B protein binds to and results in decreased activity of [CCNE1 protein binds to CDK2 protein]]15665275
C016601afimoxifeneafimoxifene results in increased cleavage of CCNE1 protein23624423
C016601afimoxifeneGPER1 protein affects the reaction [afimoxifene results in increased cleavage of CCNE1 protein]23624423
C016601afimoxifeneU 0126 inhibits the reaction [afimoxifene results in increased cleavage of CCNE1 protein]23624423
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CCNE1 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of CCNE1 gene27153756
D016604Aflatoxin B1[Zearalenone co-treated with Aflatoxin B1] results in increased expression of CCNE1 mRNA28965971
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CCNE1 mRNA23630614
C430898AGN 194204AGN 194204 results in decreased expression of CCNE1 protein15318936
C002055alloseallose results in decreased expression of CCNE1 mRNA18930000
D000517alpha-Chlorohydrinalpha-Chlorohydrin analog results in decreased expression of CCNE1 protein26072098
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of CCNE1 mRNA17023530
C077990alvocidibalvocidib results in decreased expression of CCNE1 protein15014036
D017311AmlodipineAmlodipine results in decreased activity of CCNE1 protein17217918
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CCNE1 mRNA16483693
D000677AmsacrineAmsacrine results in increased expression of CCNE1 protein11774253
C030419andrographolideandrographolide results in decreased expression of CCNE1 protein23845849
C030419andrographolideandrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCNE1 protein]27475717
D000732Androstanols"Androstanols inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CCNE1 protein]"12807759
C023650anilineaniline results in increased expression of CCNE1 mRNA21070798
C023650anilineaniline results in increased expression of CCNE1 protein21070798
C545357antroquinonolantroquinonol results in decreased expression of and results in decreased localization of CCNE1 protein19723512
C102351apicidinapicidin results in decreased expression of CCNE1 protein18313654
D001151ArsenicArsenic results in increased expression of CCNE1 mRNA11134558
C006632arsenic trioxidearsenic trioxide affects the expression of CCNE1 protein12962562
C006632arsenic trioxidearsenic trioxide promotes the reaction [CCNE1 protein binds to CDKN1A protein]10850458
C006632arsenic trioxidearsenic trioxide results in decreased expression of CCNE1 mRNA19236751
C006632arsenic trioxidearsenic trioxide results in decreased expression of CCNE1 protein12480548
C006632arsenic trioxidearsenic trioxide results in decreased expression of CCNE1 mRNA19379560
C006632arsenic trioxidearsenic trioxide results in decreased expression of CCNE1 protein19379560
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of CCNE1 mRNA"17331233
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of CCNE1 protein"21570478
C010302aspidin BBaspidin BB results in increased expression of CCNE1 protein23628508
D001241AspirinAspirin results in decreased expression of CCNE1 mRNA20457246
D001241AspirinAspirin affects the expression of CCNE1 mRNA12800193
D001285AtropineAtropine results in increased expression of CCNE1 mRNA17390078
D001285Atropine[Parathion co-treated with Atropine] results in increased expression of CCNE1 mRNA17390078
C006680baicaleinbaicalein results in decreased expression of CCNE1 protein24560969
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CCNE1 mRNA19027820
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CCNE1 protein19027820
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CCNE1 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CCNE1 mRNA20713471
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of CCNE1 mRNA"19150397
D001599BerberineBerberine results in decreased expression of CCNE1 protein16505103
D004958EstradiolEstradiol results in increased cleavage of CCNE1 protein23624423
D004958EstradiolEstradiol results in increased expression of CCNE1 mRNA15897899|2561626
D004958EstradiolEstradiol results in increased expression of CCNE1 protein26344002|2753925
D004958EstradiolEstriol inhibits the reaction [Estradiol results in increased cleavage of CCNE1 protein]23624423
D004958EstradiolEthidium inhibits the reaction [Estradiol results in increased expression of CCNE1 mRNA]15897899
D004958Estradiolfulvestrant inhibits the reaction [Estradiol results in increased expression of CCNE1 protein]26344002|2753925
D004958EstradiolESR1 protein promotes the reaction [Estradiol results in increased expression of CCNE1 mRNA]25210133
D004958EstradiolEstradiol results in decreased expression of CCNE1 mRNA19693291
D004958EstradiolEstradiol results in increased expression of CCNE1 mRNA25210133
C095105bexarotenebexarotene results in decreased expression of CCNE1 mRNA17849452
C099952bifenthrinbifenthrin inhibits the reaction [CGA protein results in increased expression of CCNE1 mRNA]21251947
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of CCNE1 protein28808208
C543008bis(4-hydroxyphenyl)sulfonefulvestrant inhibits the reaction [bis(4-hydroxyphenyl)sulfone results in increased expression of CCNE1 protein]28808208
C006780bisphenol Abisphenol A results in increased expression of CCNE1 mRNA29027980
C006780bisphenol Abisphenol A results in decreased expression of CCNE1 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of CCNE1 protein25933419|2880820
C006780bisphenol Afulvestrant inhibits the reaction [bisphenol A results in increased expression of CCNE1 protein]28808208
C006780bisphenol AMYC protein promotes the reaction [bisphenol A results in increased expression of CCNE1 protein]25933419
C006780bisphenol AAcetylcysteine inhibits the reaction [bisphenol A results in decreased expression of CCNE1 protein]24909818
C006780bisphenol A[bisphenol A co-treated with oligomycin A] results in decreased expression of CCNE1 protein24909818
C006780bisphenol Abisphenol A results in decreased expression of CCNE1 protein24909818
C006780bisphenol Abisphenol A affects the expression of CCNE1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of CCNE1 mRNA25181051
C000611646bisphenol Fbisphenol F results in increased expression of CCNE1 protein28808208
C000611646bisphenol Ffulvestrant inhibits the reaction [bisphenol F results in increased expression of CCNE1 protein]28808208
C023623brassinolidebrassinolide results in decreased expression of CCNE1 protein20833159
C515564bromovaninbromovanin results in decreased expression of CCNE1 protein21419150
D019819BudesonideBudesonide results in decreased expression of CCNE1 mRNA17163412
D002083Butylated HydroxyanisoleButylated Hydroxyanisole results in decreased expression of CCNE1 mRNA25086368
D002084Butylated HydroxytolueneButylated Hydroxytoluene results in increased expression of CCNE1 mRNA12867420
D002084Butylated Hydroxytoluene[Butylated Hydroxytoluene results in increased expression of FOXM1 mRNA] which results in increased expression of CCNE1 mRNA12867420
D020122tert-Butylhydroperoxideginsenoside Rg1 affects the reaction [tert-Butylhydroperoxide affects the expression of CCNE1 protein]15606011
C026105butylidenephthalidebutylidenephthalide results in decreased expression of CCNE1 protein16987298
C026105butylidenephthalidebutylidenephthalide results in decreased expression of CCNE1 protein16987298
D002087ButyratesButyrates results in decreased expression of CCNE1 protein15177505
D020148Butyric AcidButyric Acid results in decreased expression of CCNE1 mRNA12800193
D002104CadmiumCadmium promotes the reaction [CDKN1A protein binds to CDK1 protein binds to CCNE1 protein]20839231
D002104CadmiumCadmium results in increased expression of CCNE1 mRNA24376830
D002104CadmiumCadmium results in increased expression of CCNE1 protein27071802
D002104CadmiumHMGA2 protein affects the reaction [Cadmium results in increased expression of CCNE1 protein]27071802
D002104CadmiumCadmium results in increased expression of CCNE1 mRNA22666406
C028031cadmium acetatecadmium acetate results in decreased activity of [CCNE1 protein binds to CDK1 protein]20839231
D019256Cadmium Chloride"[2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [Cadmium Chloride results in increased expression of CCNE1 protein]"26385184
D019256Cadmium ChlorideATG4A protein affects the reaction [Cadmium Chloride results in increased expression of CCNE1 protein]29179951
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CCNE1 mRNA20219890|2647268
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CCNE1 protein20219890|2638518
D019256Cadmium Chloridetyrphostin AG 1478 inhibits the reaction [Cadmium Chloride results in increased expression of CCNE1 protein]26385184
C055494caffeic acid phenethyl ester[Tretinoin co-treated with caffeic acid phenethyl ester] inhibits the reaction [CDK2 protein binds to CCNE1 protein]16766008
C055494caffeic acid phenethyl estercaffeic acid phenethyl ester inhibits the reaction [CDK2 protein binds to CCNE1 protein]15885897
D002185CannabidiolCannabidiol results in decreased expression of CCNE1 mRNA21542829
D002220CarbamazepineCarbamazepine affects the expression of CCNE1 mRNA24752500
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of CCNE1 mRNA17484886
C038590cardanolcardanol results in decreased expression of CCNE1 mRNA26694491
D002330CarmustineCarmustine results in increased expression of CCNE1 mRNA16005536
C103436CB 1093CB 1093 results in decreased expression of CCNE1 protein12907249
C474928CB 403CB 403 results in decreased expression of CCNE1 protein12694875
D002509CephaloridineCephaloridine results in increased expression of CCNE1 mRNA18500788
D002794CholineCholine results in increased expression of CCNE1 mRNA16014740
D002794CholineCholine results in increased expression of CCNE1 mRNA16014740
C043867cicaprostcicaprost results in decreased activity of [CCNE1 protein binds to CDK2 protein]12869629
C043867cicaprostPertussis Toxin inhibits the reaction [cicaprost results in decreased activity of [CCNE1 protein binds to CDK2 protein]]12869629
D002939CiprofloxacinCiprofloxacin results in decreased expression of CCNE1 protein10741713
D002953CitrininCitrinin results in increased expression of CCNE1 mRNA23856526
D003300Copper[Thiosemicarbazones binds to Copper] which results in decreased expression of CCNE1 protein20931265
D019327Copper SulfateCopper Sulfate results in decreased expression of CCNE1 mRNA19549813
D003345CorticosteroneCorticosterone results in decreased expression of CCNE1 protein12807724
C030123coumarincoumarin results in increased expression of CCNE1 mRNA18480146
D003375CoumestrolCoumestrol results in decreased expression of CCNE1 protein28986287
C477330CP-654577CP-654577 results in decreased expression of CCNE1 protein12907618
D003471CuprizoneCuprizone results in decreased expression of CCNE1 mRNA26577399
D003474CurcuminCurcumin results in decreased expression of CCNE1 protein17148446
D003474CurcuminCurcumin results in increased degradation of CCNE1 protein18156803
D003474Curcuminlactacystin inhibits the reaction [Curcumin results in increased degradation of CCNE1 protein]18156803
D003474CurcuminCurcumin results in decreased expression of CCNE1 mRNA18299980
C000541cyclopamineCCNE1 protein results in increased susceptibility to cyclopamine22923130
C000541cyclopaminecyclopamine results in decreased expression of CCNE1 protein22923130
D016572CyclosporineCyclosporine results in decreased expression of CCNE1 mRNA25562108
C108338cyprodinilcyprodinil results in increased expression of CCNE1 protein26344002
C108338cyprodinilfulvestrant inhibits the reaction [cyprodinil results in increased expression of CCNE1 protein]26344002
D003630DaunorubicinDaunorubicin affects the expression of CCNE1 mRNA12656675
C014347decitabinedecitabine results in increased expression of CCNE1 mRNA27915011
D003676DeferoxamineDeferoxamine results in increased expression of CCNE1 protein11468187
D003703DemecolcineDemecolcine results in decreased expression of CCNE1 mRNA23649840
C007262deoxynivalenoldeoxynivalenol results in decreased expression of CCNE1 mRNA27456127
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of CCNE1 mRNA]27941970
D003907Dexamethasone[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCNE1 protein27475717
D003907Dexamethasone"5,7-dihydroxy-2-methyl-8-(4-(3-hydroxy-1-methyl)-piperidinyl)-4H-1-benzopyran-4-one inhibits the reaction [[INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in increased expression of CCNE1 protein]"24646949
D003907Dexamethasoneandrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCNE1 protein]27475717
D003907DexamethasoneDexamethasone results in decreased expression of CCNE1 mRNA21041162
D003907Dexamethasone[INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in increased expression of CCNE1 protein24646949
D003976DiazinonDiazinon affects the expression of CCNE1 mRNA22546817
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of CCNE1 mRNA23242528
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of CCNE1 mRNA28962523
D002945CisplatinCCNE1 protein affects the susceptibility to Cisplatin16217747
D002945CisplatinCCNE1 results in increased susceptibility to Cisplatin21103391
D002945Cisplatin[Cisplatin co-treated with Quercetin] results in increased expression of CCNE1 mRNA27514524
D002945CisplatinCisplatin results in decreased activity of [CCNE1 protein binds to CDK2 protein]21592546
D002945CisplatinCisplatin results in increased expression of CCNE1 mRNA27594783
D004008DiclofenacDiclofenac affects the expression of CCNE1 mRNA24752500
D004026DieldrinDieldrin affects the expression of CCNE1 mRNA22546817
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of CCNE1 mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of CCNE1 mRNA19467301|2501614
C020283diethanolaminediethanolamine results in increased expression of CCNE1 mRNA16014740
C020283diethanolaminediethanolamine results in increased expression of CCNE1 mRNA16014740
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of CCNE1 mRNA25701202
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of CCNE1 mRNA24535843
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CCNE1 mRNA14633663
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of CCNE1 protein10906429|1183136
D004052DiethylnitrosamineIFNA1 protein inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CCNE1 mRNA]14633663
D004052Diethylnitrosaminemalachite green promotes the reaction [Diethylnitrosamine results in increased expression of CCNE1 protein]10906429
D004052Diethylnitrosaminemetanil yellow promotes the reaction [Diethylnitrosamine results in increased expression of CCNE1 protein]10906429
D004052DiethylnitrosaminePhenobarbital promotes the reaction [Diethylnitrosamine results in increased expression of CCNE1 protein]10906429
D004052Diethylnitrosaminethymoquinone inhibits the reaction [Diethylnitrosamine results in increased expression of CCNE1 protein]24012840
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of CCNE1 mRNA21041162
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of CCNE1 mRNA"22485181
D004317DoxorubicinDoxorubicin inhibits the reaction [HDAC2 protein binds to CCNE1 promoter]25124555
D004317DoxorubicinDoxorubicin promotes the reaction [E2F1 protein binds to CCNE1 promoter]25124555
D004317DoxorubicinDoxorubicin results in decreased expression of CCNE1 protein16036217
D004317DoxorubicinDoxorubicin results in increased expression of CCNE1 mRNA25124555
D004317DoxorubicinDoxorubicin results in increased expression of CCNE1 protein25124555
D004317DoxorubicinE2F1 protein promotes the reaction [Doxorubicin results in increased expression of CCNE1 protein]25124555
D004317DoxorubicinSETD7 protein promotes the reaction [Doxorubicin inhibits the reaction [HDAC2 protein binds to CCNE1 promoter]]25124555
D004317DoxorubicinSETD7 protein promotes the reaction [Doxorubicin promotes the reaction [E2F1 protein binds to CCNE1 promoter]]25124555
D004317DoxorubicinSETD7 protein promotes the reaction [Doxorubicin results in increased expression of CCNE1 mRNA]25124555
D004317DoxorubicinSETD7 protein promotes the reaction [Doxorubicin results in increased expression of CCNE1 protein]25124555
D004317Doxorubicin[zoledronic acid co-treated with Doxorubicin] results in decreased expression of CCNE1 protein19789217
D004317DoxorubicinDoxorubicin promotes the reaction [TAF1 protein results in increased expression of CCNE1 protein]15124910
D004317DoxorubicinCCNE1 protein results in decreased susceptibility to Doxorubicin19385967
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in decreased expression of CCNE1 protein"15456542
C031818enterotoxin B, staphylococcal"enterotoxin B, staphylococcal results in increased expression of CCNE1 mRNA"25556216
C118739entinostat[fludarabine co-treated with entinostat] results in decreased expression of CCNE1 protein15059916
C498475equiguardequiguard results in decreased expression of CCNE1 protein15547720
C007633estragoleestragole results in increased expression of CCNE1 mRNA29054680
D004964EstriolEstriol inhibits the reaction [Estradiol results in increased cleavage of CCNE1 protein]23624423
D004996EthidiumEthidium inhibits the reaction [Estradiol results in increased expression of CCNE1 mRNA]15897899
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of CCNE1 mRNA20227414
D015025Zearalenone[Zearalenone co-treated with Aflatoxin B1] results in increased expression of CCNE1 mRNA28965971
D005411Flame RetardantsFlame Retardants results in decreased expression of CCNE1 protein18952254
D044950FlavanonesFlavanones results in decreased expression of CCNE1 protein21616090
C024352fludarabine[fludarabine co-treated with entinostat] results in decreased expression of CCNE1 protein15059916
C108339fludioxonilfludioxonil results in increased expression of CCNE1 protein27539251
C108339fludioxonilfulvestrant inhibits the reaction [fludioxonil results in increased expression of CCNE1 protein]27539251
C012976flumequine"[flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCNE1 mRNA"23681119
D0150732-Acetylaminofluorene2-Acetylaminofluorene inhibits the reaction [CDK2 protein binds to CCNE1 protein]10708481
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in decreased activity of CCNE1 protein10708481
D0150732-Acetylaminofluorene[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CCNE1 mRNA14633663
D0150732-AcetylaminofluoreneIFNA1 protein inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CCNE1 mRNA]14633663
D005472FluorouracilFluorouracil results in decreased expression of CCNE1 mRNA18930000
D005472FluorouracilFluorouracil results in increased expression of CCNE1 mRNA16101138
D005472FluorouracilFluorouracil results in increased expression of CCNE1 protein9930367
D005472Fluorouracil[Leucovorin co-treated with Fluorouracil] results in increased expression of CCNE1 mRNA15342418
D005473FluoxetineFluoxetine affects the expression of CCNE1 mRNA18371935
D005473Fluoxetine[Fluoxetine results in decreased activity of CKS1B protein] which results in decreased degradation of CCNE1 protein18371935
D005473FluoxetineFluoxetine results in decreased expression of CCNE1 mRNA21497159
D005492Folic AcidFolic Acid affects the expression of CCNE1 mRNA16361273
D002955Leucovorin[Leucovorin co-treated with Fluorouracil] results in increased expression of CCNE1 mRNA15342418
C096856FTI 277[Tamoxifen co-treated with FTI 277] promotes the reaction [CDKN1A protein binds to [CCNE1 protein binds to CDK2 protein]]12866041
C096856FTI 277[Tamoxifen co-treated with FTI 277] promotes the reaction [CDKN1B protein binds to [CCNE1 protein binds to CDK2 protein]]12866041
C096856FTI 277[Tamoxifen co-treated with FTI 277] results in decreased activity of [CCNE1 protein binds to CDK2 protein]12866041
C070081fulvestrantfulvestrant inhibits the reaction [bis(4-hydroxyphenyl)sulfone results in increased expression of CCNE1 protein]28808208
C070081fulvestrantfulvestrant inhibits the reaction [bisphenol A results in increased expression of CCNE1 protein]28808208
C070081fulvestrantfulvestrant inhibits the reaction [bisphenol F results in increased expression of CCNE1 protein]28808208
C070081fulvestrantfulvestrant inhibits the reaction [cyprodinil results in increased expression of CCNE1 protein]26344002
C070081fulvestrantfulvestrant inhibits the reaction [Estradiol results in increased expression of CCNE1 protein]26344002|2753925
C070081fulvestrantfulvestrant inhibits the reaction [fludioxonil results in increased expression of CCNE1 protein]27539251
C070081fulvestrant"fulvestrant inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of CCNE1 protein]"26344002
C070081fulvestrantfulvestrant results in decreased expression of CCNE1 mRNA20215421
D062610Fungal PolysaccharidesFungal Polysaccharides results in decreased expression of CCNE1 mRNA24060681
D062610Fungal PolysaccharidesFungal Polysaccharides results in decreased expression of CCNE1 protein24060681
C039281furanfuran results in increased expression of CCNE1 mRNA20124500|2207923
C038958gadolinium chloridegadolinium chloride results in increased expression of CCNE119184457
D005707Gallic AcidGallic Acid results in decreased expression of CCNE1 protein22245431
D017965gamma-Linolenic Acidgamma-Linolenic Acid results in decreased expression of CCNE1 protein15318936
D024504gamma-Tocopherolgamma-Tocopherol results in decreased expression of CCNE1 protein12368234
D019833GenisteinGenistein results in increased expression of CCNE1 mRNA26792615
D019833Genistein[Genistein co-treated with Methoxychlor] results in decreased expression of CCNE1 mRNA21782745
C002963geranylgeranyl pyrophosphategeranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of CCNE1 protein]26577051
C007845gingerolgingerol results in decreased expression of CCNE1 mRNA28249781
C007845gingerolgingerol results in decreased expression of CCNE1 protein28249781
C035054ginsenoside Rg1ginsenoside Rg1 affects the reaction [tert-Butylhydroperoxide affects the expression of CCNE1 protein]15606011
D005947GlucoseGlucose results in increased expression of CCNE1 protein24971582
D005947Glucoseresveratrol inhibits the reaction [Glucose results in increased expression of CCNE1 protein]24971582
C010974glyphosateglyphosate results in increased expression of CCNE1 protein24073338
D005679G(M3) GangliosideG(M3) Ganglioside analog results in decreased expression of CCNE1 mRNA17317719
D005679G(M3) GangliosideG(M3) Ganglioside analog results in decreased expression of CCNE1 protein17317719
C089796hexabromocyclododecanehexabromocyclododecane results in increased expression of CCNE1 protein26804032
C089796hexabromocyclododecanehexabromocyclododecane affects the expression of CCNE1 mRNA24680724
D006581HexachlorobenzeneHexachlorobenzene promotes the reaction [CDK2 protein binds to CCNE1 protein]28215542
D006581HexachlorobenzeneHexachlorobenzene promotes the reaction [CDKN1B protein binds to CCNE1 protein]28215542
C014026hexamethylene bisacetamidehexamethylene bisacetamide results in decreased expression of CCNE1 mRNA17349212
D006588HexanonesHexanones results in decreased expression of CCNE1 mRNA14757120
D006588HexanonesHexanones results in decreased expression of CCNE1 protein14757120
C403899HS 1030HS 1030 results in decreased expression of CCNE1 protein15202011
C403900HS 1183HS 1183 results in decreased activity of CCNE1 protein12969788
C403900HS 1183HS 1183 results in decreased expression of CCNE1 protein15202011
C503536HS-1199HS-1199 results in decreased expression of CCNE1 protein15202011
C479128HS 1200HS 1200 results in decreased activity of CCNE1 protein12969788
C479128HS 1200HS 1200 results in decreased expression of CCNE1 protein15202011
D006843Hydrocarbons, Chlorinated"Hydrocarbons, Chlorinated results in decreased expression of CCNE1 mRNA"14757120
D006843Hydrocarbons, Chlorinated"Hydrocarbons, Chlorinated results in decreased expression of CCNE1 protein"14757120
D006851Hydrochloric AcidHydrochloric Acid results in increased expression of CCNE1 mRNA15046208
D006918HydroxyureaHydroxyurea results in increased expression of CCNE1 protein11468187
D006918HydroxyureaHydroxyurea results in increased expression of CCNE1 mRNA27208086
C489023hypsiziprenol A9hypsiziprenol A9 results in decreased expression of CCNE1 protein15246556
D007052IbuprofenIbuprofen results in decreased expression of CCNE1 mRNA28201806
C016517indole-3-carbinolindole-3-carbinol affects the localization of CCNE1 protein15611077
C016517indole-3-carbinolindole-3-carbinol affects the localization of [CDK2 protein binds to CCNE1 protein alternative form]15611077
C016517indole-3-carbinolindole-3-carbinol promotes the reaction [CDK2 protein binds to CCNE1 protein alternative form]15611077
C016517indole-3-carbinolindole-3-carbinol results in decreased expression of CCNE116082211
D007213IndomethacinIndomethacin inhibits the reaction [FGF2 protein results in increased expression of CCNE1 protein]11170841
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CCNE1 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCNE1 protein27475717
D0150561-Methyl-3-isobutylxanthine"5,7-dihydroxy-2-methyl-8-(4-(3-hydroxy-1-methyl)-piperidinyl)-4H-1-benzopyran-4-one inhibits the reaction [[INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in increased expression of CCNE1 protein]"24646949
D0150561-Methyl-3-isobutylxanthineandrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCNE1 protein]27475717
D0150561-Methyl-3-isobutylxanthine[INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in increased expression of CCNE1 protein24646949
C561695(+)-JQ1 compound[(+)-JQ1 compound co-treated with vemurafenib] results in decreased expression of CCNE1 mRNA27169980
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CCNE1 protein27006472
C410337K 7174K 7174 results in decreased expression of CCNE1 mRNA24086573
D007608Kainic AcidKainic Acid results in increased expression of CCNE1 protein12941380
C074279KH 1060KH 1060 results in decreased expression of CCNE1 protein12907249
C572783kuguacin Jkuguacin J results in decreased expression of CCNE1 protein22266361
C500368labedipinedilol Alabedipinedilol A results in decreased expression of CCNE1 protein19056458
C067713lactacystinlactacystin inhibits the reaction [Curcumin results in increased degradation of CCNE1 protein]18156803
C490728lapatinib[afimoxifene co-treated with lapatinib] promotes the reaction [CDKN1B protein binds to and results in decreased activity of [CCNE1 protein binds to CDK2 protein]]15665275
C490728lapatiniblapatinib promotes the reaction [CDKN1B protein binds to and results in decreased activity of [CCNE1 protein binds to CDK2 protein]]15665275
C008261lead acetatelead acetate results in decreased expression of CCNE1 mRNA25270620
C095104LG 100268LG 100268 results in decreased expression of CCNE1 protein15729575
D008012LidocaineLidocaine affects the expression of CCNE1 mRNA18931217
C094099LY 293111LY 293111 results in decreased expression of CCNE1 mRNA16151469
C094099LY 293111LY 293111 results in decreased expression of CCNE1 protein16151469
C015329lycopenelycopene results in decreased expression of CCNE1 protein17337101
C015329lycopenelycopene results in increased expression of CCNE1 mRNA16886892
C005498magnololmagnolol results in decreased expression of CCNE1 mRNA23274740
C005498magnololmagnolol results in decreased expression of CCNE1 protein23274740
C005095malachite greenmalachite green promotes the reaction [Diethylnitrosamine results in increased expression of CCNE1 protein]10906429
D015122MercaptopurineMercaptopurine results in decreased expression of CCNE1 mRNA23358152
C005108metanil yellowmetanil yellow promotes the reaction [Diethylnitrosamine results in increased expression of CCNE1 protein]10906429
C005108metanil yellowmetanil yellow results in increased expression of CCNE1 protein10906429
D008687MetforminMetformin inhibits the reaction [FSHB protein results in increased expression of CCNE1 protein]16760380
D008687MetforminMetformin results in decreased expression of CCNE1 protein16760380
D008694MethamphetamineMethamphetamine results in decreased expression of CCNE1 protein28341135
D008727MethotrexateMethotrexate affects the expression of CCNE1 mRNA18502557
D008727MethotrexateMethotrexate results in increased expression of CCNE1 mRNA16005536
C013598methoxyacetic acidmethoxyacetic acid affects the expression of CCNE1 mRNA20864626
D008731Methoxychlor[Genistein co-treated with Methoxychlor] results in decreased expression of CCNE1 mRNA21782745
C008461methyl isocyanatemethyl isocyanate affects the expression of CCNE1 protein19513903
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CCNE1 protein17760861
C004925methylmercuric chloridemethylmercuric chloride results in increased cleavage of CCNE1 protein17760861
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CCNE1 protein]26577051
D015735MifepristoneMifepristone inhibits the reaction [CDK2 protein binds to CCNE1 protein]17545545
D015735MifepristoneMifepristone results in decreased expression of and results in decreased localization of CCNE1 protein17545545
C060893MK-886MK-886 inhibits the reaction [Nicotine results in increased expression of CCNE1 protein]20061081
C070571ML 7ML 7 inhibits the reaction [EGF protein results in increased expression of CCNE1 protein]16799973
C020300monomethylarsonic acidmonomethylarsonic acid results in increased expression of CCNE1 mRNA17481689
D009151Mustard GasMustard Gas results in increased expression of CCNE1 mRNA15674843
C451426N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide"fulvestrant inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of CCNE1 protein]"26344002
C451426N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide"N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of CCNE1 protein"26344002
C479831N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea"[N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea results in decreased activity of GSK3B protein] results in increased susceptibility to [troglitazone results in decreased expression of CCNE1 protein]"20540935
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CCNE1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CCNE1 mRNA"25554681
C005274naringinnaringin results in decreased expression of CCNE1 protein18296682
C005274naringinnaringin results in decreased expression of CCNE1 protein18951945
C017096n-butoxyethanoln-butoxyethanol results in increased expression of CCNE1 mRNA19812364
C115174netoglitazonenetoglitazone results in decreased expression of CCNE1 protein14977855
D009532NickelNickel results in increased expression of CCNE1 mRNA25583101
C022838nickel chloridenickel chloride affects the expression of CCNE1 mRNA22546817
D009538NicotineMK-886 inhibits the reaction [Nicotine results in increased expression of CCNE1 protein]20061081
D009538NicotineNicotine results in increased expression of CCNE1 protein20061081
D009583NitrofurazoneAcetylcysteine inhibits the reaction [Nitrofurazone results in increased expression of CCNE1 mRNA]15945272
D009583NitrofurazoneNitrofurazone results in increased expression of CCNE1 mRNA15945272
C025256nonylphenolnonylphenol results in increased expression of CCNE1 mRNA27260121
C025589ochratoxin Aochratoxin A results in increased expression of CCNE1 mRNA25636497
C025589ochratoxin ATRP53 gene mutant form promotes the reaction [ochratoxin A results in increased expression of CCNE1 mRNA]25636497
C025589ochratoxin Aochratoxin A results in increased expression of CCNE1 mRNA19237604|2335814
C013168olaquindoxCDKN1A protein affects the reaction [olaquindox results in increased expression of CCNE1 protein]28757460
C013168olaquindoxolaquindox results in increased expression of CCNE1 protein28757460
C031004oligomycin A[bisphenol A co-treated with oligomycin A] results in decreased expression of CCNE1 protein24909818
C000594117ON123300ON123300 results in increased expression of CCNE1 mRNA26873845
C030110oxaliplatinoxaliplatin results in increased expression of CCNE1 protein15204521
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of CCNE1 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of CCNE1 mRNA25729387
D010126OzoneOzone results in decreased expression of CCNE1 mRNA24336422
D010126OzoneOzone results in increased expression of CCNE1 mRNA16330353
C500026palbociclibCCNE1 protein results in decreased susceptibility to palbociclib21278246
C500026palbociclibpalbociclib results in decreased expression of CCNE1 protein23708653
C500026palbociclibpalbociclib results in increased expression of CCNE1 protein17537993|2188072
C482884panduratin Apanduratin A results in decreased expression of CCNE1 protein16497706
D010278Parathion[Parathion co-treated with Atropine] results in increased expression of CCNE1 mRNA17390078
D010278ParathionParathion results in increased expression of CCNE1 mRNA17390078
D052638Particulate MatterParticulate Matter results in decreased expression of CCNE1 mRNA23454527
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CCNE1 mRNA"25510870
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of CCNE1 mRNA18593933
D010416PentachlorophenolPentachlorophenol results in increased expression of CCNE1 protein19442831
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of CCNE1 mRNA23427857
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of CCNE1 mRNA25868421
D037342Pertussis ToxinPertussis Toxin inhibits the reaction [cicaprost results in decreased activity of [CCNE1 protein binds to CDK2 protein]]12869629
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in decreased expression of CCNE1 protein26678675
D010634PhenobarbitalPhenobarbital promotes the reaction [Diethylnitrosamine results in increased expression of CCNE1 protein]10906429
D010713PhosphatidylcholinesPhosphatidylcholines promotes the reaction [rubitecan results in decreased expression of CCNE1 protein]21695227
D016226Phosphorus, Dietary"Phosphorus, Dietary affects the expression of CCNE1 mRNA"17651324
C049032pinosylvinpinosylvin results in decreased expression of CCNE1 protein23333577
C060836pioglitazonepioglitazone results in decreased expression of CCNE1 protein15729575
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CCNE1 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of CCNE1 mRNA19162173
D010936Plant ExtractsPlant Extracts results in decreased expression of CCNE1 protein24677778
C060540polyhexamethyleneguanidinepolyhexamethyleneguanidine results in decreased expression of CCNE1 mRNA24583197
C035988procymidoneprocymidone results in increased expression of CCNE1 mRNA15686871
D011374ProgesteroneProgesterone results in decreased expression of CCNE1 mRNA23012394
D011374ProgesteroneProgesterone results in decreased expression of CCNE1 mRNA16966611
D011374ProgesteroneProgesterone results in increased expression of CCNE1 mRNA19847363
C107773pterostilbenepterostilbene results in decreased expression of CCNE1 protein20398797
C572726pycnidionepycnidione results in decreased expression of CCNE1 protein22450442
C020972pyrrolidine dithiocarbamic acidpyrrolidine dithiocarbamic acid results in decreased expression of CCNE1 protein14603533
D011794Quercetin[Cisplatin co-treated with Quercetin] results in increased expression of CCNE1 mRNA27514524
D011794QuercetinQuercetin inhibits the reaction [TNF protein results in increased expression of CCNE1 protein]12589822
D011794QuercetinQuercetin promotes the reaction [CDKN1A protein binds to CCNE1 protein]12934110
D011794QuercetinQuercetin results in decreased expression of CCNE1 protein22431435|2529387
D011794QuercetinQuercetin results in increased expression of CCNE1 mRNA21632981
C059514resveratrolresveratrol affects the expression of CCNE1 protein12392819
C059514resveratrolresveratrol inhibits the reaction [TNF protein results in increased expression of CCNE1 protein]16317118
C059514resveratrolresveratrol results in decreased expression of CCNE1 protein17050787|1834718
C059514resveratrolresveratrol results in increased expression of CCNE1 protein11481417|1150706
C059514resveratrolresveratrol results in decreased expression of CCNE1 mRNA24330398
C059514resveratrolresveratrol inhibits the reaction [Glucose results in increased expression of CCNE1 protein]24971582
C059514resveratrolresveratrol results in decreased expression of CCNE1 protein20972827
C009166retinol acetateretinol acetate results in increased expression of CCNE1 mRNA16772331
C547185riccardin Driccardin D results in decreased expression of CCNE1 mRNA24069304
C547185riccardin Driccardin D results in decreased expression of CCNE1 protein24069304
C084904Ro 41-5253Ro 41-5253 inhibits the reaction [Tretinoin promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCNE1 protein]]12421932
C089730rosiglitazonerosiglitazone results in decreased expression of CCNE1 protein15729575
C079905rubitecanPhosphatidylcholines promotes the reaction [rubitecan results in decreased expression of CCNE1 protein]21695227
C079905rubitecanrubitecan results in decreased expression of CCNE1 protein21695227
C064116S-(1,1,2,2-tetrafluoroethyl)cysteine"S-(1,1,2,2-tetrafluoroethyl)cysteine results in decreased expression of CCNE1 mRNA"16678137
C468919SANT-1 compoundCCNE1 protein results in increased susceptibility to SANT-1 compound22923130
C078903seocalcitolseocalcitol results in decreased expression of CCNE1 protein12907249
C016101shikoninshikonin results in decreased expression of CCNE1 protein16061028
D012822Silicon DioxideSilicon Dioxide results in increased expression of CCNE1 mRNA25351596
D012834SilverSilver results in increased expression of CCNE1 protein22546375
D012834SilverSilver results in decreased expression of CCNE1 mRNA27131904
D012835Silver NitrateSilver Nitrate analog results in increased expression of CCNE1 mRNA22831968
D012835Silver NitrateSilver Nitrate results in increased expression of CCNE1 mRNA22831968
D019821Simvastatingeranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of CCNE1 protein]26577051
D019821SimvastatinMevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CCNE1 protein]26577051
D019821SimvastatinSimvastatin results in decreased expression of CCNE1 protein26577051
C017947sodium arsenitesodium arsenite affects the expression of CCNE1 mRNA16507464
C017947sodium arsenitesodium arsenite inhibits the reaction [PDK4 gene mutant form results in increased expression of CCNE1 protein]28003426
C017947sodium arsenitesodium arsenite results in decreased expression of CCNE1 protein20336670
C016104sodium bichromatesodium bichromate affects the expression of CCNE1 mRNA22110744
C016104sodium bichromatesodium bichromate results in increased expression of CCNE1 mRNA12325037
D018038Sodium SeleniteSodium Selenite results in increased expression of CCNE1 mRNA16705456
C471405sorafenibsorafenib inhibits the reaction [Acids results in increased expression of CCNE1 protein]18512153
C471405sorafenibsorafenib inhibits the reaction [Taurocholic Acid results in increased expression of CCNE1 protein]18512153
D013467SulindacSulindac results in decreased expression of CCNE1 protein16488075
D014284TriiodothyronineTriiodothyronine results in increased expression of CCNE1 protein16021636
D014284TriiodothyronineTriiodothyronine results in increased expression of CCNE1 mRNA16021636
D014284TriiodothyronineTriiodothyronine results in increased expression of CCNE1 protein16021636
D013629TamoxifenCCNE1 protein affects the susceptibility to Tamoxifen19148479
D013629Tamoxifen[Tamoxifen co-treated with FTI 277] promotes the reaction [CDKN1A protein binds to [CCNE1 protein binds to CDK2 protein]]12866041
D013629Tamoxifen[Tamoxifen co-treated with FTI 277] promotes the reaction [CDKN1B protein binds to [CCNE1 protein binds to CDK2 protein]]12866041
D013629Tamoxifen[Tamoxifen co-treated with FTI 277] results in decreased activity of [CCNE1 protein binds to CDK2 protein]12866041
D013629TamoxifenTamoxifen results in increased expression of CCNE1 mRNA20215421
D013629TamoxifenTamoxifen results in increased expression of CCNE1 protein20215421
D013629TamoxifenTamoxifen results in increased expression of CCNE1 protein15642790
D013629TamoxifenTamoxifen results in decreased expression of CCNE1 mRNA12602925
D013629TamoxifenTamoxifen results in decreased expression of CCNE1 protein12602925
D013656Taurocholic Acidsorafenib inhibits the reaction [Taurocholic Acid results in increased expression of CCNE1 protein]18512153
D013656Taurocholic AcidTaurocholic Acid results in increased expression of CCNE1 protein18512153
D013656Taurocholic AcidU 0126 inhibits the reaction [Taurocholic Acid results in increased expression of CCNE1 protein]18512153
D013739TestosteroneTestosterone results in increased expression of CCNE1 mRNA19693291
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CCNE1 protein27312872
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CCNE1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of CCNE1 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [CCNE1 protein binds to CDK2 protein]16636136
D013749Tetrachlorodibenzodioxin"Tetrachlorodibenzodioxin promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [CDK2 protein binds to CCNE1 protein]]"20637255
D013749Tetrachlorodibenzodioxin"Tetrachlorodibenzodioxin promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [CDK2 protein binds to CCNE1 protein binds to CDKN1A protein]]"20637255
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [CDK2 protein binds to CCNE1 protein binds to CDKN1A protein]]] which results in decreased activity of CDK2 protein"20637255
D013749Tetrachlorodibenzodioxin"Tetrachlorodibenzodioxin promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [CDK2 protein binds to CCNE1 protein binds to CDKN1B protein]]"20637255
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [CDK2 protein binds to CCNE1 protein binds to CDKN1B protein]]] which results in decreased activity of CDK2 protein"20637255
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CCNE1 promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CCNE1 mRNA16120747|1837239
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CCNE1 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CCNE1 mRNA22298810
D013755Tetradecanoylphorbol Acetate"4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCNE1 protein]"12421932
D013755Tetradecanoylphorbol AcetateIL2 protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCNE1 protein]12421932
D013755Tetradecanoylphorbol AcetateRo 41-5253 inhibits the reaction [Tretinoin promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCNE1 protein]]12421932
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of CCNE1 protein12421932|2407333
D013755Tetradecanoylphorbol AcetateTretinoin promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCNE1 protein]12421932
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CCNE1 mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of CCNE1 mRNA22659510|2341159
D013866ThioguanineThioguanine results in increased expression of CCNE1 mRNA16005536
D013882Thiosemicarbazones[Thiosemicarbazones binds to Copper] which results in decreased expression of CCNE1 protein20931265
C036680thorium nitratethorium nitrate analog results in increased expression of CCNE1 protein24462957
C003466thymoquinonethymoquinone inhibits the reaction [Diethylnitrosamine results in increased expression of CCNE1 protein]24012840
C009495titanium dioxide[Vitallium analog binds to titanium dioxide] which results in decreased expression of CCNE1 mRNA23825117
C009495titanium dioxidetitanium dioxide results in increased expression of CCNE1 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of CCNE1 protein27087172
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of CCNE1 mRNA28065790
D024505TocopherolsTocopherols results in decreased expression of CCNE1 mRNA12504091
D024505TocopherolsTocopherols results in decreased expression of CCNE1 protein12504091
D019772TopotecanTopotecan results in decreased expression of CCNE1 protein15923621
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of CCNE1 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of CCNE1 mRNA25729387
C099150trabectedintrabectedin results in increased expression of CCNE1 mRNA15961672
D014212TretinoinRo 41-5253 inhibits the reaction [Tretinoin promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCNE1 protein]]12421932
D014212Tretinoin[Tretinoin co-treated with caffeic acid phenethyl ester] inhibits the reaction [CDK2 protein binds to CCNE1 protein]16766008
D014212TretinoinTretinoin inhibits the reaction [CDK2 protein binds to CCNE1 protein]16766008
D014212TretinoinTretinoin promotes the reaction [CDK2 protein binds to CCNE1 protein]16765349
D014212TretinoinTretinoin promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCNE1 protein]12421932
D014212TretinoinTretinoin results in decreased degradation of CCNE1 protein20935519
D014212TretinoinTretinoin results in decreased expression of CCNE1 mRNA15194426|1605412
D014212TretinoinTretinoin results in decreased expression of CCNE1 protein15194426
D014212TretinoinTretinoin results in decreased expression of CCNE1 mRNA22498432
D014212Tretinoin[Tretinoin results in increased activity of RXRA protein] which results in increased expression of CCNE1 mRNA20035057
D014212TretinoinTretinoin results in increased expression of CCNE1 protein15231690
D014212TretinoinTretinoin inhibits the reaction [FGF2 protein results in increased expression of CCNE1 mRNA]11675954
D014212TretinoinTretinoin results in decreased expression of CCNE1 protein11675954
C012589trichostatin Atrichostatin A results in increased expression of CCNE1 mRNA24935251
C012589trichostatin Atrichostatin A results in increased expression of CCNE1 protein15179185
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of CCNE1 mRNA19042947
C052920trimethylarsine oxidetrimethylarsine oxide results in increased expression of CCNE1 mRNA17481689
C005445triphenyl phosphatetriphenyl phosphate results in decreased expression of CCNE1 mRNA26898711
C001899triptolidetriptolide results in increased expression of CCNE1 protein26990902
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of CCNE1 mRNA"26179874
C080938tris(2-carboxyethyl)phosphinetris(2-carboxyethyl)phosphine results in decreased expression of CCNE1 protein18952254
C057693troglitazoneGSK3B protein affects the susceptibility to [troglitazone results in decreased expression of CCNE1 protein]20540935
C057693troglitazone"[N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea results in decreased activity of GSK3B protein] results in increased susceptibility to [troglitazone results in decreased expression of CCNE1 protein]"20540935
C057693troglitazonetroglitazone results in decreased expression of CCNE1 protein11834241|1572957
C101044tyrphostin AG 1478tyrphostin AG 1478 inhibits the reaction [Cadmium Chloride results in increased expression of CCNE1 protein]26385184
C101044tyrphostin AG 1478tyrphostin AG 1478 inhibits the reaction [EGF protein results in increased expression of CCNE1 protein]26385184
C101044tyrphostin AG 1478tyrphostin AG 1478 results in decreased expression of CCNE1 protein15923621
C113580U 0126"[2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine co-treated with U 0126] results in decreased expression of CCNE1 protein"22101421
C113580U 0126U 0126 inhibits the reaction [afimoxifene results in increased cleavage of CCNE1 protein]23624423
C113580U 0126U 0126 inhibits the reaction [Taurocholic Acid results in increased expression of CCNE1 protein]18512153
C113580U 0126U 0126 results in decreased expression of CCNE1 protein14757120|2210142
C005466ursolic acidursolic acid results in decreased expression of CCNE1 protein24802810
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CCNE1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of CCNE1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of CCNE1 mRNA22580532
D014635Valproic AcidValproic Acid results in decreased methylation of CCNE1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of CCNE1 mRNA23179753|2438349
D014638Vanadates2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Vanadates results in increased expression of CCNE1 protein]14971663
D014638VanadatesVanadates results in increased expression of CCNE1 protein14971663
D014638Vanadateswortmannin inhibits the reaction [Vanadates results in increased expression of CCNE1 protein]14971663
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of CCNE1 mRNA23454527
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CCNE1 gene25560391
C551177vemurafenib[(+)-JQ1 compound co-treated with vemurafenib] results in decreased expression of CCNE1 mRNA27169980
C025643vinclozolinvinclozolin results in decreased expression of CCNE1 mRNA23555832
D014750VincristineVincristine results in decreased expression of CCNE1 mRNA23649840
D014800Vitallium[Vitallium analog binds to titanium dioxide] which results in decreased expression of CCNE1 mRNA23825117
D014800VitalliumVitallium analog results in decreased expression of CCNE1 mRNA23825117
D002762CholecalciferolCholecalciferol results in decreased expression of CCNE1 protein12907249
D014810Vitamin EVitamin E affects the expression of CCNE1 mRNA16298738
D024483Vitamin K 3Vitamin K 3 affects the expression of CCNE1 mRNA20044591
C111237vorinostatvorinostat results in decreased expression of CCNE123686769
C111237vorinostatvorinostat results in decreased expression of CCNE123686769
C009687wortmannin"[2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [Cadmium Chloride results in increased expression of CCNE1 protein]"26385184
C009687wortmannin"[2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [EGF protein results in increased expression of CCNE1 protein]"26385184
C009687wortmanninwortmannin inhibits the reaction [Vanadates results in increased expression of CCNE1 protein]14971663
C094299ZD 9331ZD 9331 results in increased expression of CCNE1 mRNA15342418
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of CCNE1 mRNA18593933
C088658zoledronic acid[zoledronic acid co-treated with Doxorubicin] results in decreased expression of CCNE1 protein19789217

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003713transcription coactivator activity-NAS15572661  
GO:0004672protein kinase activityCONTRIBUTES_TOIBA21873635  
GO:0004693cyclin-dependent protein serine/threonine kinase activity-TAS-  
GO:0005515protein binding-IPI8553588  8756624  9840943  9891079  10330164  11533444  
16223725  16504183  16721056  16765349  17254966  17254967  
17434132  17525332  19470470  21092281  21952639  21988832  
23455922  23602568  23853094  24358021  25241761  25852190  
GO:0016538cyclin-dependent protein serine/threonine kinase regulator activity-IBA21873635  
GO:0016538cyclin-dependent protein serine/threonine kinase regulator activity-IEA-  
GO:0019901protein kinase binding-IBA21873635  
GO:0019901protein kinase binding-IEA-  
GO:0050681androgen receptor binding-NAS15572661  
GO ID GO Term Qualifier Evidence PubMed
GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity-IBA21873635  
GO:0000082G1/S transition of mitotic cell cycle-NAS8207080  
GO:0000082G1/S transition of mitotic cell cycle-TAS-  
GO:0000083regulation of transcription involved in G1/S transition of mitotic cell cycle-TAS-  
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0000278mitotic cell cycle-IBA21873635  
GO:0000723telomere maintenance-IEA-  
GO:0006270DNA replication initiation-IEA-  
GO:0006468protein phosphorylation-IMP10500095  
GO:0007088regulation of mitotic nuclear division-IBA21873635  
GO:0007129synapsis-IBA21873635  
GO:0007129synapsis-IEA-  
GO:0008284positive regulation of cell proliferation-IBA21873635  
GO:0016055Wnt signaling pathway-IEA-  
GO:0030521androgen receptor signaling pathway-NAS15572661  
GO:0045787positive regulation of cell cycle-IBA21873635  
GO:0045859regulation of protein kinase activity-IEA-  
GO:0045893positive regulation of transcription, DNA-templated-NAS15572661  
GO:0051301cell division-IEA-  
GO:0051726regulation of cell cycle-IEA-  
GO:1903827regulation of cellular protein localization-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000307cyclin-dependent protein kinase holoenzyme complex-IBA21873635  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA16109376  19942931  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IBA21873635  
GO:0005813centrosome-IBA21873635  
GO:0005829cytosol-TAS-  
GO:0097134cyclin E1-CDK2 complex-IBA21873635  
GO:0097134cyclin E1-CDK2 complex-IEA-  
KEGG ID KEGG Term
hsa04110Cell cycle
hsa04114Oocyte meiosis
hsa04115p53 signaling pathway
hsa05200Pathways in cancer
hsa05215Prostate cancer
hsa05222Small cell lung cancer
Reactome ID Reactome Term Evidence
R-HSA-1538133G0 and Early G1TAS
R-HSA-162582Signal TransductionTAS
R-HSA-1640170Cell CycleTAS
R-HSA-187577SCF(Skp2)-mediated degradation of p27/p21TAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-2559583Cellular SenescenceTAS
R-HSA-2559586DNA Damage/Telomere Stress Induced SenescenceTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-390466Chaperonin-mediated protein foldingIEA
R-HSA-390471Association of TriC/CCT with target proteins during biosynthesisIEA
R-HSA-391251Protein foldingIEA
R-HSA-392499Metabolism of proteinsIEA
R-HSA-453279Mitotic G1-G1/S phasesTAS
R-HSA-539107Activation of E2F1 target genes at G1/STAS
R-HSA-6791312TP53 Regulates Transcription of Cell Cycle GenesTAS
R-HSA-6804116TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle ArrestTAS
R-HSA-69017CDK-mediated phosphorylation and removal of Cdc6TAS
R-HSA-69052Switching of origins to a post-replicative stateTAS
R-HSA-69200Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexesTAS
R-HSA-69202Cyclin E associated events during G1/S transition TAS
R-HSA-69205G1/S-Specific TranscriptionTAS
R-HSA-69206G1/S TransitionTAS
R-HSA-69239Synthesis of DNATAS
R-HSA-69242S PhaseTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-69306DNA ReplicationTAS
R-HSA-69563p53-Dependent G1 DNA Damage ResponseTAS
R-HSA-69580p53-Dependent G1/S DNA damage checkpointTAS
R-HSA-69615G1/S DNA Damage CheckpointsTAS
R-HSA-69620Cell Cycle CheckpointsTAS
R-HSA-69656Cyclin A:Cdk2-associated events at S phase entryTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8848021Signaling by PTK6TAS
R-HSA-8849470PTK6 Regulates Cell CycleTAS
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-9006927Signaling by Non-Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
14581353Gene amplification in esophageal adenocarcinomas and Barrett's with high-grade dysplasia. (2003 Oct 15)Miller CTClin Cancer Res
18549475Genome wide SNP comparative analysis between EGFR and KRAS mutated NSCLC and characterization of two models of oncogenic cooperation in non-small cell lung carcinoma. (2008 Jun 12)Blons HBMC Med Genomics
29028944Identification and replication of the interplay of four genetic high-risk variants for urinary bladder cancer. (2017 Dec 7)Selinski SCarcinogenesis
20972438A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. (2010 Nov)Rothman NNat Genet