Gene: KCNK17

89822
K2p17.1|TALK-2|TALK2|TASK-4|TASK4
potassium two pore domain channel subfamily K member 17
protein-coding
6p21.2
Ensembl:ENSG00000124780 MIM:607370 Vega:OTTHUMG00000014646 UniprotKB:Q96T54
NG_047208.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.712e-1 (AD)  3.207e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FRZB0.564
ITIH20.552
EDN30.525
SEMA3G0.502
LRRC170.49
TDGF10.487
MYLK20.474
CLEC3B0.474
C1QTNF70.464
GPC30.462

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ANGPTL4-0.344
CHI3L1-0.333
BAG3-0.319
SERPINA3-0.317
PYCR1-0.293
BCL6-0.286
SLC44A3-0.284
NUAK2-0.277
ITPKC-0.276
GLIS3-0.274

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D001151ArsenicArsenic affects the expression of KCNK17 mRNA18414638

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005244voltage-gated ion channel activity-IEA-  
GO:0005267potassium channel activity-IDA11248242  
GO:0005267potassium channel activity-TAS-  
GO:0022841potassium ion leak channel activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006813potassium ion transport-IDA11248242  
GO:0030322stabilization of membrane potential-IBA21873635  
GO:0034765regulation of ion transmembrane transport-IEA-  
GO:0071805potassium ion transmembrane transport-IBA21873635  
GO:0071805potassium ion transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-112316Neuronal SystemTAS
R-HSA-1296071Potassium ChannelsTAS
R-HSA-1296346Tandem pore domain potassium channelsTAS
R-HSA-1299361TWIK-related alkaline pH activated K+ channel (TALK)TAS
R-HSA-397014Muscle contractionTAS
R-HSA-5576886Phase 4 - resting membrane potentialTAS
R-HSA-5576891Cardiac conductionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24268366Comparison of genome-wide DNA methylation in urothelial carcinomas of patients with and without arsenic exposure. (2014 Jan)Yang TYEnviron Res