Gene: CHRFAM7A

89832
CHRNA7|CHRNA7-DR1|D-10
CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion
protein-coding
15q13.2
Ensembl:ENSG00000166664 MIM:609756 Vega:OTTHUMG00000175645 UniprotKB:Q494W8
NC_000015.10
PubMed
0   ANCO-SNPs
ND
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LRRTM40.733
LINGO20.728
IGSF30.726
KCNH50.726
CHRNA70.711
TMEM178B0.71
RASGRF20.706
NR3C20.705
MTUS20.703
FREM30.702

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HEY2-0.491
GNG8-0.455
CPM-0.437
TGFB3-0.429
BCAS1-0.426
LPAR1-0.425
MYL3-0.423
SEPT10-0.418
FAM107B-0.418
CTNNA3-0.417

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB07494(3-EXO)-3-(10,11-DIHYDRO-5H-DIBENZO[A,D][7]ANNULEN-5-YLOXY)-8,8-DIMETHYL-8-AZONIABICYCLO[3.2.1]OCTANESmall MoleculeExperimentalTarget
DB07720EpibatidineSmall Molecule140111-52-0ExperimentalTarget
DB08620{(2Z)-3-[(6-chloropyridin-3-yl)methyl]-1,3-thiazolidin-2-ylidene}cyanamideSmall MoleculeExperimentalTarget
DB11421ImidaclopridSmall Molecule105827-78-9Target
ID Drug Name Action PubMed
C051904dinophysistoxin 1dinophysistoxin 1 results in increased expression of CHRFAM7A mRNA28939011
C012589trichostatin Atrichostatin A results in increased expression of CHRFAM7A mRNA24935251
D014520UrethaneUrethane results in increased expression of CHRFAM7A mRNA28818685
D014635Valproic AcidValproic Acid results in increased methylation of CHRFAM7A gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004888transmembrane signaling receptor activity-IEA-  
GO:0005230extracellular ligand-gated ion channel activityCONTRIBUTES_TOIBA21873635  
GO:0005230extracellular ligand-gated ion channel activity-IEA-  
GO:0015464acetylcholine receptor activityCONTRIBUTES_TOIBA21873635  
GO:0042166acetylcholine binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-IBA21873635  
GO:0007165signal transduction-IEA-  
GO:0007268chemical synaptic transmission-IBA21873635  
GO:0007271synaptic transmission, cholinergic-IBA21873635  
GO:0034220ion transmembrane transport-IBA21873635  
GO:0034220ion transmembrane transport-IEA-  
GO:0042391regulation of membrane potential-IBA21873635  
GO:0050877nervous system process-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005892acetylcholine-gated channel complex-IBA21873635  
GO:0016021integral component of membrane-IEA-  
GO:0043005neuron projection-IBA21873635  
GO:0045202synapse-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-181431Acetylcholine binding and downstream eventsTAS
R-HSA-622327Postsynaptic nicotinic acetylcholine receptorsTAS
R-HSA-629594Highly calcium permeable postsynaptic nicotinic acetylcholine receptorsTAS
R-HSA-629602Activation of Nicotinic Acetylcholine ReceptorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19462340Smoking in adult attention-deficit/hyperactivity disorder: interaction between 15q13 nicotinic genes and Temperament Character Inventory scores. (2010 Mar)Manchia MWorld J Biol Psychiatry
28978081Expression patterns for nicotinic acetylcholine receptor subunit genes in smoking-related lung cancers. (2017 Sep 15)Bordas AOncotarget
29305655CHRFAM7A gene expression in schizophrenia: clinical correlates and the effect of antipsychotic treatment. (2018 Apr)Kalmady SVJ Neural Transm (Vienna)
22441542Nicotinic acetylcholine receptor expression and susceptibility to cholinergic immunomodulation in human monocytes of smoking individuals. (2012)van der Zanden EPNeuroimmunomodulation
26575444CHRNA7 and CHRFAM7A: psychosis and smoking? Blame the neighbors! (2015 Nov 1)Akbarian SAm J Psychiatry