Gene: AQP10

89872
AQPA_HUMAN
aquaporin 10
protein-coding
1q21.3
Ensembl:ENSG00000143595 MIM:606578 Vega:OTTHUMG00000035980 UniprotKB:Q96PS8
NC_000001.11
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.730e-1 (AD)  2.424e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ENTHD10.798
GPR1010.776
SAG0.771
DRD30.761
DGKK0.76
AMBN0.755
TMPRSS60.755
PRLR0.754
GPR10.752
ZBED20.738

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC17A7-0.399
TBR1-0.336
KCNC2-0.326
NXPH3-0.324
TESPA1-0.324
SOHLH1-0.323
NEUROD2-0.321
TMEM155-0.32
GALNT9-0.319
SYTL2-0.316

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0152621,6-hexamethylene diisocyanate"1,6-hexamethylene diisocyanate affects the expression of AQP10 mRNA"19527780
C018453ammonium hexachloroplatinateammonium hexachloroplatinate affects the expression of AQP10 mRNA19527780
D001151ArsenicAQP10 protein results in increased transport of Arsenic22214486
C042120arsenic pentoxidearsenic pentoxide results in decreased expression of AQP10 mRNA22214486
C006632arsenic trioxidearsenic trioxide results in increased expression of AQP10 mRNA22214486
D005990GlycerolAQP10 protein results in increased transport of Glycerol19684221
D005990GlycerolAQP10 protein results in increased uptake of Glycerol12084581
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of AQP10 mRNA17183730
D008628MercuryMercury inhibits the reaction [AQP10 protein results in increased transport of Water]19684221
D008628MercuryMercury affects the activity of AQP10 protein12084581
D008628MercuryMercury results in decreased activity of AQP10 protein11573934
D014212TretinoinTretinoin results in decreased expression of AQP10 mRNA23724009
C015559trimellitic anhydridetrimellitic anhydride affects the expression of AQP10 mRNA19527780
D014508UreaAQP10 protein results in increased transport of Urea19684221
D014508UreaAQP10 protein results in increased uptake of Urea12084581
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of AQP10 mRNA17183730
D014867WaterAQP10 protein results in increased transport of Water19684221
D014867WaterMercury inhibits the reaction [AQP10 protein results in increased transport of Water]19684221

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0015204urea transmembrane transporter activity-IBA21873635  
GO:0015250water channel activity-EXP1373524  1510932  7530250  9369468  9405233  9806845  
9829975  10318966  10510269  10564231  11001937  11034202  
11076974  11573934  12084581  14701836  15948717  16596446  
17178220  18202181  18501347  18511455  18762715  21251984  
GO:0015254glycerol channel activity-EXP9369468  9405233  10510269  10564231  11573934  12084581  
16596446  18762715  
GO:0015265urea channel activity-EXP10564231  11573934  12084581  18762715  
GO ID GO Term Qualifier Evidence PubMed
GO:0006833water transport-TAS-  
GO:0009636response to toxic substance-IDA17575980  
GO:0015793glycerol transport-IEA-  
GO:0071918urea transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-382551Transport of small moleculesTAS
R-HSA-432047Passive transport by AquaporinsTAS
R-HSA-445717Aquaporin-mediated transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29132311Weighted gene co-expression network analysis of expression data of monozygotic twins identifies specific modules and hub genes related to BMI. (2017 Nov 13)Wang WBMC Genomics