Gene info: ID 8989

Gene: TRPA1

GENE ID: 8989

Synonyms: ANKTM1|FEPS|FEPS1

Description: transient receptor potential cation channel subfamily A member 1

Gene type: protein-coding

Location: 8q21.11

dbXrefs: Ensembl:ENSG00000104321 MIM:604775 Vega:OTTHUMG00000164516 UniprotKB:O75762

RefSeq: NG_033890.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 7

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 3.224e-1 (AD) 6.779e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
NYAP2	0.616
MYO5B	0.611
NXPH2	0.604
KCNH7	0.602
ZNF385D	0.599
MYO16	0.584
PCDHGC4	0.582
KIAA1024	0.582
SERTM1	0.58
GRIP2	0.579

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ROM1	-0.469
ATOH8	-0.425
AGTRAP	-0.412
HEBP2	-0.404
CSF1	-0.398
OTOS	-0.387
ITPKB	-0.385
ZHX2	-0.385
TGFB3	-0.383
MT1M	-0.381

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00825	Menthol	Small Molecule	2216-51-5	Approved	Target
DB09061	Cannabidiol	Small Molecule	13956-29-1	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C040756	1,2-naphthoquinone	"1,2-naphthoquinone results in increased activity of TRPA1 protein"	21591660
C031763	1,3-butadiene	"1,3-butadiene binds to and results in increased activity of TRPA1 protein"	21591660
C060229	1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione	"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [cinnamic aldehyde results in increased activity of TRPA1 protein]"	15046718
C016614	1-nitronaphthalene	1-nitronaphthalene results in increased activity of TRPA1 protein	21591660
C038237	1-oleoyl-2-acetylglycerol	1-oleoyl-2-acetylglycerol results in increased activity of TRPA1 protein	15046718
C038237	1-oleoyl-2-acetylglycerol	Ruthenium Red inhibits the reaction [1-oleoyl-2-acetylglycerol results in increased activity of TRPA1 protein]	15046718
C552888	2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide	"2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [cinnamic aldehyde results in increased activity of TRPA1 protein]"	22791718
C552888	2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide	"2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [cinnamic aldehyde results in increased activity of TRPA1 protein]"	20720158
C552888	2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide	"2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [Dibutyl Phthalate results in increased activity of TRPA1 protein]"	22935519
C552888	2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide	"2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased activity of TRPA1 protein]"	20720158
C552888	2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide	"2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide binds to and results in decreased activity of TRPA1 protein"	19458046
C552888	2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide	"2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of TRPA1 protein]"	21689654
C552888	2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide	"2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]"	21689654\|2773585
C552888	2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide	"2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [cinnamic aldehyde results in increased activity of TRPA1 protein]"	21689654
C552888	2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide	"2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide binds to and results in decreased activity of TRPA1 protein"	19847360
C552888	2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide	"[2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide binds to and results in decreased activity of TRPA1 protein] which results in decreased susceptibility to Cyclophosphamide"	23523557
C552888	2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide	"[2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide binds to and results in decreased activity of TRPA1 protein] which results in decreased susceptibility to Eugenol"	22426238
C552888	2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide	"2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]"	27735854
C552888	2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide	"2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [Formaldehyde results in increased activity of TRPA1 protein]"	19847360
C552888	2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide	"2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide binds to and results in decreased activity of TRPA1 protein"	19845671\|2004289
C041942	2,3,4-tri-O-acetylarabinopyranosyl isothiocyanate	"2,3,4-tri-O-acetylarabinopyranosyl isothiocyanate results in increased activity of TRPA1 protein"	22155782\|2754587
C056559	2,4-di-tert-butylphenol	"2,4-di-tert-butylphenol results in increased activity of TRPA1 protein"	21591660
C109986	2-aminoethoxydiphenyl borate	2-aminoethoxydiphenyl borate results in increased activity of TRPA1 protein	22791718
C109986	2-aminoethoxydiphenyl borate	2-aminoethoxydiphenyl borate results in increased activity of TRPA1 protein	22791718
C012796	2-butenal	2-butenal results in increased activity of TRPA1 protein	18568077
C012796	2-butenal	2-butenal results in increased activity of TRPA1 protein	18568077
C012796	2-butenal	2-butenal results in increased activity of TRPA1 protein	18568077
C031278	2-chloroethyl ethyl sulfide	2-chloroethyl ethyl sulfide results in increased activity of TRPA1 protein	27738742
C031278	2-chloroethyl ethyl sulfide	[2-chloroethyl ethyl sulfide results in increased activity of TRPA1 protein] which results in increased uptake of Calcium	27738742
C031278	2-chloroethyl ethyl sulfide	4-(4-chlorophenyl)-3-methylbut-3-en-2-oxime inhibits the reaction [[2-chloroethyl ethyl sulfide results in increased activity of TRPA1 protein] which results in increased uptake of Calcium]	27738742
C031278	2-chloroethyl ethyl sulfide	TRPA1 protein results in increased susceptibility to 2-chloroethyl ethyl sulfide	25395009\|2773874
C031278	2-chloroethyl ethyl sulfide	2-chloroethyl ethyl sulfide results in increased activity of TRPA1 protein	25395009
C034017	2-ethylhexanol	2-ethylhexanol results in increased activity of TRPA1 protein	27545873
C054649	3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol	"3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of TRPA1 protein"	18550765
C000602225	4-(4-chlorophenyl)-3-methylbut-3-en-2-oxime	4-(4-chlorophenyl)-3-methylbut-3-en-2-oxime inhibits the reaction [[2-chloroethyl ethyl sulfide results in increased activity of TRPA1 protein] which results in increased uptake of Calcium]	27738742
C000602225	4-(4-chlorophenyl)-3-methylbut-3-en-2-oxime	4-(4-chlorophenyl)-3-methylbut-3-en-2-oxime inhibits the reaction [Mustard Gas results in increased activity of TRPA1 protein]	27738742
C000602225	4-(4-chlorophenyl)-3-methylbut-3-en-2-oxime	4-(4-chlorophenyl)-3-methylbut-3-en-2-oxime inhibits the reaction [[Mustard Gas results in increased activity of TRPA1 protein] which results in increased uptake of Calcium]	27738742
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRPA1 mRNA"	27188386
C024896	4-anisaldehyde	4-anisaldehyde results in increased activity of TRPA1 protein	21591660
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in increased activity of TRPA1 protein	17684094
C027576	4-hydroxy-2-nonenal	Ruthenium Red inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of TRPA1 protein]	17684094
C027576	4-hydroxy-2-nonenal	TRPA1 gene mutant form inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of TRPA1 protein]	17684094\|1768409
C027576	4-hydroxy-2-nonenal	"2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of TRPA1 protein]"	21689654
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in increased activity of TRPA1 protein	21689654
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in increased activity of TRPA1 protein	17684094
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRPA1 mRNA"	27188386
C560402	A 967079	A 967079 results in decreased activity of TRPA1 protein	28919489
C560402	A 967079	TRPA1 protein results in increased susceptibility to A 967079	28919489
D000082	Acetaminophen	TRPA1 affects the susceptibility to Acetaminophen	20720158
C038699	acetophenone	acetophenone results in increased activity of TRPA1 protein	27545873
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [[allyl isothiocyanate results in increased activity of TRPA1 protein] which results in increased uptake of Calcium]	27738742
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [[Mustard Gas results in increased activity of TRPA1 protein] which results in increased uptake of Calcium]	27738742
D000157	Aconitine	TRPA1 results in increased susceptibility to [Vehicle Emissions co-treated with Aconitine]	21377951
D000171	Acrolein	Acrolein results in increased activity of TRPA1 protein	22791718
D000171	Acrolein	Acrolein results in increased activity of TRPA1 protein	18568077
D000171	Acrolein	Acrolein results in increased activity of TRPA1 protein	21591660
D000171	Acrolein	TRPA1 mRNA affects the reaction [Acrolein results in increased secretion of Serotonin]	19507004
D000171	Acrolein	TRPA1 mRNA affects the reaction [Acrolein results in increased uptake of Calcium]	19507004
D000171	Acrolein	TRPA1 mRNA affects the susceptibility to Acrolein	19507004
D000171	Acrolein	Acrolein results in increased activity of TRPA1 protein	18568077
D000171	Acrolein	TRPA1 gene mutant form results in increased susceptibility to Acrolein	27592100
D000171	Acrolein	TRPA1 protein affects the susceptibility to Acrolein	27746315
D000171	Acrolein	Acrolein results in increased activity of TRPA1 protein	18568077
D000171	Acrolein	Acrolein results in increased activity of TRPA1 protein	22791718
D000171	Acrolein	Acrolein results in increased activity of TRPA1 protein	17684094\|2060163
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of TRPA1 mRNA	22100608
C110795	agathic acid	agathic acid results in increased activity of TRPA1 protein	23541125
C110795	agathic acid	Glutathione inhibits the reaction [agathic acid results in increased activity of TRPA1 protein]	23541125
C006452	allicin	allicin binds to and results in increased activity of TRPA1 protein	17825279
C006452	allicin	allicin binds to and results in increased activity of TRPA1 protein	20086034
C006452	allicin	[allicin binds to and results in increased activity of TRPA1 protein] which results in increased transport of Calcium	20086034
C006452	allicin	allicin results in increased activity of TRPA1 protein	17684094
C004471	allyl isothiocyanate	allyl isothiocyanate results in increased activity of TRPA1 protein	22791718
C004471	allyl isothiocyanate	allyl isothiocyanate results in increased activity of TRPA1 protein alternative form	27038267
C004471	allyl isothiocyanate	allyl isothiocyanate results in increased activity of TRPA1 protein	20797863
C004471	allyl isothiocyanate	allyl isothiocyanate results in increased activity of TRPA1 protein	25827167
C004471	allyl isothiocyanate	Acetylcysteine inhibits the reaction [[allyl isothiocyanate results in increased activity of TRPA1 protein] which results in increased uptake of Calcium]	27738742
C004471	allyl isothiocyanate	[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK1 protein	23994502
C004471	allyl isothiocyanate	[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK3 protein	23994502
C004471	allyl isothiocyanate	allyl isothiocyanate results in increased activity of TRPA1 protein	22935519\|2399450
C004471	allyl isothiocyanate	[allyl isothiocyanate results in increased activity of TRPA1 protein] which results in increased uptake of Calcium	27738742
C004471	allyl isothiocyanate	BDKRB2 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]	17571167
C004471	allyl isothiocyanate	edelfosine inhibits the reaction [F2RL1 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]]	17571167
C004471	allyl isothiocyanate	F2RL1 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]	17571167
C004471	allyl isothiocyanate	"Phosphatidylinositol 4,5-Diphosphate inhibits the reaction [F2RL1 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]]"	17571167
C004471	allyl isothiocyanate	Ruthenium Red inhibits the reaction [[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK1 protein]	23994502
C004471	allyl isothiocyanate	Ruthenium Red inhibits the reaction [[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK3 protein]	23994502
C004471	allyl isothiocyanate	TRPA1 mRNA affects the reaction [allyl isothiocyanate results in increased secretion of Serotonin]	19507004
C004471	allyl isothiocyanate	TRPA1 mRNA affects the reaction [allyl isothiocyanate results in increased uptake of Calcium]	19507004
C004471	allyl isothiocyanate	TRPA1 mRNA affects the susceptibility to allyl isothiocyanate	19507004
C004471	allyl isothiocyanate	TRPA1 protein polymorphism affects the susceptibility to allyl isothiocyanate	26039217
C004471	allyl isothiocyanate	"2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]"	21689654\|2773585
C004471	allyl isothiocyanate	allyl isothiocyanate binds to and results in increased activity of TRPA1 protein	15843607\|1782527
C004471	allyl isothiocyanate	allyl isothiocyanate results in increased activity of TRPA1 protein	15046718\|2168965
C004471	allyl isothiocyanate	Amiloride inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]	15843607
C004471	allyl isothiocyanate	Gadolinium inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]	15843607
C004471	allyl isothiocyanate	Gentamicins inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]	15843607
C004471	allyl isothiocyanate	Indomethacin inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]	27735854
C004471	allyl isothiocyanate	Ruthenium Red inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]	15843607
C004471	allyl isothiocyanate	TRPA1 affects the susceptibility to allyl isothiocyanate	20442136\|2072015
C004471	allyl isothiocyanate	TRPA1 gene mutant form inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]	27735854\|2773585
C004471	allyl isothiocyanate	"2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]"	27735854
C004471	allyl isothiocyanate	allyl isothiocyanate binds to and results in increased activity of TRPA1 protein	20086034
C004471	allyl isothiocyanate	[allyl isothiocyanate binds to and results in increased activity of TRPA1 protein] which results in increased transport of Calcium	20086034
C004471	allyl isothiocyanate	allyl isothiocyanate results in increased activity of TRPA1 protein	17314320
C004471	allyl isothiocyanate	allyl isothiocyanate results in increased activity of TRPA1 protein	22791718
C004471	allyl isothiocyanate	allyl isothiocyanate binds to and results in increased activity of TRPA1 protein	17942619\|1883881
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in increased expression of TRPA1 mRNA	21298039
C439263	AM 1241	AM 1241 results in increased activity of TRPA1 protein	18234885
C439263	AM 1241	TRPA1 affects the susceptibility to AM 1241	18234885
C439263	AM 1241	TRPA1 affects the reaction [AM 1241 results in increased abundance of Calcium]	18234885
D000584	Amiloride	Amiloride inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]	15843607
D016718	Arachidonic Acid	Arachidonic Acid results in increased activity of TRPA1 protein	15046718
D016718	Arachidonic Acid	Ruthenium Red inhibits the reaction [Arachidonic Acid results in increased activity of TRPA1 protein]	15046718
C547126	AZM551248	AZM551248 results in increased expression of TRPA1 mRNA	22323515
D001554	Benzene	Benzene results in increased activity of TRPA1 protein	21591660
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of TRPA1 mRNA"	20382639
C006780	bisphenol A	bisphenol A results in decreased expression of TRPA1 mRNA	25181051
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of TRPA1 mRNA	22079614
D019256	Cadmium Chloride	Cadmium Chloride results in increased methylation of TRPA1 promoter	22457795
D002118	Calcium	[2-chloroethyl ethyl sulfide results in increased activity of TRPA1 protein] which results in increased uptake of Calcium	27738742
D002118	Calcium	4-(4-chlorophenyl)-3-methylbut-3-en-2-oxime inhibits the reaction [[2-chloroethyl ethyl sulfide results in increased activity of TRPA1 protein] which results in increased uptake of Calcium]	27738742
D002118	Calcium	4-(4-chlorophenyl)-3-methylbut-3-en-2-oxime inhibits the reaction [[Mustard Gas results in increased activity of TRPA1 protein] which results in increased uptake of Calcium]	27738742
D002118	Calcium	Acetylcysteine inhibits the reaction [[allyl isothiocyanate results in increased activity of TRPA1 protein] which results in increased uptake of Calcium]	27738742
D002118	Calcium	Acetylcysteine inhibits the reaction [[Mustard Gas results in increased activity of TRPA1 protein] which results in increased uptake of Calcium]	27738742
D002118	Calcium	[allyl isothiocyanate results in increased activity of TRPA1 protein] which results in increased uptake of Calcium	27738742
D002118	Calcium	[cinnamic aldehyde results in increased activity of TRPA1 protein] which results in increased transport of Calcium	22863862
D002118	Calcium	[cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester co-treated with TRPA1 protein] results in increased uptake of Calcium	17314320
D002118	Calcium	[Mustard Gas results in increased activity of TRPA1 protein] which results in increased uptake of Calcium	27738742
D002118	Calcium	[Pyruvaldehyde results in increased activity of TRPA1 protein] which results in increased transport of Calcium	22863862
D002118	Calcium	TRPA1 mRNA affects the reaction [Acrolein results in increased uptake of Calcium]	19507004
D002118	Calcium	TRPA1 mRNA affects the reaction [allyl isothiocyanate results in increased uptake of Calcium]	19507004
D002118	Calcium	TRPA1 mRNA affects the reaction [cinnamic aldehyde results in increased uptake of Calcium]	19507004
D002118	Calcium	Calcium affects the activity of TRPA1 protein	15843607
D002118	Calcium	[allicin binds to and results in increased activity of TRPA1 protein] which results in increased transport of Calcium	20086034
D002118	Calcium	[allyl isothiocyanate binds to and results in increased activity of TRPA1 protein] which results in increased transport of Calcium	20086034
D002118	Calcium	Calcium affects the reaction [Capsaicin inhibits the reaction [TRPA1 protein affects the susceptibility to mustard oil]]	17590514
D002118	Calcium	[cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester co-treated with TRPA1 protein] results in increased uptake of Calcium	17314320
D002118	Calcium	TRPA1 affects the reaction [AM 1241 results in increased abundance of Calcium]	18234885
D002118	Calcium	TRPA1 promotes the reaction [mustard oil results in increased abundance of Calcium]	18234885
D002118	Calcium	TRPA1 promotes the reaction [Win 55212-2 results in increased abundance of Calcium]	18234885
D002164	Camphor	Camphor binds to and results in decreased activity of TRPA1 protein	19845671\|2146681
D002185	Cannabidiol	Cannabidiol binds to and results in increased activity of TRPA1 protein	18550765
C073718	cannabidiol hydroxyquinone	cannabidiol hydroxyquinone binds to and results in increased activity of TRPA1 protein	18550765
D002211	Capsaicin	Capsaicin results in increased activity of TRPA1 protein	29054683
D002211	Capsaicin	Calcium affects the reaction [Capsaicin inhibits the reaction [TRPA1 protein affects the susceptibility to mustard oil]]	17590514
D002211	Capsaicin	Capsaicin results in decreased expression of TRPA1 mRNA	18079164
D002245	Carbon Dioxide	Carbon Dioxide results in increased activity of TRPA1 protein	20881114
C073316	carvacrol	carvacrol results in increased activity of TRPA1 protein	22791718
C073316	carvacrol	carvacrol results in increased activity of TRPA1 protein	22935519
C073316	carvacrol	carvacrol results in increased activity of TRPA1 protein	16617338
C073316	carvacrol	carvacrol results in increased activity of TRPA1 protein	22791718
C073316	carvacrol	carvacrol binds to and results in increased activity of TRPA1 protein	20086034
C073316	carvacrol	carvacrol results in increased activity of TRPA1 protein	19135721
D002713	Chlorine	Chlorine results in increased activity of TRPA1 protein	20601631
C012843	cinnamic aldehyde	"2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [cinnamic aldehyde results in increased activity of TRPA1 protein]"	22791718
C012843	cinnamic aldehyde	cinnamic aldehyde results in increased activity of TRPA1 protein	22791718
C012843	cinnamic aldehyde	cinnamic aldehyde results in increased activity of TRPA1 protein alternative form	27038267
C012843	cinnamic aldehyde	cinnamic aldehyde results in increased activity of TRPA1 protein	25827167
C012843	cinnamic aldehyde	"2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [cinnamic aldehyde results in increased activity of TRPA1 protein]"	20720158
C012843	cinnamic aldehyde	cinnamic aldehyde results in increased activity of TRPA1 protein	20720158\|2286386
C012843	cinnamic aldehyde	[cinnamic aldehyde results in increased activity of TRPA1 protein] which results in increased transport of Calcium	22863862
C012843	cinnamic aldehyde	edelfosine inhibits the reaction [F2RL1 protein promotes the reaction [cinnamic aldehyde results in increased activity of TRPA1 protein]]	17571167
C012843	cinnamic aldehyde	F2RL1 protein promotes the reaction [cinnamic aldehyde results in increased activity of TRPA1 protein]	17571167
C012843	cinnamic aldehyde	TRPA1 mRNA affects the reaction [cinnamic aldehyde results in increased secretion of Serotonin]	19507004
C012843	cinnamic aldehyde	TRPA1 mRNA affects the reaction [cinnamic aldehyde results in increased uptake of Calcium]	19507004
C012843	cinnamic aldehyde	TRPA1 mRNA affects the susceptibility to cinnamic aldehyde	19507004
C012843	cinnamic aldehyde	TRPA1 protein results in increased susceptibility to cinnamic aldehyde	15046718
C012843	cinnamic aldehyde	"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [cinnamic aldehyde results in increased activity of TRPA1 protein]"	15046718
C012843	cinnamic aldehyde	"2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [cinnamic aldehyde results in increased activity of TRPA1 protein]"	21689654
C012843	cinnamic aldehyde	cinnamic aldehyde binds to and results in increased activity of TRPA1 protein	17991581
C012843	cinnamic aldehyde	cinnamic aldehyde results in increased activity of TRPA1 protein	15046718\|2135338
C012843	cinnamic aldehyde	isopentenyl pyrophosphate inhibits the reaction [cinnamic aldehyde results in increased activity of TRPA1 protein]	21353389
C012843	cinnamic aldehyde	Ruthenium Red inhibits the reaction [cinnamic aldehyde results in increased activity of TRPA1 protein]	15046718
C012843	cinnamic aldehyde	TRPA1 affects the susceptibility to cinnamic aldehyde	20442136
C012843	cinnamic aldehyde	TRPA1 protein results in increased susceptibility to cinnamic aldehyde	15046718
C012843	cinnamic aldehyde	cinnamic aldehyde results in increased activity of TRPA1 protein	20720158
C012843	cinnamic aldehyde	cinnamic aldehyde results in increased activity of TRPA1 protein	22791718
C012843	cinnamic aldehyde	Ruthenium Red inhibits the reaction [cinnamic aldehyde results in increased activity of TRPA1 protein]	22791718
C012843	cinnamic aldehyde	cinnamic aldehyde binds to and results in increased activity of TRPA1 protein	17942619\|1806069
C012843	cinnamic aldehyde	cinnamic aldehyde binds to TRPA1 protein	17237762
C012843	cinnamic aldehyde	cinnamic aldehyde results in increased activity of TRPA1 protein	17237762
C012843	cinnamic aldehyde	Menthol inhibits the reaction [cinnamic aldehyde results in increased activity of TRPA1 protein]	17237762
C108217	citronellal	citronellal results in increased activity of TRPA1 protein	20797863\|2644713
C108217	citronellal	citronellal results in increased activity of TRPA1 protein alternative form	27038267
C108217	citronellal	citronellal results in increased activity of TRPA1 protein	20797863\|2644713
C108217	citronellal	citronellal results in increased activity of TRPA1 protein	25827167
C108217	citronellal	citronellal results in increased activity of TRPA1 protein	26447139
D060729	Coal Ash	Coal Ash affects the activity of TRPA1 protein	22155782
D060729	Coal Ash	Coal Ash binds to and results in increased activity of TRPA1 protein	21591660
D060729	Coal Ash	TRPA1 protein polymorphism affects the susceptibility to Coal Ash	26039217
C075384	coniferaldehyde	coniferaldehyde results in increased activity of TRPA1 protein	23541125
C500528	cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester	[cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester co-treated with TRPA1 protein] results in increased uptake of Calcium	17314320
C500528	cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester	cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester results in increased activity of TRPA1 protein	17314320
C500528	cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester	[cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester co-treated with TRPA1 protein] results in increased uptake of Calcium	17314320
C500528	cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester	cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester results in increased activity of TRPA1 protein	17314320
D003520	Cyclophosphamide	"[2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide binds to and results in decreased activity of TRPA1 protein] which results in decreased susceptibility to Cyclophosphamide"	23523557
D000069439	Dasatinib	Dasatinib results in decreased expression of TRPA1 mRNA	20579391
D013759	Dronabinol	Dronabinol binds to and results in increased activity of TRPA1 protein	18550765
C007262	deoxynivalenol	TRPA1 affects the reaction [deoxynivalenol results in increased secretion of CCK protein]	25787141
D003993	Dibutyl Phthalate	"2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [Dibutyl Phthalate results in increased activity of TRPA1 protein]"	22935519
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased activity of TRPA1 protein	22935519
C063304	dibutyrylglycerol	dibutyrylglycerol analog results in increased activity of TRPA1 protein	29198882
D002945	Cisplatin	Cisplatin results in increased activity of TRPA1 protein	21481532
D002945	Cisplatin	TRPA1 protein modified form results in increased susceptibility to Cisplatin	21481532
D004229	Dithiothreitol	Dithiothreitol inhibits the reaction [N-biotinylaminoethyl methanethiosulfonate results in increased activity of TRPA1 protein]	17237762
C026659	edelfosine	edelfosine inhibits the reaction [F2RL1 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]]	17571167
C026659	edelfosine	edelfosine inhibits the reaction [F2RL1 protein promotes the reaction [cinnamic aldehyde results in increased activity of TRPA1 protein]]	17571167
D015117	5,8,11,14-Eicosatetraynoic Acid	"5,8,11,14-Eicosatetraynoic Acid results in increased activity of TRPA1 protein"	15046718
C118739	entinostat	entinostat results in increased expression of TRPA1 mRNA	27188386
D005054	Eugenol	"[2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide binds to and results in decreased activity of TRPA1 protein] which results in decreased susceptibility to Eugenol"	22426238
D005054	Eugenol	Eugenol results in increased activity of TRPA1 protein	22426238
D016650	Fluorescein-5-isothiocyanate	Fluorescein-5-isothiocyanate binds to TRPA1 protein	27129696
D005492	Folic Acid	Folic Acid results in increased expression of TRPA1 mRNA	25006883
D005557	Formaldehyde	Formaldehyde results in increased activity of TRPA1 protein	21591660
D005557	Formaldehyde	"2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [Formaldehyde results in increased activity of TRPA1 protein]"	19847360
D005557	Formaldehyde	Formaldehyde results in increased activity of TRPA1 protein	19847360
D005682	Gadolinium	Gadolinium inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]	15843607
D005839	Gentamicins	Gentamicins inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]	15843607
D005839	Gentamicins	Gentamicins binds to and results in decreased activity of TRPA1 protein	19845671
D005978	Glutathione	Glutathione inhibits the reaction [agathic acid results in increased activity of TRPA1 protein]	23541125
D005978	Glutathione	Glutathione inhibits the reaction [Particulate Matter results in increased activity of TRPA1 protein]	23541125
D012701	Serotonin	TRPA1 mRNA affects the reaction [Acrolein results in increased secretion of Serotonin]	19507004
D012701	Serotonin	TRPA1 mRNA affects the reaction [allyl isothiocyanate results in increased secretion of Serotonin]	19507004
D012701	Serotonin	TRPA1 mRNA affects the reaction [cinnamic aldehyde results in increased secretion of Serotonin]	19507004
D006862	Hydrogen Sulfide	Hydrogen Sulfide results in increased activity of TRPA1 protein	18031925
D006862	Hydrogen Sulfide	Hydrogen Sulfide results in increased activity of TRPA1 protein	18031925
C031927	hydroquinone	hydroquinone results in increased activity of TRPA1 protein	21591660
C490483	icilin	icilin binds to and results in increased activity of TRPA1 protein	15843607\|1782527
C490483	icilin	icilin results in increased activity of TRPA1 protein	18930858
D007213	Indomethacin	Indomethacin inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]	27735854
D007460	Iodoacetamide	Iodoacetamide binds to and results in increased activity of TRPA1 protein	17237762
C110793	isocupressic acid	isocupressic acid results in increased activity of TRPA1 protein	23541125
D017953	Isocyanates	TRPA1 protein results in increased susceptibility to Isocyanates	19036859
C004809	isopentenyl pyrophosphate	isopentenyl pyrophosphate inhibits the reaction [cinnamic aldehyde results in increased activity of TRPA1 protein]	21353389
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of TRPA1 mRNA	24796395
D008012	Lidocaine	Lidocaine results in increased activity of TRPA1 protein	18172555
D008012	Lidocaine	Lidocaine results in increased activity of TRPA1 protein	18172555
C018584	linalool	linalool results in increased activity of TRPA1 protein	27735854
D008610	Menthol	Menthol results in increased activity of TRPA1 protein	29054683
D008610	Menthol	Menthol inhibits the reaction [cinnamic aldehyde results in increased activity of TRPA1 protein]	17237762
D008610	Menthol	Menthol inhibits the reaction [mustard oil results in increased activity of TRPA1 protein]	17237762
D008610	Menthol	Menthol inhibits the reaction [N-biotinylaminoethyl methanethiosulfonate results in increased activity of TRPA1 protein]	17237762
D008610	Menthol	Menthol results in increased activity of TRPA1 protein	18930858
C008461	methyl isocyanate	methyl isocyanate results in increased activity of TRPA1 protein	20601631
D009151	Mustard Gas	4-(4-chlorophenyl)-3-methylbut-3-en-2-oxime inhibits the reaction [Mustard Gas results in increased activity of TRPA1 protein]	27738742
D009151	Mustard Gas	4-(4-chlorophenyl)-3-methylbut-3-en-2-oxime inhibits the reaction [[Mustard Gas results in increased activity of TRPA1 protein] which results in increased uptake of Calcium]	27738742
D009151	Mustard Gas	Acetylcysteine inhibits the reaction [[Mustard Gas results in increased activity of TRPA1 protein] which results in increased uptake of Calcium]	27738742
D009151	Mustard Gas	Mustard Gas results in increased activity of TRPA1 protein	27738742
D009151	Mustard Gas	[Mustard Gas results in increased activity of TRPA1 protein] which results in increased uptake of Calcium	27738742
C027793	mustard oil	mustard oil results in increased activity of TRPA1 protein	17684094
C027793	mustard oil	TRPA1 results in increased susceptibility to mustard oil	18234885
C027793	mustard oil	Calcium affects the reaction [Capsaicin inhibits the reaction [TRPA1 protein affects the susceptibility to mustard oil]]	17590514
C027793	mustard oil	mustard oil binds to and results in increased activity of TRPA1 protein	18550765
C027793	mustard oil	TRPA1 promotes the reaction [mustard oil results in increased abundance of Calcium]	18234885
C027793	mustard oil	Menthol inhibits the reaction [mustard oil results in increased activity of TRPA1 protein]	17237762
C027793	mustard oil	mustard oil binds to and results in increased activity of TRPA1 protein	16617338\|1823488
C027793	mustard oil	mustard oil binds to TRPA1 protein	17237762
C027793	mustard oil	mustard oil results in increased activity of TRPA1 protein	17237762
C028473	N-acetyl-4-benzoquinoneimine	"2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased activity of TRPA1 protein]"	20720158
C028473	N-acetyl-4-benzoquinoneimine	N-acetyl-4-benzoquinoneimine results in increased activity of TRPA1 protein	20720158
C028473	N-acetyl-4-benzoquinoneimine	TRPA1 affects the susceptibility to N-acetyl-4-benzoquinoneimine	20720158
C028473	N-acetyl-4-benzoquinoneimine	N-acetyl-4-benzoquinoneimine results in increased activity of TRPA1 protein	20720158
C031721	naphthalene	TRPA1 results in increased susceptibility to naphthalene	20176620
C027029	naphthoresorcinol	naphthoresorcinol results in increased activity of TRPA1 protein	21591660
C419543	N-biotinylaminoethyl methanethiosulfonate	Dithiothreitol inhibits the reaction [N-biotinylaminoethyl methanethiosulfonate results in increased activity of TRPA1 protein]	17237762
C419543	N-biotinylaminoethyl methanethiosulfonate	Menthol inhibits the reaction [N-biotinylaminoethyl methanethiosulfonate results in increased activity of TRPA1 protein]	17237762
C419543	N-biotinylaminoethyl methanethiosulfonate	N-biotinylaminoethyl methanethiosulfonate results in increased activity of TRPA1 protein	17237762
C527323	N-methylmaleimide	N-methylmaleimide results in increased activity of TRPA1 protein	26447139
C030110	oxaliplatin	oxaliplatin results in increased activity of TRPA1 protein	21481532
D010126	Ozone	Ozone results in increased activity of TRPA1 protein	20008466
D010126	Ozone	TRPA1 affects the susceptibility to Ozone	20008466
D010269	Paraquat	TRPA1 results in increased susceptibility to Paraquat	25158689
D052638	Particulate Matter	Glutathione inhibits the reaction [Particulate Matter results in increased activity of TRPA1 protein]	23541125
D052638	Particulate Matter	Particulate Matter results in increased activity of TRPA1 protein	23541125
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in decreased expression of TRPA1 mRNA	26705709
C038036	phenalen-1-one	phenalen-1-one results in increased activity of TRPA1 protein	23541125
D019269	Phosphatidylinositol 4,5-Diphosphate	"Phosphatidylinositol 4,5-Diphosphate inhibits the reaction [F2RL1 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]]"	17571167
D011765	Pyruvaldehyde	Pyruvaldehyde results in increased activity of TRPA1 protein	22863862
D011765	Pyruvaldehyde	[Pyruvaldehyde results in increased activity of TRPA1 protein] which results in increased transport of Calcium	22863862
D012430	Ruthenium Red	Ruthenium Red inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of TRPA1 protein]	17684094
D012430	Ruthenium Red	Ruthenium Red inhibits the reaction [[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK1 protein]	23994502
D012430	Ruthenium Red	Ruthenium Red inhibits the reaction [[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK3 protein]	23994502
D012430	Ruthenium Red	Ruthenium Red results in decreased activity of TRPA1 protein	23994502
D012430	Ruthenium Red	Ruthenium Red inhibits the reaction [1-oleoyl-2-acetylglycerol results in increased activity of TRPA1 protein]	15046718
D012430	Ruthenium Red	Ruthenium Red inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]	15843607
D012430	Ruthenium Red	Ruthenium Red inhibits the reaction [Arachidonic Acid results in increased activity of TRPA1 protein]	15046718
D012430	Ruthenium Red	Ruthenium Red inhibits the reaction [cinnamic aldehyde results in increased activity of TRPA1 protein]	15046718
D012430	Ruthenium Red	Ruthenium Red inhibits the reaction [cinnamic aldehyde results in increased activity of TRPA1 protein]	22791718
D012430	Ruthenium Red	Ruthenium Red binds to and results in decreased activity of TRPA1 protein	19507004\|2766731
D012906	Smoke	Smoke analog results in increased activity of TRPA1 protein	23541125
D012965	Sodium Chloride	Sodium Chloride results in increased activity of TRPA1 protein	21266172
D020058	Styrene	TRPA1 results in increased susceptibility to Styrene	20176620
C005830	tributyrin	tributyrin results in increased activity of TRPA1 protein	29198882
C012589	trichostatin A	trichostatin A results in increased expression of TRPA1 mRNA	24935251
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRPA1 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid results in decreased methylation of TRPA1 gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of TRPA1 mRNA	23179753\|2438349
D001335	Vehicle Emissions	Vehicle Emissions analog results in increased activity of TRPA1 protein	23541125
D001335	Vehicle Emissions	Vehicle Emissions binds to and results in increased activity of TRPA1 protein	21591660
D001335	Vehicle Emissions	Vehicle Emissions affects the methylation of TRPA1 gene	25560391
D001335	Vehicle Emissions	TRPA1 results in increased susceptibility to [Vehicle Emissions co-treated with Aconitine]	21377951
D024483	Vitamin K 3	Vitamin K 3 results in increased activity of TRPA1 protein	21591660
C070417	Win 55212-2	Win 55212-2 results in increased activity of TRPA1 protein	18234885
C070417	Win 55212-2	TRPA1 results in increased susceptibility to Win 55212-2	18234885
C070417	Win 55212-2	TRPA1 promotes the reaction [Win 55212-2 results in increased abundance of Calcium]	18234885
C070417	Win 55212-2	Win 55212-2 binds to and results in increased activity of TRPA1 protein	18550765
C016837	zinc chloride	zinc chloride results in increased activity of TRPA1 protein	28919489

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005262	calcium channel activity	-	TAS	-
GO:0015267	channel activity	-	TAS	10066796
GO:0015278	calcium-release channel activity	-	IDA	20547126
GO:0015278	calcium-release channel activity	-	IMP	25855297
GO:0042802	identical protein binding	-	IPI	25855297
GO:0097604	temperature-gated cation channel activity	-	IDA	20547126

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006811	ion transport	-	TAS	10066796
GO:0007166	cell surface receptor signaling pathway	-	IEA	-
GO:0009409	response to cold	-	IEA	-
GO:0010033	response to organic substance	-	IMP	20547126
GO:0014070	response to organic cyclic compound	-	IEA	-
GO:0019233	sensory perception of pain	-	IMP	20547126
GO:0042542	response to hydrogen peroxide	-	IEA	-
GO:0048265	response to pain	-	IEA	-
GO:0050955	thermoception	-	IEA	-
GO:0050966	detection of mechanical stimulus involved in sensory perception of pain	-	IEA	-
GO:0050968	detection of chemical stimulus involved in sensory perception of pain	-	IEA	-
GO:0051209	release of sequestered calcium ion into cytosol	-	IEA	-
GO:0051289	protein homotetramerization	-	IDA	25855297
GO:0070588	calcium ion transmembrane transport	-	IMP	20547126 25855297
GO:0070588	calcium ion transmembrane transport	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IMP	20547126 25855297
GO:0032421	stereocilium bundle	-	IEA	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-2672351	Stimuli-sensing channels	TAS
R-HSA-3295583	TRP channels	TAS
R-HSA-382551	Transport of small molecules	TAS
R-HSA-983712	Ion channel transport	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
19749751	Nicotine activates the chemosensory cation channel TRPA1. (2009 Oct)	Talavera K	Nat Neurosci
21719896	Menthol preference among smokers: association with TRPA1 variants. (2011 Dec)	Uhl GR	Nicotine Tob Res
22209625	Effect of cigarette smoking on cough reflex induced by TRPV1 and TRPA1 stimulations. (2012 Mar)	Kanezaki M	Respir Med
21903934	Menthol attenuates respiratory irritation responses to multiple cigarette smoke irritants. (2011 Dec)	Willis DN	FASEB J
28936178	A Comparison of Oral Sensory Effects of Three TRPA1 Agonists in Young Adult Smokers and Non-smokers. (2017)	Hansen EO	Front Physiol
23926288	Bimodal concentration-response of nicotine involves the nicotinic acetylcholine receptor, transient receptor potential vanilloid type 1, and transient receptor potential ankyrin 1 channels in mouse trachea and sensory neurons. (2013 Nov)	Kichko TI	J Pharmacol Exp Ther
22443337	Transient receptor potential genes, smoking, occupational exposures and cough in adults. (2012 Mar 23)	Smit LA	Respir Res