Gene: SELENBP1

8991
HEL-S-134P|LPSB|MTO|SBP56|SP56|hSBP
selenium binding protein 1
protein-coding
1q21.3
Ensembl:ENSG00000143416 MIM:604188 Vega:OTTHUMG00000012498 UniprotKB:Q13228
NC_000001.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.610e-1 (AD)  3.458e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EZR0.915
CDC42EP40.889
EMX20.887
MLC10.885
ACSS10.883
PRODH0.883
METTL7A0.882
SLC25A180.88
SNTA10.88
ACSF20.879

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.479
OR4F29-0.464
GABRG3-0.432
MUM1L1-0.406
PAQR9-0.404
IL12RB2-0.404
TYRP1-0.397
HTR7-0.396
OSBPL10-0.395
ANKRD34C-0.389

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of SELENBP1 mRNA"28903501
C0166141-nitronaphthalene1-nitronaphthalene metabolite binds to SELENBP1 protein16453347
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of SELENBP1 mRNA19933214
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of SELENBP1 mRNA"25614096
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SELENBP1 mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of SELENBP1 mRNA"21346803
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of SELENBP1 mRNA25088246
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of SELENBP1 protein26194647
C0502243,5,5-trimethylhexanoylferrocene"3,5,5-trimethylhexanoylferrocene results in increased expression of SELENBP1 protein"22649188
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SELENBP1 mRNA"27188386
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of SELENBP1 mRNA"21346803
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of SELENBP1 mRNA12419474
C0293704-toluidine4-toluidine results in increased expression of SELENBP1 mRNA27638505
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SELENBP1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of SELENBP1 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of SELENBP1 mRNA15606129
D020106AcrylamideAcrylamide results in increased expression of SELENBP1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of SELENBP1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SELENBP1 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SELENBP1 mRNA19770486
D000393Air PollutantsAir Pollutants analog results in decreased expression of SELENBP1 mRNA21757418
D000393Air PollutantsAir Pollutants results in decreased expression of SELENBP1 mRNA23649983
D000517alpha-Chlorohydrinalpha-Chlorohydrin analog results in decreased expression of SELENBP1 protein26597043
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of SELENBP1 mRNA28522335
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of SELENBP1 mRNA16631469
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SELENBP1 mRNA16483693
D000728AndrogensAndrogens results in decreased expression of SELENBP1 mRNA16380993
D000728AndrogensAndrogens results in decreased expression of SELENBP1 protein16380993
C023650anilineaniline results in increased nitrosation of SELENBP1 protein21708182
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of SELENBP1 mRNA24449571
D001280AtrazineAtrazine results in increased expression of SELENBP1 mRNA25929836
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of SELENBP1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SELENBP1 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SELENBP1 mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SELENBP1 mRNA14625279|1977048
D001564Benzo(a)pyrene[Potassium Dichromate co-treated with potassium chromate(VI)] inhibits the reaction [Benzo(a)pyrene results in increased expression of SELENBP1 mRNA]14625279
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of SELENBP1 mRNA25566086
D004958EstradiolEstradiol results in decreased expression of SELENBP1 mRNA17912697
D004958EstradiolEstradiol results in decreased expression of SELENBP1 mRNA15159206|2010694
D001663BilirubinBilirubin results in decreased expression of SELENBP1 mRNA20196124
C006780bisphenol Abisphenol A results in decreased expression of SELENBP1 mRNA15159206
C006780bisphenol Abisphenol A results in increased expression of SELENBP1 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of SELENBP1 mRNA25181051
C006780bisphenol Abisphenol A results in decreased expression of SELENBP1 protein22649256
C006780bisphenol Abisphenol A results in increased methylation of SELENBP1 gene28505145
D001761BleomycinBleomycin results in decreased expression of SELENBP1 protein25933445
C032036bromobenzenebromobenzene metabolite binds to SELENBP1 protein17305373
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of SELENBP1 mRNA12419474
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of SELENBP1 mRNA15003993
D002104CadmiumCadmium results in increased expression of SELENBP1 protein25343288
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SELENBP1 mRNA18804290
C037123cadmium sulfatecadmium sulfate results in increased expression of SELENBP1 mRNA19274763
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of SELENBP1 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of SELENBP1 mRNA27339419
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of SELENBP1 protein17109383
D007631ChlordeconeChlordecone results in decreased expression of SELENBP1 protein19666090
D002737ChloropreneChloroprene results in increased expression of SELENBP1 mRNA23125180
D002922CiguatoxinsCiguatoxins affects the expression of SELENBP1 mRNA18353800
D002994ClofibrateClofibrate results in decreased expression of SELENBP1 protein19952500
D002994ClofibrateClofibrate results in decreased expression of SELENBP1 mRNA17585979
C018021cobaltous chloridecobaltous chloride results in decreased expression of SELENBP1 mRNA19376846
D003300CopperSELENBP1 gene SNP affects the abundance of Copper23720494
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in decreased expression of SELENBP1 mRNA19167446
C029892cupric chloridecupric chloride results in increased expression of SELENBP1 protein19616320
D003471CuprizoneCuprizone results in decreased expression of SELENBP1 mRNA27523638
D016572CyclosporineCyclosporine results in decreased expression of SELENBP1 mRNA20106945|2556210
D013759DronabinolDronabinol results in increased expression of SELENBP1 mRNA16616335
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of SELENBP1 mRNA]27941970
D003907DexamethasoneDexamethasone results in increased expression of SELENBP1 mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of SELENBP1 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SELENBP1 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SELENBP1 mRNA21266533
D004041Dietary FatsDietary Fats results in decreased expression of SELENBP1 mRNA15238619
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of SELENBP1 mRNA15159206
D004121Dimethyl SulfoxideSELENBP1 gene mutant form results in increased abundance of Dimethyl Sulfoxide29255262
D004237DiuronDiuron results in decreased expression of SELENBP1 mRNA25152437
D004237DiuronDiuron results in increased expression of SELENBP1 mRNA21551480
D004726Endosulfan[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SELENBP1 mRNA26159488
C118739entinostatentinostat results in increased expression of SELENBP1 mRNA27188386
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of SELENBP1 protein23301498
D000069347Erlotinib HydrochlorideErlotinib Hydrochloride results in decreased expression of SELENBP1 mRNA27720938
D004964EstriolEstriol results in decreased expression of SELENBP1 mRNA15159206
D004970EstroneEstrone results in decreased expression of SELENBP1 mRNA15159206
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of SELENBP1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SELENBP1 mRNA17942748
D005485FlutamideFlutamide results in decreased expression of SELENBP1 mRNA24793618
D005485FlutamideFlutamide results in increased expression of SELENBP1 mRNA24136188
C069837fullerene C60fullerene C60 results in increased expression of SELENBP1 mRNA19167457
D019833GenisteinGenistein results in decreased expression of SELENBP1 mRNA15159206
D005839GentamicinsGentamicins results in decreased expression of SELENBP1 mRNA20623750
D005897GlafenineGlafenine results in decreased expression of SELENBP1 mRNA24136188
D005944GlucosamineGlucosamine results in decreased expression of SELENBP1 mRNA17109745
C071834glycidamideglycidamide results in decreased expression of SELENBP1 mRNA17822822
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of SELENBP1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of SELENBP1 mRNA28628672
D007529IsoflavonesIsoflavones results in increased expression of SELENBP1 mRNA17374662
C410337K 7174K 7174 results in decreased expression of SELENBP1 mRNA24086573
C045463leflunomideleflunomide results in increased expression of SELENBP1 mRNA24136188
D001556LindaneLindane results in increased expression of SELENBP1 mRNA18804290
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of SELENBP1 mRNA19136613
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of SELENBP1 mRNA21641980
D008731MethoxychlorMethoxychlor results in decreased expression of SELENBP1 mRNA15159206
D008748MethylcholanthreneMethylcholanthrene results in increased expression of SELENBP1 mRNA18804290
C005231methylmercaptanSELENBP1 protein results in increased metabolism of methylmercaptan29255262
C005231methylmercaptanSELENBP1 gene mutant form results in decreased metabolism of methylmercaptan29255262
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SELENBP1 mRNA28001369
D008777MethyltestosteroneMethyltestosterone results in increased expression of SELENBP1 mRNA29191790
D015741MetriboloneMetribolone results in decreased expression of SELENBP1 protein17152098
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SELENBP1 mRNA"25554681|2562005
D037742Nanotubes, Carbon"[Nanotubes, Carbon co-treated with Polyethylene Glycols] results in decreased expression of SELENBP1 protein"28807745
D037742Nanotubes, Carbon"[Nanotubes, Carbon co-treated with Polysorbates] results in decreased expression of SELENBP1 protein"28807745
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SELENBP1 mRNA"25554681|2562005
C031721naphthalene[naphthalene co-treated with CFTR gene mutant form] results in decreased expression of SELENBP1 protein19438287
C051752nefazodonenefazodone results in increased expression of SELENBP1 mRNA24136188
D009532NickelNickel results in decreased expression of SELENBP1 mRNA24768652|2558310
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in decreased expression of SELENBP1 mRNA17616710
C025256nonylphenolnonylphenol results in decreased expression of SELENBP1 mRNA15159206
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of SELENBP1 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of SELENBP1 mRNA25729387
D010100OxygenOxygen deficiency results in increased expression of SELENBP1 mRNA17193925|2088007
D010396PenicillaminePenicillamine results in decreased expression of SELENBP1 mRNA19575532
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of SELENBP1 mRNA18804290
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in decreased expression of SELENBP1 mRNA17616710
D010634PhenobarbitalPhenobarbital results in decreased expression of SELENBP1 protein19952500
D010656PhenylephrinePhenylephrine results in decreased expression of SELENBP1 mRNA18158353
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SELENBP1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of SELENBP1 mRNA26272509
D028321Plant PreparationsPlant Preparations affects the expression of SELENBP1 mRNA16251609
D011092Polyethylene Glycols"[Nanotubes, Carbon co-treated with Polyethylene Glycols] results in decreased expression of SELENBP1 protein"28807745
D011136Polysorbates"[Nanotubes, Carbon co-treated with Polysorbates] results in decreased expression of SELENBP1 protein"28807745
C027373potassium chromate(VI)[Potassium Dichromate co-treated with potassium chromate(VI)] inhibits the reaction [Benzo(a)pyrene results in increased expression of SELENBP1 mRNA]14625279
D011192Potassium Dichromate[Potassium Dichromate co-treated with potassium chromate(VI)] inhibits the reaction [Benzo(a)pyrene results in increased expression of SELENBP1 mRNA]14625279
D011374ProgesteroneProgesterone affects the expression of SELENBP1 mRNA17251523
C045950propiconazolepropiconazole results in increased metabolism of SELENBP1 protein19714882
D054328Proton Pump InhibitorsProton Pump Inhibitors results in increased expression of SELENBP1 mRNA25626140
D011794QuercetinQuercetin results in decreased expression of SELENBP1 mRNA21632981
D011794QuercetinQuercetin affects the expression of SELENBP1 mRNA18178720
C059514resveratrol[Coumestrol co-treated with resveratrol] results in decreased expression of SELENBP1 mRNA19167446
D012643SeleniumSelenium results in increased expression of SELENBP1 mRNA16380993
D012643SeleniumSelenium results in increased expression of SELENBP1 protein16380993
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SELENBP1 mRNA25895662
C017947sodium arsenitesodium arsenite results in decreased expression of SELENBP1 protein24866292
C017947sodium arsenitesodium arsenite results in decreased expression of SELENBP1 protein24866292
D012999SomanSoman results in decreased expression of SELENBP1 mRNA19281266
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of SELENBP1 mRNA21641980
D013629TamoxifenTamoxifen affects the expression of SELENBP1 mRNA17555576
D013749Tetrachlorodibenzodioxin[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SELENBP1 mRNA26159488
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SELENBP1 mRNA20106945
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SELENBP1 mRNA26377647
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of SELENBP1 mRNA16214954
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of SELENBP1 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SELENBP1 mRNA17035482|1977048
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SELENBP1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SELENBP1 mRNA21215274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SELENBP1 protein19492234
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of SELENBP1 mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of SELENBP1 mRNA28111298
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of SELENBP1 protein27319396
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of SELENBP1 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of SELENBP1 mRNA25729387
D014212TretinoinTretinoin results in increased expression of SELENBP1 mRNA20488242
D014241TrichloroethyleneTrichloroethylene results in increased methylation of SELENBP1 gene27618143
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of SELENBP1 mRNA19042947
D014303TrinitrotolueneTrinitrotoluene affects the expression of SELENBP1 mRNA21346803
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of SELENBP1 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of SELENBP1 mRNA12732648
C057693troglitazone[troglitazone co-treated with TNF protein] results in decreased expression of SELENBP1 mRNA12732648
D014635Valproic AcidValproic Acid affects the expression of SELENBP1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of SELENBP1 mRNA23179753|2800136
D014635Valproic AcidValproic Acid results in increased methylation of SELENBP1 gene29154799
D014638VanadatesVanadates results in decreased expression of SELENBP1 mRNA22714537
D014640VancomycinVancomycin results in increased expression of SELENBP1 mRNA18930951
C025643vinclozolinvinclozolin affects the expression of SELENBP1 mRNA19015723
C025643vinclozolinvinclozolin results in increased expression of SELENBP1 mRNA22570695
C029297vinylidene chloridevinylidene chloride results in decreased expression of SELENBP1 mRNA26682919
D015032ZincZinc deficiency results in decreased expression of SELENBP1 mRNA16140947
D015032ZincZinc inhibits the reaction [Zinc deficiency results in decreased expression of SELENBP1 mRNA]16140947

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16189514  19118533  
GO:0008430selenium binding-IEA-  
GO:0018549methanethiol oxidase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0015031protein transport-IEA-  
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001650fibrillar center-IDA-  
GO:0005615extracellular space-HDA16502470  
GO:0005730nucleolus-IDA-  
GO:0005829cytosol-IEA-  
GO:0016020membrane-IEA-  
GO:0070062extracellular exosome-HDA19056867  23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24046282Analyses of synovial tissues from arthritic and protected congenic rat strains reveal a new core set of genes associated with disease severity. (2013 Nov 15)Brenner MPhysiol Genomics