Gene info: ID 8997

Gene: KALRN

GENE ID: 8997

Description: kalirin RhoGEF kinase

Gene type: protein-coding

Location: 3q21.1-q21.2

dbXrefs: Ensembl:ENSG00000160145 MIM:604605 Vega:OTTHUMG00000125545 UniprotKB:O60229

RefSeq: NG_012742.2

Retrived from: PubMed|SNP Mapped

SNPs: 2 ANCO-SNPs

Phenotype: ND|AD

# Publications: 3

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.292e-1 (AD) 8.262e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs6438847	chr3:124578798 (GRCh38.p7)	A>C	alcohol dependence	SNV(Single Nucleotide Variation)
rs555540	chr3:124448118 (GRCh38.p7)	G>A / G>T	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MYH10	0.978
TLN2	0.969
KIAA1549L	0.969
LMTK2	0.968
DOCK3	0.967
INPP4A	0.965
PI4KA	0.963
DLGAP1	0.962
MADD	0.961
UNC13A	0.961

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
HEY2	-0.558
MYL3	-0.526
YES1	-0.524
RAB13	-0.524
RAI14	-0.522
SNHG18	-0.52
WWTR1	-0.512
CSAG1	-0.504
RNF135	-0.5
REST	-0.499

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione affects the expression of KALRN mRNA"	19162173
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of KALRN mRNA"	25510870
C081766	2,4,4'-trichlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of KALRN mRNA"	25510870
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of KALRN mRNA"	25510870
C009828	2,4,5,2',5'-pentachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of KALRN mRNA"	25510870
C009407	2,5,2',5'-tetrachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of KALRN mRNA"	25510870
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of KALRN mRNA"	21346803
C496492	abrine	abrine results in increased expression of KALRN mRNA	22595364
D000082	Acetaminophen	Acetaminophen affects the expression of KALRN mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of KALRN mRNA	22100608
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in increased expression of KALRN mRNA	21298039
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of KALRN mRNA	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of KALRN mRNA	24449571
D001151	Arsenic	Arsenic affects the methylation of KALRN gene	25304211
C006632	arsenic trioxide	arsenic trioxide results in increased expression of KALRN mRNA	20458559\|2670570
C015001	arsenite	arsenite results in decreased expression of KALRN mRNA	18929588
C015001	arsenite	TRP53 protein affects the reaction [arsenite results in decreased expression of KALRN mRNA]	18929588
D019324	beta-Naphthoflavone	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of KALRN mRNA	18164116
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of KALRN mRNA	26238291
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased mutagenesis of KALRN gene	25435355
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of KALRN mRNA	21964900
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of KALRN mRNA	22228805
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of KALRN mRNA"	26238291
C006780	bisphenol A	bisphenol A affects the expression of KALRN mRNA	25181051
C018475	butyraldehyde	butyraldehyde results in increased expression of KALRN mRNA	26079696
C028031	cadmium acetate	cadmium acetate results in decreased expression of KALRN mRNA	18155341
C055494	caffeic acid phenethyl ester	[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of KALRN mRNA	20360939
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of KALRN mRNA	17484886
C074702	chromium hexavalent ion	chromium hexavalent ion affects the expression of KALRN mRNA	28472532
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of KALRN mRNA	24386269
D003042	Cocaine	Cocaine affects the expression of KALRN mRNA	20187946
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of KALRN mRNA	19549813
D003471	Cuprizone	Cuprizone results in decreased expression of KALRN mRNA	26577399
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of KALRN mRNA	27392435
D019422	Dietary Sucrose	Dietary Sucrose results in increased expression of KALRN mRNA	26033743
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of KALRN mRNA	18164116
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of KALRN mRNA	20360939
C024629	dimethyl phthalate	dimethyl phthalate affects the expression of KALRN mRNA	26924002
D005419	Flavonoids	Flavonoids results in decreased expression of KALRN mRNA	18035473
C069837	fullerene C60	fullerene C60 results in decreased expression of KALRN mRNA	19167457
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of KALRN mRNA	20044591
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of KALRN mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of KALRN mRNA	26752646
D007608	Kainic Acid	Kainic Acid results in increased expression of KALRN mRNA	19700661
C008261	lead acetate	lead acetate results in decreased expression of KALRN mRNA	22609695
C008261	lead acetate	lead acetate results in increased expression of KALRN mRNA	20542052
C045463	leflunomide	leflunomide results in increased expression of KALRN mRNA	28988120
D008558	Melphalan	Melphalan results in decreased expression of KALRN mRNA	22363485
D008727	Methotrexate	Methotrexate results in increased expression of KALRN mRNA	24449571
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in decreased expression of KALRN mRNA	22401849
D037742	Nanotubes, Carbon	"Nanotubes, Carbon affects the expression of KALRN mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of KALRN mRNA"	25554681\|2562005
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of KALRN mRNA"	25554681
D009532	Nickel	Nickel results in decreased expression of KALRN mRNA	25583101
C028007	nickel monoxide	nickel monoxide results in decreased expression of KALRN mRNA	19167457
C410127	PCB 180	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of KALRN mRNA"	25510870
D010634	Phenobarbital	Phenobarbital affects the expression of KALRN mRNA	23091169
C006253	pirinixic acid	pirinixic acid results in decreased expression of KALRN mRNA	23811191
C006253	pirinixic acid	pirinixic acid results in increased expression of KALRN mRNA	19162173
D011441	Propylthiouracil	Propylthiouracil results in increased expression of KALRN mRNA	24780913
C017947	sodium arsenite	sodium arsenite affects the methylation of KALRN gene	28589171
D012999	Soman	Soman results in decreased expression of KALRN mRNA	19281266
C025462	sulindac sulfide	sulindac sulfide results in decreased expression of KALRN mRNA	16184548
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of KALRN mRNA	26377647
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of KALRN mRNA	18796159
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of KALRN mRNA	22298810
C009495	titanium dioxide	titanium dioxide results in increased expression of KALRN mRNA	23557971
C032910	triadimefon	triadimefon results in decreased expression of KALRN mRNA	26705709
C012589	trichostatin A	trichostatin A results in decreased expression of KALRN mRNA	27188386
C012589	trichostatin A	trichostatin A results in increased expression of KALRN mRNA	24935251
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of KALRN mRNA"	26179874
D014635	Valproic Acid	Valproic Acid affects the expression of KALRN mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased methylation of KALRN gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of KALRN mRNA	24935251
C025643	vinclozolin	vinclozolin affects the expression of KALRN mRNA	19015723
C111237	vorinostat	vorinostat results in decreased expression of KALRN mRNA	27188386

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004674	protein serine/threonine kinase activity	-	IEA	-
GO:0005085	guanyl-nucleotide exchange factor activity	-	EXP	12546821
GO:0005085	guanyl-nucleotide exchange factor activity	-	TAS	-
GO:0005089	Rho guanyl-nucleotide exchange factor activity	-	TAS	-
GO:0005096	GTPase activator activity	-	TAS	-
GO:0005524	ATP binding	-	IEA	-
GO:0030676	Rac guanyl-nucleotide exchange factor activity	-	IEA	-
GO:0046872	metal ion binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001662	behavioral fear response	-	IEA	-
GO:0006468	protein phosphorylation	-	IEA	-
GO:0007165	signal transduction	-	TAS	9285789
GO:0007186	G-protein coupled receptor signaling pathway	-	TAS	-
GO:0007266	Rho protein signal transduction	-	IEA	-
GO:0007399	nervous system development	-	ISS	-
GO:0007528	neuromuscular junction development	-	IEA	-
GO:0007595	lactation	-	IEA	-
GO:0007613	memory	-	IEA	-
GO:0008344	adult locomotory behavior	-	IEA	-
GO:0009612	response to mechanical stimulus	-	IEA	-
GO:0014909	smooth muscle cell migration	-	IEA	-
GO:0016192	vesicle-mediated transport	-	TAS	9285789
GO:0035023	regulation of Rho protein signal transduction	-	IEA	-
GO:0035176	social behavior	-	IEA	-
GO:0035556	intracellular signal transduction	-	ISS	-
GO:0042711	maternal behavior	-	IEA	-
GO:0043065	positive regulation of apoptotic process	-	TAS	-
GO:0043547	positive regulation of GTPase activity	-	IEA	-
GO:0046959	habituation	-	IEA	-
GO:0048013	ephrin receptor signaling pathway	-	TAS	-
GO:0048148	behavioral response to cocaine	-	IEA	-
GO:0048168	regulation of neuronal synaptic plasticity	-	IEA	-
GO:0048659	smooth muscle cell proliferation	-	IEA	-
GO:0051056	regulation of small GTPase mediated signal transduction	-	TAS	-
GO:0051966	regulation of synaptic transmission, glutamatergic	-	IEA	-
GO:0060125	negative regulation of growth hormone secretion	-	IEA	-
GO:0060137	maternal process involved in parturition	-	IEA	-
GO:0061003	positive regulation of dendritic spine morphogenesis	-	IEA	-
GO:0061368	behavioral response to formalin induced pain	-	IEA	-
GO:1900273	positive regulation of long-term synaptic potentiation	-	IEA	-
GO:1903076	regulation of protein localization to plasma membrane	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005654	nucleoplasm	-	IDA	-
GO:0005829	cytosol	-	IDA	-
GO:0005829	cytosol	-	TAS	-
GO:0014069	postsynaptic density	-	IEA	-
GO:0015629	actin cytoskeleton	-	TAS	10023074
GO:0070062	extracellular exosome	-	HDA	19056867

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-1266738	Developmental Biology	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-193648	NRAGE signals death through JNK	TAS
R-HSA-193704	p75 NTR receptor-mediated signalling	TAS
R-HSA-194315	Signaling by Rho GTPases	TAS
R-HSA-194840	Rho GTPase cycle	TAS
R-HSA-204998	Cell death signalling via NRAGE, NRIF and NADE	TAS
R-HSA-2682334	EPH-Ephrin signaling	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-3928662	EPHB-mediated forward signaling	TAS
R-HSA-416476	G alpha (q) signalling events	TAS
R-HSA-416482	G alpha (12/13) signalling events	TAS
R-HSA-422475	Axon guidance	TAS
R-HSA-5683057	MAPK family signaling cascades	TAS
R-HSA-5687128	MAPK6/MAPK4 signaling	TAS
R-HSA-73887	Death Receptor Signalling	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25917671	KALRN Rare and Common Variants and Susceptibility to Ischemic Stroke in Chinese Han Population. (2015 Sep)	Dang M	Neuromolecular Med
19706030	Validation study of genetic associations with coronary artery disease on chromosome 3q13-21 and potential effect modification by smoking. (2009 Nov)	Horne BD	Ann Hum Genet
25345847	The association of thyroid peroxidase antibody risk loci with susceptibility to and phenotype of Graves' disease. (2015 Oct)	Kus A	Clin Endocrinol (Oxf)