Gene: HAP1

9001
HAP2|HIP5|HLP|hHLP1
huntingtin associated protein 1
protein-coding
17q21.2
Ensembl:ENSG00000173805 MIM:600947 Vega:OTTHUMG00000133498 UniprotKB:P54257
NC_000017.11
PubMed
0   ANCO-SNPs
ND|AD
7   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.185e-1 (AD)  8.968e-2 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg16255816chr17:39889811HAP11.200e-9Maternal smoking in pregnancy27040690
cg03373393chr17:39890193HAP15.190e-9Maternal smoking in pregnancy27040690
cg16255816chr17:39889811HAP15.460e-9Maternal smoking in pregnancy27040690
cg16255816chr17:39889811HAP12.200e-12Smoking27651444
cg03373393chr17:39890193HAP11.500e-9Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PYGL0.76
SFN0.757
TNFRSF12A0.755
FABP50.754
PDLIM40.748
TIMP10.748
ZBTB420.746
MYD880.734
EMP30.733
MAPKAPK20.726

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NEUROD6-0.463
CASC15-0.42
PPEF1-0.417
SLC7A4-0.412
ABCC12-0.408
EDN3-0.401
CALHM1-0.393
CDCA5-0.38
ESRRG-0.377
KCNB2-0.377

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0131862,3-pentanedione"2,3-pentanedione results in decreased expression of HAP1 mRNA"25710175
D000082AcetaminophenAcetaminophen results in increased expression of HAP1 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of HAP1 mRNA17562736
D000643Ammonium ChlorideAmmonium Chloride affects the expression of HAP1 mRNA16483693
D001280AtrazineAtrazine results in increased expression of HAP1 mRNA22378314
C547126AZM551248AZM551248 results in decreased expression of HAP1 mRNA22323515
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of HAP1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HAP1 mRNA27195522
C006780bisphenol Abisphenol A results in increased expression of HAP1 mRNA25181051
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of HAP1 gene20938992
C018021cobaltous chloridecobaltous chloride results in increased expression of HAP1 mRNA24386269
D003300CopperCopper deficiency results in increased expression of HAP1 mRNA26033743
D003471CuprizoneCuprizone results in increased expression of HAP1 mRNA26577399
D013759DronabinolDronabinol results in decreased expression of HAP1 mRNA16616335
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of HAP1 mRNA27392435
D004041Dietary FatsDietary Fats results in decreased expression of HAP1 mRNA25016146
D019422Dietary SucroseDietary Sucrose results in increased expression of HAP1 mRNA26033743
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of HAP1 mRNA17005392
D004237DiuronDiuron results in increased expression of HAP1 mRNA21551480
C017690fenvaleratefenvalerate affects the methylation of HAP1 gene23548413
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of HAP1 gene20938992
C039281furanfuran results in increased methylation of HAP1 gene22079235
D007545IsoproterenolIsoproterenol results in increased expression of HAP1 mRNA21335049
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of HAP1 mRNA27392435
D007649KetamineKetamine results in increased expression of HAP1 mRNA20080153
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of HAP1 mRNA12057914
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of HAP1 mRNA12057914
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of HAP1 gene20938992
D008731MethoxychlorMethoxychlor results in increased methylation of HAP1 gene23303685
D009151Mustard GasMustard Gas results in increased expression of HAP1 mRNA15674843
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of HAP1 mRNA"25554681
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of HAP1 mRNA19812364
D011441PropylthiouracilPropylthiouracil results in increased expression of HAP1 mRNA24780913
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of HAP1 mRNA21427059
C017947sodium arsenitesodium arsenite results in decreased expression of HAP1 protein19072884
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HAP1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HAP1 mRNA20558275
C009495titanium dioxidetitanium dioxide results in increased expression of HAP1 mRNA23557971
D014520UrethaneUrethane results in increased expression of HAP1 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of HAP1 mRNA17292431
D014635Valproic AcidValproic Acid results in increased expression of HAP1 mRNA20546886|2142705
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of HAP1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-IBA21873635  
GO:0005515protein binding-IPI7477378  9668110  18192679  20515468  21386698  23532844  
25074808  
GO:0017022myosin binding-IBA21873635  
GO:0044325ion channel binding-ISS-  
GO:0048403brain-derived neurotrophic factor binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006605protein targeting-IBA21873635  
GO:0006887exocytosis-IEA-  
GO:0006914autophagy-IEA-  
GO:0007268chemical synaptic transmission-TAS9361024  
GO:0007420brain development-NAS7477378  
GO:0008089anterograde axonal transport-IBA21873635  
GO:0008089anterograde axonal transport-ISS-  
GO:0008090retrograde axonal transport-ISS-  
GO:0008104protein localization-IBA21873635  
GO:0008104protein localization-IMP18922795  
GO:0015031protein transport-IEA-  
GO:0017157regulation of exocytosis-ISS-  
GO:0021549cerebellum development-IEA-  
GO:0021979hypothalamus cell differentiation-IEA-  
GO:0022008neurogenesis-IBA21873635  
GO:0030030cell projection organization-IEA-  
GO:0031587positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity-ISS-  
GO:0032230positive regulation of synaptic transmission, GABAergic-ISS-  
GO:0032901positive regulation of neurotrophin production-ISS-  
GO:0045742positive regulation of epidermal growth factor receptor signaling pathway-ISS-  
GO:0047496vesicle transport along microtubule-IBA21873635  
GO:0047496vesicle transport along microtubule-IEA-  
GO:0048011neurotrophin TRK receptor signaling pathway-IBA21873635  
GO:0048011neurotrophin TRK receptor signaling pathway-ISS-  
GO:0048311mitochondrion distribution-IBA21873635  
GO:0050769positive regulation of neurogenesis-IEA-  
GO:0098957anterograde axonal transport of mitochondrion-IBA21873635  
GO:1902430negative regulation of amyloid-beta formation-ISS-  
GO:1902513regulation of organelle transport along microtubule-ISS-  
GO:1902857positive regulation of non-motile cilium assembly-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005739mitochondrion-IBA21873635  
GO:0005739mitochondrion-IEA-  
GO:0005764lysosome-IEA-  
GO:0005776autophagosome-IEA-  
GO:0005783endoplasmic reticulum-IEA-  
GO:0005813centrosome-IEA-  
GO:0005814centriole-IEA-  
GO:0005856cytoskeleton-TAS9361024  
GO:0008021synaptic vesicle-IEA-  
GO:0015629actin cytoskeleton-TAS9361024  
GO:0016234inclusion body-IDA21386698  
GO:0030054cell junction-IEA-  
GO:0030425dendrite-IBA21873635  
GO:0031410cytoplasmic vesicle-IBA21873635  
GO:0032839dendrite cytoplasm-IBA21873635  
GO:1904115axon cytoplasm-IEA-  
KEGG ID KEGG Term
hsa05016Huntington's disease
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19120064Genomewide SNP screen to detect quantitative trait loci for alcohol preference in the high alcohol preferring and low alcohol preferring mice. (2009 Mar)Bice PAlcohol Clin Exp Res
17009596Association of hsp70 polymorphisms with risk of noise-induced hearing loss in Chinese automobile workers. (2006 Autumn)Yang MCell Stress Chaperones
19282111Haplotype-tagging single nucleotide polymorphisms in the GSTP1 gene promoter and susceptibility to lung cancer. (2009)Tan XLCancer Detect Prev
22757960Chronic free-choice drinking in crossed high alcohol preferring mice leads to sustained blood ethanol levels and metabolic tolerance without evidence of liver damage. (2013 Feb)Matson LAlcohol Clin Exp Res
22126215Pharmacologically relevant intake during chronic, free-choice drinking rhythms in selectively bred high alcohol-preferring mice. (2013 Nov)Matson LMAddict Biol
19389183High-alcohol preferring mice are more impulsive than low-alcohol preferring mice as measured in the delay discounting task. (2009 Jul)Oberlin BGAlcohol Clin Exp Res
25081373Evaluating the association of polymorphisms in the HAP1 gene with lung cancer risk: a meta-analysis. (2014 Nov)Wang WTumour Biol