Gene: SYT8

90019
-
synaptotagmin 8
protein-coding
11p15.5
Ensembl:ENSG00000149043 MIM:607719 Vega:OTTHUMG00000009026 UniprotKB:Q8NBV8
NG_034029.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.907e-1 (AD)  9.518e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs907609chr11:1836040 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PLA2G4F0.444
LCE3D0.442
CLDN30.44
KRT140.419
LGALS70.41
LCE2D0.4
CALML50.394
CASP140.392
RNF1860.376
SPRR40.376

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TM4SF20-0.229
MDGA1-0.228
SERPINA10-0.217
MN1-0.212
OR13D1-0.212
MTNR1B-0.208
TRPV3-0.207
GPR39-0.206
GNRH2-0.205
IGSF11-0.204

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of SYT8 mRNA"20406850
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of SYT8 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SYT8 mRNA16483693
D001280AtrazineAtrazine results in increased expression of SYT8 mRNA22378314
C006780bisphenol Abisphenol A results in decreased methylation of SYT8 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of SYT8 mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of SYT8 mRNA26079696
C010063carbonyl sulfidecarbonyl sulfide results in increased expression of SYT8 mRNA19395590
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of SYT8 mRNA28472532
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of SYT8 mRNA]27941970
D003976DiazinonDiazinon results in increased methylation of SYT8 gene22964155
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of SYT8 mRNA27392435
D002945CisplatinCisplatin results in increased expression of SYT8 mRNA27392435
D002117CalcitriolCalcitriol results in increased expression of SYT8 mRNA26485663
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of SYT8 mRNA"22485181
C069837fullerene C60fullerene C60 results in decreased expression of SYT8 mRNA19167457
D005839GentamicinsGentamicins results in decreased expression of SYT8 mRNA22061828
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of SYT8 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SYT8 mRNA26752646
D008627Mercuric ChlorideMercuric Chloride results in increased expression of SYT8 mRNA27188386
D009151Mustard GasMustard Gas results in increased expression of SYT8 mRNA15674843
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SYT8 mRNA"25554681
C028007nickel monoxidenickel monoxide results in decreased expression of SYT8 mRNA19167457
D010634PhenobarbitalPhenobarbital results in decreased expression of SYT8 mRNA19084549
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SYT8 mRNA19710929
D010936Plant ExtractsPlant Extracts results in decreased expression of SYT8 mRNA23557933
C017947sodium arsenitesodium arsenite affects the methylation of SYT8 gene28589171
D053260SootSoot results in increased expression of SYT8 mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SYT8 mRNA22298810
D014520UrethaneUrethane results in decreased expression of SYT8 mRNA28818685
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SYT8 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IBA21873635  
GO:0005544calcium-dependent phospholipid binding-IBA21873635  
GO:0019905syntaxin binding-IBA21873635  
GO:0030276clathrin binding-IBA21873635  
GO:0048306calcium-dependent protein binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006906vesicle fusion-IBA21873635  
GO:0007340acrosome reaction-IEA-  
GO:0016079synaptic vesicle exocytosis-IBA21873635  
GO:0017158regulation of calcium ion-dependent exocytosis-IBA21873635  
GO:0048488synaptic vesicle endocytosis-IBA21873635  
GO:0048791calcium ion-regulated exocytosis of neurotransmitter-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001669acrosomal vesicle-IEA-  
GO:0005886plasma membrane-IBA21873635  
GO:0016021integral component of membrane-IEA-  
GO:0030672synaptic vesicle membrane-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-199991Membrane TraffickingTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-8856825Cargo recognition for clathrin-mediated endocytosisTAS
R-HSA-8856828Clathrin-mediated endocytosisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal