| Probe | Locus(GRCh37) | Gene | Region | p-val | Trait | PubMed ID |
| cg03636183 | chr19:17000585 | F2RL3 | 1.100e-20 | Smoking | 27651444 | |
| cg03636183 | chr19:17000585 | F2RL3 | 2.800e-67 | Tobacco smoking | 28225026 | |
| cg03636183 | chr19:17000585 | F2RL3 | 7.260e-96 | Smoking | 28686328 |
| Gene Symbol | Pearson Correlation Coefficient |
|---|---|
| SLC30A2 | 0.615 |
| STX11 | 0.612 |
| ZC3H12A | 0.61 |
| NOS3 | 0.609 |
| BCL6B | 0.608 |
| F11R | 0.604 |
| SEMA3F | 0.604 |
| CSF3 | 0.603 |
| PLAUR | 0.593 |
| HYAL2 | 0.592 |
| Gene Symbol | Pearson Correlation Coefficient |
|---|---|
| NXPH1 | -0.309 |
| KCNMB2 | -0.3 |
| TACR1 | -0.27 |
| GPR85 | -0.263 |
| LHX6 | -0.257 |
| PDGFRA | -0.255 |
| KIT | -0.253 |
| HAPLN1 | -0.249 |
| LRRTM3 | -0.248 |
| LRRC38 | -0.247 |
| ID | Drug Name | Drug Type | CAS Num | Status | Role |
|---|---|---|---|---|---|
| DB11300 | Thrombin | Small Molecule | Approved|Investigational | Target |
| ID | Drug Name | Action | PubMed |
|---|---|---|---|
| C009505 | 4,4'-diaminodiphenylmethane | "4,4'-diaminodiphenylmethane results in decreased expression of F2RL3 mRNA" | 18648102 |
| C496492 | abrine | abrine results in decreased expression of F2RL3 mRNA | 22595364 |
| D000082 | Acetaminophen | Acetaminophen results in decreased expression of F2RL3 mRNA | 22230336 |
| D000242 | Cyclic AMP | [GYPGKF-NH(2) binds to and results in increased activity of F2RL3 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP] | 22207716 |
| D000242 | Cyclic AMP | [GYPGKF-NH(2) binds to and results in increased activity of F2RL3 protein] which results in decreased chemical synthesis of Cyclic AMP | 22207716 |
| C455901 | alanyl-tyrosyl-prolyl-glycyl-lysyl-phenylalanine | [alanyl-tyrosyl-prolyl-glycyl-lysyl-phenylalanine binds to and results in increased activity of F2RL3 protein] which results in increased uptake of Calcium | 16702038 |
| C455901 | alanyl-tyrosyl-prolyl-glycyl-lysyl-phenylalanine | alanyl-tyrosyl-prolyl-glycyl-lysyl-phenylalanine binds to and results in increased activity of F2RL3 protein | 16702038 |
| D000535 | Aluminum | [APP protein modified form binds to Aluminum] which results in increased expression of F2RL3 mRNA | 21298039 |
| C074619 | bivalirudin | bivalirudin results in decreased activity of F2RL3 protein | 19124943 |
| D002118 | Calcium | [alanyl-tyrosyl-prolyl-glycyl-lysyl-phenylalanine binds to and results in increased activity of F2RL3 protein] which results in increased uptake of Calcium | 16702038 |
| D002118 | Calcium | F2RL3 protein affects the localization of and affects the transport of Calcium | 17707436 |
| D005576 | Colforsin | [GYPGKF-NH(2) binds to and results in increased activity of F2RL3 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP] | 22207716 |
| D003300 | Copper | Copper deficiency results in increased expression of F2RL3 mRNA | 26033743 |
| D003520 | Cyclophosphamide | Cyclophosphamide results in increased expression of F2RL3 protein | 15643279 |
| D019422 | Dietary Sucrose | Dietary Sucrose results in increased expression of F2RL3 mRNA | 26033743 |
| C061365 | flusilazole | flusilazole results in decreased expression of F2RL3 mRNA | 28263823 |
| C069837 | fullerene C60 | fullerene C60 results in decreased expression of F2RL3 mRNA | 19167457 |
| C482002 | GYPGKF-NH(2) | [GYPGKF-NH(2) binds to and results in increased activity of F2RL3 protein] inhibits the reaction [CGB3 protein results in increased chemical synthesis of Progesterone] | 22207716 |
| C482002 | GYPGKF-NH(2) | [GYPGKF-NH(2) binds to and results in increased activity of F2RL3 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP] | 22207716 |
| C482002 | GYPGKF-NH(2) | [GYPGKF-NH(2) binds to and results in increased activity of F2RL3 protein] which results in decreased chemical synthesis of Cyclic AMP | 22207716 |
| C482002 | GYPGKF-NH(2) | GYPGKF-NH(2) binds to and results in increased activity of F2RL3 protein | 22207716 |
| C482199 | lipopolysaccharide, E coli O55-B5 | "lipopolysaccharide, E coli O55-B5 results in increased expression of F2RL3 protein" | 12598324 |
| D008070 | Lipopolysaccharides | Lipopolysaccharides results in increased expression of F2RL3 mRNA | 12057914 |
| D008713 | Methimazole | Methimazole results in increased expression of F2RL3 mRNA | 22504374 |
| D015058 | 1-Naphthylisothiocyanate | F2RL3 gene mutant form results in increased susceptibility to 1-Naphthylisothiocyanate | 27475285 |
| C028007 | nickel monoxide | nickel monoxide results in decreased expression of F2RL3 mRNA | 19167457 |
| C572573 | N-nitroso-tris-chloroethylurea | [N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of F2RL3 mRNA | 27935865 |
| C030110 | oxaliplatin | [oxaliplatin co-treated with Topotecan] results in increased expression of F2RL3 mRNA | 25729387 |
| D010936 | Plant Extracts | Plant Extracts results in decreased expression of F2RL3 mRNA | 23557933 |
| D011192 | Potassium Dichromate | Potassium Dichromate results in decreased expression of F2RL3 mRNA | 23608068 |
| D011374 | Progesterone | [GYPGKF-NH(2) binds to and results in increased activity of F2RL3 protein] inhibits the reaction [CGB3 protein results in increased chemical synthesis of Progesterone] | 22207716 |
| D011441 | Propylthiouracil | Propylthiouracil results in increased expression of F2RL3 mRNA | 22504374 |
| C045037 | testosterone-3-carboxymethyloxime-bovine serum albumin conjugate | testosterone-3-carboxymethyloxime-bovine serum albumin conjugate results in decreased expression of F2RL3 mRNA | 20189893 |
| D013917 | Thrombin | Thrombin binds to and results in increased activity of [F2R protein binds to F2RL3 protein] | 16505172 |
| D014028 | Tobacco Smoke Pollution | Tobacco Smoke Pollution results in decreased methylation of F2RL3 gene | 26756918|2686493 |
| D014028 | Tobacco Smoke Pollution | Tobacco Smoke Pollution results in increased methylation of F2RL3 gene | 24273234 |
| D019772 | Topotecan | [oxaliplatin co-treated with Topotecan] results in increased expression of F2RL3 mRNA | 25729387 |
| C032910 | triadimefon | triadimefon results in decreased expression of F2RL3 mRNA | 28263823 |
| D014241 | Trichloroethylene | Trichloroethylene results in increased expression of F2RL3 mRNA | 15363585 |
| C015559 | trimellitic anhydride | trimellitic anhydride results in increased expression of F2RL3 mRNA | 19042947 |
| D014635 | Valproic Acid | Valproic Acid results in increased methylation of F2RL3 gene | 29154799 |
| C581157 | XL147 | [N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of F2RL3 mRNA | 27935865 |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0004930 | G-protein coupled receptor activity | - | IBA | 21873635 |
| GO:0004930 | G-protein coupled receptor activity | - | TAS | - |
| GO:0015057 | thrombin-activated receptor activity | - | IEA | - |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0007165 | signal transduction | - | TAS | 9618465 10702240 |
| GO:0007186 | G-protein coupled receptor signaling pathway | - | TAS | - |
| GO:0007200 | phospholipase C-activating G-protein coupled receptor signaling pathway | - | TAS | 9618465 |
| GO:0007596 | blood coagulation | - | TAS | 10500152 |
| GO:0009611 | response to wounding | - | TAS | 9618465 |
| GO:0030168 | platelet activation | - | TAS | - |
| GO:0035025 | positive regulation of Rho protein signal transduction | - | IBA | 21873635 |
| GO:0051281 | positive regulation of release of sequestered calcium ion into cytosol | - | IDA | 18480058 |
| GO:0051482 | positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway | - | IBA | 21873635 |
| GO:0060155 | platelet dense granule organization | - | IC | 18480058 |
| GO:0070493 | thrombin-activated receptor signaling pathway | - | IEA | - |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0005576 | extracellular region | - | TAS | - |
| GO:0005886 | plasma membrane | - | TAS | - |
| GO:0005887 | integral component of plasma membrane | - | IBA | 21873635 |
| GO:0005887 | integral component of plasma membrane | - | TAS | 9618465 |
| KEGG ID | KEGG Term |
|---|---|
| hsa04080 | Neuroactive ligand-receptor interaction |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-HSA-109582 | Hemostasis | TAS |
| R-HSA-109582 | Hemostasis | IEA |
| R-HSA-162582 | Signal Transduction | TAS |
| R-HSA-372790 | Signaling by GPCR | TAS |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | TAS |
| R-HSA-375276 | Peptide ligand-binding receptors | TAS |
| R-HSA-388396 | GPCR downstream signalling | TAS |
| R-HSA-416476 | G alpha (q) signalling events | TAS |
| R-HSA-456926 | Thrombin signalling through proteinase activated receptors (PARs) | TAS |
| R-HSA-456926 | Thrombin signalling through proteinase activated receptors (PARs) | IEA |
| R-HSA-500792 | GPCR ligand binding | TAS |
| R-HSA-76002 | Platelet activation, signaling and aggregation | TAS |
| R-HSA-76002 | Platelet activation, signaling and aggregation | IEA |
| PMID | Title (Year) | Author | Journal |
|---|---|---|---|
| 29149250 | Modeling the Causal Role of DNA Methylation in the Association Between Cigarette Smoking and Inflammation in African Americans: A 2-Step Epigenetic Mendelian Randomization Study. (2017 Nov 15) | Jhun MA | Am J Epidemiol |
| 29207374 | Age-related gene expression changes, and transcriptome wide association study of physical and cognitive aging traits, in the Lothian Birth Cohort 1936. (2017 Dec 1) | Harris SE | Aging (Albany NY) |
| 24273234 | F2RL3 methylation as a biomarker of current and lifetime smoking exposures. (2014 Feb) | Zhang Y | Environ Health Perspect |
| 29055820 | IgG glycosylation and DNA methylation are interconnected with smoking. (2018 Mar) | Wahl A | Biochim Biophys Acta |
| 26043106 | Novel epigenetic changes unveiled by monozygotic twins discordant for smoking habits. (2015) | Allione A | PLoS One |
| 28453567 | Performance of urine cotinine and hypomethylation of AHRR and F2RL3 as biomarkers for smoking exposure in a population-based cohort. (2017) | Lee DH | PLoS One |
| 27924164 | Smoking-associated DNA methylation markers predict lung cancer incidence. (2016) | Zhang Y | Clin Epigenetics |
| 29722794 | DNA-methylation of the cancer-related genes F2RL3 and AHRR is associated with occupational exposure to polycyclic aromatic hydrocarbons. (2018 May 2) | Alhamdow A | Carcinogenesis |
| 22511653 | Smoking, F2RL3 methylation, and prognosis in stable coronary heart disease. (2012 Nov) | Breitling LP | Eur Heart J |
| 25821117 | F2RL3 methylation, lung cancer incidence and mortality. (2015 Oct 1) | Zhang Y | Int J Cancer |
| 24510982 | F2RL3 methylation in blood DNA is a strong predictor of mortality. (2014 Aug) | Zhang Y | Int J Epidemiol |
| 23175441 | Epigenome-wide association study in the European Prospective Investigation into Cancer and Nutrition (EPIC-Turin) identifies novel genetic loci associated with smoking. (2013 Mar 1) | Shenker NS | Hum Mol Genet |
| 22492999 | Cigarette smoking behaviors and time since quitting are associated with differential DNA methylation across the human genome. (2012 Jul 1) | Wan ES | Hum Mol Genet |
| 27632354 | DNA methylation changes measured in pre-diagnostic peripheral blood samples are associated with smoking and lung cancer risk. (2017 Jan 1) | Baglietto L | Int J Cancer |
| 23657504 | Epigenomic association analysis identifies smoking-related DNA methylation sites in African Americans. (2013 Sep) | Sun YV | Hum Genet |
| 29456763 | Causal effect of smoking on DNA methylation in peripheral blood: a twin and family study. (2018) | Li S | Clin Epigenetics |
| 23640490 | Current genetics and epigenetics of smoking/tobacco-related cardiovascular disease. (2013 Jul) | Breitling LP | Arterioscler Thromb Vasc Biol |
| 26478754 | DNA methylation changes of whole blood cells in response to active smoking exposure in adults: a systematic review of DNA methylation studies. (2015) | Gao X | Clin Epigenetics |