Gene: TAF1A

9015
MGC:17061|RAFI48|SL1|TAFI48
TATA-box binding protein associated factor, RNA polymerase I subunit A
protein-coding
1q41
Ensembl:ENSG00000143498 MIM:604903 Vega:OTTHUMG00000037544 UniprotKB:Q15573
NC_000001.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.085e-1 (AD)  7.166e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2936032chr1:222578449 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SEC24A0.819
RBM270.781
CEPT10.768
FAM208B0.762
OTUD6B0.76
FASTKD20.759
NAA150.756
MTDH0.752
ACBD30.747
PBRM10.747

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.34
OR4F29-0.309
NUTM2E-0.266
NEU4-0.255
LCN1-0.246
HIGD1B-0.245
FZD9-0.235
HES5-0.221
ARSF-0.218
PTGDR2-0.218

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of TAF1A mRNA28329830
D000082AcetaminophenAcetaminophen affects the expression of TAF1A mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of TAF1A mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of TAF1A protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TAF1A mRNA22100608|2715375
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TAF1A mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TAF1A mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TAF1A mRNA17879257|2010694
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TAF1A mRNA"20018196|2038263
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of TAF1A mRNA25566086
D004958EstradiolEstradiol affects the expression of TAF1A mRNA22574217
C044887beta-methylcholinebeta-methylcholine affects the expression of TAF1A mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of TAF1A mRNA25181051
D019327Copper SulfateCopper Sulfate results in increased expression of TAF1A mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of TAF1A mRNA20106945|2556210
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of TAF1A mRNA]27941970
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of TAF1A mRNA27392435
D004041Dietary FatsDietary Fats results in increased expression of TAF1A mRNA25016146
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of TAF1A mRNA28329830
D005557FormaldehydeFormaldehyde results in decreased expression of TAF1A mRNA23649840
D007213IndomethacinIndomethacin results in increased expression of TAF1A mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TAF1A mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of TAF1A mRNA27392435
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of TAF1A mRNA26011545
D009532NickelNickel results in increased expression of TAF1A mRNA25583101
D011794QuercetinQuercetin results in decreased expression of TAF1A mRNA21632981
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TAF1A mRNA20106945|2163298
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TAF1A mRNA25613284
D013806TheophyllineTheophylline results in increased expression of TAF1A mRNA18951874
D014212TretinoinTretinoin results in decreased expression of TAF1A mRNA21934132
D014241TrichloroethyleneTrichloroethylene results in increased expression of TAF1A protein22771849
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of TAF1A mRNA"26179874
D014520UrethaneUrethane results in decreased expression of TAF1A mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of TAF1A mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of TAF1A mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased expression of TAF1A mRNA29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IEA-  
GO:0005515protein binding-IPI17318177  20075868  25416956  26496610  
GO ID GO Term Qualifier Evidence PubMed
GO:0006355regulation of transcription, DNA-templated-IEA-  
GO:0006360transcription by RNA polymerase I-TAS7801123  
GO:0006361transcription initiation from RNA polymerase I promoter-TAS-  
GO:0006363termination of RNA polymerase I transcription-TAS-  
GO:0006366transcription by RNA polymerase II-TAS7801123  
GO:0045815positive regulation of gene expression, epigenetic-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000120RNA polymerase I transcription factor complex-IEA-  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0015630microtubule cytoskeleton-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-212165Epigenetic regulation of gene expressionTAS
R-HSA-212165Epigenetic regulation of gene expressionIEA
R-HSA-427359SIRT1 negatively regulates rRNA expressionIEA
R-HSA-427413NoRC negatively regulates rRNA expressionIEA
R-HSA-5250913Positive epigenetic regulation of rRNA expressionTAS
R-HSA-5250924B-WICH complex positively regulates rRNA expressionTAS
R-HSA-5250941Negative epigenetic regulation of rRNA expressionIEA
R-HSA-73762RNA Polymerase I Transcription InitiationIEA
R-HSA-73762RNA Polymerase I Transcription InitiationTAS
R-HSA-73772RNA Polymerase I Promoter EscapeTAS
R-HSA-73777RNA Polymerase I Chain ElongationTAS
R-HSA-73854RNA Polymerase I Promoter ClearanceIEA
R-HSA-73854RNA Polymerase I Promoter ClearanceTAS
R-HSA-73863RNA Polymerase I Transcription TerminationTAS
R-HSA-73864RNA Polymerase I TranscriptionIEA
R-HSA-73864RNA Polymerase I TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-74160Gene expression (Transcription)IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal