Gene: HS6ST2

90161
-
heparan sulfate 6-O-sulfotransferase 2
protein-coding
Xq26.2
Ensembl:ENSG00000171004 MIM:300545 Vega:OTTHUMG00000022430 UniprotKB:Q96MM7
NG_012840.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs243446chrX:132694662 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PAM0.912
PEG30.899
RNF1280.895
TUSC30.895
RAB3C0.894
ELMOD10.891
GPR1580.89
ITFG10.888
REEP10.887
NETO20.885

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.538
SYDE1-0.523
ZIC2-0.523
NFATC1-0.516
CHST14-0.509
RNF135-0.507
STON2-0.506
SIX5-0.499
EVC2-0.499
AGTRAP-0.498

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of HS6ST2 mRNA"19114083
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of HS6ST2 mRNA"19167446
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HS6ST2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HS6ST2 mRNA"27188386
D020106AcrylamideAcrylamide results in increased expression of HS6ST2 mRNA28959563
C006418adrenocorticotropin zincadrenocorticotropin zinc results in decreased expression of HS6ST2 mRNA19920212
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of HS6ST2 mRNA24449571
C015001arsenitearsenite results in increased methylation of HS6ST2 promoter23974009
C015001arsenite[arsenite co-treated with Benzo(a)pyrene] results in decreased expression of HS6ST2 mRNA15894712
C015001arsenitearsenite results in decreased expression of HS6ST2 mRNA15894712
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of HS6ST2 mRNA22316170
D001564Benzo(a)pyrene[arsenite co-treated with Benzo(a)pyrene] results in decreased expression of HS6ST2 mRNA15894712
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HS6ST2 mRNA15034205|1589471
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of HS6ST2 mRNA"19150397
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of HS6ST2 mRNA20660070
C044887beta-methylcholinebeta-methylcholine affects the expression of HS6ST2 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of HS6ST2 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of HS6ST2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of HS6ST2 gene28505145
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of HS6ST2 mRNA17484886
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of HS6ST2 mRNA20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of HS6ST2 gene20938992
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of HS6ST2 mRNA15467011
D003300CopperCopper deficiency results in increased expression of HS6ST2 mRNA26033743
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of HS6ST2 mRNA"19167446
D004008DiclofenacDiclofenac results in increased expression of HS6ST2 mRNA26934552
D019422Dietary SucroseDietary Sucrose results in increased expression of HS6ST2 mRNA26033743
D002117CalcitriolCalcitriol results in increased expression of HS6ST2 mRNA16002434
C118739entinostatentinostat results in increased expression of HS6ST2 mRNA27188386
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of HS6ST2 mRNA29097150
D005472FluorouracilFluorouracil results in decreased expression of HS6ST2 mRNA16510598
C061365flusilazoleflusilazole results in decreased expression of HS6ST2 mRNA22382673
C061365flusilazoleflusilazole results in increased expression of HS6ST2 mRNA22382673
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of HS6ST2 mRNA20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of HS6ST2 gene20938992
C071834glycidamideglycidamide results in decreased expression of HS6ST2 mRNA17822822
C004312glycidolglycidol results in increased expression of HS6ST2 mRNA24915197
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of HS6ST2 mRNA24796395
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of HS6ST2 mRNA26644586
D007854LeadLead affects the expression of HS6ST2 mRNA28903495
C045463leflunomideleflunomide results in decreased expression of HS6ST2 mRNA19751817
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of HS6ST2 mRNA20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of HS6ST2 gene20938992
D008727MethotrexateMethotrexate results in increased expression of HS6ST2 mRNA24449571
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of HS6ST2 mRNA27188386|2800136
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of HS6ST2 mRNA26272509
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HS6ST2 mRNA"27188386
D009020MorphineMorphine results in increased expression of HS6ST2 mRNA21178816
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of HS6ST2 mRNA"25554681
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of HS6ST2 mRNA26705709
C471071perfluorohexanesulfonic acidperfluorohexanesulfonic acid results in increased expression of HS6ST2 mRNA22790973
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of HS6ST2 mRNA20660070
C005556propionaldehydepropionaldehyde results in increased expression of HS6ST2 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of HS6ST2 mRNA24780913
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of HS6ST2 mRNA23806026
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HS6ST2 mRNA15034205
C009495titanium dioxidetitanium dioxide results in increased expression of HS6ST2 mRNA23557971
D014212TretinoinTretinoin results in decreased expression of HS6ST2 mRNA23724009
C012589trichostatin Atrichostatin A results in increased expression of HS6ST2 mRNA24935251|2718838
D014635Valproic AcidValproic Acid affects the expression of HS6ST2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of HS6ST2 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of HS6ST2 gene29154799
D014635Valproic AcidValproic Acid affects the expression of HS6ST2 mRNA17963808
D001335Vehicle EmissionsVehicle Emissions affects the methylation of HS6ST2 gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of HS6ST2 mRNA26682919
C111237vorinostatvorinostat results in increased expression of HS6ST2 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0017095heparan sulfate 6-O-sulfotransferase activity-IBA21873635  
GO:0017095heparan sulfate 6-O-sulfotransferase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006024glycosaminoglycan biosynthetic process-TAS-  
GO:0015015heparan sulfate proteoglycan biosynthetic process, enzymatic modification-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0005654nucleoplasm-IDA-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa00534Glycosaminoglycan biosynthesis - heparan sulfate / heparin
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1630316Glycosaminoglycan metabolismTAS
R-HSA-1638091Heparan sulfate/heparin (HS-GAG) metabolismTAS
R-HSA-2022928HS-GAG biosynthesisTAS
R-HSA-71387Metabolism of carbohydratesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal