Gene: CCNH

902
CAK|CycH|p34|p37
cyclin H
protein-coding
5q14.3
Ensembl:ENSG00000134480 MIM:601953 Vega:OTTHUMG00000119077 UniprotKB:P51946
NC_000005.10
PubMed|SNP Mapped
0   ANCO-SNPs
ND|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.168e-2 (AD)  6.805e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PPP1R20.925
ENY20.917
WDR610.902
TAF90.898
PRKAG10.897
CDC420.894
BCAS20.893
NFU10.892
SRP190.891
PRKRA0.888

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.623
OR4F29-0.593
MTRNR2L6-0.367
MTRNR2L9-0.338
MTRNR2L10-0.322
FOXJ1-0.319
MIA-0.315
RAX2-0.305
CCDC102A-0.298
EVC2-0.296

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CCNH mRNA"26988655
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CCNH mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of CCNH mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of CCNH mRNA"21346803
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CCNH mRNA"12606953
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CCNH protein"12606953
D000082AcetaminophenAcetaminophen results in decreased expression of CCNH mRNA21807079
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CCNH mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 affects the expression of CCNH mRNA19770486
D001115ArecolineArecoline results in decreased expression of CCNH mRNA17682004
C006632arsenic trioxidearsenic trioxide results in decreased expression of CCNH mRNA11940349
C006632arsenic trioxidearsenic trioxide results in increased expression of CCNH mRNA17530438
D001280AtrazineAtrazine results in increased expression of CCNH mRNA25929836
C006780bisphenol Abisphenol A results in decreased expression of CCNH mRNA29097150
C006780bisphenol Abisphenol A results in increased expression of CCNH mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of CCNH mRNA17553608
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of CCNH mRNA18804290
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of CCNH mRNA21297351
D002220CarbamazepineCarbamazepine affects the expression of CCNH mRNA24752500|2597931
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of CCNH mRNA24763279
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of CCNH mRNA28472532
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CCNH mRNA17602206
C408982CPG-oligonucleotideCPG-oligonucleotide results in increased expression of CCNH mRNA21878529
D016572CyclosporineCyclosporine results in increased expression of CCNH mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of CCNH mRNA19770486
C014347decitabinedecitabine results in decreased expression of CCNH mRNA27915011
D003976DiazinonDiazinon affects the expression of CCNH mRNA22546817
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of CCNH mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of CCNH mRNA27392435
D004008DiclofenacDiclofenac affects the expression of CCNH mRNA24752500
C000944dicrotophosdicrotophos results in decreased expression of CCNH mRNA28302478
D004026DieldrinDieldrin affects the expression of CCNH mRNA22546817
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of CCNH mRNA18691550
D004052DiethylnitrosamineMAPK14 protein inhibits the reaction [Diethylnitrosamine results in increased expression of CCNH mRNA]18691550
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CCNH mRNA17602206
D004785Environmental PollutantsEnvironmental Pollutants affects the expression of CCNH mRNA19118595
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CCNH mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CCNH mRNA17942748
C026098etiracetametiracetam results in increased expression of CCNH mRNA20345932
D005485FlutamideFlutamide results in decreased expression of CCNH mRNA21126777
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of CCNH mRNA24763279
D017313FenretinideFenretinide results in decreased expression of CCNH mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CCNH mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of CCNH mRNA27392435
C544151jinfukangjinfukang results in decreased expression of CCNH mRNA27392435
C045463leflunomideleflunomide results in increased expression of CCNH mRNA28988120
C000589248LL-202LL-202 results in decreased expression of CCNH protein24752227
D008713MethimazoleMethimazole results in decreased expression of CCNH mRNA17403546
D008713MethimazoleMethimazole results in increased expression of CCNH mRNA17399805
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of CCNH mRNA26011545
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in increased expression of CCNH mRNA12634122
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CCNH mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CCNH mRNA"25620056
C022838nickel chloridenickel chloride affects the expression of CCNH mRNA22546817
D017239PaclitaxelPaclitaxel results in increased expression of CCNH protein15907983
C016030pantogabpantogab results in decreased expression of CCNH mRNA17379144
C494474perchlorateperchlorate results in decreased expression of CCNH mRNA17403546
C494474perchlorateperchlorate results in increased expression of CCNH mRNA17399805
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of CCNH mRNA18804290
C006253pirinixic acidpirinixic acid results in decreased expression of CCNH mRNA18445702
D011441PropylthiouracilPropylthiouracil results in decreased expression of CCNH mRNA17403546
D011441PropylthiouracilPropylthiouracil results in increased expression of CCNH mRNA17399805
D012402RotenoneRotenone results in increased expression of CCNH mRNA18191903
C017947sodium arsenitesodium arsenite results in increased expression of CCNH mRNA17879257
D014284TriiodothyronineTriiodothyronine results in increased expression of CCNH mRNA17403546
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CCNH mRNA22574217
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CCNH mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CCNH mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CCNH mRNA25613284
D014212TretinoinTretinoin inhibits the reaction [CCNH protein binds to and results in increased phosphorylation of PML protein mutant form]16935935
D014212TretinoinTretinoin inhibits the reaction [CCNH protein binds to and results in increased phosphorylation of RARA protein mutant form]16935935
D014212TretinoinTretinoin results in decreased activity of CCNH protein15126328
C012589trichostatin Atrichostatin A results in increased expression of CCNH mRNA23770000
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of CCNH mRNA19042947
D014635Valproic AcidValproic Acid affects the expression of CCNH mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of CCNH mRNA22580532
D014635Valproic AcidValproic Acid results in increased expression of CCNH mRNA29154799
C025643vinclozolinvinclozolin results in increased expression of CCNH mRNA23555832

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI8521818  9840943  16189514  16769902  17353931  21516116  
21988832  23393140  25416956  26340423  26496610  
GO:0008094DNA-dependent ATPase activitycontributes_toIDA9852112  
GO:0008353RNA polymerase II carboxy-terminal domain kinase activitycontributes_toIDA9852112  
GO:0016538cyclin-dependent protein serine/threonine kinase regulator activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006283transcription-coupled nucleotide-excision repair-TAS-  
GO:0006294nucleotide-excision repair, preincision complex assembly-TAS-  
GO:0006361transcription initiation from RNA polymerase I promoter-TAS-  
GO:0006363termination of RNA polymerase I transcription-TAS-  
GO:0006366transcription by RNA polymerase II-IDA9852112  
GO:0006366transcription by RNA polymerase II-TAS-  
GO:0006367transcription initiation from RNA polymerase II promoter-TAS-  
GO:0006368transcription elongation from RNA polymerase II promoter-TAS-  
GO:00063707-methylguanosine mRNA capping-TAS-  
GO:0006468protein phosphorylation-IEA-  
GO:0007049cell cycle-IEA-  
GO:0045737positive regulation of cyclin-dependent protein serine/threonine kinase activity-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA8692841  
GO:0050821protein stabilization-IMP23393140  
GO:1901409positive regulation of phosphorylation of RNA polymerase II C-terminal domain-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000307cyclin-dependent protein kinase holoenzyme complex-IBA21873635  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-TAS7936635  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005675holo TFIIH complex-IDA9852112  
GO:0019907cyclin-dependent protein kinase activating kinase holoenzyme complex-IDA8692842  
GO:0019907cyclin-dependent protein kinase activating kinase holoenzyme complex-IMP23393140  
GO:0070985TFIIK complex-IEA-  
KEGG ID KEGG Term
hsa03420Nucleotide excision repair
hsa04110Cell cycle
Reactome ID Reactome Term Evidence
R-HSA-112382Formation of RNA Pol II elongation complex TAS
R-HSA-113418Formation of the Early Elongation ComplexTAS
R-HSA-162587HIV Life CycleIEA
R-HSA-162599Late Phase of HIV Life CycleIEA
R-HSA-162906HIV InfectionIEA
R-HSA-1640170Cell CycleTAS
R-HSA-1643685DiseaseIEA
R-HSA-167152Formation of HIV elongation complex in the absence of HIV TatIEA
R-HSA-167158Formation of the HIV-1 Early Elongation ComplexIEA
R-HSA-167160RNA Pol II CTD phosphorylation and interaction with CE during HIV infectionIEA
R-HSA-167161HIV Transcription InitiationIEA
R-HSA-167162RNA Polymerase II HIV Promoter EscapeIEA
R-HSA-167169HIV Transcription ElongationIEA
R-HSA-167172Transcription of the HIV genomeIEA
R-HSA-167200Formation of HIV-1 elongation complex containing HIV-1 TatIEA
R-HSA-167246Tat-mediated elongation of the HIV-1 transcriptIEA
R-HSA-212165Epigenetic regulation of gene expressionIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-427413NoRC negatively regulates rRNA expressionIEA
R-HSA-453274Mitotic G2-G2/M phasesTAS
R-HSA-453279Mitotic G1-G1/S phasesTAS
R-HSA-5250941Negative epigenetic regulation of rRNA expressionIEA
R-HSA-5663205Infectious diseaseIEA
R-HSA-5696395Formation of Incision Complex in GG-NERTAS
R-HSA-5696398Nucleotide Excision RepairTAS
R-HSA-5696399Global Genome Nucleotide Excision Repair (GG-NER)TAS
R-HSA-674695RNA Polymerase II Pre-transcription EventsTAS
R-HSA-6781823Formation of TC-NER Pre-Incision ComplexTAS
R-HSA-6781827Transcription-Coupled Nucleotide Excision Repair (TC-NER)TAS
R-HSA-6782135Dual incision in TC-NERTAS
R-HSA-6782210Gap-filling DNA repair synthesis and ligation in TC-NERTAS
R-HSA-6796648TP53 Regulates Transcription of DNA Repair GenesTAS
R-HSA-69202Cyclin E associated events during G1/S transition TAS
R-HSA-69206G1/S TransitionTAS
R-HSA-69231Cyclin D associated events in G1TAS
R-HSA-69236G1 PhaseTAS
R-HSA-69242S PhaseTAS
R-HSA-69273Cyclin A/B1/B2 associated events during G2/M transitionTAS
R-HSA-69275G2/M TransitionTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-69656Cyclin A:Cdk2-associated events at S phase entryTAS
R-HSA-72086mRNA CappingTAS
R-HSA-73762RNA Polymerase I Transcription InitiationTAS
R-HSA-73772RNA Polymerase I Promoter EscapeTAS
R-HSA-73776RNA Polymerase II Promoter EscapeTAS
R-HSA-73777RNA Polymerase I Chain ElongationTAS
R-HSA-73779RNA Polymerase II Transcription Pre-Initiation And Promoter OpeningTAS
R-HSA-73854RNA Polymerase I Promoter ClearanceTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-73863RNA Polymerase I Transcription TerminationTAS
R-HSA-73864RNA Polymerase I TranscriptionTAS
R-HSA-73894DNA RepairTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-74160Gene expression (Transcription)IEA
R-HSA-75953RNA Polymerase II Transcription InitiationTAS
R-HSA-75955RNA Polymerase II Transcription ElongationTAS
R-HSA-76042RNA Polymerase II Transcription Initiation And Promoter ClearanceTAS
R-HSA-77075RNA Pol II CTD phosphorylation and interaction with CETAS
R-HSA-8878171Transcriptional regulation by RUNX1TAS
R-HSA-8939236RUNX1 regulates transcription of genes involved in differentiation of HSCsTAS
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17728339High-order interactions among genetic polymorphisms in nucleotide excision repair pathway genes and smoking in modulating bladder cancer risk. (2007 Oct)Chen MCarcinogenesis
16492920Nucleotide excision repair gene polymorphisms and risk of advanced colorectal adenoma: XPC polymorphisms modify smoking-related risk. (2006 Feb)Huang WYCancer Epidemiol Biomarkers Prev
17575242Nucleotide excision repair pathway genes and oral premalignant lesions. (2007 Jun 15)Wang YClin Cancer Res