Gene: MAP3K14

9020
FTDCR1B|HS|HSNIK|NIK
mitogen-activated protein kinase kinase kinase 14
protein-coding
17q21.31
Ensembl:ENSG00000006062 MIM:604655 Vega:OTTHUMG00000180364 UniprotKB:Q99558
NG_033823.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.136e-1 (AD)  1.241e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg00146864chr17:43392332MAP3K141.400e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
VPS37C0.778
BRPF10.756
NKIRAS20.751
NUP980.749
MAP2K30.748
ISG20L20.745
TXLNA0.745
ELL0.745
SLC39A140.742
COLGALT10.741

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.413
OR4F29-0.382
KLRC2-0.27
P2RY14-0.231
KLRC3-0.212
PDE11A-0.202
RERGL-0.196
OR1E1-0.188
TCL1A-0.186
DIAPH3-0.177

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0479481'-acetoxychavicol acetate1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of MAP3K14 protein]15905586
C0038982-anisidine2-anisidine results in decreased expression of MAP3K14 mRNA28089782
C0261373-hydroxyacetanilide3-hydroxyacetanilide results in increased expression of MAP3K14 mRNA18544908
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAP3K14 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAP3K14 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAP3K14 mRNA"27188386
C4771875-(4-methylpiperazin-1-yl)-2-(2'-(3,4-dimethoxyphenyl)-5'-benzimidazolyl)benzimidazole"5-(4-methylpiperazin-1-yl)-2-(2'-(3,4-dimethoxyphenyl)-5'-benzimidazolyl)benzimidazole results in increased expression of MAP3K14 mRNA"22745752
C4771875-(4-methylpiperazin-1-yl)-2-(2'-(3,4-dimethoxyphenyl)-5'-benzimidazolyl)benzimidazole"MAP3K14 mutant form inhibits the reaction [5-(4-methylpiperazin-1-yl)-2-(2'-(3,4-dimethoxyphenyl)-5'-benzimidazolyl)benzimidazole results in increased phosphorylation of CHUK protein]"22745752
C4771875-(4-methylpiperazin-1-yl)-2-(2'-(3,4-dimethoxyphenyl)-5'-benzimidazolyl)benzimidazole"MAP3K14 mutant form inhibits the reaction [5-(4-methylpiperazin-1-yl)-2-(2'-(3,4-dimethoxyphenyl)-5'-benzimidazolyl)benzimidazole results in increased phosphorylation of IKBKB protein]"22745752
C4771875-(4-methylpiperazin-1-yl)-2-(2'-(3,4-dimethoxyphenyl)-5'-benzimidazolyl)benzimidazole"MAP3K14 protein promotes the reaction [5-(4-methylpiperazin-1-yl)-2-(2'-(3,4-dimethoxyphenyl)-5'-benzimidazolyl)benzimidazole results in increased phosphorylation of CHUK protein]"22745752
C4771875-(4-methylpiperazin-1-yl)-2-(2'-(3,4-dimethoxyphenyl)-5'-benzimidazolyl)benzimidazole"MAP3K14 protein promotes the reaction [5-(4-methylpiperazin-1-yl)-2-(2'-(3,4-dimethoxyphenyl)-5'-benzimidazolyl)benzimidazole results in increased phosphorylation of IKBKB protein]"22745752
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAP3K14 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAP3K14 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAP3K14 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of MAP3K14 mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of MAP3K14 mRNA18544908
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of MAP3K14 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MAP3K14 mRNA19770486
C088115anacardic acidanacardic acid results in decreased activity of MAP3K14 protein18349320
C015001arsenitearsenite inhibits the reaction [MAP3K14 protein results in increased activity of CHUK protein]10967126
C015001arsenitearsenite inhibits the reaction [MAP3K14 protein results in increased activity of IKBKB protein]10967126
D001280AtrazineAtrazine results in decreased expression of MAP3K14 mRNA25929836
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of MAP3K14 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MAP3K14 mRNA26238291
C006780bisphenol Abisphenol A results in increased expression of MAP3K14 mRNA29027980
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of MAP3K14 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of MAP3K14 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of MAP3K14 mRNA28628672
C018475butyraldehydebutyraldehyde results in increased expression of MAP3K14 mRNA26079696
C584509C646 compoundC646 compound results in decreased expression of MAP3K14 mRNA26191083
D002101Cacodylic AcidCacodylic Acid results in increased expression of MAP3K14 mRNA17441966
D002104CadmiumCadmium results in increased expression of MAP3K14 mRNA22562489
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of MAP3K14 mRNA17484886
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAP3K14 mRNA"27188386
D002922CiguatoxinsCiguatoxins affects the expression of MAP3K14 mRNA18353800
C012843cinnamic aldehydecinnamic aldehyde results in decreased phosphorylation of MAP3K14 protein17486422
D019327Copper SulfateCopper Sulfate results in increased expression of MAP3K14 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of MAP3K14 mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of MAP3K14 mRNA20106945|2556210
C089595cylindrospermopsincylindrospermopsin results in increased expression of MAP3K14 mRNA24921660
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of MAP3K14 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of MAP3K14 mRNA28628672
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of MAP3K14 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of MAP3K14 mRNA27392435
C000944dicrotophosdicrotophos results in increased expression of MAP3K14 mRNA28302478
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of MAP3K14 mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of MAP3K14 mRNA]19850644
D002117CalcitriolCalcitriol results in increased expression of MAP3K14 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of MAP3K14 mRNA21592394
C045651epigallocatechin gallateepigallocatechin gallate results in decreased expression of MAP3K14 mRNA12628509
C020748ferrous sulfateMAP3K14 protein affects the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]17172471
C020748ferrous sulfateMAP3K14 protein affects the reaction [ferrous sulfate results in increased secretion of TNF protein]17172471
C002469fusarenon-Xfusarenon-X results in increased expression of MAP3K14 mRNA24983900
D019833GenisteinGenistein results in decreased expression of MAP3K14 mRNA22228119
C103280goniothalamingoniothalamin results in decreased activity of MAP3K14 protein23845509
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of MAP3K14 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of MAP3K14 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MAP3K14 mRNA25613284
D007501IronMAP3K14 protein affects the reaction [Iron results in increased phosphorylation of NFKBIA protein]17172471
D007501IronMAP3K14 protein affects the reaction [Iron results in increased secretion of TNF protein]17172471
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of MAP3K14 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of MAP3K14 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of MAP3K14 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of MAP3K14 mRNA27392435
C045463leflunomideleflunomide results in increased expression of MAP3K14 mRNA28988120
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of MAP3K14 mRNA25613284
D008070LipopolysaccharidesMAP3K14 protein affects the reaction [Manganese promotes the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]15010209
D008345ManganeseMAP3K14 protein affects the reaction [Manganese promotes the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]15010209
C013592mangiferinmangiferin results in decreased phosphorylation of MAP3K14 protein26996543
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAP3K14 mRNA"27188386
D008727MethotrexateMethotrexate results in increased expression of MAP3K14 mRNA21678067
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of MAP3K14 mRNA28001369
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium affects the expression of MAP3K14 mRNA12710931
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MAP3K14 mRNA"25620056
D009532NickelNickel results in increased expression of MAP3K14 mRNA25583101
C028007nickel monoxidenickel monoxide results in increased expression of MAP3K14 protein27464988
C029938nickel sulfatenickel sulfate results in increased expression of MAP3K14 mRNA16780908
C464660obeticholic acidobeticholic acid results in decreased expression of MAP3K14 mRNA27939613
C551803PCI 32765MAP3K14 protein mutant form results in decreased susceptibility to PCI 3276526254443
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of MAP3K14 mRNA18593933
D010416PentachlorophenolPentachlorophenol results in increased expression of MAP3K14 mRNA23892564
D010634PhenobarbitalPhenobarbital affects the expression of MAP3K14 mRNA19136022
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAP3K14 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of MAP3K14 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of MAP3K14 mRNA19710929
C006253pirinixic acidpirinixic acid affects the expression of MAP3K14 mRNA19136022
C006253pirinixic acidpirinixic acid results in decreased expression of MAP3K14 mRNA20813756
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of MAP3K14 mRNA22714537
D011794QuercetinQuercetin results in increased expression of MAP3K14 mRNA21632981
C059514resveratrolresveratrol results in decreased expression of MAP3K14 mRNA25888808
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of MAP3K14 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of MAP3K14 mRNA23221170
D012834SilverSilver results in increased expression of MAP3K14 mRNA26014281|2895954
D019821SimvastatinSimvastatin results in decreased expression of MAP3K14 mRNA17277159
C533467SM 164SM 164 results in increased expression of MAP3K14 protein22241084
C017947sodium arsenitesodium arsenite results in increased expression of MAP3K14 mRNA10910055
D018038Sodium SeleniteSodium Selenite results in decreased expression of MAP3K14 mRNA16705456
D053260Soot[Soot co-treated with Sulfates] affects the methylation of MAP3K14 promoter25395096
D013431Sulfates[Soot co-treated with Sulfates] affects the methylation of MAP3K14 promoter25395096
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of MAP3K14 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of MAP3K14 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MAP3K14 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MAP3K14 mRNA12167310
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of MAP3K14 mRNA10910055
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MAP3K14 mRNA25613284
D014212TretinoinTretinoin results in increased expression of MAP3K14 mRNA23724009
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of MAP3K14 mRNA"26179874
C004218tylophorinetylophorine analog results in increased expression of MAP3K14 mRNA19284764
D014520UrethaneUrethane results in increased expression of MAP3K14 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of MAP3K14 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of MAP3K14 mRNA28001369|2915479
D014639VanadiumVanadium results in decreased expression of MAP3K14 mRNA19000753
C403304zerumbonezerumbone inhibits the reaction [MAP3K14 protein results in increased activity of [NFKB1 protein binds to RELA protein]]16007145
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of MAP3K14 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004672protein kinase activity-IDA15001576  
GO:0004674protein serine/threonine kinase activity-EXP9520446  
GO:0004674protein serine/threonine kinase activity-IBA21873635  
GO:0004704NF-kappaB-inducing kinase activity-ISS-  
GO:0004709MAP kinase kinase kinase activity-IEA-  
GO:0005515protein binding-IPI9020361  9520446  10094049  10733566  12884866  14743216  
15208311  16286467  16498412  17158868  22939624  25036637  
25241761  25416956  
GO:0005524ATP binding-IEA-  
GO:0016301kinase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-IEA-  
GO:0000186activation of MAPKK activity-IEA-  
GO:0006955immune response-ISS-  
GO:0007249I-kappaB kinase/NF-kappaB signaling-ISS-  
GO:0007346regulation of mitotic cell cycle-IBA21873635  
GO:0023014signal transduction by protein phosphorylation-IBA21873635  
GO:0032147activation of protein kinase activity-IBA21873635  
GO:0033209tumor necrosis factor-mediated signaling pathway-TAS-  
GO:0038061NIK/NF-kappaB signaling-TAS-  
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling-IBA21873635  
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling-IMP10094049  
GO:0051607defense response to virus-IDA21478870  
GO:0071260cellular response to mechanical stimulus-IEP19593445  
GO ID GO Term Qualifier Evidence PubMed
GO:0001650fibrillar center-IDA-  
GO:0005634nucleus-IDA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
hsa04210Apoptosis
hsa04380Osteoclast differentiation
hsa04660T cell receptor signaling pathway
hsa04672Intestinal immune network for IgA production
hsa05120Epithelial cell signaling in Helicobacter pylori infection
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-388841Costimulation by the CD28 familyTAS
R-HSA-389356CD28 co-stimulationTAS
R-HSA-389357CD28 dependent PI3K/Akt signalingTAS
R-HSA-5607761Dectin-1 mediated noncanonical NF-kB signalingTAS
R-HSA-5607764CLEC7A (Dectin-1) signalingTAS
R-HSA-5621481C-type lectin receptors (CLRs)TAS
R-HSA-5668541TNFR2 non-canonical NF-kB pathwayTAS
R-HSA-5676590NIK-->noncanonical NF-kB signalingTAS
R-HSA-5676594TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathwayTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

There is no Interaction data for this gene.

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19706323A model to identify novel targets involved in oxidative stress-induced apoptosis in human lung epithelial cells by RNA interference. (2010 Feb)Wixted WEToxicol In Vitro
24776844Associations between functional polymorphisms in the NFkappaB signaling pathway and response to anti-TNF treatment in Danish patients with inflammatory bowel disease. (2014 Dec)Bank SPharmacogenomics J