Gene: SOCS3

9021
ATOD4|CIS3|Cish3|SOCS-3|SSI-3|SSI3
suppressor of cytokine signaling 3
protein-coding
17q25.3
Ensembl:ENSG00000184557 MIM:604176 Vega:OTTHUMG00000177513 UniprotKB:O14543
NG_016851.1
PubMed
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.765e-1 (AD)  3.225e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg10508317chr17:76355146SOCS32.300e-10Smoking27651444
cg22749855chr17:76353952SOCS31.200e-9Smoking27651444
cg18181703chr17:76354621SOCS31.800e-8Smoking27651444
cg18181703chr17:76354621SOCS39.170e-11Alcohol consumption per day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
YBX30.919
CDKN1A0.888
GPR40.875
CDK20.87
EMP10.867
CEBPD0.863
IL4R0.852
GADD45B0.846
BCL30.845
PLSCR10.845

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NEUROD6-0.586
ABCC12-0.555
SLC7A4-0.545
VWC2-0.54
MARCH4-0.535
PPEF1-0.534
EDN3-0.53
HAPLN1-0.529
CASC15-0.527
F7-0.521

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0523831,1-bis(4-hydroxyphenyl)-2-phenylbut-1-ene"1,1-bis(4-hydroxyphenyl)-2-phenylbut-1-ene results in decreased expression of SOCS3 mRNA"23373633
C0636091,2-dimethyl-4-nitrobenzene"1,2-dimethyl-4-nitrobenzene results in decreased expression of SOCS3 mRNA"19784758
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of SOCS3 mRNA"28903501
C09724015-deoxy-delta(12,14)-prostaglandin J2"15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of SOCS3 mRNA"12584205
C0152621,6-hexamethylene diisocyanate"1,6-hexamethylene diisocyanate affects the expression of SOCS3 mRNA"19110044
C5580481,7-diphenyl-4,6-heptadien-3-ol"1,7-diphenyl-4,6-heptadien-3-ol results in increased expression of SOCS3 mRNA"25575267
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of SOCS3 mRNA28329830
C4656642-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SOCS3 protein]23782265
C1202272-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide"2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [[[Colforsin co-treated with Rolipram] results in increased abundance of Cyclic AMP] which results in increased expression of SOCS3 protein]"23782265
C1202272-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide"2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [flavone results in increased expression of SOCS3 mRNA]"23782265
C1202272-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide"2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [flavone results in increased expression of SOCS3 protein]"23782265
C0612822-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine promotes the reaction [Oxygen deficiency results in increased expression of SOCS3 mRNA]27289578
C0612822-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine promotes the reaction [Oxygen deficiency results in increased expression of SOCS3 protein]27289578
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SOCS3 protein"24978599
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SOCS3 protein"24978599
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in increased expression of SOCS3 protein"24978599
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SOCS3 protein"24978599
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in increased expression of SOCS3 protein"24978599
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,5,2',5'-pentachlorobiphenyl co-treated with PCB 180] results in increased expression of SOCS3 protein"24978599
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SOCS3 mRNA]25712622
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Gemfibrozil results in increased expression of SOCS3 mRNA]22685291
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Gemfibrozil results in increased expression of SOCS3 protein]22685291
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of SOCS3 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOCS3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOCS3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOCS3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOCS3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOCS3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOCS3 mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of SOCS3 mRNA19191707
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [[[Colforsin co-treated with Rolipram] results in increased abundance of Cyclic AMP] which results in increased expression of SOCS3 protein]"23782265
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [flavone results in increased expression of SOCS3 protein]"23782265
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOCS3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOCS3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOCS3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOCS3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOCS3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOCS3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [Cyclic AMP results in increased expression of SOCS3]"23782265
C0006253616-hydroxy-3-O-methylkaempferol 6-O-glucopyranoside6-hydroxy-3-O-methylkaempferol 6-O-glucopyranoside results in decreased expression of SOCS3 protein29031523
C0006253616-hydroxy-3-O-methylkaempferol 6-O-glucopyranosideSOCS3 protein inhibits the reaction [6-hydroxy-3-O-methylkaempferol 6-O-glucopyranoside promotes the reaction [interferon alfa-2a results in increased expression of JAK1 protein modified form]]29031523
C0006253616-hydroxy-3-O-methylkaempferol 6-O-glucopyranosideSOCS3 protein inhibits the reaction [6-hydroxy-3-O-methylkaempferol 6-O-glucopyranoside promotes the reaction [interferon alfa-2a results in increased expression of STAT1 protein modified form]]29031523
C0006253616-hydroxy-3-O-methylkaempferol 6-O-glucopyranosideSOCS3 protein inhibits the reaction [6-hydroxy-3-O-methylkaempferol 6-O-glucopyranoside promotes the reaction [interferon alfa-2a results in increased expression of TYK2 protein modified form]]29031523
D000082AcetaminophenAcetaminophen affects the expression of SOCS3 mRNA17562736
D000082Acetaminophen[Acetaminophen co-treated with IL22 protein] results in increased expression of SOCS3 mRNA23375450
D000082Acetaminophen[Acetaminophen co-treated with Ozone] results in increased expression of SOCS3 mRNA20123758
D000082AcetaminophenAcetaminophen results in increased expression of SOCS3 mRNA20123758|2526557
D000082Acetaminophensaikosaponin inhibits the reaction [Acetaminophen results in increased expression of SOCS3 mRNA]25265579
D000082AcetaminophenAcetaminophen affects the expression of SOCS3 mRNA19784758
D000082AcetaminophenAcetaminophen results in decreased expression of SOCS3 mRNA19784758
D000082AcetaminophenAcetaminophen results in increased expression of SOCS3 mRNA19784758
D020106AcrylamideAcrylamide results in decreased expression of SOCS3 mRNA28959563
D000242Cyclic AMP"2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [[[Colforsin co-treated with Rolipram] results in increased abundance of Cyclic AMP] which results in increased expression of SOCS3 protein]"23782265
D000242Cyclic AMP"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [[[Colforsin co-treated with Rolipram] results in increased abundance of Cyclic AMP] which results in increased expression of SOCS3 protein]"23782265
D000242Cyclic AMP[[Colforsin co-treated with Rolipram] results in increased abundance of Cyclic AMP] which results in increased expression of SOCS3 protein23782265
D000242Cyclic AMP"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [Cyclic AMP results in increased expression of SOCS3]"23782265
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SOCS3 mRNA16483693
C018453ammonium hexachloroplatinateammonium hexachloroplatinate affects the expression of SOCS3 mRNA19110044
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of SOCS3 mRNA"22863853
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of SOCS3 mRNA24449571
D047310ApigeninApigenin results in increased expression of SOCS3 mRNA23782265
D016718Arachidonic AcidArachidonic Acid promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of SOCS3 mRNA]19063610
C081565arachidonyltrifluoromethanearachidonyltrifluoromethane inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SOCS3 mRNA]19063610
D034341Aristolochic AcidsAristolochic Acids results in increased expression of SOCS3 mRNA21834575
D001151ArsenicArsenic affects the expression of SOCS3 mRNA18414638
D001151ArsenicArsenic results in increased expression of SOCS3 mRNA18039032
D001152ArsenicalsArsenicals results in increased expression of SOCS3 mRNA28025110
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of SOCS3 mRNA"25757056
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of SOCS3 mRNA"18687144
D001285Atropine[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of SOCS3 mRNA]22245128
D001374AzacitidineAzacitidine affects the expression of SOCS3 protein18443271
C517975AZD 6244AZD 6244 inhibits the reaction [flavone results in increased expression of SOCS3 mRNA]23782265
C517975AZD 6244AZD 6244 inhibits the reaction [flavone results in increased expression of SOCS3 protein]23782265
C487081belinostatbelinostat results in decreased expression of SOCS3 mRNA26272509
D001554BenzeneBenzene results in increased expression of SOCS3 mRNA15929907
D001554BenzeneBenzene results in decreased expression of SOCS3 mRNA15120971|1512265
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of SOCS3 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SOCS3 mRNA21871943|2231617
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SOCS3 mRNA22228805
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of SOCS3 protein23782265
D004958EstradiolEstradiol promotes the reaction [ESR1 protein binds to SOCS3 promoter]16055089
D004958EstradiolEstradiol results in decreased expression of SOCS3 mRNA23373633
D004958EstradiolEstradiol results in increased expression of SOCS3 mRNA16055089
D004958Estradiolfulvestrant inhibits the reaction [Estradiol results in increased expression of SOCS3 mRNA]16055089
D004958EstradiolEstradiol affects the expression of SOCS3 mRNA15598610
D004958EstradiolEstradiol promotes the reaction [sodium arsenite results in increased expression of SOCS3 mRNA]26631322
D004958EstradiolEstradiol promotes the reaction [sodium arsenite results in increased expression of SOCS3 protein]26631322
D004958EstradiolEstradiol results in increased expression of SOCS3 mRNA25210133|2557526
D004958EstradiolEstradiol promotes the reaction [Sulpiride results in increased expression of SOCS3 mRNA]18162529
D004958EstradiolEstradiol results in increased expression of SOCS3 mRNA18162529
C543008bis(4-hydroxyphenyl)sulfone[Dietary Fats co-treated with bis(4-hydroxyphenyl)sulfone] affects the expression of SOCS3 mRNA27241191
C006780bisphenol Abisphenol A results in increased expression of SOCS3 mRNA27176707
C006780bisphenol Abisphenol A results in increased expression of SOCS3 protein27176707
C006780bisphenol Abisphenol A results in increased expression of SOCS3 mRNA25181051
C025703bleomycetinbleomycetin results in increased expression of SOCS3 mRNA21040473
D000069286BortezomibBortezomib results in increased expression of SOCS3 mRNA20977926
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of SOCS3 mRNA22079614
D002185Cannabidiol"Cannabidiol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of SOCS3 mRNA]"19910459
D002220CarbamazepineCarbamazepine affects the expression of SOCS3 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of SOCS3 mRNA27339419
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of SOCS3 mRNA19784758
D002509CephaloridineCephaloridine results in decreased expression of SOCS3 mRNA18500788
D002794Choline2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SOCS3 mRNA]25712622
D002794Choline[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SOCS3 mRNA25712622
D002794CholineQuercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SOCS3 mRNA]25712622
D002794Choline[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SOCS3 mRNA25712622
D002794CholineQuercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SOCS3 mRNA]25712622
C418118CI 1044CI 1044 results in increased expression of SOCS3 mRNA17569694
D005576Colforsin"2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [[[Colforsin co-treated with Rolipram] results in increased abundance of Cyclic AMP] which results in increased expression of SOCS3 protein]"23782265
D005576Colforsin"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [[[Colforsin co-treated with Rolipram] results in increased abundance of Cyclic AMP] which results in increased expression of SOCS3 protein]"23782265
D005576Colforsin[[Colforsin co-treated with Rolipram] results in increased abundance of Cyclic AMP] which results in increased expression of SOCS3 protein23782265
D005576ColforsinColforsin results in increased expression of SOCS3 protein23782265
D005576ColforsinColforsin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SOCS3 mRNA]17407152
D019327Copper SulfateCopper Sulfate results in increased expression of SOCS3 mRNA19549813
D003474CurcuminCurcumin results in decreased expression of SOCS3 mRNA18403477|2582271
D003513CycloheximideCycloheximide results in increased expression of SOCS3 mRNA23237828
D003513CycloheximideDactinomycin inhibits the reaction [Cycloheximide results in increased expression of SOCS3 mRNA]23237828
D003513CycloheximideU 0126 inhibits the reaction [Cycloheximide results in increased expression of SOCS3 mRNA]23237828
C093628cyproconazolecyproconazole affects the expression of SOCS3 mRNA22045034
D003609DactinomycinDactinomycin inhibits the reaction [Cycloheximide results in increased expression of SOCS3 mRNA]23237828
D003703DemecolcineDemecolcine results in increased expression of SOCS3 mRNA23649840
C007262deoxynivalenoldeoxynivalenol results in increased expression of SOCS3 mRNA19625342|1980540
C007262deoxynivalenoldeoxynivalenol results in increased expression of SOCS3 protein19625342
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of SOCS3 mRNA21266533
D002945CisplatinCisplatin results in increased expression of SOCS3 mRNA19833167|2115164
D004008DiclofenacDiclofenac results in increased expression of SOCS3 mRNA26934552
D004040Dietary Carbohydrates[Dietary Fats co-treated with Dietary Carbohydrates] results in increased expression of SOCS3 protein21289251
D004040Dietary Carbohydrates[resveratrol co-treated with Plant Extracts] inhibits the reaction [[Dietary Fats co-treated with Dietary Carbohydrates] results in increased expression of SOCS3 protein]21289251
D004040Dietary Carbohydrates[resveratrol co-treated with Polyphenols] inhibits the reaction [[Dietary Fats co-treated with Dietary Carbohydrates] results in increased expression of SOCS3 protein]21289251
D004041Dietary Fats[Dietary Fats co-treated with Dietary Carbohydrates] results in increased expression of SOCS3 protein21289251
D004041Dietary Fats[resveratrol co-treated with Plant Extracts] inhibits the reaction [[Dietary Fats co-treated with Dietary Carbohydrates] results in increased expression of SOCS3 protein]21289251
D004041Dietary Fats[resveratrol co-treated with Polyphenols] inhibits the reaction [[Dietary Fats co-treated with Dietary Carbohydrates] results in increased expression of SOCS3 protein]21289251
D004041Dietary FatsDietary Fats affects the expression of SOCS3 mRNA19680557
D004041Dietary Fats[Dietary Fats affects the susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of SOCS3 mRNA28774668
D004041Dietary Fats[Dietary Fats co-treated with bis(4-hydroxyphenyl)sulfone] affects the expression of SOCS3 mRNA27241191
D004041Dietary FatsDietary Fats results in increased expression of SOCS3 mRNA22276206
D004041Dietary FatsLEPR protein promotes the reaction [Dietary Fats results in increased expression of SOCS3 mRNA]22276206
D004041Dietary Fats[Dietary Fats co-treated with resveratrol] affects the expression of SOCS3 mRNA26055348
D004041Dietary FatsDietary Fats results in increased expression of SOCS3 protein26055348
D004041Dietary Fatsresveratrol inhibits the reaction [Dietary Fats results in increased expression of SOCS3 protein]26055348
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of SOCS3 mRNA28085963
C014476diethyl maleatediethyl maleate results in decreased expression of SOCS3 mRNA25270620
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Methylcholanthrene] results in decreased expression of SOCS3 protein20970405
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Methylcholanthrene] results in increased methylation of SOCS3 promoter20970405
D004112DimercaprolDimercaprol inhibits the reaction [Mustard Gas results in increased expression of SOCS3 mRNA]16377760
D004317Doxorubicin[[MT1 protein co-treated with MT2 protein] affects the susceptibility to Doxorubicin] which affects the expression of SOCS3 mRNA21040762
D004318DoxycyclineDoxycycline inhibits the reaction [Isoproterenol results in increased expression of SOCS3 mRNA]18089841
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of SOCS3 mRNA"23811387
D015118Eicosapentaenoic AcidEicosapentaenoic Acid promotes the reaction [Lipopolysaccharides results in increased expression of SOCS3 mRNA]22169119
C118739entinostatentinostat results in decreased expression of SOCS3 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOCS3 mRNA"27188386
D000069347Erlotinib HydrochlorideErlotinib Hydrochloride results in increased expression of SOCS3 mRNA24768708
D004964EstriolEstriol results in increased expression of SOCS3 mRNA25575267
D004967EstrogensSOCS3 mutant form inhibits the reaction [Estrogens inhibits the reaction [sodium arsenite results in increased phosphorylation of STAT3 protein]]26631322
D004967EstrogensSOCS3 mutant form inhibits the reaction [Estrogens promotes the reaction [sodium arsenite results in increased expression of SQSTM1 protein]]26631322
D004967EstrogensSOCS3 mutant form inhibits the reaction [Estrogens promotes the reaction [sodium arsenite results in increased phosphorylation of MAPK1 protein]]26631322
D004967EstrogensSOCS3 mutant form inhibits the reaction [Estrogens promotes the reaction [sodium arsenite results in increased phosphorylation of MAPK3 protein]]26631322
D004967EstrogensEstrogens results in increased expression of SOCS3 mRNA18325991
D004967EstrogensProgesterone inhibits the reaction [Estrogens results in increased expression of SOCS3 mRNA]18325991
D000431EthanolEthanol promotes the reaction [ADIPOQ protein results in increased expression of SOCS3 mRNA]20052772
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of SOCS3 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol inhibits the reaction [IL1B protein results in increased expression of SOCS3 mRNA]12072388
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SOCS3 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SOCS3 mRNA17351261
D011345Fenofibrate[Fenofibrate co-treated with resveratrol] inhibits the reaction [Fructose results in increased expression of SOCS3 mRNA]26973390
D011345FenofibrateFenofibrate inhibits the reaction [Fructose results in increased expression of SOCS3 mRNA]26973390
D005284FenthionFenthion results in increased expression of SOCS3 mRNA21538558
C043562flavone"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [flavone results in increased expression of SOCS3 protein]"23782265
C043562flavoneflavone results in increased expression of SOCS3 mRNA23782265
C043562flavoneflavone results in increased expression of SOCS3 protein23782265
C043562flavone"2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [flavone results in increased expression of SOCS3 mRNA]"23782265
C043562flavone"2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [flavone results in increased expression of SOCS3 protein]"23782265
C043562flavoneAZD 6244 inhibits the reaction [flavone results in increased expression of SOCS3 mRNA]23782265
C043562flavoneAZD 6244 inhibits the reaction [flavone results in increased expression of SOCS3 protein]23782265
C043562flavoneflavone results in increased expression of SOCS3 mRNA23782265
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of SOCS3 mRNA28329830
D005557FormaldehydeFormaldehyde results in increased expression of SOCS3 mRNA20655997|2364984
D005632Fructose[Fenofibrate co-treated with resveratrol] inhibits the reaction [Fructose results in increased expression of SOCS3 mRNA]26973390
D005632FructoseFenofibrate inhibits the reaction [Fructose results in increased expression of SOCS3 mRNA]26973390
D005632FructoseFructose results in increased expression of SOCS3 mRNA26973390
D005632FructoseFructose results in increased expression of SOCS3 protein21122807|2242601
D005632FructoseQuercetin inhibits the reaction [Fructose results in increased expression of SOCS3 protein]22426011|2353347
D005632Fructoseresveratrol inhibits the reaction [Fructose results in increased expression of SOCS3 mRNA]26973390
D005632FructoseRutin inhibits the reaction [Fructose results in increased expression of SOCS3 protein]22426011
C070081fulvestrantfulvestrant inhibits the reaction [Estradiol results in increased expression of SOCS3 mRNA]16055089
C070081fulvestrantfulvestrant inhibits the reaction [Genistein results in increased expression of SOCS3 mRNA]16055089
C546771gardiquimodgardiquimod results in increased expression of SOCS3 mRNA28003376
C546771gardiquimodProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of SOCS3 mRNA]28003376
D015248Gemfibrozil2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Gemfibrozil results in increased expression of SOCS3 mRNA]22685291
D015248Gemfibrozil2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Gemfibrozil results in increased expression of SOCS3 protein]22685291
D015248GemfibrozilGemfibrozil results in increased expression of SOCS3 mRNA22685291
D015248GemfibrozilGemfibrozil results in increased expression of SOCS3 protein22685291
D015248GemfibrozilKLF4 mRNA affects the reaction [Gemfibrozil results in increased expression of SOCS3 mRNA]22685291
D015248Gemfibrozilwortmannin inhibits the reaction [Gemfibrozil results in increased expression of SOCS3 mRNA]22685291
D015248Gemfibrozilwortmannin inhibits the reaction [Gemfibrozil results in increased expression of SOCS3 protein]22685291
D019833Genisteinfulvestrant inhibits the reaction [Genistein results in increased expression of SOCS3 mRNA]16055089
D019833GenisteinGenistein results in increased expression of SOCS3 mRNA16055089
C049864ginsenoside Reginsenoside Re inhibits the reaction [TNF protein results in increased expression of SOCS3 mRNA]17885204
D005947GlucoseGlucose results in increased expression of SOCS3 mRNA17178593
C473027GW 3965GW 3965 inhibits the reaction [IL6 protein results in increased expression of SOCS3 protein]27052460
D006581HexachlorobenzeneHexachlorobenzene results in increased expression of SOCS3 mRNA15159207
C409722hexaconazolehexaconazole affects the expression of SOCS3 mRNA22045034
D017313FenretinideFenretinide results in increased expression of SOCS3 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of SOCS3 mRNA20044591
D007052IbuprofenIbuprofen affects the expression of SOCS3 mRNA17070997
C554043interferon alfa-2aSOCS3 protein inhibits the reaction [6-hydroxy-3-O-methylkaempferol 6-O-glucopyranoside promotes the reaction [interferon alfa-2a results in increased expression of JAK1 protein modified form]]29031523
C554043interferon alfa-2aSOCS3 protein inhibits the reaction [6-hydroxy-3-O-methylkaempferol 6-O-glucopyranoside promotes the reaction [interferon alfa-2a results in increased expression of STAT1 protein modified form]]29031523
C554043interferon alfa-2aSOCS3 protein inhibits the reaction [6-hydroxy-3-O-methylkaempferol 6-O-glucopyranoside promotes the reaction [interferon alfa-2a results in increased expression of TYK2 protein modified form]]29031523
C554043interferon alfa-2aSOCS3 protein inhibits the reaction [interferon alfa-2a results in increased expression of JAK1 protein modified form]29031523
C554043interferon alfa-2aSOCS3 protein inhibits the reaction [interferon alfa-2a results in increased expression of STAT1 protein modified form]29031523
C554043interferon alfa-2aSOCS3 protein inhibits the reaction [interferon alfa-2a results in increased expression of TYK2 protein modified form]29031523
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SOCS3 mRNA25613284
C036643isoeugenolisoeugenol results in increased expression of SOCS3 mRNA21969073
C036643isoeugenolisoeugenol results in increased expression of SOCS3 protein21969073
C036643isoeugenolKT 5720 inhibits the reaction [isoeugenol results in increased expression of SOCS3 mRNA]21969073
D007529IsoflavonesIsoflavones results in increased expression of SOCS3 mRNA23782265
D007545IsoproterenolDoxycycline inhibits the reaction [Isoproterenol results in increased expression of SOCS3 mRNA]18089841
D007545IsoproterenolIsoproterenol results in increased expression of SOCS3 mRNA18089841|2000320
C098607JP8 aviation fuelJP8 aviation fuel results in decreased expression of SOCS3 mRNA15618438
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [[IL6 protein co-treated with IL6R protein] promotes the reaction [STAT3 protein modified form results in increased expression of SOCS3 mRNA]]24657799
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of SOCS3 mRNA]25725100
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SOCS3 mRNA23086925
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of SOCS3 mRNA]25890327
D007649Ketamine[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of SOCS3 mRNA]22245128
C057416KT 5720KT 5720 inhibits the reaction [isoeugenol results in increased expression of SOCS3 mRNA]21969073
C482199lipopolysaccharide, E coli O55-B5"Cannabidiol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of SOCS3 mRNA]"19910459
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of SOCS3 mRNA"19910459
C482199lipopolysaccharide, E coli O55-B5"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of SOCS3 mRNA"18930950
D008070Lipopolysaccharides(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of SOCS3 mRNA]25725100
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of SOCS3 mRNA18192897|1845362
D008070LipopolysaccharidesEicosapentaenoic Acid promotes the reaction [Lipopolysaccharides results in increased expression of SOCS3 mRNA]22169119
D008070LipopolysaccharidesIL10 protein affects the reaction [[resveratrol co-treated with Lipopolysaccharides] results in increased expression of SOCS3 protein]25576658
D008070LipopolysaccharidesIL10 protein promotes the reaction [Lipopolysaccharides results in increased expression of SOCS3 mRNA]22024136
D008070Lipopolysaccharides(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of SOCS3 mRNA]25890327
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of SOCS3 mRNA22024136|2216911
D008070Lipopolysaccharides"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate inhibits the reaction [Lipopolysaccharides results in increased expression of SOCS3 mRNA]"26918785
D008070LipopolysaccharidesQuercetin inhibits the reaction [Lipopolysaccharides results in increased expression of SOCS3 mRNA]22185406
D008070Lipopolysaccharides[resveratrol co-treated with Lipopolysaccharides] results in increased expression of SOCS3 protein25576658
D008070Lipopolysaccharides"tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of SOCS3 mRNA]"22185406
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of SOCS3 mRNA25613284
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of SOCS3 mRNA21641980
C545385MequindoxMequindox affects the expression of SOCS3 mRNA21146578
D008694MethamphetamineMethamphetamine results in increased expression of SOCS3 mRNA15644446
D008715Methionine2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SOCS3 mRNA]25712622
D008715Methionine[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SOCS3 mRNA25712622
D008715MethionineQuercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SOCS3 mRNA]25712622
D008715Methionine[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SOCS3 mRNA25712622
D008715MethionineQuercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SOCS3 mRNA]25712622
D008727MethotrexateMethotrexate results in decreased expression of SOCS3 mRNA24449571
D008731MethoxychlorMethoxychlor results in increased methylation of SOCS3 gene23303685
C445068methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate inhibits the reaction [Lipopolysaccharides results in increased expression of SOCS3 mRNA]"26918785
D008748MethylcholanthreneMethylcholanthrene results in increased expression of SOCS3 mRNA23169610
D008748Methylcholanthrene[Diethylnitrosamine co-treated with Methylcholanthrene] results in decreased expression of SOCS3 protein20970405
D008748Methylcholanthrene[Diethylnitrosamine co-treated with Methylcholanthrene] results in increased methylation of SOCS3 promoter20970405
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of SOCS3 mRNA28001369
D008767Methylmercury CompoundsMethylmercury Compounds promotes the reaction [CNTF protein results in increased expression of SOCS3 protein]23845766
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of SOCS3 mRNA"20188158
D008770MethylnitrosoureaMethylnitrosourea results in decreased expression of SOCS3 mRNA25270620
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of SOCS3 mRNA22108045
D009151Mustard GasDimercaprol inhibits the reaction [Mustard Gas results in increased expression of SOCS3 mRNA]16377760
D009151Mustard GasMustard Gas results in increased expression of SOCS3 mRNA16377760
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SOCS3 mRNA]17407152
C510788N4-(2,2-dimethyl-3-oxo-4H-pyrid(1,4)oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine"N4-(2,2-dimethyl-3-oxo-4H-pyrid(1,4)oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine results in decreased expression of SOCS3 mRNA"25487280
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SOCS3 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SOCS3 mRNA"25554681|2562005
D009285NaphthoquinonesNaphthoquinones results in increased expression of SOCS3 mRNA23811387
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of SOCS3 mRNA12832660
C005273naringeninnaringenin results in increased expression of SOCS3 mRNA23782265
C005273naringeninnaringenin results in increased expression of SOCS3 mRNA23782265
C005273naringeninnaringenin results in increased expression of SOCS3 protein23782265
C017096n-butoxyethanoln-butoxyethanol results in increased expression of SOCS3 mRNA19812364
D009532NickelNickel results in increased expression of SOCS3 mRNA25583101
C029938nickel sulfatenickel sulfate results in increased expression of SOCS3 mRNA16780908
D009538NicotineNicotine results in increased expression of SOCS3 mRNA29155039
D009578NitrobenzenesNitrobenzenes analog results in decreased expression of SOCS3 mRNA19784758
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of SOCS3 mRNA19716841
D053683Oncostatin MOncostatin M promotes the reaction [BRD4 protein binds to SOCS3 promoter]24657799
D053683Oncostatin MOncostatin M promotes the reaction [STAT3 protein binds to SOCS3 promoter]24657799
D053683Oncostatin MSTAT3 protein affects the reaction [Oncostatin M promotes the reaction [BRD4 protein binds to SOCS3 promoter]]24657799
D063086OrganothiophosphatesOrganothiophosphates metabolite affects the phosphorylation of and results in increased expression of SOCS3 protein20659491
D063086OrganothiophosphatesOrganothiophosphates metabolite affects the phosphorylation of SOCS3 protein20659491
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of SOCS3 mRNA25729387
D010100Oxygen[Tetrachlorodibenzodioxin co-treated with Oxygen deficiency] results in increased expression of SOCS3 mRNA19578757
D010100Oxygen2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine promotes the reaction [Oxygen deficiency results in increased expression of SOCS3 mRNA]27289578
D010100Oxygen2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine promotes the reaction [Oxygen deficiency results in increased expression of SOCS3 protein]27289578
D010100OxygenOxygen deficiency results in increased expression of SOCS3 mRNA27289578
D010100OxygenOxygen deficiency results in increased expression of SOCS3 protein27289578
D010126Ozone[Acetaminophen co-treated with Ozone] results in increased expression of SOCS3 mRNA20123758
D010126OzoneIL10 gene mutant form affects the reaction [Ozone results in increased expression of SOCS3 mRNA]20826374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of SOCS3 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH4 gene mutant form] affects the expression of SOCS3 mRNA25658374
D010126OzoneOzone results in decreased expression of SOCS3 mRNA20123758
D010126OzoneOzone results in increased expression of SOCS3 mRNA17460151|2082637
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of SOCS3 mRNA]19555225
D000073878Palm OilPalm Oil affects the expression of SOCS3 mRNA19680557
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOCS3 mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of SOCS3 mRNA26272509
D052638Particulate MatterParticulate Matter results in increased expression of SOCS3 mRNA28412507
C410127PCB 180"[2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SOCS3 protein"24978599
C410127PCB 180"[2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SOCS3 protein"24978599
C410127PCB 180"[2,4,5,2',5'-pentachlorobiphenyl co-treated with PCB 180] results in increased expression of SOCS3 protein"24978599
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of SOCS3 mRNA18593933
D010575PesticidesPesticides results in increased expression of SOCS3 mRNA21538558
D010634PhenobarbitalPhenobarbital affects the expression of SOCS3 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOCS3 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of SOCS3 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SOCS3 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of SOCS3 mRNA18445702|2381119
C006253pirinixic acidpirinixic acid results in increased expression of SOCS3 mRNA21318169
C006253pirinixic acidPPARA protein affects the reaction [pirinixic acid results in increased expression of SOCS3 mRNA]21318169
C006253pirinixic acidpirinixic acid results in increased expression of SOCS3 mRNA12832660
D010936Plant Extracts[resveratrol co-treated with Plant Extracts] inhibits the reaction [[Dietary Fats co-treated with Dietary Carbohydrates] results in increased expression of SOCS3 protein]21289251
D011070Poly I-CPoly I-C results in increased expression of SOCS3 mRNA21195166
D059808Polyphenols[resveratrol co-treated with Polyphenols] inhibits the reaction [[Dietary Fats co-treated with Dietary Carbohydrates] results in increased expression of SOCS3 protein]21289251
D017035PravastatinPravastatin results in increased expression of SOCS3 protein19330073
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of SOCS3 mRNA28903501
D011374Progesterone[Progesterone co-treated with TGFB1 protein] results in increased expression of SOCS3 mRNA21768398
D011374ProgesteroneProgesterone results in increased expression of SOCS3 mRNA21768398
D011374ProgesteroneProgesterone affects the expression of SOCS3 mRNA17251523
D011374ProgesteroneProgesterone inhibits the reaction [Estrogens results in increased expression of SOCS3 mRNA]18325991
C045950propiconazolepropiconazole results in decreased expression of SOCS3 mRNA21278054
D015237DinoprostDinoprost results in increased expression of SOCS3 mRNA21654155
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of SOCS3 mRNA]28003376
D011794QuercetinQuercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SOCS3 mRNA]25712622
D011794QuercetinQuercetin inhibits the reaction [Lipopolysaccharides results in increased expression of SOCS3 mRNA]22185406
D011794QuercetinQuercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SOCS3 mRNA]25712622
D011794QuercetinQuercetin results in decreased expression of SOCS3 mRNA22185406
D011794QuercetinQuercetin inhibits the reaction [Fructose results in increased expression of SOCS3 protein]22426011|2353347
C059514resveratrol[resveratrol co-treated with Plant Extracts] inhibits the reaction [[Dietary Fats co-treated with Dietary Carbohydrates] results in increased expression of SOCS3 protein]21289251
C059514resveratrol[resveratrol co-treated with Polyphenols] inhibits the reaction [[Dietary Fats co-treated with Dietary Carbohydrates] results in increased expression of SOCS3 protein]21289251
C059514resveratrolresveratrol results in increased expression of SOCS3 mRNA22748497|2378226
C059514resveratrolresveratrol results in increased expression of SOCS3 protein26432044
C059514resveratrolSOCS3 protein results in decreased susceptibility to resveratrol21308719
C059514resveratrolIL10 protein affects the reaction [[resveratrol co-treated with Lipopolysaccharides] results in increased expression of SOCS3 protein]25576658
C059514resveratrol[resveratrol co-treated with Lipopolysaccharides] results in increased expression of SOCS3 protein25576658
C059514resveratrol[Dietary Fats co-treated with resveratrol] affects the expression of SOCS3 mRNA26055348
C059514resveratrol[Fenofibrate co-treated with resveratrol] inhibits the reaction [Fructose results in increased expression of SOCS3 mRNA]26973390
C059514resveratrolresveratrol inhibits the reaction [Dietary Fats results in increased expression of SOCS3 protein]26055348
C059514resveratrolresveratrol inhibits the reaction [Fructose results in increased expression of SOCS3 mRNA]26973390
C059514resveratrolresveratrol results in decreased expression of SOCS3 mRNA23419489
C059514resveratrolresveratrol inhibits the reaction [IL6 protein results in increased expression of SOCS3 mRNA]23782265
C059514resveratrolresveratrol inhibits the reaction [IL6 protein results in increased expression of SOCS3 protein]23782265
D012293Rifampin[Rifampin co-treated with NR1I2 protein] results in increased expression of SOCS3 mRNA21127053
C116926rofecoxibrofecoxib results in increased expression of SOCS3 mRNA17070997
C116926rofecoxibrofecoxib results in increased expression of SOCS3 protein17070997
D020889Rolipram"2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [[[Colforsin co-treated with Rolipram] results in increased abundance of Cyclic AMP] which results in increased expression of SOCS3 protein]"23782265
D020889Rolipram"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [[[Colforsin co-treated with Rolipram] results in increased abundance of Cyclic AMP] which results in increased expression of SOCS3 protein]"23782265
D020889Rolipram[[Colforsin co-treated with Rolipram] results in increased abundance of Cyclic AMP] which results in increased expression of SOCS3 protein23782265
D020889RolipramRolipram results in increased expression of SOCS3 protein23782265
C089730rosiglitazonerosiglitazone inhibits the reaction [Streptozocin results in decreased expression of SOCS3 protein]21599458
C089730rosiglitazonerosiglitazone results in increased expression of SOCS3 mRNA12584205
C089730rosiglitazonerosiglitazone results in increased expression of SOCS3 mRNA17394460
D012431RutinRutin inhibits the reaction [Fructose results in increased expression of SOCS3 protein]22426011
C025759saikosaponinsaikosaponin inhibits the reaction [Acetaminophen results in increased expression of SOCS3 mRNA]25265579
C025759saikosaponinsaikosaponin results in increased expression of SOCS3 mRNA25265579
C477523SC 514SC 514 results in decreased expression of SOCS3 mRNA17407152
D012822Silicon DioxideIL6RA mRNA affects the reaction [Silicon Dioxide results in increased expression of SOCS3 mRNA]20490462
D012822Silicon DioxideSilicon Dioxide results in decreased expression of SOCS3 mRNA19073995
D012822Silicon DioxideSilicon Dioxide results in increased expression of SOCS3 mRNA20490462|2322117
D012822Silicon DioxideSilicon Dioxide results in increased expression of SOCS3 protein26865670
D019821SimvastatinSimvastatin results in increased expression of SOCS3 mRNA18453621
D012906SmokeSmoke results in increased expression of SOCS3 mRNA21095227
C009277sodium arsenatesodium arsenate results in decreased expression of SOCS3 mRNA21795629
C017947sodium arsenitesodium arsenite inhibits the reaction [IL6 protein results in increased expression of SOCS3 mRNA]15116095
C017947sodium arsenitesodium arsenite results in decreased expression of SOCS317224793
C017947sodium arseniteEstradiol promotes the reaction [sodium arsenite results in increased expression of SOCS3 mRNA]26631322
C017947sodium arseniteEstradiol promotes the reaction [sodium arsenite results in increased expression of SOCS3 protein]26631322
C017947sodium arseniteSOCS3 mutant form inhibits the reaction [Estrogens inhibits the reaction [sodium arsenite results in increased phosphorylation of STAT3 protein]]26631322
C017947sodium arseniteSOCS3 mutant form inhibits the reaction [Estrogens promotes the reaction [sodium arsenite results in increased expression of SQSTM1 protein]]26631322
C017947sodium arseniteSOCS3 mutant form inhibits the reaction [Estrogens promotes the reaction [sodium arsenite results in increased phosphorylation of MAPK1 protein]]26631322
C017947sodium arseniteSOCS3 mutant form inhibits the reaction [Estrogens promotes the reaction [sodium arsenite results in increased phosphorylation of MAPK3 protein]]26631322
C017947sodium arsenitesodium arsenite results in increased expression of SOCS3 mRNA26631322
C017947sodium arsenitesodium arsenite results in increased expression of SOCS3 protein26631322
D012999Soman[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of SOCS3 mRNA]22245128
D012999SomanSoman results in increased expression of SOCS3 mRNA22245128
D012999SomanSoman results in increased expression of SOCS3 mRNA19281266
D053260SootSoot results in increased expression of SOCS3 mRNA22461453|2655175
C517409stattic[stattic co-treated with IL6 protein] results in increased expression of SOCS3 protein25740948
D013311Streptozocinrosiglitazone inhibits the reaction [Streptozocin results in decreased expression of SOCS3 protein]21599458
D013311StreptozocinStreptozocin results in decreased expression of SOCS3 protein21599458
C041711St. Thomas' Hospital cardioplegic solutionSt. Thomas' Hospital cardioplegic solution results in increased expression of SOCS3 mRNA16214533
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of SOCS3 mRNA21641980
D013469SulpirideEstradiol promotes the reaction [Sulpiride results in increased expression of SOCS3 mRNA]18162529
D013469SulpirideSulpiride results in increased expression of SOCS3 mRNA18162529
C013698tallowtallow affects the expression of SOCS3 mRNA19680557
D013629TamoxifenTamoxifen affects the expression of SOCS3 mRNA17555576|2093736
C012568terbufosterbufos results in increased expression of SOCS3 mRNA21538558
D013739TestosteroneTestosterone results in decreased expression of SOCS3 mRNA15788153
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Oxygen deficiency] results in increased expression of SOCS3 mRNA19578757
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SOCS3 mRNA21496263
D013749TetrachlorodibenzodioxinArachidonic Acid promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of SOCS3 mRNA]19063610
D013749Tetrachlorodibenzodioxinarachidonyltrifluoromethane inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SOCS3 mRNA]19063610
D013749TetrachlorodibenzodioxinColforsin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SOCS3 mRNA]17407152
D013749Tetrachlorodibenzodioxin[Dietary Fats affects the susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of SOCS3 mRNA28774668
D013749TetrachlorodibenzodioxinN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SOCS3 mRNA]17407152
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SOCS3 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of SOCS3 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to SOCS3 gene]20819909
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SOCS3 mRNA17407152|1868492
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SOCS3 mRNA22298810
D013755Tetradecanoylphorbol Acetate2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SOCS3 protein]23782265
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of SOCS3 protein23782265
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SOCS3 mRNA25613284
C528327TG101348TG101348 inhibits the reaction [IL6 protein results in increased expression of SOCS3 protein]23782265
D013853ThioacetamideThioacetamide results in decreased expression of SOCS3 mRNA19784758
C009495titanium dioxidetitanium dioxide results in increased expression of SOCS3 mRNA23557971|2776080
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of SOCS3 mRNA28065790
D014028Tobacco Smoke PollutionNFE2L2 protein affects the reaction [Tobacco Smoke Pollution affects the expression of SOCS3 mRNA]20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of SOCS3 mRNA20133372
C082097tocotrienol, delta"tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of SOCS3 mRNA]"22185406
C082097tocotrienol, delta"tocotrienol, delta results in decreased expression of SOCS3 mRNA"22185406
C479163tofacitinibtofacitinib results in decreased expression of SOCS3 mRNA25487280
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of SOCS3 mRNA25729387
D014118Toxins, Biological"Toxins, Biological affects the expression of SOCS3 mRNA"19682533
D014212TretinoinTretinoin results in increased expression of SOCS3 mRNA15982314
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOCS3 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of SOCS3 mRNA24935251|2627250
C015559trimellitic anhydridetrimellitic anhydride affects the expression of SOCS3 mRNA19110044
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of SOCS3 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SOCS3 mRNA"26179874
C080163trovafloxacin"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of SOCS3 mRNA"18930950
D014415TunicamycinTunicamycin results in increased expression of SOCS3 mRNA17127020
C113580U 0126U 0126 inhibits the reaction [Cycloheximide results in increased expression of SOCS3 mRNA]23237828
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOCS3 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of SOCS3 mRNA24383497|2493525
D014635Valproic AcidValproic Acid results in increased methylation of SOCS3 gene29154799
D014635Valproic AcidValproic Acid affects the expression of SOCS3 mRNA17963808
D014635Valproic AcidValproic Acid results in decreased expression of SOCS3 mRNA22045034
C066075vanadium pentoxidevanadium pentoxide results in increased expression of SOCS3 mRNA17459161
D001335Vehicle EmissionsVehicle Emissions affects the methylation of SOCS3 gene25560391
D014750VincristineVincristine results in increased expression of SOCS3 mRNA23649840
D014752Vinyl ChlorideVinyl Chloride results in decreased expression of SOCS3 mRNA18579281
C029297vinylidene chloridevinylidene chloride results in increased expression of SOCS3 mRNA26682919
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOCS3 mRNA"27188386
C111237vorinostatvorinostat results in decreased expression of SOCS3 mRNA26272509
C009687wortmanninwortmannin inhibits the reaction [Gemfibrozil results in increased expression of SOCS3 mRNA]22685291
C009687wortmanninwortmannin inhibits the reaction [Gemfibrozil results in increased expression of SOCS3 protein]22685291
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of SOCS3 mRNA18593933
D015054ZymosanZymosan results in increased expression of SOCS3 mRNA15188379
D015054ZymosanZymosan results in increased expression of SOCS3 protein16646036

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001784phosphotyrosine residue binding-IEA-  
GO:0004860protein kinase inhibitor activity-TAS9266833  
GO:0005515protein binding-IPI19027008  24728074  25203322  25416956  
GO:00469351-phosphatidylinositol-3-kinase regulator activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006469negative regulation of protein kinase activity-IEA-  
GO:0007259JAK-STAT cascade-IEA-  
GO:0016567protein ubiquitination-IEA-  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0040008regulation of growth-IEA-  
GO:0042531positive regulation of tyrosine phosphorylation of STAT protein-TAS-  
GO:0042532negative regulation of tyrosine phosphorylation of STAT protein-IMP25019494  
GO:0043066negative regulation of apoptotic process-IEA-  
GO:0043687post-translational protein modification-TAS-  
GO:0045597positive regulation of cell differentiation-IEA-  
GO:0046426negative regulation of JAK-STAT cascade-IMP25019494  
GO:0046627negative regulation of insulin receptor signaling pathway-IBA21873635  
GO:0046854phosphatidylinositol phosphorylation-IBA21873635  
GO:0050728negative regulation of inflammatory response-IEA-  
GO:0060334regulation of interferon-gamma-mediated signaling pathway-TAS-  
GO:0060670branching involved in labyrinthine layer morphogenesis-IEA-  
GO:0060674placenta blood vessel development-IEA-  
GO:0060707trophoblast giant cell differentiation-IEA-  
GO:0060708spongiotrophoblast differentiation-IEA-  
GO:0070102interleukin-6-mediated signaling pathway-TAS-  
GO:1990830cellular response to leukemia inhibitory factor-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0005942phosphatidylinositol 3-kinase complex-IBA21873635  
KEGG ID KEGG Term
hsa04120Ubiquitin mediated proteolysis
hsa04380Osteoclast differentiation
hsa04630Jak-STAT signaling pathway
hsa04910Insulin signaling pathway
hsa04920Adipocytokine signaling pathway
hsa04930Type II diabetes mellitus
hsa05160Hepatitis C
Reactome ID Reactome Term Evidence
R-HSA-1059683Interleukin-6 signalingTAS
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1280215Cytokine Signaling in Immune systemIEA
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-162582Signal TransductionIEA
R-HSA-162582Signal TransductionTAS
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-212436Generic Transcription PathwayIEA
R-HSA-2586552Signaling by LeptinIEA
R-HSA-392499Metabolism of proteinsTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6783589Interleukin-6 family signalingTAS
R-HSA-6785807Interleukin-4 and 13 signalingTAS
R-HSA-73857RNA Polymerase II TranscriptionIEA
R-HSA-74160Gene expression (Transcription)IEA
R-HSA-877300Interferon gamma signalingTAS
R-HSA-877312Regulation of IFNG signalingTAS
R-HSA-8848021Signaling by PTK6TAS
R-HSA-8849474PTK6 Activates STAT3TAS
R-HSA-8878171Transcriptional regulation by RUNX1IEA
R-HSA-8939242RUNX1 regulates transcription of genes involved in differentiation of keratinocytesIEA
R-HSA-8951664NeddylationTAS
R-HSA-9006927Signaling by Non-Receptor Tyrosine KinasesTAS
R-HSA-909733Interferon alpha/beta signalingTAS
R-HSA-909733Interferon alpha/beta signalingIEA
R-HSA-912694Regulation of IFNA signalingIEA
R-HSA-913531Interferon SignalingTAS
R-HSA-913531Interferon SignalingIEA
R-HSA-982772Growth hormone receptor signalingIEA
R-HSA-983168Antigen processing: Ubiquitination & Proteasome degradationTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27605026A novel chi-square statistic for detecting group differences between pathways in systems epidemiology. (2016 Dec 20)Yuan ZStat Med
19698101Induction of the interleukin 6/ signal transducer and activator of transcription pathway in the lungs of mice sub-chronically exposed to mainstream tobacco smoke. (2009 Aug 21)Halappanavar SBMC Med Genomics
27824951Epigenetic Signatures at AQP3 and SOCS3 Engage in Low-Grade Inflammation across Different Tissues. (2016)Marzi CPLoS One