Gene: UCN2

90226
SRP|UCN-II|UCNI|UR|URP
urocortin 2
protein-coding
3p21.31
Ensembl:ENSG00000145040 MIM:605902 Vega:OTTHUMG00000133533 UniprotKB:Q96RP3
NC_000003.12
PubMed
0   ANCO-SNPs
AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.005e-1 (AD)  2.949e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR7C20.544
TMPRSS130.532
POU2F20.529
PLA2G2E0.484
OTOR0.478
TRAM20.477
FAM83C0.477
CHRNE0.472
C8B0.46
FSCN30.455

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZFHX4-AS1-0.306
CHST9-0.285
HHLA2-0.271
EPM2A-0.254
SPAG16-0.248
ADARB2-0.247
C2orf88-0.236
LYPD6-0.231
MYOZ1-0.231
MGAT4C-0.228

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in increased expression of UCN2 mRNA22230336
D000324Adrenocorticotropic HormoneUCN2 protein results in increased abundance of Adrenocorticotropic Hormone16330704
D000643Ammonium ChlorideAmmonium Chloride affects the expression of UCN2 mRNA16483693
C006780bisphenol Abisphenol A results in decreased expression of UCN2 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of UCN2 mRNA26472689
C039281furanfuran results in increased methylation of UCN2 gene22079235
D006854HydrocortisoneUCN2 protein results in increased abundance of Hydrocortisone16330704
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of UCN2 mRNA17390077
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of UCN2 protein17390077
C006253pirinixic acidpirinixic acid results in decreased expression of UCN2 mRNA20813756
D010936Plant ExtractsPlant Extracts results in decreased expression of UCN2 mRNA23557933
C005556propionaldehydepropionaldehyde results in increased expression of UCN2 mRNA26079696
C041348tcdA protein, Clostridium difficile"tcdA protein, Clostridium difficile results in increased expression of UCN2 mRNA"16920976
D014635Valproic AcidValproic Acid results in increased methylation of UCN2 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001664G-protein coupled receptor binding-IBA21873635  
GO:0005179hormone activity-IEA-  
GO:0042562hormone binding-IPI11329063  
GO:0051429corticotropin-releasing hormone receptor binding-IPI11329063  
GO:0051431corticotropin-releasing hormone receptor 2 binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006950response to stress-IEA-  
GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway-IDA11329063  
GO:0007586digestion-NAS11329063  
GO:0009755hormone-mediated signaling pathway-IDA11329063  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0031669cellular response to nutrient levels-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-NAS11329063  
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005622intracellular-IDA11329063  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373080Class B/2 (Secretin family receptors)TAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22444954Urocortins: CRF's siblings and their potential role in anxiety, depression and alcohol drinking behavior. (2012 Jun)Ryabinin AEAlcohol
29056154Contribution of Urocortin to the Development of Excessive Drinking. (2017)Ryabinin AEInt Rev Neurobiol