Gene: OTULIN

90268
AIPDS|FAM105B|GUM
OTU deubiquitinase with linear linkage specificity
protein-coding
5p15.2
Ensembl:ENSG00000154124 MIM:615712 Vega:OTTHUMG00000161762 UniprotKB:Q96BN8
NG_051625.1
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.268e-1 (AD)  1.909e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs25992chr5:14707491 (GRCh38.p7)C>A / C>G / C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs25952chr5:14695138 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of OTULIN mRNA"19561079
D020106AcrylamideAcrylamide results in increased expression of OTULIN mRNA28959563
D001151ArsenicArsenic affects the expression of OTULIN mRNA18414638
D001280AtrazineAtrazine results in increased expression of OTULIN mRNA25929836
C006780bisphenol Abisphenol A results in decreased expression of OTULIN mRNA25181051
C584509C646 compoundC646 compound results in increased expression of OTULIN mRNA26191083
D002117CalcitriolCalcitriol results in increased expression of OTULIN mRNA16002434
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of OTULIN mRNA"23811387
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of OTULIN protein23301498
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of OTULIN mRNA25613284
D009285NaphthoquinonesNaphthoquinones results in increased expression of OTULIN mRNA23811387
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of OTULIN mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of OTULIN mRNA28065790
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of OTULIN mRNA19042947
D014635Valproic AcidValproic Acid results in decreased expression of OTULIN mRNA23179753
D014635Valproic AcidValproic Acid results in decreased methylation of OTULIN gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of OTULIN gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004843thiol-dependent ubiquitin-specific protease activity-IBA21873635  
GO:0004843thiol-dependent ubiquitin-specific protease activity-IDA23746843  23806334  23827681  24726323  24726327  26997266  
27523608  27559085  
GO:0005515protein binding-IPI23708998  24726323  25416956  27523608  27559085  
GO:0008234cysteine-type peptidase activity-IMP23746843  
GO ID GO Term Qualifier Evidence PubMed
GO:0002040sprouting angiogenesis-ISS-  
GO:0010803regulation of tumor necrosis factor-mediated signaling pathway-IBA21873635  
GO:0010803regulation of tumor necrosis factor-mediated signaling pathway-IDA26997266  
GO:0010803regulation of tumor necrosis factor-mediated signaling pathway-TAS-  
GO:0032088negative regulation of NF-kappaB transcription factor activity-IBA21873635  
GO:0032088negative regulation of NF-kappaB transcription factor activity-IDA23746843  24726327  27559085  
GO:0032088negative regulation of NF-kappaB transcription factor activity-IMP23806334  27523608  
GO:0045087innate immune response-IBA21873635  
GO:0045087innate immune response-IDA26997266  
GO:0045087innate immune response-IMP23806334  
GO:0050728negative regulation of inflammatory response-IBA21873635  
GO:0050728negative regulation of inflammatory response-IMP23806334  27523608  27559085  
GO:0060070canonical Wnt signaling pathway-IBA21873635  
GO:0060070canonical Wnt signaling pathway-ISS-  
GO:0070431nucleotide-binding oligomerization domain containing 2 signaling pathway-IMP23806334  
GO:1990108protein linear deubiquitination-IBA21873635  
GO:1990108protein linear deubiquitination-IDA23746843  23806334  23827681  24726323  24726327  26997266  27523608  27559085  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA23746843  
GO:0005829cytosol-TAS-  
GO:0071797LUBAC complexCOLOCALIZES_WITHIBA21873635  
GO:0071797LUBAC complex-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5357905Regulation of TNFR1 signalingTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-73887Death Receptor SignallingTAS
R-HSA-75893TNF signalingTAS
R-HSA-8852135Protein ubiquitinationTAS
R-HSA-8866652Synthesis of active ubiquitin: roles of E1 and E2 enzymesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal