Gene: SEMA5A

9037
SEMAF|semF
semaphorin 5A
protein-coding
5p15.31
Ensembl:ENSG00000112902 MIM:609297 Vega:OTTHUMG00000090501 UniprotKB:Q13591
NG_016410.1
PubMed|SNP Mapped
2   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.438e-2 (AD)  5.238e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs268487chr5:9403862 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs1805243chr5:9379998 (GRCh38.p7)T>C / T>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LHFPL30.85
LUZP20.778
STK32A0.767
STK32B0.767
CCND10.759
PCDH150.757
CCDC500.744
PDGFRA0.735
BCHE0.729
MAP3K10.72

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.372
OR4F29-0.329
GNB1L-0.324
PNLDC1-0.321
CCNO-0.315
FAM83D-0.299
LEFTY1-0.294
CA7-0.285
TIGD3-0.279
GAS2L2-0.278

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0109142,4-diaminotoluene"2,4-diaminotoluene results in increased expression of SEMA5A mRNA"20713471
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in decreased expression of SEMA5A mRNA"28591870
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SEMA5A mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SEMA5A mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SEMA5A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SEMA5A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SEMA5A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SEMA5A mRNA"27188386
C014949acetylhydrazineacetylhydrazine results in decreased expression of SEMA5A mRNA15282401
D020106AcrylamideAcrylamide results in decreased expression of SEMA5A mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SEMA5A mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SEMA5A mRNA23630614
D001149Arsenates[Atrazine co-treated with Arsenates] results in increased expression of SEMA5A mRNA18585445
D001151ArsenicArsenic affects the methylation of SEMA5A gene25304211
C015001arsenitearsenite results in decreased methylation of SEMA5A promoter23974009
C015001arsenite[arsenite co-treated with Benzo(a)pyrene] results in decreased expression of SEMA5A mRNA15894712
C015001arsenitearsenite results in decreased expression of SEMA5A mRNA15894712
D001280Atrazine[Atrazine co-treated with Arsenates] results in increased expression of SEMA5A mRNA18585445
C547126AZM551248AZM551248 results in increased expression of SEMA5A mRNA22323515
D001564Benzo(a)pyrene[arsenite co-treated with Benzo(a)pyrene] results in decreased expression of SEMA5A mRNA15894712
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SEMA5A mRNA15894712|2071347
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SEMA5A mRNA22228805|2719552
D004958EstradiolEstradiol results in decreased expression of SEMA5A mRNA28591870|2871154
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in decreased expression of SEMA5A mRNA28591870
C006780bisphenol Abisphenol A results in decreased expression of SEMA5A mRNA28591870|2871154
C006780bisphenol Abisphenol A affects the expression of SEMA5A mRNA25181051
C000611646bisphenol Fbisphenol F results in decreased expression of SEMA5A mRNA28591870
D002104CadmiumCadmium results in increased expression of SEMA5A mRNA23358150
D002220CarbamazepineCarbamazepine affects the expression of SEMA5A mRNA25979313
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of SEMA5A mRNA23650126
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SEMA5A mRNA20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SEMA5A gene20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of SEMA5A mRNA24386269
D003042CocaineCocaine affects the expression of SEMA5A mRNA15691709
C029892cupric chloridecupric chloride results in decreased expression of SEMA5A mRNA24650576
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of SEMA5A mRNA17361019|2126653
C058705diethyl malatediethyl malate affects the expression of SEMA5A mRNA24814887
C118739entinostatentinostat results in decreased expression of SEMA5A mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SEMA5A mRNA"27188386
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SEMA5A mRNA20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SEMA5A gene20938992
D005557FormaldehydeFormaldehyde results in increased expression of SEMA5A mRNA28937961
C004312glycidolglycidol results in increased expression of SEMA5A mRNA24915197
C010974glyphosateglyphosate results in decreased expression of SEMA5A mRNA28711546
D017313FenretinideFenretinide results in decreased expression of SEMA5A mRNA28973697
D006997Hypochlorous AcidHypochlorous Acid results in decreased expression of SEMA5A mRNA19376150
D007545IsoproterenolIsoproterenol results in increased expression of SEMA5A mRNA20003209
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SEMA5A mRNA24796395
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of SEMA5A mRNA"24972896
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of SEMA5A mRNA12057914
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of SEMA5A mRNA21641980
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SEMA5A mRNA20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SEMA5A gene20938992
D008748MethylcholanthreneMethylcholanthrene results in increased expression of SEMA5A mRNA20713471
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SEMA5A mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of SEMA5A mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of SEMA5A mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of SEMA5A mRNA"20188158
C008493methylselenic acidmethylselenic acid results in increased expression of SEMA5A mRNA18548127
C523799MRK 003SEMA5A results in increased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SEMA5A mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SEMA5A mRNA"25554681
D009532NickelNickel results in decreased expression of SEMA5A mRNA25583101
C029938nickel sulfatenickel sulfate results in increased expression of SEMA5A mRNA16780908
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of SEMA5A mRNA"21673326
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"PON1 protein affects the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of SEMA5A mRNA]"21673326
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SEMA5A mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of SEMA5A mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SEMA5A mRNA19710929
D011192Potassium DichromatePotassium Dichromate results in decreased expression of SEMA5A mRNA23608068
D011192Potassium DichromateThioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of SEMA5A mRNA]23608068
D011441PropylthiouracilPropylthiouracil affects the expression of SEMA5A mRNA24780913
D012645SelenomethionineSelenomethionine affects the expression of SEMA5A mRNA17222674
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SEMA5A mRNA23806026
C009277sodium arsenatesodium arsenate results in decreased expression of SEMA5A mRNA21795629
C009277sodium arsenatesodium arsenate results in increased expression of SEMA5A mRNA21795629
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of SEMA5A mRNA21641980
D013739TestosteroneTestosterone results in decreased expression of SEMA5A mRNA19693291
D008063Thioctic AcidThioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of SEMA5A mRNA]23608068
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of SEMA5A mRNA20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of SEMA5A mRNA19969065
D014050TolueneToluene results in increased expression of SEMA5A mRNA28245982
D014118Toxins, Biological"Toxins, Biological affects the expression of SEMA5A mRNA"19682533
D014212TretinoinTretinoin results in increased expression of SEMA5A mRNA23724009
C012589trichostatin Atrichostatin A results in decreased expression of SEMA5A mRNA24935251
D014635Valproic AcidValproic Acid results in decreased expression of SEMA5A mRNA23179753|2800136
D014635Valproic AcidValproic Acid results in increased expression of SEMA5A mRNA24383497|2915479
D014635Valproic AcidValproic Acid affects the expression of SEMA5A mRNA17963808
D014635Valproic AcidValproic Acid results in increased expression of SEMA5A mRNA24896083
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SEMA5A mRNA"27188386
C111237vorinostatvorinostat results in increased expression of SEMA5A mRNA26272509

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0030215semaphorin receptor binding-IBA21873635  
GO:0030215semaphorin receptor binding-ISS-  
GO:0035373chondroitin sulfate proteoglycan binding-ISS-  
GO:0043395heparan sulfate proteoglycan binding-ISS-  
GO:0045499chemorepellent activity-IBA21873635  
GO:0045545syndecan binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001755neural crest cell migration-IBA21873635  
GO:0001938positive regulation of endothelial cell proliferation-ISS-  
GO:0002043blood vessel endothelial cell proliferation involved in sprouting angiogenesis-ISS-  
GO:0007155cell adhesion-TAS9049630  
GO:0007162negative regulation of cell adhesion-ISS-  
GO:0007267cell-cell signaling-TAS9464278  
GO:0007399nervous system development-TAS9464278  
GO:0007413axonal fasciculation-ISS-  
GO:0021536diencephalon development-ISS-  
GO:0030335positive regulation of cell migration-IBA21873635  
GO:0030836positive regulation of actin filament depolymerization-ISS-  
GO:0045766positive regulation of angiogenesis-ISS-  
GO:0048842positive regulation of axon extension involved in axon guidance-ISS-  
GO:0048843negative regulation of axon extension involved in axon guidance-IBA21873635  
GO:0048843negative regulation of axon extension involved in axon guidance-ISS-  
GO:0050918positive chemotaxis-ISS-  
GO:0051897positive regulation of protein kinase B signaling-ISS-  
GO:0060326cell chemotaxis-ISS-  
GO:0071526semaphorin-plexin signaling pathway-IBA21873635  
GO:0090263positive regulation of canonical Wnt signaling pathway-ISS-  
GO:1990256signal clustering-ISS-  
GO:2000352negative regulation of endothelial cell apoptotic process-ISS-  
GO:2001028positive regulation of endothelial cell chemotaxis-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0016020membrane-ISS-  
GO:0016021integral component of membrane-IBA21873635  
GO:0016021integral component of membrane-IEA-  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
hsa04360Axon guidance
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1643685DiseaseTAS
R-HSA-373755Semaphorin interactionsTAS
R-HSA-3781865Diseases of glycosylationTAS
R-HSA-3906995Diseases associated with O-glycosylation of proteinsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-416700Other semaphorin interactionsTAS
R-HSA-422475Axon guidanceTAS
R-HSA-5083635Defective B3GALTL causes Peters-plus syndrome (PpS)TAS
R-HSA-5173105O-linked glycosylationTAS
R-HSA-5173214O-glycosylation of TSR domain-containing proteinsTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21703634A meta-analysis of two genome-wide association studies identifies 3 new loci for alcohol dependence. (2011 Nov)Wang KSJ Psychiatr Res
20802022Identification of a novel biomarker, SEMA5A, for non-small cell lung carcinoma in nonsmoking women. (2010 Oct)Lu TPCancer Epidemiol Biomarkers Prev