Gene info: ID 904

Gene: CCNT1

GENE ID: 904

Synonyms: CCNT|CYCT1|HIVE1

Description: cyclin T1

Gene type: protein-coding

Location: 12q13.11-q13.12

dbXrefs: Ensembl:ENSG00000129315 MIM:143055 Vega:OTTHUMG00000170393 UniprotKB:O60563

RefSeq: NC_000012.12

Retrived from: SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: AD

# Publications: 0

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 6.605e-1 (AD) 9.650e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs7297499	chr12:48706067 (GRCh38.p7)	T>C	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SEC24B	0.91
AFF4	0.907
NUP153	0.903
ATF6	0.901
SON	0.892
ZNF791	0.89
UBR5	0.89
CDK12	0.888
JMJD1C	0.888
ANKHD1	0.885

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.52
OR4F29	-0.487
KLRC2	-0.248
APOA1	-0.244
NANOGNB	-0.22
HES5	-0.215
SPRR2A	-0.193
SPRR2D	-0.191
LCN1	-0.183
HMHB1	-0.183

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C120275	2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone	2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone inhibits the reaction [CDK9 protein binds to CCNT1 protein]	17631934
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in decreased expression of CCNT1 mRNA	12419474
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of CCNT1 gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of CCNT1 mRNA	19770486
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in increased expression of CCNT1 mRNA	21298039
D000638	Amiodarone	Amiodarone results in increased expression of CCNT1 mRNA	19774075
D003913	Dextroamphetamine	Dextroamphetamine affects the expression of CCNT1 mRNA	12205029
D003913	Dextroamphetamine	SOD1 affects the reaction [Dextroamphetamine affects the expression of CCNT1 mRNA]	12205029
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of CCNT1 mRNA"	26238291
D001599	Berberine	Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 mRNA]	20828602
D001599	Berberine	Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 protein]	20828602
D004958	Estradiol	Estradiol results in increased expression of CCNT1 mRNA	23019147
C006780	bisphenol A	bisphenol A results in increased expression of CCNT1 mRNA	25181051
D016572	Cyclosporine	Cyclosporine results in increased expression of CCNT1 mRNA	25562108
C415250	deferasirox	deferasirox inhibits the reaction [CDK9 protein binds to CCNT1 protein]	17631934
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of CCNT1 mRNA	27392435
D004026	Dieldrin	Dieldrin results in increased expression of CCNT1 mRNA	23041725
D004040	Dietary Carbohydrates	Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 mRNA]	20828602
D004040	Dietary Carbohydrates	Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 protein]	20828602
D004040	Dietary Carbohydrates	Fenofibrate affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 mRNA]	20828602
D004040	Dietary Carbohydrates	Fenofibrate affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 protein]	20828602
D004040	Dietary Carbohydrates	rosiglitazone affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 mRNA]	20828602
D004040	Dietary Carbohydrates	rosiglitazone affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 protein]	20828602
D004040	Dietary Carbohydrates	[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 mRNA	20828602
D004040	Dietary Carbohydrates	[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 protein	20828602
D004041	Dietary Fats	Dietary Fats results in increased expression of CCNT1 mRNA	25016146
D004041	Dietary Fats	Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 mRNA]	20828602
D004041	Dietary Fats	Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 protein]	20828602
D004041	Dietary Fats	Fenofibrate affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 mRNA]	20828602
D004041	Dietary Fats	Fenofibrate affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 protein]	20828602
D004041	Dietary Fats	rosiglitazone affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 mRNA]	20828602
D004041	Dietary Fats	rosiglitazone affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 protein]	20828602
D004041	Dietary Fats	[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 mRNA	20828602
D004041	Dietary Fats	[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 protein	20828602
C118739	entinostat	entinostat results in decreased expression of CCNT1 mRNA	27188386
D011345	Fenofibrate	Fenofibrate affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 mRNA]	20828602
D011345	Fenofibrate	Fenofibrate affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 protein]	20828602
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of CCNT1 mRNA	12419474
C492448	ICG 001	ICG 001 results in decreased expression of CCNT1 mRNA	26191083
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of CCNT1 mRNA	27392435
C544151	jinfukang	jinfukang results in decreased expression of CCNT1 mRNA	27392435
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of CCNT1 mRNA	12057914
D008627	Mercuric Chloride	Mercuric Chloride results in decreased expression of CCNT1 mRNA	27188386
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of CCNT1 mRNA	19465457
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of CCNT1 mRNA	26011545
D009151	Mustard Gas	Mustard Gas results in increased expression of CCNT1 mRNA	15674843
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of CCNT1 mRNA"	15585362
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether analog results in increased expression of CCNT1 mRNA	19095052
D010634	Phenobarbital	Phenobarbital affects the expression of CCNT1 mRNA	23091169
D010656	Phenylephrine	Phenylephrine inhibits the reaction [HEXIM1 protein binds to CCNT1 protein]	17459355
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CCNT1 mRNA	19710929
D010936	Plant Extracts	Plant Extracts results in increased expression of CCNT1 mRNA	23557933
C089730	rosiglitazone	rosiglitazone affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 mRNA]	20828602
C089730	rosiglitazone	rosiglitazone affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 protein]	20828602
D013311	Streptozocin	Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 mRNA]	20828602
D013311	Streptozocin	Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 protein]	20828602
D013311	Streptozocin	Fenofibrate affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 mRNA]	20828602
D013311	Streptozocin	Fenofibrate affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 protein]	20828602
D013311	Streptozocin	rosiglitazone affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 mRNA]	20828602
D013311	Streptozocin	rosiglitazone affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 protein]	20828602
D013311	Streptozocin	[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 mRNA	20828602
D013311	Streptozocin	[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 protein	20828602
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of CCNT1 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of CCNT1 mRNA	25975270
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CCNT1 protein]	12917420
D013849	Thimerosal	Thimerosal results in decreased expression of CCNT1 mRNA	27188386
D014212	Tretinoin	Tretinoin results in increased expression of CCNT1 mRNA	15753651
D014212	Tretinoin	Tretinoin results in increased expression of CCNT1 protein	15753651
C012589	trichostatin A	trichostatin A results in decreased expression of CCNT1 mRNA	24935251
D014520	Urethane	Urethane results in increased expression of CCNT1 mRNA	28818685
D014635	Valproic Acid	Valproic Acid results in decreased expression of CCNT1 mRNA	23179753
D014635	Valproic Acid	Valproic Acid affects the expression of CCNT1 mRNA	17292431
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of CCNT1 gene	25560391
C111237	vorinostat	vorinostat results in decreased expression of CCNT1 mRNA	27188386
D015032	Zinc	Zinc deficiency results in increased expression of CCNT1 mRNA	18356318

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003677	DNA binding	-	IDA	16109376
GO:0003682	chromatin binding	-	IEA	-
GO:0004674	protein serine/threonine kinase activity	-	TAS	-
GO:0005515	protein binding	-	IPI	9491887 9499409 10944537 12832472 12944466 15107825 15563843 16135803 16601680 17289077 17690245 17724342 18281698 18483487 18566585 19387490 19883659 19914168 20153263 20535204 20562857 21729782 22190034 22959624 23455922 23602568 26659056
GO:0008134	transcription factor binding	-	IPI	25116364
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	-	IBA	21873635
GO:0019901	protein kinase binding	-	IEA	-
GO:0044212	transcription regulatory region DNA binding	-	IEA	-
GO:0070063	RNA polymerase binding	-	IPI	15563843
GO:0097322	7SK snRNA binding	-	IDA	11713533

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	-	TAS	9499409
GO:0006366	transcription by RNA polymerase II	-	TAS	-
GO:0006368	transcription elongation from RNA polymerase II promoter	-	TAS	-
GO:0006468	protein phosphorylation	-	IPI	16109376
GO:0007049	cell cycle	-	IEA	-
GO:0016032	viral process	-	IEA	-
GO:0042795	snRNA transcription by RNA polymerase II	-	TAS	-
GO:0043923	positive regulation by host of viral transcription	-	NAS	25116364
GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity	-	IBA	21873635
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IBA	21873635
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IDA	15563843
GO:0045944	positive regulation of transcription by RNA polymerase II	-	TAS	-
GO:0050434	positive regulation of viral transcription	-	TAS	-
GO:0051301	cell division	-	IEA	-
GO:1900364	negative regulation of mRNA polyadenylation	-	IMP	19575011
GO:1901409	positive regulation of phosphorylation of RNA polymerase II C-terminal domain	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000307	cyclin-dependent protein kinase holoenzyme complex	-	IBA	21873635
GO:0005634	nucleus	-	IBA	21873635
GO:0005634	nucleus	-	IDA	12944466
GO:0005654	nucleoplasm	-	IDA	-
GO:0005654	nucleoplasm	-	TAS	-
GO:0005730	nucleolus	NOT	IDA	16109376
GO:0008024	cyclin/CDK positive transcription elongation factor complex	-	IDA	9499409 15905409

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-112382	Formation of RNA Pol II elongation complex	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-162587	HIV Life Cycle	IEA
R-HSA-162587	HIV Life Cycle	TAS
R-HSA-162599	Late Phase of HIV Life Cycle	IEA
R-HSA-162599	Late Phase of HIV Life Cycle	TAS
R-HSA-162906	HIV Infection	IEA
R-HSA-162906	HIV Infection	TAS
R-HSA-162909	Host Interactions of HIV factors	TAS
R-HSA-1643685	Disease	IEA
R-HSA-1643685	Disease	TAS
R-HSA-167152	Formation of HIV elongation complex in the absence of HIV Tat	IEA
R-HSA-167169	HIV Transcription Elongation	TAS
R-HSA-167169	HIV Transcription Elongation	IEA
R-HSA-167172	Transcription of the HIV genome	IEA
R-HSA-167172	Transcription of the HIV genome	TAS
R-HSA-167200	Formation of HIV-1 elongation complex containing HIV-1 Tat	TAS
R-HSA-167200	Formation of HIV-1 elongation complex containing HIV-1 Tat	IEA
R-HSA-167238	Pausing and recovery of Tat-mediated HIV elongation	IEA
R-HSA-167243	Tat-mediated HIV elongation arrest and recovery	IEA
R-HSA-167246	Tat-mediated elongation of the HIV-1 transcript	TAS
R-HSA-167246	Tat-mediated elongation of the HIV-1 transcript	IEA
R-HSA-167287	HIV elongation arrest and recovery	IEA
R-HSA-167290	Pausing and recovery of HIV elongation	IEA
R-HSA-170834	Signaling by TGF-beta Receptor Complex	TAS
R-HSA-176034	Interactions of Tat with host cellular proteins	TAS
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-2173793	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	TAS
R-HSA-2173796	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	TAS
R-HSA-3700989	Transcriptional Regulation by TP53	TAS
R-HSA-5663205	Infectious disease	IEA
R-HSA-5663205	Infectious disease	TAS
R-HSA-674695	RNA Polymerase II Pre-transcription Events	TAS
R-HSA-6796648	TP53 Regulates Transcription of DNA Repair Genes	TAS
R-HSA-6807505	RNA polymerase II transcribes snRNA genes	TAS
R-HSA-6807505	RNA polymerase II transcribes snRNA genes	IEA
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-73857	RNA Polymerase II Transcription	IEA
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-74160	Gene expression (Transcription)	IEA
R-HSA-75955	RNA Polymerase II Transcription Elongation	TAS
R-HSA-8939211	ESR-mediated signaling	TAS
R-HSA-9006931	Signaling by Nuclear Receptors	TAS
R-HSA-9006936	Signaling by TGF-beta family members	TAS
R-HSA-9018519	Estrogen-dependent gene expression	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal