Gene: BMF

90427
-
Bcl2 modifying factor
protein-coding
15q15.1
Ensembl:ENSG00000104081 MIM:606266 Vega:OTTHUMG00000129875 UniprotKB:Q96LC9
NC_000015.10
PubMed
0   ANCO-SNPs
ND|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.648e-1 (AD)  7.626e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg09749364chr15:40384779BMF4.000e-10Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IL10RA0.914
NFAM10.861
KLHL60.848
CLEC7A0.844
TNFRSF1B0.836
CD370.831
TBXAS10.831
ADAM280.828
CMTM70.827
INPP5D0.825

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NEUROD6-0.376
HAS1-0.368
MARCH4-0.366
KCNB2-0.366
ATOH7-0.36
WFDC1-0.358
SLC7A4-0.346
C1orf53-0.346
ZNF835-0.345
MAGIX-0.342

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5768821-(2-trifluoromethoxyphenyl)-2-nitroethanone1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in decreased expression of BMF mRNA25596134
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of BMF mRNA"21354444|2269881
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of BMF mRNA19933214
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in decreased expression of BMF mRNA"25575267
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of BMF mRNA"19167446
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of BMF mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of BMF mRNA"21346803
C4861844,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol"4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol results in decreased expression of BMF mRNA"25575267
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of BMF mRNA"25380136
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of BMF mRNA"21346803
C106812adefovir dipivoxiladefovir dipivoxil results in decreased expression of BMF mRNA25596134
D0157614-Aminopyridine4-Aminopyridine results in increased expression of BMF mRNA24378259
D000638AmiodaroneAmiodarone affects the expression of BMF mRNA19483382
D000643Ammonium ChlorideAmmonium Chloride affects the expression of BMF mRNA16483693
C006632arsenic trioxidearsenic trioxide results in increased expression of BMF mRNA19417148
D001241AspirinAspirin results in increased expression of BMF mRNA19936928
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of BMF mRNA26377693
D001553BenzbromaroneBenzbromarone affects the expression of BMF mRNA19483382
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of BMF mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of BMF mRNA20106945|2163298
D004958Estradiol[Estradiol binds to ESR2 protein] which results in decreased expression of BMF mRNA20404318
D004958Estradiol[Estradiol co-treated with EGF protein] results in decreased expression of BMF mRNA24758408
D004958EstradiolEstradiol results in decreased expression of BMF mRNA19167446|2301914
D004958EstradiolEstradiol results in increased expression of BMF mRNA18556351
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of BMF mRNA18556351
D004958EstradiolEstradiol results in decreased expression of BMF mRNA25575267
C006780bisphenol Abisphenol A results in decreased expression of BMF mRNA25575267
C006780bisphenol Abisphenol A results in increased methylation of BMF promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of BMF mRNA25181051
C584509C646 compoundC646 compound inhibits the reaction [selenomethylselenocysteine metabolite results in increased expression of BMF mRNA]25321483
C584509C646 compoundC646 compound results in decreased expression of BMF mRNA25321483
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of BMF mRNA25596134
C004656chloroacetaldehydechloroacetaldehyde results in decreased expression of BMF mRNA25596134
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of BMF mRNA16934159
C059262cidofovircidofovir results in increased expression of BMF mRNA25596134
D002922CiguatoxinsCiguatoxins affects the expression of BMF mRNA18353800
D002994ClofibrateClofibrate results in decreased expression of BMF mRNA23811191
D002994ClofibrateClofibrate affects the expression of BMF mRNA19483382
D019327Copper SulfateCopper Sulfate results in decreased expression of BMF mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of BMF mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in decreased expression of BMF mRNA19167446
D003375CoumestrolCoumestrol results in decreased expression of BMF mRNA19167446
D003471CuprizoneCuprizone results in decreased expression of BMF mRNA26577399|2752363
D016572CyclosporineCyclosporine results in decreased expression of BMF mRNA25562108|2559613
D016572CyclosporineCyclosporine results in decreased expression of BMF mRNA25596134
C017160cypermethrincypermethrin results in increased expression of BMF mRNA27704156
C515055darinaparsinBMF protein affects the susceptibility to darinaparsin19417148
C515055darinaparsindarinaparsin results in increased expression of BMF mRNA19417148
C014347decitabine[decitabine co-treated with Depsipeptides] results in increased expression of BMF mRNA17064661
D013759DronabinolDronabinol results in decreased expression of BMF mRNA16616335
D047630Depsipeptides[decitabine co-treated with Depsipeptides] results in increased expression of BMF mRNA17064661
D003907DexamethasoneDexamethasone results in decreased expression of BMF mRNA25047013
D003976DiazinonDiazinon affects the expression of BMF mRNA22546817
D003976DiazinonDiazinon results in decreased expression of BMF mRNA17452286
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of BMF mRNA28962523
D002945CisplatinCisplatin results in decreased expression of BMF mRNA27392435
D002945CisplatinCisplatin results in increased expression of BMF mRNA27594783
C014476diethyl maleatediethyl maleate results in decreased expression of BMF mRNA21161181
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of BMF mRNA24535843
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of BMF mRNA25575267
D004964EstriolEstriol results in decreased expression of BMF mRNA25575267
D005001EthionineEthionine affects the expression of BMF mRNA19483382
D011345FenofibrateFenofibrate results in increased expression of BMF mRNA25572481|2559613
D011345FenofibrateFenofibrate results in decreased expression of BMF mRNA25596134
C039281furanfuran results in decreased expression of BMF mRNA24183702
C039281furanfuran results in decreased expression of BMF mRNA25539665|2619464
C039281furanfuran results in increased methylation of BMF gene22079235
D019833GenisteinGenistein results in decreased expression of BMF mRNA23019147
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of BMF mRNA25613284
D007545IsoproterenolIsoproterenol results in increased expression of BMF mRNA24286936
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of BMF mRNA26752646
C045463leflunomideleflunomide results in increased expression of BMF mRNA28988120
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of BMF mRNA"24972896
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of BMF mRNA25890327|2658214
D008687MetforminMetformin results in decreased expression of BMF mRNA25596134
D009151Mustard GasMustard Gas results in increased expression of BMF mRNA18955075
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of BMF mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of BMF mRNA"25554681|2562005
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of BMF mRNA25380136
C022838nickel chloridenickel chloride affects the expression of BMF mRNA22546817
D009853OmeprazoleOmeprazole affects the expression of BMF mRNA19483382
D010100OxygenOxygen deficiency results in decreased expression of BMF mRNA25596134
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of BMF mRNA16221955
D010634PhenobarbitalPhenobarbital results in decreased expression of BMF mRNA23091169
C006253pirinixic acidpirinixic acid results in increased expression of BMF mRNA23811191
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in decreased expression of BMF mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of BMF mRNA20813756|2381119
C006253pirinixic acidpirinixic acid affects the expression of BMF mRNA19483382
D010936Plant ExtractsPlant Extracts results in increased expression of BMF mRNA21297082
C019536potassium bromatepotassium bromate affects the expression of BMF mRNA27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [potassium bromate affects the expression of BMF mRNA]27082013
D011192Potassium DichromatePotassium Dichromate results in decreased expression of BMF mRNA23608068
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of BMF mRNA18556351
C045950propiconazolepropiconazole results in decreased expression of BMF mRNA21278054
D011441PropylthiouracilPropylthiouracil affects the expression of BMF mRNA19483382
D011441PropylthiouracilPropylthiouracil results in decreased expression of BMF mRNA24780913
C031280pyrazolepyrazole results in decreased expression of BMF mRNA17945193
C502851quinocetonequinocetone results in decreased expression of BMF mRNA27046791
C059514resveratrol[Coumestrol co-treated with resveratrol] results in decreased expression of BMF mRNA19167446
C089730rosiglitazonerosiglitazone results in decreased expression of BMF mRNA25596134
C002979selenomethylselenocysteineBMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of CASP3 protein modified form]25321483
C002979selenomethylselenocysteineBMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of CASP6 protein modified form]25321483
C002979selenomethylselenocysteineBMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of CASP9 protein modified form]25321483
C002979selenomethylselenocysteineBMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of PARP1 protein modified form]25321483
C002979selenomethylselenocysteineC646 compound inhibits the reaction [selenomethylselenocysteine metabolite results in increased expression of BMF mRNA]25321483
C002979selenomethylselenocysteineHDAC8 inhibits the reaction [selenomethylselenocysteine metabolite results in increased expression of BMF mRNA]25321483
C002979selenomethylselenocysteineselenomethylselenocysteine metabolite inhibits the reaction [HDAC8 protein binds to BMF promoter]25321483
C002979selenomethylselenocysteineselenomethylselenocysteine metabolite inhibits the reaction [STAT3 protein binds to BMF promoter]25321483
C002979selenomethylselenocysteineselenomethylselenocysteine metabolite promotes the reaction [EP300 protein binds to BMF promoter]25321483
C002979selenomethylselenocysteineselenomethylselenocysteine metabolite promotes the reaction [SP3 protein binds to BMF promoter]25321483
C002979selenomethylselenocysteineselenomethylselenocysteine metabolite results in increased expression of BMF mRNA25321483
C002979selenomethylselenocysteineselenomethylselenocysteine metabolite results in increased expression of BMF protein25321483
C002979selenomethylselenocysteineSTAT3 protein inhibits the reaction [selenomethylselenocysteine metabolite results in increased expression of BMF mRNA]25321483
C002979selenomethylselenocysteineselenomethylselenocysteine metabolite results in increased expression of BMF protein25321483
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of BMF mRNA25895662
D012834SilverSilver results in decreased expression of BMF mRNA27131904
C016104sodium bichromatesodium bichromate results in decreased expression of BMF mRNA25993096
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of BMF mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of BMF mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of BMF mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of BMF mRNA21570461|2892240
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of BMF mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to BMF gene]20819909
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of BMF mRNA19770486|1993321
D013749TetrachlorodibenzodioxinAHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of BMF mRNA]21215274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of BMF mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of BMF mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of BMF mRNA25613284
D013853ThioacetamideThioacetamide affects the expression of BMF mRNA19483382
D013853ThioacetamideThioacetamide results in decreased expression of BMF mRNA23411599
C009495titanium dioxidetitanium dioxide results in increased expression of BMF mRNA23131501|2355797
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of BMF mRNA18087596
D014212TretinoinTretinoin results in increased expression of BMF mRNA23830798
D014241TrichloroethyleneTrichloroethylene results in decreased expression of BMF mRNA25549359
D014241TrichloroethyleneTrichloroethylene results in increased methylation of BMF gene27618143
C012589trichostatin Atrichostatin A affects the expression of BMF mRNA28542535
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of BMF mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of BMF mRNA29024780
C057693troglitazonetroglitazone results in decreased expression of BMF mRNA28973697
D014520UrethaneUrethane results in decreased expression of BMF mRNA28818685
C406224valdecoxibvaldecoxib results in decreased expression of BMF mRNA24136188
D014635Valproic AcidValproic Acid results in decreased expression of BMF mRNA29154799
D014635Valproic AcidValproic Acid results in increased methylation of BMF gene28853863
C025643vinclozolinvinclozolin results in decreased expression of BMF mRNA23034163
C111237vorinostatvorinostat results in increased expression of BMF mRNA21652541
C111237vorinostatvorinostat results in increased expression of BMF protein21652541
C111237vorinostatvorinostat inhibits the reaction [HDAC1 protein binds to BMF promoter]25321483
C111237vorinostatvorinostat inhibits the reaction [HDAC8 protein binds to BMF promoter]25321483
C111237vorinostatvorinostat inhibits the reaction [STAT3 protein binds to BMF promoter]25321483
C111237vorinostatvorinostat results in increased expression of BMF mRNA25321483
C088658zoledronic acidzoledronic acid results in increased expression of BMF mRNA24714768|2559613

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI11546872  25416956  26871637  
GO ID GO Term Qualifier Evidence PubMed
GO:0001844protein insertion into mitochondrial membrane involved in apoptotic signaling pathway-TAS-  
GO:0010507negative regulation of autophagy-IDA23629966  
GO:0032464positive regulation of protein homooligomerization-ISS-  
GO:0034644cellular response to UV-IDA23629966  
GO:0043065positive regulation of apoptotic process-IMP19671867  
GO:0043276anoikis-IDA11546872  
GO:0090200positive regulation of release of cytochrome c from mitochondria-ISS-  
GO:2001244positive regulation of intrinsic apoptotic signaling pathway-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001669acrosomal vesicle-IEA-  
GO:0005741mitochondrial outer membrane-TAS-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0016459myosin complex-ISS11546872  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109581ApoptosisTAS
R-HSA-109606Intrinsic Pathway for ApoptosisTAS
R-HSA-111453BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 membersTAS
R-HSA-114452Activation of BH3-only proteinsTAS
R-HSA-139910Activation of BMF and translocation to mitochondriaTAS
R-HSA-5357801Programmed Cell DeathTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28373815Systemic treatment of non-small cell lung cancer brain metastases. (2016)Cedrych IContemp Oncol (Pozn)
20301779Dyskeratosis Congenita (1993)Savage SA-
27352093Causes of macrocytic anemia among 628 patients: mean corpuscular volumes of 114 and 130 fL as critical markers for categorization. (2016 Sep)Takahashi NInt J Hematol