Gene: RPL14

9045
CAG-ISL-7|CTG-B33|L14|RL14|hRL14
ribosomal protein L14
protein-coding
3p22.1
Ensembl:ENSG00000188846 MIM:617414 Vega:OTTHUMG00000156046 UniprotKB:P50914
NC_000003.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.133e-1 (AD)  7.637e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RPL7A0.967
RPL240.966
RPL60.964
RPS70.964
RPL30.964
RPL170.962
RPL50.958
EEF1G0.958
RPL270.956
RPL35A0.955

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.884
OR4F5-0.871
PCDHAC1-0.095
PCDHA12-0.077
MAS1-0.077
SERPINA11-0.076
SSX5-0.076
P2RX2-0.074
HCRTR1-0.073
DSG3-0.072

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB11638ArtenimolSmall Molecule71939-50-9Approved|InvestigationalTarget
ID Drug Name Action PubMed
C00202917alpha-ethynylestr-5(10)-ene-3alpha,17beta-diol"[17alpha-ethynylestr-5(10)-ene-3alpha,17beta-diol co-treated with Paraquat co-treated with Tetrachlorodibenzodioxin] results in increased expression of RPL14 mRNA"17275934
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of RPL14 mRNA"18648102
D000082AcetaminophenAcetaminophen results in decreased expression of RPL14 mRNA22230336
D000643Ammonium ChlorideAmmonium Chloride affects the expression of RPL14 mRNA16483693
C006632arsenic trioxidearsenic trioxide results in increased expression of RPL14 mRNA20458559
D001280AtrazineAtrazine results in decreased expression of RPL14 mRNA22378314
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of RPL14 mRNA"19150397
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of RPL14 mRNA26496021
C006780bisphenol Abisphenol A affects the expression of RPL14 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of RPL14 mRNA26496021
D002104CadmiumCadmium results in increased oxidation of RPL14 protein24077948
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of RPL14 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of RPL14 mRNA27339419
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of RPL14 mRNA15963342
C100187chloropicrinchloropicrin affects the expression of RPL14 mRNA26352163
C100187chloropicrinchloropicrin results in increased expression of RPL14 mRNA28476498
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of RPL14 mRNA28472532
D016572CyclosporineCyclosporine results in increased expression of RPL14 mRNA20106945
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of RPL14 mRNA21266533
C000944dicrotophosdicrotophos results in decreased expression of RPL14 mRNA28302478
C039060dihydroartemisinindihydroartemisinin analog binds to RPL14 protein modified form26340163
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of RPL14 mRNA22079256
D005419FlavonoidsFlavonoids results in decreased expression of RPL14 mRNA18035473
D005485FlutamideFlutamide results in increased expression of RPL14 mRNA24136188
C069837fullerene C60fullerene C60 results in decreased expression of RPL14 mRNA19167457
C039281furanfuran results in increased expression of RPL14 mRNA26194646
D005839GentamicinsGentamicins results in increased expression of RPL14 mRNA22061828
D005897GlafenineGlafenine results in increased expression of RPL14 mRNA24136188
D017313FenretinideFenretinide results in increased expression of RPL14 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of RPL14 mRNA21179406
D007213IndomethacinIndomethacin results in increased expression of RPL14 mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RPL14 mRNA25613284
D008627Mercuric ChlorideMercuric Chloride affects the expression of RPL14 mRNA20353558
D008777MethyltestosteroneMethyltestosterone results in decreased expression of RPL14 mRNA29191790
C038541N-benzyloxycarbonylprolylprolinalN-benzyloxycarbonylprolylprolinal results in increased expression of RPL14 mRNA21487212
D009532NickelNickel results in increased expression of RPL14 mRNA24468838
C025256nonylphenolnonylphenol results in decreased expression of RPL14 mRNA22982499
D010269Paraquat"[17alpha-ethynylestr-5(10)-ene-3alpha,17beta-diol co-treated with Paraquat co-treated with Tetrachlorodibenzodioxin] results in increased expression of RPL14 mRNA"17275934
D052638Particulate MatterParticulate Matter results in decreased expression of RPL14 mRNA24769257
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of RPL14 protein26879310
C006253pirinixic acidpirinixic acid results in increased expression of RPL14 mRNA18301758
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of RPL14 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of RPL14 mRNA22079256
C015586propiverinepropiverine binds to RPL14 protein29273565
D012643SeleniumSelenium results in decreased expression of RPL14 mRNA19244175
D012834SilverSilver results in decreased expression of RPL14 mRNA27131904
D012969Sodium FluorideSodium Fluoride results in decreased expression of RPL14 protein28918527
D018038Sodium SeleniteSodium Selenite results in increased expression of RPL14 mRNA18175754
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in decreased expression of RPL14 mRNA"26680231
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RPL14 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of RPL14 mRNA16214954
D013749Tetrachlorodibenzodioxin"[17alpha-ethynylestr-5(10)-ene-3alpha,17beta-diol co-treated with Paraquat co-treated with Tetrachlorodibenzodioxin] results in increased expression of RPL14 mRNA"17275934
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RPL14 mRNA17275934
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RPL14 mRNA25613284
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of RPL14 mRNA19042947
C057693troglitazonetroglitazone results in decreased expression of RPL14 mRNA28973697
D014635Valproic AcidValproic Acid results in decreased methylation of RPL14 gene29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of RPL14 gene25560391
D014810Vitamin EVitamin E results in decreased expression of RPL14 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  22681889  
GO:0003735structural constituent of ribosome-NAS12962325  
GO:0005515protein binding-IPI11369516  24725412  
GO:0045296cadherin binding-HDA25468996  
GO ID GO Term Qualifier Evidence PubMed
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay-TAS-  
GO:0006364rRNA processing-IMP18697920  
GO:0006412translation-NAS12962325  
GO:0006413translational initiation-TAS-  
GO:0006614SRP-dependent cotranslational protein targeting to membrane-TAS-  
GO:0042273ribosomal large subunit biogenesis-IBA21873635  
GO:0042273ribosomal large subunit biogenesis-IMP18697920  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0016020membrane-HDA19946888  
GO:0022625cytosolic large ribosomal subunit-HDA12962325  
GO:0022625cytosolic large ribosomal subunit-IBA21873635  
GO:0070062extracellular exosome-HDA20458337  
KEGG ID KEGG Term
hsa03010Ribosome
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyIEA
R-HSA-1430728MetabolismIEA
R-HSA-156827L13a-mediated translational silencing of Ceruloplasmin expressionTAS
R-HSA-156842Eukaryotic Translation ElongationIEA
R-HSA-156902Peptide chain elongationIEA
R-HSA-1643685DiseaseTAS
R-HSA-168254Influenza InfectionTAS
R-HSA-168255Influenza Life CycleTAS
R-HSA-168273Influenza Viral RNA Transcription and ReplicationTAS
R-HSA-1799339SRP-dependent cotranslational protein targeting to membraneIEA
R-HSA-1799339SRP-dependent cotranslational protein targeting to membraneTAS
R-HSA-192823Viral mRNA TranslationTAS
R-HSA-2408522Selenoamino acid metabolismIEA
R-HSA-2408557Selenocysteine synthesisIEA
R-HSA-376176Signaling by ROBO receptorsIEA
R-HSA-392499Metabolism of proteinsTAS
R-HSA-392499Metabolism of proteinsIEA
R-HSA-422475Axon guidanceIEA
R-HSA-5663205Infectious diseaseTAS
R-HSA-6791226Major pathway of rRNA processing in the nucleolus and cytosolTAS
R-HSA-71291Metabolism of amino acids and derivativesIEA
R-HSA-72312rRNA processingTAS
R-HSA-72613Eukaryotic Translation InitiationTAS
R-HSA-72689Formation of a pool of free 40S subunitsTAS
R-HSA-72706GTP hydrolysis and joining of the 60S ribosomal subunitTAS
R-HSA-72737Cap-dependent Translation InitiationTAS
R-HSA-72764Eukaryotic Translation TerminationIEA
R-HSA-72766TranslationTAS
R-HSA-72766TranslationIEA
R-HSA-8868773rRNA processing in the nucleus and cytosolTAS
R-HSA-8953854Metabolism of RNATAS
R-HSA-9010553Regulation of expression of SLITs and ROBOsIEA
R-HSA-927802Nonsense-Mediated Decay (NMD)TAS
R-HSA-975956Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)TAS
R-HSA-975957Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20887155Gene expression profiling of peripheral blood leukocytes identifies potential novel biomarkers of chronic obstructive pulmonary disease in current and former smokers. (2010 Dec)Edmiston JSBiomarkers