Gene: ERI1

90459
3'HEXO|HEXO|THEX1
exoribonuclease 1
protein-coding
8p23.1
Ensembl:ENSG00000104626 MIM:608739 Vega:OTTHUMG00000129328 UniprotKB:Q8IV48
NC_000008.11
SNP Mapped
0   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.734e-2 (AD)  9.747e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HPS50.83
MCMBP0.827
PPIL40.819
RHBDD10.814
LMAN10.809
PGM30.809
TMEM170A0.808
ATL30.807
SH3GLB10.806
SLC35F50.798

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CYP1A1-0.389
ADRA1D-0.378
LHX6-0.358
NMU-0.356
ABCC12-0.346
CRH-0.346
F7-0.339
OR4F5-0.338
PHOSPHO1-0.338
KCNG2-0.336

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ERI1 mRNA"25510870
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of ERI1 mRNA"25614096
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ERI1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ERI1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ERI1 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ERI1 mRNA"25510870
D000082AcetaminophenAcetaminophen results in decreased expression of ERI1 mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ERI1 mRNA19770486
C006780bisphenol Abisphenol A results in decreased expression of ERI1 mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of ERI1 mRNA17484886
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ERI1 gene20938992
D019327Copper SulfateCopper Sulfate results in decreased expression of ERI1 mRNA19549813
D003976DiazinonDiazinon results in increased methylation of ERI1 gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ERI1 mRNA21266533
D004147DioxinsDioxins affects the expression of ERI1 mRNA20463971
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ERI1 gene20938992
C492448ICG 001ICG 001 results in increased expression of ERI1 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ERI1 mRNA25613284
D007854LeadLead affects the expression of ERI1 mRNA28903495
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of ERI1 mRNA"24972896
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ERI1 gene20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of ERI1 mRNA26011545
D009532NickelNickel results in increased expression of ERI1 mRNA24768652|2558310
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ERI1 mRNA"25510870
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ERI1 mRNA22574217
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ERI1 mRNA25613284
C012589trichostatin Atrichostatin A affects the expression of ERI1 mRNA28542535
D014635Valproic AcidValproic Acid affects the expression of ERI1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ERI1 mRNA28001369
D014635Valproic AcidValproic Acid results in increased expression of ERI1 mRNA29154799
D014635Valproic AcidValproic Acid affects the expression of ERI1 mRNA17963808
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of ERI1 gene25560391
C111237vorinostatvorinostat results in increased expression of ERI1 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:00001753'-5'-exoribonuclease activity-IBA21873635  
GO:00001753'-5'-exoribonuclease activity-TAS-  
GO:0005515protein binding-IPI23329046  
GO:00084083'-5' exonuclease activity-IDA14536070  16912046  
GO:0019843rRNA binding-ISS-  
GO:0043022ribosome binding-ISS-  
GO:0046872metal ion binding-IEA-  
GO:0071207histone pre-mRNA stem-loop binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000467exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)-IBA21873635  
GO:0000738DNA catabolic process, exonucleolytic-IBA21873635  
GO:0006259DNA metabolic process-IBA21873635  
GO:0006364rRNA processing-TAS-  
GO:0031047gene silencing by RNA-IEA-  
GO:0031125rRNA 3'-end processing-ISS-  
GO:0071044histone mRNA catabolic processNOTIMP18172165  
GO:0090503RNA phosphodiester bond hydrolysis, exonucleolytic-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-ISS-  
GO:0005654nucleoplasm-TAS-  
GO:0005730nucleolus-IBA21873635  
GO:0005730nucleolus-IDA16912046  
GO:0005730nucleolus-ISS-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA16912046  
GO:0005737cytoplasm-ISS-  
GO:0071204histone pre-mRNA 3'end processing complex-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-6791226Major pathway of rRNA processing in the nucleolus and cytosolTAS
R-HSA-72312rRNA processingTAS
R-HSA-8868773rRNA processing in the nucleus and cytosolTAS
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal