Gene: ARTN

9048
ART|ENOVIN|EVN|NBN
artemin
protein-coding
1p34.1
Ensembl:ENSG00000117407 MIM:603886 Vega:OTTHUMG00000007705 UniprotKB:Q5T4W7
NC_000001.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.130e-1 (AD)  8.549e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PTP4A30.635
PI150.626
JAK30.619
LPAR20.594
ARHGAP40.587
CHEK20.585
PLCB20.577
OR5M80.576
C1RL0.576
IGFBP40.572

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BTBD8-0.251
ABCD2-0.248
DCHS2-0.24
HHATL-0.236
GABRG1-0.226
HPSE2-0.224
GLIPR1L2-0.224
ZNF98-0.223
FUT9-0.217
REN-0.217

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0067181,12-benzoperylene"1,12-benzoperylene results in increased expression of ARTN mRNA"26377693
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of ARTN mRNA19933214
D020106AcrylamideAcrylamide results in increased expression of ARTN mRNA28959563
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ARTN mRNA16483693
D001151ArsenicArsenic affects the expression of ARTN protein24675094
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of ARTN mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ARTN mRNA22228805
D004958EstradiolARTN protein inhibits the reaction [fulvestrant inhibits the reaction [Estradiol results in increased expression of BCL2 protein]]20305694
D004958EstradiolARTN protein inhibits the reaction [Tamoxifen inhibits the reaction [Estradiol results in increased expression of BCL2 protein]]20305694
D004958Estradiol[Estradiol co-treated with EGF protein] results in increased expression of ARTN mRNA24758408
D004958EstradiolEstradiol results in increased expression of ARTN mRNA20305694
D004958EstradiolEstradiol results in increased expression of ARTN protein20305694
D004958Estradiolfulvestrant inhibits the reaction [Estradiol results in increased expression of ARTN mRNA]20305694
D004958EstradiolTamoxifen inhibits the reaction [[Estradiol co-treated with EGF protein] results in increased expression of ARTN mRNA]24758408
D004958EstradiolTamoxifen inhibits the reaction [Estradiol results in increased expression of ARTN mRNA]20305694
D004958EstradiolYC137 inhibits the reaction [ARTN protein inhibits the reaction [fulvestrant inhibits the reaction [Estradiol results in increased expression of BCL2 protein]]]20305694
D004958EstradiolYC137 inhibits the reaction [ARTN protein inhibits the reaction [Tamoxifen inhibits the reaction [Estradiol results in increased expression of BCL2 protein]]]20305694
C006780bisphenol Abisphenol A results in increased expression of ARTN mRNA25181051
D002166CamptothecinARTN mRNA results in decreased susceptibility to Camptothecin25269479
D002330CarmustineCarmustine results in decreased expression of ARTN mRNA15980968
D003907DexamethasoneDexamethasone results in decreased expression of ARTN mRNA22733784
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of ARTN mRNA27392435
D002945CisplatinCisplatin results in decreased expression of ARTN mRNA27392435
D005620Freund's AdjuvantFreund's Adjuvant results in increased expression of ARTN mRNA16914685
C070081fulvestrantARTN protein inhibits the reaction [fulvestrant inhibits the reaction [Estradiol results in increased expression of BCL2 protein]]20305694
C070081fulvestrantARTN protein results in decreased susceptibility to fulvestrant20305694
C070081fulvestrantfulvestrant inhibits the reaction [Estradiol results in increased expression of ARTN mRNA]20305694
C070081fulvestrantYC137 inhibits the reaction [ARTN protein inhibits the reaction [fulvestrant inhibits the reaction [Estradiol results in increased expression of BCL2 protein]]]20305694
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of ARTN mRNA27392435
D007854LeadLead results in decreased expression of ARTN mRNA19921347
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of ARTN mRNA"20188158
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of ARTN mRNA22401849
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ARTN mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ARTN mRNA"25554681
D010936Plant ExtractsPlant Extracts results in decreased expression of ARTN mRNA23557933
D011441PropylthiouracilPropylthiouracil results in decreased expression of ARTN mRNA24780913
D015474Isotretinoin[vorinostat co-treated with Isotretinoin] results in increased expression of ARTN mRNA18769122
D012822Silicon DioxideSilicon Dioxide results in decreased expression of ARTN mRNA25351596
D053260SootSoot results in increased expression of ARTN mRNA26551751
D013629TamoxifenARTN protein inhibits the reaction [Tamoxifen inhibits the reaction [Estradiol results in increased expression of BCL2 protein]]20305694
D013629TamoxifenARTN protein results in decreased susceptibility to Tamoxifen20305694
D013629TamoxifenTamoxifen inhibits the reaction [[Estradiol co-treated with EGF protein] results in increased expression of ARTN mRNA]24758408
D013629TamoxifenTamoxifen inhibits the reaction [Estradiol results in increased expression of ARTN mRNA]20305694
D013629TamoxifenYC137 inhibits the reaction [ARTN protein inhibits the reaction [Tamoxifen inhibits the reaction [Estradiol results in increased expression of BCL2 protein]]]20305694
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ARTN mRNA19933214
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ARTN mRNA25447457
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of ARTN mRNA20133372
C111237vorinostat[vorinostat co-treated with Isotretinoin] results in increased expression of ARTN mRNA18769122
C493272YC137YC137 inhibits the reaction [ARTN protein inhibits the reaction [fulvestrant inhibits the reaction [Estradiol results in increased expression of BCL2 protein]]]20305694
C493272YC137YC137 inhibits the reaction [ARTN protein inhibits the reaction [Tamoxifen inhibits the reaction [Estradiol results in increased expression of BCL2 protein]]]20305694

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005088Ras guanyl-nucleotide exchange factor activity-TAS-  
GO:0005102signaling receptor binding-TAS9883723  
GO:0005515protein binding-IPI16765900  
GO:0008083growth factor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-TAS-  
GO:0007165signal transduction-TAS9883723  
GO:0007405neuroblast proliferation-TAS9883723  
GO:0007411axon guidance-TAS-  
GO:0007422peripheral nervous system development-IEA-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0050930induction of positive chemotaxis-IEA-  
GO:0061146Peyer's patch morphogenesis-IEA-  
GO:0097021lymphocyte migration into lymphoid organs-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IEA-  
GO:0005622intracellular-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-162582Signal TransductionTAS
R-HSA-375165NCAM signaling for neurite out-growthIEA
R-HSA-419037NCAM1 interactionsIEA
R-HSA-422475Axon guidanceTAS
R-HSA-422475Axon guidanceIEA
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-8853659RET signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25975578The RET fusion gene and its correlation with demographic and clinicopathological features of non-small cell lung cancer: a meta-analysis. (2015)Lin CCancer Biol Ther