Gene info: ID 9052

Gene: GPRC5A

GENE ID: 9052

Synonyms: GPCR5A|PEIG-1|RAI3|RAIG1|TIG1

Description: G protein-coupled receptor class C group 5 member A

Gene type: protein-coding

Location: 12p13.1

dbXrefs: Ensembl:ENSG00000013588 MIM:604138 Vega:OTTHUMG00000168710 UniprotKB:Q8NFJ5

RefSeq: NC_000012.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 3.316e-2 (AD) 5.421e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PLAUR	0.808
ITGA5	0.793
LIF	0.789
STX11	0.786
IL6	0.779
SERPINE1	0.771
ITGB3	0.767
STC1	0.764
TNFAIP3	0.757
ICAM1	0.736

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
TMEM179	-0.414
MARCH4	-0.403
NEUROD6	-0.397
KCNIP3	-0.384
CDK5R2	-0.383
SPRN	-0.377
SCRT1	-0.376
SMIM18	-0.376
FBLL1	-0.375
EXTL1	-0.372

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00755	Tretinoin	Small Molecule	302-79-4	Approved\|Investigational\|Nutraceutical	Target

ID	Drug Name	Action	PubMed
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of GPRC5A mRNA	19933214
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether analog results in decreased expression of GPRC5A mRNA"	19095052
C029497	2,3-bis(3'-hydroxybenzyl)butyrolactone	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of GPRC5A mRNA"	19167446
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GPRC5A mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GPRC5A mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GPRC5A mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GPRC5A mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in increased expression of GPRC5A mRNA	21420995
D020106	Acrylamide	Acrylamide results in decreased expression of GPRC5A mRNA	28959563
D000393	Air Pollutants	Air Pollutants analog results in increased expression of GPRC5A mRNA	21757418
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in increased expression of GPRC5A mRNA	21298039
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of GPRC5A mRNA	24449571
C006632	arsenic trioxide	GPRC5A protein results in decreased susceptibility to arsenic trioxide	20707922
C547126	AZM551248	AZM551248 results in increased expression of GPRC5A mRNA	22323515
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of GPRC5A mRNA	19770486
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of GPRC5A mRNA"	19150397
D004958	Estradiol	EGF protein inhibits the reaction [Estradiol results in decreased expression of GPRC5A mRNA]	24758408
D004958	Estradiol	Estradiol affects the expression of GPRC5A mRNA	14699072
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in decreased expression of GPRC5A mRNA	20660070
D004958	Estradiol	Estradiol results in decreased expression of GPRC5A mRNA	16474171\|2475840
D004958	Estradiol	Estradiol results in increased expression of GPRC5A mRNA	20106945
C053541	bicalutamide	bicalutamide results in decreased expression of GPRC5A mRNA	15638997
C006780	bisphenol A	bisphenol A affects the expression of GPRC5A mRNA	20170705
C006780	bisphenol A	bisphenol A results in decreased expression of GPRC5A mRNA	16474171
C006780	bisphenol A	bisphenol A affects the expression of GPRC5A mRNA	25181051
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in increased phosphorylation of GPRC5A protein	22174045
C018475	butyraldehyde	butyraldehyde results in increased expression of GPRC5A mRNA	26079696
C037123	cadmium sulfate	cadmium sulfate results in increased expression of GPRC5A mRNA	12064557\|1467641
C459604	candoxin	candoxin results in decreased expression of GPRC5A mRNA	16309724
C018021	cobaltous chloride	cobaltous chloride results in increased expression of GPRC5A mRNA	19376846
D019327	Copper Sulfate	Copper Sulfate results in increased expression of GPRC5A mRNA	19549813
D003375	Coumestrol	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of GPRC5A mRNA"	19167446
D003375	Coumestrol	[Coumestrol co-treated with resveratrol] results in decreased expression of GPRC5A mRNA	19167446
D003375	Coumestrol	Coumestrol results in decreased expression of GPRC5A mRNA	19167446
D016572	Cyclosporine	Cyclosporine results in decreased expression of GPRC5A mRNA	22147139
D016572	Cyclosporine	Cyclosporine results in increased expression of GPRC5A mRNA	20106945\|2163298
C089595	cylindrospermopsin	cylindrospermopsin results in increased expression of GPRC5A mRNA	24921660
C014347	decitabine	decitabine inhibits the reaction [Smoke results in decreased expression of GPRC5A mRNA]	21095227
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of GPRC5A mRNA	21266533
C118739	entinostat	entinostat results in increased expression of GPRC5A mRNA	27188386
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of GPRC5A mRNA	20170705\|2686566
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of GPRC5A mRNA	18936297
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of GPRC5A mRNA	20170705\|2686566
C039281	furan	furan results in increased expression of GPRC5A mRNA	27387713
D019833	Genistein	Genistein affects the expression of GPRC5A mRNA	26865667
D019833	Genistein	Genistein results in decreased expression of GPRC5A mRNA	16474171
C004312	glycidol	glycidol results in increased expression of GPRC5A mRNA	24915197
C010178	heliotrine	heliotrine results in increased expression of GPRC5A mRNA	26100227
D006418	Heme	Heme metabolite results in increased expression of GPRC5A mRNA	19191707
D017313	Fenretinide	Fenretinide results in increased expression of GPRC5A mRNA	15958647
D017313	Fenretinide	Fenretinide results in increased expression of GPRC5A mRNA	28973697
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of GPRC5A mRNA	20044591
C492448	ICG 001	ICG 001 results in increased expression of GPRC5A mRNA	26191083
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of GPRC5A mRNA	25613284
D007501	Iron	Iron deficiency results in increased expression of GPRC5A mRNA	16629162
C544151	jinfukang	jinfukang results in decreased expression of GPRC5A mRNA	27392435
C042720	mercuric bromide	mercuric bromide results in increased expression of GPRC5A mRNA	26272509
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GPRC5A mRNA"	27188386
D008727	Methotrexate	Methotrexate results in increased expression of GPRC5A mRNA	17379860
C523799	MRK 003	GPRC5A results in increased susceptibility to MRK 003	19903844
D009151	Mustard Gas	Mustard Gas results in increased expression of GPRC5A mRNA	25102026
D037742	Nanotubes, Carbon	"Nanotubes, Carbon affects the expression of GPRC5A protein"	21135415
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of GPRC5A mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of GPRC5A mRNA"	25620056
D052638	Particulate Matter	Particulate Matter results in decreased expression of GPRC5A mRNA	22178795
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether analog results in decreased expression of GPRC5A mRNA	19095052
D010634	Phenobarbital	Phenobarbital affects the expression of GPRC5A mRNA	23091169
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GPRC5A mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of GPRC5A mRNA	26272509
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of GPRC5A mRNA	19710929
D010936	Plant Extracts	Plant Extracts results in decreased expression of GPRC5A mRNA	23557933
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls analog results in decreased expression of GPRC5A mRNA	16474171
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in decreased expression of GPRC5A mRNA	20660070
C005556	propionaldehyde	propionaldehyde results in increased expression of GPRC5A mRNA	26079696
C513428	pyrachlostrobin	pyrachlostrobin results in increased expression of GPRC5A mRNA	27029645
D011763	Pyrrolizidine Alkaloids	Pyrrolizidine Alkaloids results in increased expression of GPRC5A mRNA	26100227
D011794	Quercetin	Quercetin results in increased expression of GPRC5A mRNA	21632981
C059514	resveratrol	[Coumestrol co-treated with resveratrol] results in decreased expression of GPRC5A mRNA	19167446
C010327	salinomycin	salinomycin results in decreased expression of GPRC5A mRNA	19682730
C541923	sandostatinLAR	sandostatinLAR results in increased expression of GPRC5A mRNA	17210224
C009237	senecionine	senecionine results in increased expression of GPRC5A mRNA	26100227
C009238	senkirkine	senkirkine results in increased expression of GPRC5A mRNA	26100227
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of GPRC5A mRNA	25895662
D012834	Silver	Silver results in increased expression of GPRC5A mRNA	28959546
D012834	Silver	Silver results in increased expression of GPRC5A mRNA	27131904
D012906	Smoke	decitabine inhibits the reaction [Smoke results in decreased expression of GPRC5A mRNA]	21095227
C009277	sodium arsenate	sodium arsenate results in decreased expression of GPRC5A mRNA	21795629
C017947	sodium arsenite	sodium arsenite results in decreased expression of GPRC5A mRNA	28595984
D012999	Soman	Soman results in increased expression of GPRC5A mRNA	19281266
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in increased expression of GPRC5A mRNA	25172293
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of GPRC5A mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of GPRC5A mRNA	19770486\|1993321
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of GPRC5A mRNA	25613284
C009495	titanium dioxide	titanium dioxide results in decreased expression of GPRC5A mRNA	23409001
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of GPRC5A mRNA	28065790
D014212	Tretinoin	Tretinoin results in increased expression of GPRC5A mRNA	16249480\|2193413
D014212	Tretinoin	Tretinoin results in increased expression of GPRC5A mRNA	20488242
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate affects the expression of GPRC5A mRNA	29024780
D014635	Valproic Acid	Valproic Acid results in increased expression of GPRC5A mRNA	23179753\|2915479
D014635	Valproic Acid	Valproic Acid results in increased methylation of GPRC5A gene	29154799
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of GPRC5A gene	25560391
C025643	vinclozolin	vinclozolin affects the expression of GPRC5A mRNA	19015723
D024483	Vitamin K 3	Vitamin K 3 affects the expression of GPRC5A mRNA	20044591
C088658	zoledronic acid	zoledronic acid results in decreased expression of GPRC5A mRNA	24714768

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004930	G-protein coupled receptor activity	-	IEA	-
GO:0005515	protein binding	-	IPI	25311788
GO:0045296	cadherin binding	-	HDA	25468996

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0007165	signal transduction	-	TAS	9857033
GO:0007175	negative regulation of epidermal growth factor-activated receptor activity	-	ISS	-
GO:0007186	G-protein coupled receptor signaling pathway	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005730	nucleolus	-	IDA	-
GO:0005886	plasma membrane	-	IDA	18000218
GO:0005887	integral component of plasma membrane	-	TAS	9857033
GO:0030659	cytoplasmic vesicle membrane	-	IEA	-
GO:0031982	vesicle	-	IDA	25468996
GO:0043231	intracellular membrane-bounded organelle	-	IDA	-
GO:0070062	extracellular exosome	-	HDA	19056867 19199708 23533145

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
29382653	Genome-Wide Gene Expression Changes in the Normal-Appearing Airway during the Evolution of Smoking-Associated Lung Adenocarcinoma. (2018 Apr)	Kantrowitz J	Cancer Prev Res (Phila)
22239913	Enhancement of lung tumorigenesis in a Gprc5a Knockout mouse by chronic extrinsic airway inflammation. (2012 Jan 12)	Barta P	Mol Cancer