Gene: SHF

90525
-
Src homology 2 domain containing F
protein-coding
15q21.1
Ensembl:ENSG00000138606 MIM:617313 Vega:OTTHUMG00000131353 UniprotKB:Q7M4L6
NC_000015.10
PubMed
0   ANCO-SNPs
ND|AD
1   
2.633e-1 (AD)  2.858e-1 (ND)   (Frontal_Cortex)
7.491e-1 (AD)  2.010e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EFNB30.859
DNAL40.854
GRK60.853
AP1S10.851
ORAI20.845
CELF30.838
EFNA30.837
GDAP1L10.837
CELF50.836
BLCAP0.835

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.478
OR4F29-0.447
REST-0.419
LATS2-0.412
CDC14A-0.409
OLAH-0.405
MAGEA12-0.391
CNN2-0.39
EVC2-0.384
CSAG1-0.384

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SHF mRNA"19114083
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SHF gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of SHF mRNA24449571
C006780bisphenol Abisphenol A results in decreased expression of SHF mRNA25181051
D003471CuprizoneCuprizone results in decreased expression of SHF mRNA26577399
C039281furanfuran results in decreased expression of SHF mRNA26194646
D017313FenretinideFenretinide results in decreased expression of SHF mRNA28973697
C045463leflunomideleflunomide results in decreased expression of SHF mRNA28988120
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of SHF mRNA"24972896
D018021Lithium ChlorideLithium Chloride results in decreased expression of SHF mRNA23527032
D008694MethamphetamineMethamphetamine results in decreased expression of SHF mRNA26307267
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SHF mRNA"25620056
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of SHF mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of SHF mRNA19482888
C006253pirinixic acidpirinixic acid results in decreased expression of SHF mRNA25270620
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SHF mRNA25895662
D016559TacrolimusTacrolimus results in decreased expression of SHF mRNA25270620
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SHF mRNA27913140
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SHF mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SHF mRNA22298810
D013853ThioacetamideThioacetamide results in decreased expression of SHF mRNA23411599
D014635Valproic AcidValproic Acid results in increased expression of SHF mRNA29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of SHF gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001784phosphotyrosine residue binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006915apoptotic process-IEA-  
GO:0007165signal transduction-IBA21873635  
GO:0009967positive regulation of signal transduction-IEA-  
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23369673Airway obstruction in systolic heart failure--COPD or congestion? (2013 Oct 3)Brenner SInt J Cardiol