Gene: COX19

90639
-
COX19, cytochrome c oxidase assembly factor
protein-coding
7p22.3
Ensembl:ENSG00000240230 MIM:610429 Vega:OTTHUMG00000151476 UniprotKB:Q49B96
NC_000007.14
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.282e-1 (AD)  2.881e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10272099chr7:977312 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
USP140.872
RPUSD40.87
POLE30.865
RAE10.864
SLC4A1AP0.861
RPAIN0.86
TRIM270.86
TMEM2420.859
SECISBP20.859
SARS0.858

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.534
OR4F29-0.506
MTRNR2L9-0.427
MTRNR2L10-0.417
MTRNR2L6-0.415
KLRB1-0.372
TTLL10-0.357
MTRNR2L2-0.349
ASB4-0.346
MTRNR2L8-0.333

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of COX19 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of COX19 mRNA"27188386
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of COX19 mRNA"19150397
C044887beta-methylcholinebeta-methylcholine affects the expression of COX19 mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of COX19 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of COX19 mRNA26079696
C584509C646 compoundC646 compound results in increased expression of COX19 mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of COX19 mRNA20883709
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of COX19 mRNA20971185
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of COX19 mRNA23649840
D018120FinasterideFinasteride results in increased expression of COX19 mRNA24136188
D005485FlutamideFlutamide results in increased expression of COX19 mRNA24136188
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of COX19 mRNA22634610
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of COX19 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of COX19 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of COX19 mRNA"25554681
C051752nefazodonenefazodone results in increased expression of COX19 mRNA24136188
C012655nimesulidenimesulide results in increased expression of COX19 mRNA24136188
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of COX19 mRNA20971185
C006253pirinixic acidpirinixic acid results in increased expression of COX19 mRNA23811191
D010936Plant ExtractsPlant Extracts results in increased expression of COX19 mRNA23557933
D011794QuercetinQuercetin results in increased expression of COX19 mRNA21632981
C017947sodium arsenitesodium arsenite results in decreased expression of COX19 mRNA20883709
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of COX19 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of COX19 mRNA16214954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of COX19 mRNA18796159|2597527
D013752TetracyclineTetracycline results in decreased expression of COX19 mRNA24489787
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of COX19 mRNA"26179874
D014520UrethaneUrethane results in decreased expression of COX19 mRNA28818685
C406224valdecoxibvaldecoxib results in increased expression of COX19 mRNA24136188
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of COX19 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of COX19 mRNA23179753|2627250
C111237vorinostatvorinostat results in decreased expression of COX19 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI23676665  
GO ID GO Term Qualifier Evidence PubMed
GO:0006878cellular copper ion homeostasis-IMP23345593  
GO:0033617mitochondrial respiratory chain complex IV assembly-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IDA23345593  23676665  
GO:0005758mitochondrial intermembrane space-IBA21873635  
GO:0005758mitochondrial intermembrane space-IDA23345593  23676665  
GO:0005829cytosol-IDA23345593  23676665  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1268020Mitochondrial protein importIEA
R-HSA-392499Metabolism of proteinsIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal