Gene: CLDN6

9074
-
claudin 6
protein-coding
16p13.3
Ensembl:ENSG00000184697 MIM:615798 Vega:OTTHUMG00000128999 UniprotKB:P56747
NC_000016.10
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.492e-1 (AD)  5.355e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg20035459chr16:3068707CLDN6Promoter6.460e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FOXD4L30.567
ASTL0.535
FAM83D0.504
NPY1R0.498
HAS30.495
ATF7IP20.483
EPPK10.482
RDH120.48
MARCH110.479
SGSM10.469

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CYP11A1-0.275
MYL3-0.274
HOGA1-0.273
MT1H-0.269
MBNL3-0.267
HAAO-0.265
ACSF2-0.263
PDE3A-0.263
PARD3B-0.26
RHOD-0.259

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLDN6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLDN6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLDN6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLDN6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLDN6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLDN6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLDN6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLDN6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLDN6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLDN6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLDN6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLDN6 mRNA"27188386
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of CLDN6 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of CLDN6 mRNA]17585979
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CLDN6 mRNA23630614
D001280AtrazineAtrazine affects the expression of CLDN6 mRNA25929836
D001374AzacitidineAzacitidine results in decreased methylation of CLDN6 promoter18661270
D001374AzacitidineAzacitidine results in increased expression of CLDN6 mRNA18661270
D001374Azacitidine[trichostatin A co-treated with Azacitidine] results in decreased methylation of CLDN6 promoter18661270
C006780bisphenol Abisphenol A results in decreased expression of CLDN6 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of CLDN6 promoter22457795
D002220CarbamazepineCarbamazepine affects the expression of CLDN6 mRNA25979313
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CLDN6 gene20938992
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of CLDN6 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of CLDN6 mRNA]17585979
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in decreased expression of CLDN6 mRNA15467011
D003976DiazinonDiazinon results in increased methylation of CLDN6 gene22964155
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of CLDN6 mRNA27392435
D004041Dietary FatsDietary Fats results in increased expression of CLDN6 mRNA25016146
D004121Dimethyl SulfoxideDimethyl Sulfoxide inhibits the reaction [Hydrogen Peroxide results in decreased expression of CLDN6 mRNA]18661270
D004121Dimethyl SulfoxideDimethyl Sulfoxide results in decreased methylation of CLDN6 promoter18661270
D004121Dimethyl SulfoxideDimethyl Sulfoxide results in increased expression of CLDN6 mRNA18661270
C118739entinostatentinostat results in increased expression of CLDN6 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLDN6 mRNA"27188386
D005031EthylenethioureaEthylenethiourea results in decreased expression of CLDN6 mRNA18801409
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CLDN6 gene20938992
D004397FonofosFonofos results in increased methylation of CLDN6 promoter22847954
C039281furanfuran results in increased methylation of CLDN6 gene22079235
D006861Hydrogen PeroxideDimethyl Sulfoxide inhibits the reaction [Hydrogen Peroxide results in decreased expression of CLDN6 mRNA]18661270
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of CLDN6 mRNA18661270
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of CLDN6 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of CLDN6 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of CLDN6 mRNA26752646
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CLDN6 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of CLDN6 mRNA26272509
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLDN6 mRNA"27188386
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of CLDN6 mRNA24810058
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of CLDN6 mRNA22321834
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLDN6 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of CLDN6 mRNA26272509
D010278ParathionParathion results in increased methylation of CLDN6 promoter22847954
C494474perchlorateperchlorate results in decreased expression of CLDN6 mRNA18801409
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLDN6 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of CLDN6 mRNA26272509
D011374ProgesteroneProgesterone results in decreased expression of CLDN6 mRNA22238285
D011692Puromycin AminonucleosidePuromycin Aminonucleoside affects the localization of CLDN6 protein18367650
C012568terbufosterbufos results in increased methylation of CLDN6 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CLDN6 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CLDN6 mRNA21570461
D013752TetracyclineTetracycline results in decreased expression of CLDN6 mRNA28882639
D013853ThioacetamideThioacetamide results in increased expression of CLDN6 mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of CLDN6 mRNA27404394
D014212TretinoinTretinoin results in increased expression of CLDN6 mRNA16236135
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLDN6 mRNA"27188386
C012589trichostatin A[trichostatin A co-treated with Azacitidine] results in decreased methylation of CLDN6 promoter18661270
C012589trichostatin Atrichostatin A results in decreased methylation of CLDN6 promoter18661270
C012589trichostatin Atrichostatin A results in increased expression of CLDN6 mRNA18661270|2493525
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of CLDN6 mRNA"26179874
D014415TunicamycinTunicamycin results in increased expression of CLDN6 mRNA17127020
D014520UrethaneUrethane results in decreased expression of CLDN6 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLDN6 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of CLDN6 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of CLDN6 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001618virus receptor activity-IMP20375010  
GO:0005198structural molecule activity-IEA-  
GO:0005515protein binding-IPI20375010  
GO:0042802identical protein binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0016338calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules-ISS-  
GO:0045216cell-cell junction organization-IEA-  
GO:0046718viral entry into host cell-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IDA20375010  
GO:0005923bicellular tight junction-ISS-  
GO:0016021integral component of membrane-IEA-  
GO:0016327apicolateral plasma membrane-IEA-  
KEGG ID KEGG Term
hsa04514Cell adhesion molecules (CAMs)
hsa04530Tight junction
hsa04670Leukocyte transendothelial migration
hsa05160Hepatitis C
Reactome ID Reactome Term Evidence
R-HSA-1500931Cell-Cell communicationIEA
R-HSA-420029Tight junction interactionsIEA
R-HSA-421270Cell-cell junction organizationIEA
R-HSA-446728Cell junction organizationIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27982694Cigarette smoke and decreased oxygen tension inhibit pulmonary claudin-6 expression. (2016 Oct - Dec)Jimenez FRExp Lung Res
19472401The presence of aberrant DNA methylation in noncancerous esophageal mucosae in association with smoking history: a target for risk diagnosis and prevention of esophageal cancers. (2009 Aug 1)Oka DCancer