Gene: CLDN2

9075
-
claudin 2
protein-coding
Xq22.3
Ensembl:ENSG00000165376 MIM:300520 Vega:OTTHUMG00000022154 UniprotKB:P57739
NG_016445.1
PubMed
0   ANCO-SNPs
ND|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TNFAIP30.579
NOS30.573
CXCL30.567
F11R0.566
HPD0.55
B4GALT10.545
TNFRSF10A0.544
ZNF4420.543
ITGA50.543
FLT40.541

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CHAD-0.3
WNT7A-0.29
KCNIP3-0.289
NEU4-0.286
NXPH1-0.273
GPR17-0.267
SMIM18-0.261
SPRN-0.261
KCNMB2-0.26
FLRT1-0.258

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CLDN2 mRNA"25510870
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [CLDN2 protein results in increased expression of IL1B mRNA]15350541
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [CLDN2 protein results in increased expression of IL1B protein]15350541
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CLDN2 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CLDN2 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CLDN2 mRNA"25510870
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CLDN2 protein results in increased expression of IL1B protein]15350541
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CLDN2 mRNA"25510870
D000082AcetaminophenAcetaminophen results in decreased expression of CLDN2 mRNA21420995
D020106AcrylamideAcrylamide results in decreased expression of CLDN2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CLDN2 gene27153756
D000452AldrinAldrin results in increased expression of CLDN2 mRNA18579281
D024502alpha-Tocopherolalpha-Tocopherol inhibits the reaction [Potassium Dichromate affects the localization of CLDN2 protein]19766176
C547126AZM551248AZM551248 results in increased expression of CLDN2 mRNA22323515
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of CLDN2 mRNA26377693
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with Dextran Sulfate] results in decreased expression of CLDN2 mRNA26271895
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CLDN2 mRNA19770486|2719552
C006780bisphenol Abisphenol A affects the expression of CLDN2 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of CLDN2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CLDN2 gene28505145
D002084Butylated HydroxytolueneButylated Hydroxytoluene results in increased expression of CLDN2 mRNA19925653
C018475butyraldehydebutyraldehyde results in decreased expression of CLDN2 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of CLDN2 mRNA25851441
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CLDN2 mRNA25851441
D0027314-Chloromercuribenzenesulfonate4-Chloromercuribenzenesulfonate results in decreased activity of CLDN2 protein mutant form19690347
C018021cobaltous chloridecobaltous chloride results in decreased expression of CLDN2 mRNA24386269
D019327Copper SulfateCopper Sulfate results in increased expression of CLDN2 mRNA18579281
D003471CuprizoneCuprizone results in increased expression of CLDN2 mRNA26577399
D003474CurcuminCurcumin inhibits the reaction [maleic acid results in decreased expression of CLDN2]25119790
D016572CyclosporineCyclosporine results in decreased expression of CLDN2 mRNA24907557|2798913
C014347decitabinedecitabine results in increased expression of CLDN2 mRNA18845559
C107676deguelindeguelin results in increased expression of CLDN2 mRNA19861542
C007262deoxynivalenoldeoxynivalenol affects the expression of CLDN2 protein24568843
C007262deoxynivalenoldeoxynivalenol results in increased expression of CLDN2 mRNA24568843
D016264Dextran Sulfate[Benzo(a)pyrene co-treated with Dextran Sulfate] results in decreased expression of CLDN2 mRNA26271895
C028009diallyl disulfidediallyl disulfide results in decreased expression of CLDN2 mRNA20600798
C028009diallyl disulfidediallyl disulfide results in decreased expression of CLDN2 protein20600798
C042577diallyl trisulfidediallyl trisulfide results in decreased expression of CLDN2 mRNA24084732
C042577diallyl trisulfidediallyl trisulfide results in decreased expression of CLDN2 protein24084732
D002945CisplatinCisplatin results in decreased expression of CLDN2 mRNA22023808
D004026DieldrinDieldrin results in decreased expression of CLDN2 mRNA23153324
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of CLDN2 mRNA29097150
D005472FluorouracilFluorouracil results in decreased expression of CLDN2 protein26310874
D005472Fluorouracilresveratrol inhibits the reaction [Fluorouracil results in decreased expression of CLDN2 protein]26310874
D005485FlutamideFlutamide results in decreased expression of CLDN2 mRNA24793618
C039281furanfuran results in decreased expression of CLDN2 mRNA25539665|2619464
C419708gefitinib[gefitinib co-treated with naphthalene] affects the expression of CLDN2 mRNA20935109
D019833GenisteinGenistein results in increased methylation of CLDN2 gene28505145
D017313FenretinideFenretinide results in increased expression of CLDN2 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of CLDN2 mRNA18661270
C051890irinotecanirinotecan affects the expression of CLDN2 mRNA20097248
D007501IronIron deficiency results in increased expression of CLDN2 mRNA16629162
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CLDN2 mRNA26752646
C030272maleic acidCurcumin inhibits the reaction [maleic acid results in decreased expression of CLDN2]25119790
C030272maleic acidmaleic acid results in decreased expression of CLDN225119790
C074502methanethiosulfonatemethanethiosulfonate results in decreased activity of CLDN2 protein mutant form19690347
D015735MifepristoneMifepristone inhibits the reaction [Progesterone results in decreased expression of CLDN2 protein]17478549
D009020MorphineMorphine results in increased expression of CLDN2 mRNA21178816
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CLDN2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CLDN2 mRNA"25554681
C031721naphthalene[gefitinib co-treated with naphthalene] affects the expression of CLDN2 mRNA20935109
C025589ochratoxin Aochratoxin A results in decreased expression of CLDN2 mRNA28710020
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CLDN2 mRNA"25510870
D010416PentachlorophenolPentachlorophenol results in increased expression of CLDN2 mRNA23892564
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of CLDN2 mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of CLDN2 mRNA19429403
D010578PetroleumPetroleum results in increased expression of CLDN2 mRNA25208076
D010634PhenobarbitalPhenobarbital affects the expression of CLDN2 mRNA23091169
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CLDN2 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of CLDN2 mRNA18445702
D011192Potassium Dichromatealpha-Tocopherol inhibits the reaction [Potassium Dichromate affects the localization of CLDN2 protein]19766176
D011192Potassium DichromatePotassium Dichromate affects the localization of CLDN2 protein19766176
D011374ProgesteroneMifepristone inhibits the reaction [Progesterone results in decreased expression of CLDN2 protein]17478549
D011374ProgesteroneProgesterone results in decreased expression of CLDN2 protein17478549
D011374ProgesteroneProgesterone results in increased expression of CLDN2 mRNA19690047
C513428pyrachlostrobinpyrachlostrobin results in increased expression of CLDN2 mRNA27029645
C059514resveratrolresveratrol inhibits the reaction [Fluorouracil results in decreased expression of CLDN2 protein]26310874
C059514resveratrolresveratrol results in increased expression of CLDN2 protein26310874
C005705sanguinarinesanguinarine results in decreased expression of CLDN2 protein19063874
C093642SB 203580SB 203580 inhibits the reaction [CLDN2 protein results in increased expression of IL1B mRNA]15350541
C093642SB 203580SB 203580 inhibits the reaction [CLDN2 protein results in increased expression of IL1B protein]15350541
C009277sodium arsenatesodium arsenate results in increased expression of CLDN2 mRNA23922661
C016104sodium bichromatesodium bichromate results in increased expression of CLDN2 mRNA22155349
C016104sodium bichromatesodium bichromate results in increased expression of CLDN2 mRNA22561333
D013311StreptozocinStreptozocin results in decreased expression of CLDN2 mRNA25905778
D013629TamoxifenTamoxifen affects the expression of CLDN2 mRNA20937368
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CLDN2 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CLDN2 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CLDN2 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CLDN2 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CLDN2 mRNA15644576
D013752TetracyclineTetracycline results in decreased expression of CLDN2 mRNA28882639
D013853ThioacetamideThioacetamide results in decreased expression of CLDN2 mRNA23411599
D013853ThioacetamideThioacetamide results in increased expression of CLDN2 protein15350541
D014520UrethaneUrethane results in decreased expression of CLDN2 mRNA28818685
C406224valdecoxibvaldecoxib results in decreased expression of CLDN2 mRNA24136188
D014635Valproic AcidValproic Acid affects the expression of CLDN2 mRNA17963808
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CLDN2 gene25560391
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in increased expression of CLDN2 mRNA"25208076
C088658zoledronic acidzoledronic acid results in decreased expression of CLDN2 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005198structural molecule activity-IEA-  
GO:0005515protein binding-IPI25416956  
GO:0042802identical protein binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0016338calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IEA-  
GO:0005923bicellular tight junction-ISS-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa04514Cell adhesion molecules (CAMs)
hsa04530Tight junction
hsa04670Leukocyte transendothelial migration
hsa05160Hepatitis C
Reactome ID Reactome Term Evidence
R-HSA-1500931Cell-Cell communicationIEA
R-HSA-420029Tight junction interactionsIEA
R-HSA-421270Cell-cell junction organizationIEA
R-HSA-446728Cell junction organizationIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24624459Pancreatitis Overview (1993)LaRusch J-
25253127Polymorphisms at PRSS1-PRSS2 and CLDN2-MORC4 loci associate with alcoholic and non-alcoholic chronic pancreatitis in a European replication study. (2015 Sep)Derikx MHGut
27687058Claudin-1 Protein Expression Is a Good Prognostic Factor in Non-Small Cell Lung Cancer, but only in Squamous Cell Carcinoma Cases. (2017 Jan)Moldvay JPathol Oncol Res