Gene: CLDN1

9076
CLD1|ILVASC|SEMP1
claudin 1
protein-coding
3q28
Ensembl:ENSG00000163347 MIM:603718 Vega:OTTHUMG00000156214 UniprotKB:O95832
NG_021418.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.913e-2 (AD)  3.954e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SCD0.51
SAPCD20.505
RAPGEF40.505
PCDH150.501
RMDN10.478
LIMA10.471
FRS20.469
NDRG20.469
SNX220.466
SKA20.463

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HSD11B2-0.366
FTCD-AS1-0.357
GPR6-0.355
S100A5-0.353
TUBA8-0.336
SLC47A2-0.329
TPX2-0.322
HIST3H2BB-0.313
ROS1-0.312
ALOX15-0.311

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of CLDN1 mRNA"28903501
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CLDN1 mRNA"20056577
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran results in decreased expression of CLDN1 mRNA"21724226
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"2,3-bis(3'-hydroxybenzyl)butyrolactone results in decreased expression of CLDN1 mRNA"19167446
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of CLDN1 mRNA"19167446
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of CLDN1 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of CLDN1 mRNA"21346803
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of CLDN1 mRNA25088246
C5850042-monochloropropanediol2-monochloropropanediol results in increased expression of CLDN1 mRNA28522335
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of CLDN1 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLDN1 mRNA"27188386
C0757734-phenylbutyric acid4-phenylbutyric acid results in decreased expression of CLDN1 mRNA14583596
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLDN1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of CLDN1 mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of CLDN1 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of CLDN1 mRNA17562736
D000111AcetylcysteineAcetylcysteine inhibits the reaction [arsenic trioxide results in decreased expression of CLDN1 protein]28115242
D000111Acetylcysteine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CLDN1 mRNA22129741
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CLDN1 mRNA27153756
D000393Air PollutantsAir Pollutants analog results in increased expression of CLDN1 mRNA21757418
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of CLDN1 mRNA28522335
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CLDN1 mRNA16483693
D001151ArsenicArsenic affects the localization of CLDN1 protein24349408
C006632arsenic trioxideAcetylcysteine inhibits the reaction [arsenic trioxide results in decreased expression of CLDN1 protein]28115242
C006632arsenic trioxidearsenic trioxide results in decreased expression of CLDN1 protein28115242
C006632arsenic trioxidearsenic trioxide results in increased expression of CLDN1 mRNA26705709
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of CLDN1 mRNA"25757056
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of CLDN1 mRNA"18687144|2535159
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of CLDN1 protein"25351596
D001205Ascorbic AcidAscorbic Acid inhibits the reaction [Ethanol results in decreased expression of CLDN1 mRNA]24239723
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of CLDN1 mRNA26377693
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CLDN1 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CLDN1 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CLDN1 mRNA27195522
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of CLDN1 mRNA"20382639
D004958EstradiolEGF protein inhibits the reaction [Estradiol results in decreased expression of CLDN1 mRNA]24758408
D004958Estradiol[Estradiol co-treated with EGF protein] results in increased expression of CLDN1 mRNA24758408
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of CLDN1 mRNA20660070
D004958EstradiolEstradiol results in decreased expression of CLDN1 mRNA19167446|2475840
C070515bisindolylmaleimide Ibisindolylmaleimide I inhibits the reaction [puag-haad results in increased expression of CLDN1 mRNA]28780155
C006780bisphenol Abisphenol A results in decreased expression of CLDN1 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of CLDN1 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of CLDN1 mRNA22079614
C584509C646 compoundC646 compound results in decreased expression of CLDN1 mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CLDN1 mRNA25851441
D002211CapsaicinCapsaicin results in increased expression of CLDN1 mRNA16278290
C054133casticincasticin results in decreased expression of CLDN1 mRNA27862857
C100187chloropicrinchloropicrin affects the expression of CLDN1 mRNA26352163
D002738ChloroquineChloroquine results in increased expression of CLDN1 mRNA25752684
D002922CiguatoxinsCiguatoxins affects the expression of CLDN1 mRNA18353800
C011730clay[clay analog co-treated with deoxynivalenol] results in increased expression of CLDN1 mRNA23922676
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CLDN1 mRNA17602206
D003300Copper[Disulfiram binds to Copper] which results in increased expression of CLDN1 mRNA24690739
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of CLDN1 mRNA20971185
D003300CopperCopper results in increased expression of CLDN1 mRNA17205981
D019327Copper SulfateCopper Sulfate results in increased expression of CLDN1 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of CLDN1 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in decreased expression of CLDN1 mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of CLDN1 mRNA27989131
D016572CyclosporineCyclosporine results in decreased expression of CLDN1 mRNA19770486|2241607
C031071decanoic aciddecanoic acid affects the localization of CLDN1 protein16566947
C007262deoxynivalenol[clay analog co-treated with deoxynivalenol] results in increased expression of CLDN1 mRNA23922676
C007262deoxynivalenol[deoxynivalenol co-treated with Zearalenone] results in decreased expression of CLDN1 mRNA28935499
C007262deoxynivalenol[deoxynivalenol co-treated with Zearalenone] results in decreased expression of CLDN1 protein28865950
C007262deoxynivalenoldeoxynivalenol results in decreased expression of and affects the localization of CLDN1 protein24568843
C007262deoxynivalenoldeoxynivalenol results in decreased expression of CLDN1 protein28865950
C007262deoxynivalenoldeoxynivalenol results in increased expression of CLDN1 mRNA24568843
C007262deoxynivalenoldeoxynivalenol affects the expression of CLDN1 protein24568843
C042577diallyl trisulfidediallyl trisulfide results in decreased expression of CLDN1 mRNA24084732
C042577diallyl trisulfidediallyl trisulfide results in decreased expression of CLDN1 protein24084732
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of CLDN1 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of CLDN1 mRNA27392435
D002945Cisplatin[Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in decreased expression of CLDN1 mRNA23625948
D004041Dietary FatsDietary Fats affects the expression of CLDN1 mRNA19680557
D004041Dietary FatsDietary Fats results in increased expression of CLDN1 mRNA18042831
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CLDN1 mRNA18164116
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CLDN1 mRNA17602206
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CLDN1 mRNA22129741
C087758difructose anhydride IIIdifructose anhydride III affects the localization of CLDN1 protein16566947
D002117CalcitriolCalcitriol results in decreased expression of CLDN1 mRNA16002434
D004178DiquatDiquat results in decreased expression of CLDN1 protein26338884
D004221Disulfiram[Disulfiram binds to Copper] which results in increased expression of CLDN1 mRNA24690739
D004237DiuronDiuron results in decreased expression of CLDN1 mRNA25152437
D004317DoxorubicinDoxorubicin results in decreased expression of CLDN1 mRNA16404146
C118739entinostatentinostat results in increased expression of CLDN1 mRNA26272509
D000431EthanolAscorbic Acid inhibits the reaction [Ethanol results in decreased expression of CLDN1 mRNA]24239723
D000431EthanolEthanol results in decreased expression of CLDN1 mRNA24239723
D000431EthanolSilymarin inhibits the reaction [Ethanol results in decreased expression of CLDN1 mRNA]24239723
C024565ethylene dichlorideethylene dichloride results in increased expression of CLDN1 mRNA28189721
D015025Zearalenone[deoxynivalenol co-treated with Zearalenone] results in decreased expression of CLDN1 mRNA28935499
D015025Zearalenone[deoxynivalenol co-treated with Zearalenone] results in decreased expression of CLDN1 protein28865950
D015025ZearalenoneZearalenone results in decreased expression of CLDN1 protein28865950
D005485FlutamideFlutamide results in decreased expression of CLDN1 mRNA24136188
D004397FonofosFonofos results in increased methylation of CLDN1 promoter22847954
D019833GenisteinESR2 promotes the reaction [Genistein results in increased expression of CLDN1 protein]20884965
D019833GenisteinGenistein results in increased expression of CLDN1 mRNA18847459
D019833GenisteinGenistein results in increased expression of CLDN1 protein20884965
D005839GentamicinsGentamicins results in increased expression of CLDN1 mRNA22061828
C049864ginsenoside Reginsenoside Re inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of CLDN1 protein]22849695
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of CLDN1 mRNA18661270
D006886HydroxychloroquineHydroxychloroquine results in increased expression of CLDN1 mRNA25752684
C492448ICG 001ICG 001 results in increased expression of CLDN1 mRNA26191083
C082359imidaclopridimidacloprid results in decreased expression of CLDN1 mRNA27792329
C016517indole-3-carbinolindole-3-carbinol affects the expression of CLDN1 mRNA21396975
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CLDN1 mRNA22129741
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CLDN1 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of CLDN1 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of CLDN1 mRNA27392435
C008261lead acetatelead acetate affects the expression of CLDN1 mRNA21864555
C045463leflunomideleflunomide results in increased expression of CLDN1 mRNA28988120
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of CLDN1 mRNA"24972896
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CLDN1 mRNA25613284
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of CLDN1 mRNA22092031
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of CLDN1 protein22092031
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of CLDN1 protein22092031
D008154LucanthoneLucanthone results in decreased expression of CLDN1 mRNA21148553
D019290Megestrol AcetateMegestrol Acetate results in decreased expression of and affects the localization of CLDN1 protein22883527
D019290Megestrol AcetateMegestrol Acetate results in decreased expression of CLDN1 mRNA22883527
D008727MethotrexateMethotrexate results in increased expression of CLDN1 mRNA21678067
D008727MethotrexateMethotrexate affects the expression of CLDN1 mRNA18502557
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CLDN1 mRNA28001369
D015735MifepristoneMifepristone inhibits the reaction [Progesterone results in decreased expression of CLDN1 protein]17478549
D015735MifepristoneMifepristone results in decreased expression of CLDN1 mRNA25972201
C500085muraglitazarmuraglitazar results in increased expression of CLDN1 mRNA21515302
D009151Mustard GasMustard Gas results in increased expression of CLDN1 mRNA25102026
D009151Mustard GasMustard Gas results in decreased expression of CLDN1 mRNA18988085
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of CLDN1 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CLDN1 mRNA"24389112
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CLDN1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CLDN1 mRNA"25620056
C031721naphthalenenaphthalene analog results in decreased expression of CLDN1 mRNA24976557
D009532NickelCLDN1 gene SNP affects the susceptibility to Nickel23136956
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of CLDN1 mRNA17616710
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of CLDN1 mRNA20971185
C558013NSC 689534NSC 689534 results in increased expression of CLDN1 mRNA20971185
D009930Organic ChemicalsCLDN1 gene SNP affects the susceptibility to Organic Chemicals23136956
D000073878Palm OilPalm Oil affects the expression of CLDN1 mRNA19680557
D000073878Palm OilPalm Oil results in increased expression of CLDN1 mRNA18042831
C496932panobinostatpanobinostat results in increased expression of CLDN1 mRNA26272509
C016030pantogabpantogab results in decreased expression of CLDN1 mRNA17379144
D010278ParathionParathion results in increased methylation of CLDN1 promoter22847954
D052638Particulate MatterParticulate Matter results in decreased expression of CLDN1 protein28341207
D010365PatulinPatulin affects the localization of CLDN1 protein19013514
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of CLDN1 mRNA26705709
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of CLDN1 mRNA27153767
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of CLDN1 mRNA27153767
D010476PerfumeCLDN1 gene SNP affects the susceptibility to Perfume23136956
D010634PhenobarbitalPhenobarbital affects the expression of CLDN1 mRNA23091169
D010634PhenobarbitalPhenobarbital results in decreased expression of CLDN1 mRNA19270015
D019800PhenolPhenol affects the localization of CLDN1 protein19679145
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLDN1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of CLDN1 mRNA26272509
C014153pirimiphos methylpirimiphos methyl results in increased expression of CLDN1 mRNA27845199
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CLDN1 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of CLDN1 mRNA18445702|2081375
C060540polyhexamethyleneguanidinepolyhexamethyleneguanidine results in increased expression of CLDN1 mRNA24583197
C060540polyhexamethyleneguanidinepolyhexamethyleneguanidine results in increased expression of CLDN1 protein24583197
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of CLDN1 mRNA22714537
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of CLDN1 mRNA20660070
D011374ProgesteroneMifepristone inhibits the reaction [Progesterone results in decreased expression of CLDN1 protein]17478549
D011374ProgesteroneProgesterone results in decreased expression of CLDN1 protein17478549
C045950propiconazolepropiconazole results in decreased expression of CLDN1 mRNA19423681
D011441PropylthiouracilPropylthiouracil results in increased expression of CLDN1 mRNA24780913
C034912puag-haadbisindolylmaleimide I inhibits the reaction [puag-haad results in increased expression of CLDN1 mRNA]28780155
C034912puag-haadpuag-haad results in increased expression of CLDN1 mRNA28780155
C034912puag-haadpuag-haad results in increased expression of CLDN1 protein28780155
D011794QuercetinQuercetin affects the localization of CLDN1 protein19297429
D011794QuercetinQuercetin results in decreased expression of CLDN1 mRNA21632981
C031389resorcinolresorcinol results in decreased expression of CLDN1 mRNA22623647
C059514resveratrol[Coumestrol co-treated with resveratrol] results in decreased expression of CLDN1 mRNA19167446
C059514resveratrolresveratrol results in decreased expression of CLDN1 mRNA19167446
C059514resveratrolresveratrol results in increased expression of CLDN1 mRNA17257620
C089730rosiglitazonerosiglitazone results in increased expression of CLDN1 mRNA23166672
C089730rosiglitazonerosiglitazone results in decreased expression of CLDN1 mRNA21515302
C085746rottlerinrottlerin affects the localization of CLDN1 protein19297429
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of CLDN1 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of CLDN1 mRNA25351596
D012822Silicon DioxideSilicon Dioxide results in increased expression of CLDN1 protein25351596
D012822Silicon DioxideSilicon Dioxide results in decreased expression of CLDN1 mRNA23221170
D012838SilymarinSilymarin inhibits the reaction [Ethanol results in decreased expression of CLDN1 mRNA]24239723
C009277sodium arsenatesodium arsenate results in decreased expression of CLDN1 mRNA23922661
C017947sodium arsenitesodium arsenite results in decreased expression of CLDN1 mRNA28595984
C017947sodium arsenitesodium arsenite results in decreased expression of CLDN1 protein28336213
C017947sodium arsenitesodium arsenite affects the localization of CLDN1 protein24349408
D013311StreptozocinStreptozocin results in decreased expression of CLDN1 mRNA25905778
D010042OuabainOuabain results in decreased expression of CLDN1 protein18247327
C446685systhanesysthane results in decreased expression of CLDN1 mRNA19423681
D016559TacrolimusTacrolimus results in decreased expression of CLDN1 mRNA22416070
D013629TamoxifenTamoxifen affects the expression of CLDN1 mRNA20937368
C012568terbufosterbufos results in increased methylation of CLDN1 promoter22847954
C501413tesaglitazartesaglitazar results in increased expression of CLDN1 mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CLDN1 mRNA21632981
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CLDN1 mRNA28922406
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of CLDN1 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CLDN1 mRNA19770486|2415448
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CLDN1 mRNA17035482|2188995
D013749TetrachlorodibenzodioxinAHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of CLDN1 mRNA]21215274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CLDN1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CLDN1 mRNA21215274|2172422
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CLDN1 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of CLDN1 mRNA23131501
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of CLDN1 mRNA27404394
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of CLDN1 mRNA20133372
C496197trans-10,cis-12-conjugated linoleic acid"trans-10,cis-12-conjugated linoleic acid results in decreased expression of CLDN1 mRNA"16650747
D014212TretinoinCYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of CLDN1 mRNA]17035595
D014212TretinoinTretinoin results in increased expression of CLDN1 mRNA17035595
D014212TretinoinTretinoin results in increased expression of CLDN1 protein17035595
C032910triadimefontriadimefon results in decreased expression of CLDN1 mRNA26705709
C032910triadimefontriadimefon results in decreased expression of CLDN1 mRNA19423681
C012589trichostatin Atrichostatin A results in decreased expression of CLDN1 mRNA24935251
C012589trichostatin Atrichostatin A results in increased expression of CLDN1 mRNA24935251|2670570
C012589trichostatin Atrichostatin A results in decreased expression of CLDN1 mRNA15901671
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of CLDN1 mRNA19042947
D014302Trinitrobenzenesulfonic Acidginsenoside Re inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of CLDN1 protein]22849695
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in decreased expression of CLDN1 protein22849695
C057693troglitazonetroglitazone results in increased expression of CLDN1 mRNA19140230
C057693troglitazonetroglitazone results in decreased expression of CLDN1 mRNA28973697
C057693troglitazonetroglitazone results in decreased expression of CLDN1 mRNA21515302
D014635Valproic AcidValproic Acid results in decreased expression of CLDN1 mRNA26272509
D014635Valproic AcidValproic Acid results in increased expression of CLDN1 mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in decreased expression of CLDN1 mRNA15901671
C034028vanadyl sulfatevanadyl sulfate results in increased expression of CLDN1 mRNA16330358
D014640VancomycinVancomycin results in decreased expression of CLDN1 mRNA18930951
C025643vinclozolinvinclozolin results in increased expression of CLDN1 mRNA23160963
C029297vinylidene chloridevinylidene chloride results in increased expression of CLDN1 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001618virus receptor activity-IMP20375010  
GO:0005198structural molecule activity-IEA-  
GO:0005515protein binding-IPI20375010  20651236  
GO:0042802identical protein binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007568aging-IEA-  
GO:0008065establishment of blood-nerve barrier-IEA-  
GO:0016338calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules-ISS-  
GO:0032496response to lipopolysaccharide-IEA-  
GO:0042538hyperosmotic salinity response-IEA-  
GO:0045216cell-cell junction organization-IMP20164257  
GO:0045471response to ethanol-IEA-  
GO:0046718viral entry into host cell-IEA-  
GO:0051260protein homooligomerization-IMP25849148  
GO:0051291protein heterooligomerization-IGI25849148  
GO:0061436establishment of skin barrier-IMP23407391  
GO:0061772drug transport across blood-nerve barrier-IEA-  
GO:0070673response to interleukin-18-IEA-  
GO:0070830bicellular tight junction assembly-IMP25849148  
GO:0071284cellular response to lead ion-IEA-  
GO:0071346cellular response to interferon-gamma-IEA-  
GO:0071356cellular response to tumor necrosis factor-IEA-  
GO:0071548response to dexamethasone-IEA-  
GO:0071560cellular response to transforming growth factor beta stimulus-IEA-  
GO:0090557establishment of endothelial intestinal barrier-IEA-  
GO:0097421liver regeneration-IEA-  
GO:1903348positive regulation of bicellular tight junction assembly-IEA-  
GO:1903545cellular response to butyrate-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
GO:0005887integral component of plasma membrane-IMP23407391  
GO:0005923bicellular tight junction-IDA20375010  23407391  25849148  
GO:0005923bicellular tight junction-ISS-  
GO:0016021integral component of membrane-TAS9931503  
GO:0016323basolateral plasma membrane-IDA20375010  
GO:0016324apical plasma membrane-IEA-  
GO:0016328lateral plasma membrane-IEA-  
KEGG ID KEGG Term
hsa04514Cell adhesion molecules (CAMs)
hsa04530Tight junction
hsa04670Leukocyte transendothelial migration
hsa05130Pathogenic Escherichia coli infection
hsa05160Hepatitis C
Reactome ID Reactome Term Evidence
R-HSA-1500931Cell-Cell communicationIEA
R-HSA-420029Tight junction interactionsIEA
R-HSA-421270Cell-cell junction organizationIEA
R-HSA-446728Cell junction organizationIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27687058Claudin-1 Protein Expression Is a Good Prognostic Factor in Non-Small Cell Lung Cancer, but only in Squamous Cell Carcinoma Cases. (2017 Jan)Moldvay JPathol Oncol Res