Gene: IL33

90865
C9orf26|DVS27|IL1F11|NF-HEV|NFEHEV
interleukin 33
protein-coding
9p24.1
Ensembl:ENSG00000137033 MIM:608678 Vega:OTTHUMG00000019516 UniprotKB:O95760
NG_047209.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.317e-1 (AD)  8.922e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SDC20.862
FGF20.857
ARHGEF260.855
BMPR1B0.844
EDNRB0.835
PDLIM50.835
FERMT20.831
SUCLG20.827
RGS200.826
SLC2A100.824

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CACNA1F-0.51
RHO-0.468
THEM5-0.467
TRABD2A-0.464
CALHM1-0.46
OVOL2-0.459
OSBPL10-0.459
IL12RB2-0.455
FAM160A1-0.455
AGMAT-0.453

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of IL33 mRNA"19162173
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of IL33 mRNA19933214
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of IL33 mRNA"19114083
C0131862,3-pentanedione"2,3-pentanedione results in increased expression of IL33 mRNA"25710175
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of IL33 mRNA"16984957
C0230353,4,5,3',4'-pentachlorobiphenyl"[3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of IL33 mRNA"16984957
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of IL33 mRNA"16984957|2095900
C4340033-(4-methylphenylsulfonyl)-2-propenenitrile3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [IL33 protein results in increased expression of CXCL8 mRNA]23585867
C4340033-(4-methylphenylsulfonyl)-2-propenenitrile3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [IL33 protein results in increased expression of CXCL8 protein]23585867
C4340033-(4-methylphenylsulfonyl)-2-propenenitrile3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [IL33 protein results in increased expression of IL1B mRNA]23585867
C4340033-(4-methylphenylsulfonyl)-2-propenenitrile3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [IL33 protein results in increased expression of IL1B protein]23585867
C4340033-(4-methylphenylsulfonyl)-2-propenenitrile3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [IL33 protein results in increased expression of IL6 mRNA]23585867
C4340033-(4-methylphenylsulfonyl)-2-propenenitrile3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [IL33 protein results in increased expression of IL6 protein]23585867
C4340033-(4-methylphenylsulfonyl)-2-propenenitrile3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [IL33 protein results in increased expression of TNF mRNA]23585867
C4340033-(4-methylphenylsulfonyl)-2-propenenitrile3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [IL33 protein results in increased expression of TNF protein]23585867
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of IL33 mRNA"25380136
D000082AcetaminophenAcetaminophen results in decreased expression of IL33 mRNA27761495
D000082AcetaminophenAcetaminophen affects the expression of IL33 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of IL33 mRNA28959563
D000276Adjuvants, Immunologic"Adjuvants, Immunologic results in increased secretion of IL33 protein"22967010
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of IL33 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of IL33 mRNA21641981
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of IL33 mRNA19770486
D000393Air PollutantsAir Pollutants results in decreased expression of IL33 mRNA25056781
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in increased expression of IL33 protein"25172162
D000395Air Pollutants, Occupational"TLR4 protein affects the reaction [Air Pollutants, Occupational results in increased expression of IL33 protein]"25172162
D000485AllergensAllergens results in increased expression of IL33 protein25015831
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of IL33 mRNA28522335
D000535AluminumAluminum results in increased secretion of IL33 protein22967010
D000638AmiodaroneAmiodarone affects the expression of IL33 mRNA18355885
D000639AmitriptylineAmitriptyline affects the expression of IL33 mRNA18355885
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of IL33 mRNA"28865757
D039741Antigens, Dermatophagoides"Antigens, Dermatophagoides results in increased expression of IL33 protein"26304032
D039741Antigens, Dermatophagoides"Oligosaccharides analog inhibits the reaction [Antigens, Dermatophagoides results in increased expression of IL33 mRNA]"26304032
D039741Antigens, Dermatophagoides"Oligosaccharides analog inhibits the reaction [Antigens, Dermatophagoides results in increased expression of IL33 protein]"26304032
D039741Antigens, Dermatophagoides"[Particulate Matter co-treated with Antigens, Dermatophagoides] results in increased expression of IL33 protein"27315767
D039741Antigens, Dermatophagoides"[Vehicle Emissions co-treated with Antigens, Dermatophagoides] results in increased expression of IL33 protein"27315767
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of IL3320472598
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of IL33 mRNA"25757056
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of IL33 mRNA20660070
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of IL33 mRNA17404688
D004958EstradiolEstradiol results in increased expression of IL33 mRNA19484750
C006780bisphenol Abisphenol A affects the expression of IL33 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of IL33 mRNA25993096
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of IL33 mRNA]16221973
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of IL33 mRNA18178546
D002737ChloropreneChloroprene results in decreased expression of IL33 mRNA23125180
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of IL33 mRNA28472532
D002997ClomipramineClomipramine affects the expression of IL33 mRNA18355885
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in decreased expression of IL33 mRNA15467011
D013759DronabinolDronabinol results in decreased expression of IL33 mRNA16616335
C007262deoxynivalenoldeoxynivalenol results in increased expression of IL33 mRNA26304032
C007262deoxynivalenoldeoxynivalenol results in increased expression of IL33 protein26304032
C007262deoxynivalenolOligosaccharides analog inhibits the reaction [deoxynivalenol results in increased expression of IL33 mRNA]26304032
C007262deoxynivalenolOligosaccharides analog inhibits the reaction [deoxynivalenol results in increased expression of IL33 protein]26304032
D003907DexamethasoneDexamethasone results in decreased expression of IL33 mRNA22733784
D002945CisplatinCD4 mutant form inhibits the reaction [[Cisplatin co-treated with IL33] results in increased expression of CXCL1]21949094
D002945Cisplatin[Cisplatin co-treated with IL33] results in increased expression of CXCL121949094
D002945CisplatinCisplatin results in increased expression of IL33 protein21949094
D004008DiclofenacDiclofenac results in decreased expression of IL33 mRNA26934552
D004008DiclofenacDiclofenac results in increased expression of IL33 mRNA26934552
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of IL33 mRNA24535843
D002117CalcitriolCalcitriol results in increased expression of IL33 mRNA26485663
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of IL33 mRNA"19480007
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of IL33 mRNA25380136
D004237DiuronDiuron metabolite results in increased expression of IL33 mRNA24172598
D004237DiuronDiuron results in decreased expression of IL33 mRNA21551480|2515243
D000431Ethanol[Fish Oils co-treated with Ethanol] results in increased expression of IL33 mRNA17347304
D005395Fish Oils[Fish Oils co-treated with Ethanol] results in increased expression of IL33 mRNA17347304
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in increased expression of IL33 mRNA17317680
D005485FlutamideFlutamide results in decreased expression of IL33 mRNA24136188|2479361
D005492Folic Acid[Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of IL33 mRNA22975265
D005557FormaldehydeFormaldehyde results in decreased expression of IL33 mRNA27664576
C069837fullerene C60fullerene C60 results in decreased expression of IL33 mRNA19167457
C039281furanfuran results in increased methylation of IL33 gene22079235
D005944GlucosamineGlucosamine results in decreased expression of IL33 mRNA17109745
D005978GlutathioneGlutathione deficiency results in increased expression of IL33 mRNA20621112
C010974glyphosateglyphosate results in increased expression of IL33 protein25172162
C010974glyphosateIL13 protein affects the reaction [glyphosate results in increased expression of IL33 protein]25172162
D017313FenretinideFenretinide results in increased expression of IL33 mRNA28973697
D007099ImipramineImipramine affects the expression of IL33 mRNA18355885
C016517indole-3-carbinolindole-3-carbinol affects the expression of IL33 mRNA21396975
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL33 mRNA25613284
C544151jinfukangjinfukang results in increased expression of IL33 mRNA27392435
D007654KetoconazoleKetoconazole affects the expression of IL33 mRNA18355885
D007840LatexLatex analog results in increased expression of IL33 mRNA24768652
C045463leflunomideleflunomide results in decreased expression of IL33 mRNA24136188
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL33 protein"25980587
C440499lipopolysaccharide, Escherichia coli O111 B4"vinpocetine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL33 protein]"25980587
D008628MercuryMercury analog results in decreased expression of IL33 mRNA25056781
C523799MRK 003IL33 results in decreased susceptibility to MRK 00319903844
C500085muraglitazarmuraglitazar results in decreased expression of IL33 mRNA21515302
D009151Mustard GasMustard Gas affects the expression of IL33 mRNA15651846
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of IL33 mRNA"25511174
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of IL33 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of IL33 mRNA"22293422|2555468
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased secretion of IL33 protein"19371758
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of IL33 mRNA25380136
C051752nefazodonenefazodone results in decreased expression of IL33 mRNA24136188
D009532NickelNickel results in decreased expression of IL33 mRNA24768652
C028007nickel monoxidenickel monoxide results in decreased expression of IL33 mRNA19167457
C002741N-nitrosomorpholineN-nitrosomorpholine results in decreased expression of IL33 mRNA19716841
D009844Oligosaccharides"Oligosaccharides analog inhibits the reaction [Antigens, Dermatophagoides results in increased expression of IL33 mRNA]"26304032
D009844Oligosaccharides"Oligosaccharides analog inhibits the reaction [Antigens, Dermatophagoides results in increased expression of IL33 protein]"26304032
D009844OligosaccharidesOligosaccharides analog inhibits the reaction [deoxynivalenol results in increased expression of IL33 mRNA]26304032
D009844OligosaccharidesOligosaccharides analog inhibits the reaction [deoxynivalenol results in increased expression of IL33 protein]26304032
D009966OrphenadrineOrphenadrine affects the expression of IL33 mRNA23665939
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of IL33 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of IL33 mRNA25729387
D010126OzoneLEP protein affects the reaction [Ozone results in increased expression of IL33 protein]27472835
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of IL33 mRNA25658374
D010126OzoneOzone results in decreased expression of IL33 mRNA17095637
D010126OzoneOzone results in increased expression of IL33 protein27472835
D052638Particulate Matter"[Particulate Matter co-treated with Antigens, Dermatophagoides] results in increased expression of IL33 protein"27315767
D000068437Pemetrexed[Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of IL33 mRNA22975265
C046012pentanalpentanal results in increased expression of IL33 mRNA26079696
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of IL33 mRNA27153767
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of IL33 mRNA19162173
D010476PerfumePerfume results in decreased expression of IL33 mRNA24768652
D010634PhenobarbitalPhenobarbital results in decreased expression of IL33 mRNA19162173
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of IL33 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of IL33 mRNA17426115|2081375
C006253pirinixic acidpirinixic acid results in decreased expression of IL33 mRNA19162173
C060540polyhexamethyleneguanidinepolyhexamethyleneguanidine results in increased expression of IL33 protein29175452
D011192Potassium DichromatePotassium Dichromate results in increased expression of IL33 mRNA23608068
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of IL33 mRNA19162173
D011374ProgesteroneProgesterone results in increased expression of IL33 mRNA23012394
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of IL33 mRNA20660070
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of IL33 mRNA17404688
D011374ProgesteroneProgesterone results in decreased expression of IL33 mRNA17404688
D011374ProgesteroneProgesterone results in increased expression of IL33 mRNA21770760
D011441PropylthiouracilPropylthiouracil results in increased expression of IL33 mRNA24780913
D011799QuinazolinesQuinazolines inhibits the reaction [IL33 protein results in increased expression of CXCL8 mRNA]23585867
D011799QuinazolinesQuinazolines inhibits the reaction [IL33 protein results in increased expression of CXCL8 protein]23585867
D011799QuinazolinesQuinazolines inhibits the reaction [IL33 protein results in increased expression of IL1B mRNA]23585867
D011799QuinazolinesQuinazolines inhibits the reaction [IL33 protein results in increased expression of IL1B protein]23585867
D011799QuinazolinesQuinazolines inhibits the reaction [IL33 protein results in increased expression of IL6 mRNA]23585867
D011799QuinazolinesQuinazolines inhibits the reaction [IL33 protein results in increased expression of IL6 protein]23585867
D011799QuinazolinesQuinazolines inhibits the reaction [IL33 protein results in increased expression of TNF mRNA]23585867
D011799QuinazolinesQuinazolines inhibits the reaction [IL33 protein results in increased expression of TNF protein]23585867
D011799QuinazolinesQuinazolines inhibits the reaction [IL33 protein results in increased phosphorylation of and results in increased localization of and results in increased activity of RELA protein]23585867
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of IL33 mRNA23806026
D012822Silicon DioxideSilicon Dioxide results in increased expression of IL33 mRNA23221170
C016104sodium bichromatesodium bichromate results in increased expression of IL33 mRNA22155349
C016104sodium bichromatesodium bichromate results in increased expression of IL33 mRNA22561333
D053260SootSoot results in increased expression of IL33 mRNA22461453|2655175
C075117squalestatin 1squalestatin 1 results in decreased expression of IL33 mRNA27225895
C075117squalestatin 1squalestatin 1 results in decreased expression of IL33 mRNA27225895
C501413tesaglitazartesaglitazar results in decreased expression of IL33 mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of IL33 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of IL33 mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of IL33 mRNA18178546|2095900
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL33 mRNA25613284
D013853ThioacetamideThioacetamide results in decreased expression of IL33 mRNA23411599
C009495titanium dioxidetitanium dioxide results in increased expression of IL33 mRNA23409001|2355797
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of IL33 mRNA28111298
D014050TolueneToluene results in decreased expression of IL33 mRNA22967744
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of IL33 mRNA25729387
D019772TopotecanTopotecan results in increased expression of IL33 mRNA25729387
D014260TriclosanTriclosan results in decreased expression of IL33 protein26048654
D014260TriclosanTriclosan results in decreased expression of IL33 protein26048654
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of IL33 mRNA19042947
C057693troglitazonetroglitazone results in increased expression of IL33 mRNA21515302
D014612VaccinesIL33 gene mutant form affects the susceptibility to Vaccines22967010
D014635Valproic AcidValproic Acid results in decreased methylation of IL33 gene29154799
D001335Vehicle Emissions"[Vehicle Emissions co-treated with Antigens, Dermatophagoides] results in increased expression of IL33 protein"27315767
C025643vinclozolinvinclozolin affects the expression of IL33 mRNA19015723
C013983vinpocetine"vinpocetine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL33 protein]"25980587

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005125cytokine activity-IBA21873635  
GO:0005125cytokine activity-IDA19841166  
GO:0005515protein binding-IPI16286016  18688256  
GO ID GO Term Qualifier Evidence PubMed
GO:0001819positive regulation of cytokine production-IBA21873635  
GO:0002282microglial cell activation involved in immune response-IEA-  
GO:0002686negative regulation of leukocyte migration-IEA-  
GO:0002826negative regulation of T-helper 1 type immune response-IEA-  
GO:0002830positive regulation of type 2 immune response-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0016579protein deubiquitination-TAS-  
GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process-IEA-  
GO:0032689negative regulation of interferon-gamma production-IEA-  
GO:0032736positive regulation of interleukin-13 production-IEA-  
GO:0032753positive regulation of interleukin-4 production-IEA-  
GO:0032754positive regulation of interleukin-5 production-IEA-  
GO:0032755positive regulation of interleukin-6 production-IEA-  
GO:0038172interleukin-33-mediated signaling pathway-TAS-  
GO:0043032positive regulation of macrophage activation-IDA19841166  
GO:0045944positive regulation of transcription by RNA polymerase II-ISS19841166  
GO:0050729positive regulation of inflammatory response-IBA21873635  
GO:0050729positive regulation of inflammatory response-ISS19841166  
GO:0051024positive regulation of immunoglobulin secretion-IEA-  
GO:0051025negative regulation of immunoglobulin secretion-IEA-  
GO:0051607defense response to virus-IEA-  
GO:0061518microglial cell proliferation-IEA-  
GO:0090197positive regulation of chemokine secretion-IDA19841166  
GO:0097191extrinsic apoptotic signaling pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IEA-  
GO:0005654nucleoplasm-TAS-  
GO:0005694chromosome-IEA-  
GO:0030133transport vesicle-IEA-  
KEGG ID KEGG Term
hsa04623Cytosolic DNA-sensing pathway
Reactome ID Reactome Term Evidence
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-162582Signal TransductionTAS
R-HSA-168256Immune SystemTAS
R-HSA-199418Negative regulation of the PI3K/AKT networkTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-446652Interleukin-1 family signalingTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-5688426DeubiquitinationTAS
R-HSA-5689880Ub-specific processing proteasesTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6811558PI5P, PP2A and IER3 Regulate PI3K/AKT SignalingTAS
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-9014843Interleukin-33 signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25673187Association of IL33/ST2 signal pathway gene polymorphisms with myocardial infarction in a Chinese Han population. (2015 Feb)Yang JHJ Huazhong Univ Sci Technolog Med Sci
27058054Asthma susceptibility variants are more strongly associated with clinically similar subgroups. (2016 Nov)Lavoie-Charland EJ Asthma