Gene: PKMYT1

9088
MYT1|PPP1R126
protein kinase, membrane associated tyrosine/threonine 1
protein-coding
16p13.3
Ensembl:ENSG00000127564 MIM:602474 Vega:OTTHUMG00000128975 UniprotKB:Q99640
NC_000016.10
PubMed
0   ANCO-SNPs
AD
0   
8.356e-1 (AD)  3.459e-1 (ND)   (Frontal_Cortex)
1.895e-1 (AD)  6.742e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BRF10.764
SEMA7A0.757
PKD10.755
TECPR10.755
TRIM30.755
PAQR40.754
ZNF7750.754
GGT70.751
ZNF6960.749
KLC40.748

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FAM89A-0.406
PHEX-0.399
YES1-0.395
LRAT-0.394
MTRNR2L10-0.39
ARHGEF35-0.382
PROK2-0.378
ALAS2-0.375
CXCR2-0.374
EGFLAM-0.372

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of PKMYT1 mRNA"22698814|2890350
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of PKMYT1 mRNA"19167446
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of PKMYT1 mRNA"21346803
D000082AcetaminophenAcetaminophen results in increased expression of PKMYT1 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of PKMYT1 mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of PKMYT1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PKMYT1 mRNA22100608
D047310ApigeninApigenin results in decreased expression of PKMYT1 mRNA22359648
C006632arsenic trioxidearsenic trioxide results in decreased expression of PKMYT1 mRNA20458559
C006632arsenic trioxidearsenic trioxide results in increased expression of PKMYT1 mRNA20862710
D001280AtrazineAtrazine results in increased expression of PKMYT1 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PKMYT1 mRNA20064835
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of PKMYT1 mRNA"19150397
C006780bisphenol Abisphenol A results in decreased expression of PKMYT1 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of PKMYT1 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of PKMYT1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of PKMYT1 gene28505145
C584509C646 compoundC646 compound results in decreased expression of PKMYT1 mRNA26191083
D002104CadmiumCadmium results in increased expression of PKMYT1 mRNA24376830
D002509CephaloridineCephaloridine results in increased expression of PKMYT1 mRNA18500788
C018021cobaltous chloridecobaltous chloride results in increased expression of PKMYT1 mRNA24386269
D019327Copper SulfateCopper Sulfate affects the expression of PKMYT1 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of PKMYT1 mRNA"19167446
D003375CoumestrolCoumestrol results in increased expression of PKMYT1 mRNA19167446
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of PKMYT1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of PKMYT1 mRNA27594783
D002117CalcitriolCalcitriol results in decreased expression of PKMYT1 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of PKMYT1 mRNA21592394
C039281furanfuran results in increased expression of PKMYT1 mRNA25539665
C039281furanfuran results in increased methylation of PKMYT1 gene22079235
C004312glycidolglycidol results in increased expression of PKMYT1 mRNA24915197
D017313FenretinideFenretinide results in decreased expression of PKMYT1 mRNA28973697
D006997Hypochlorous AcidHypochlorous Acid results in decreased expression of PKMYT1 mRNA19376150
C492448ICG 001ICG 001 results in decreased expression of PKMYT1 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PKMYT1 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of PKMYT1 mRNA27392435
C544151jinfukangjinfukang results in increased expression of PKMYT1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PKMYT1 mRNA24796395
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of PKMYT1 mRNA"26251327
C568376MT19c compoundMT19c compound results in decreased expression of PKMYT1 mRNA21781307
C025589ochratoxin Aochratoxin A results in increased expression of PKMYT1 mRNA25636497
C025589ochratoxin ATRP53 gene mutant form promotes the reaction [ochratoxin A results in increased expression of PKMYT1 mRNA]25636497
D010100OxygenOxygen deficiency results in decreased expression of PKMYT1 mRNA26516004
D010634PhenobarbitalPhenobarbital affects the expression of PKMYT1 mRNA19136022
C006253pirinixic acidpirinixic acid affects the expression of PKMYT1 mRNA19136022
C006253pirinixic acidpirinixic acid results in increased expression of PKMYT1 mRNA23811191
D010936Plant ExtractsPlant Extracts results in decreased expression of PKMYT1 mRNA23557933
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of PKMYT1 mRNA22698814
D011441PropylthiouracilPropylthiouracil results in increased expression of PKMYT1 mRNA24780913
D011794QuercetinQuercetin results in increased expression of PKMYT1 mRNA21632981
D019821SimvastatinSimvastatin results in decreased expression of PKMYT1 mRNA17428261
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of PKMYT1 mRNA"26680231
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of PKMYT1 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of PKMYT1 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PKMYT1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PKMYT1 mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PKMYT1 mRNA25613284
D019284ThapsigarginThapsigargin results in decreased expression of PKMYT1 mRNA22378314
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased methylation of PKMYT1 gene26756918
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of PKMYT1 mRNA19042947
C057693troglitazonetroglitazone results in decreased expression of PKMYT1 mRNA19140230
D014415TunicamycinTunicamycin results in decreased expression of PKMYT1 mRNA22378314
D014635Valproic AcidValproic Acid results in increased methylation of PKMYT1 gene29154799
D014638VanadatesVanadates results in increased expression of PKMYT1 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of PKMYT1 gene25560391
D015215Zidovudine[Zidovudine co-treated with IFNA1 protein] results in decreased expression of PKMYT1 mRNA20370541

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004672protein kinase activity-IBA21873635  
GO:0004672protein kinase activity-TAS9001210  
GO:0004674protein serine/threonine kinase activity-IEA-  
GO:0005515protein binding-IPI10373560  23397142  23602568  25852190  26496610  
GO:0005524ATP binding-IEA-  
GO:0016301kinase activity-IDA9268380  
GO:0016301kinase activity-TAS-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity-TAS9001210  
GO:0000086G2/M transition of mitotic cell cycle-TAS-  
GO:0000278mitotic cell cycle-TAS9001210  
GO:0006468protein phosphorylation-IEA-  
GO:0007088regulation of mitotic nuclear division-TAS9001210  
GO:0010923negative regulation of phosphatase activity-IDA19389623  
GO:0051321meiotic cell cycle-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-IEA-  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005730nucleolus-IDA-  
GO:0005783endoplasmic reticulum-TAS9001210  
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0005794Golgi apparatus-IDA-  
GO:0005829cytosol-TAS-  
GO:0016020membrane-HDA19946888  
KEGG ID KEGG Term
hsa04110Cell cycle
hsa04114Oocyte meiosis
hsa04914Progesterone-mediated oocyte maturation
Reactome ID Reactome Term Evidence
R-HSA-156711Polo-like kinase mediated eventsTAS
R-HSA-1640170Cell CycleTAS
R-HSA-1640170Cell CycleIEA
R-HSA-453274Mitotic G2-G2/M phasesTAS
R-HSA-453274Mitotic G2-G2/M phasesIEA
R-HSA-69273Cyclin A/B1/B2 associated events during G2/M transitionTAS
R-HSA-69273Cyclin A/B1/B2 associated events during G2/M transitionIEA
R-HSA-69275G2/M TransitionTAS
R-HSA-69275G2/M TransitionIEA
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-69278Cell Cycle, MitoticIEA
R-HSA-69478G2/M DNA replication checkpointTAS
R-HSA-69481G2/M CheckpointsTAS
R-HSA-69620Cell Cycle CheckpointsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal