Gene: CD1A

909
CD1|FCB6|HTA1|R4|T6
CD1a molecule
protein-coding
1q23.1
Ensembl:ENSG00000158477 MIM:188370 Vega:OTTHUMG00000017512 UniprotKB:P06126
NC_000001.11
PubMed
ND
43   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.229e-1 (AD)  9.583e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLDN80.532
OR6C10.51
WDR720.505
OR4L10.5
DNAJB30.499
TRIM64C0.487
OR4N50.478
TMEM2390.477
TP630.474
OR4M20.472

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZNF488-0.298
C16orf46-0.281
TENM4-0.261
PAQR4-0.256
THAP8-0.256
BOLA1-0.255
PCDH9-0.254
SRD5A3-0.253
PCDHB10-0.251
SLC13A3-0.25

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00098Antithymocyte immunoglobulin (rabbit)BiotechDrugApprovedTarget
ID Drug Name Action PubMed
C02835824,25-epoxycholesterol"24,25-epoxycholesterol results in decreased expression of CD1A protein"17475839
C4574992-chloro-5-nitrobenzanilide2-chloro-5-nitrobenzanilide inhibits the reaction [alitretinoin results in decreased expression of CD1A protein]17475839
C4574992-chloro-5-nitrobenzanilide2-chloro-5-nitrobenzanilide inhibits the reaction [rosiglitazone results in decreased expression of CD1A protein]17475839
C0541893,5-di-tert-butylchalcone 4'-carboxylic acid"3,5-di-tert-butylchalcone 4'-carboxylic acid results in decreased expression of CD1A protein"17475839
D000082AcetaminophenAcetaminophen results in decreased expression of CD1A mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of CD1A gene27153756
C103303alitretinoin2-chloro-5-nitrobenzanilide inhibits the reaction [alitretinoin results in decreased expression of CD1A protein]17475839
C103303alitretinoin[alitretinoin co-treated with rosiglitazone] results in decreased expression of CD1A protein17475839
C103303alitretinoinalitretinoin results in decreased expression of CD1A protein17475839
C103303alitretinoinHX 630 inhibits the reaction [alitretinoin results in decreased expression of CD1A protein]17475839
D000534Alum CompoundsAlum Compounds inhibits the reaction [[CSF2 protein co-treated with IL4 protein] results in increased expression of CD1A protein]18390722
D000536Aluminum HydroxideAluminum Hydroxide inhibits the reaction [[CSF2 protein co-treated with IL4 protein] results in increased expression of CD1A protein]18390722
C068073Am 580Am 580 results in decreased expression of CD1A mRNA16982809
D001151ArsenicArsenic affects the expression of CD1A mRNA28793237
D001151Arsenic[Arsenic results in increased abundance of Cacodylic Acid] which affects the expression of CD1A mRNA28793237
D002101Cacodylic Acid[Arsenic results in increased abundance of Cacodylic Acid] which affects the expression of CD1A mRNA28793237
D002104CadmiumCadmium results in decreased expression of CD1A mRNA24376830
C422175HX 630HX 630 inhibits the reaction [alitretinoin results in decreased expression of CD1A protein]17475839
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of CD1A protein"25680285
D008070LipopolysaccharidesLipopolysaccharides inhibits the reaction [[CSF2 protein co-treated with IL4 protein] results in increased expression of CD1A protein]18390722
C480546lupanelupane results in increased expression of CD1A protein16388738
D008727MethotrexateMethotrexate results in decreased expression of CD1A mRNA24449571
C089950MF59 oil emulsionMF59 oil emulsion inhibits the reaction [[CSF2 protein co-treated with IL4 protein] results in increased expression of CD1A protein]18390722
C089730rosiglitazone2-chloro-5-nitrobenzanilide inhibits the reaction [rosiglitazone results in decreased expression of CD1A protein]17475839
C089730rosiglitazone[alitretinoin co-treated with rosiglitazone] results in decreased expression of CD1A protein17475839
C089730rosiglitazonerosiglitazone results in decreased expression of CD1A mRNA16982809
C089730rosiglitazonerosiglitazone results in decreased expression of CD1A protein17475839
C017947sodium arsenitesodium arsenite inhibits the reaction [[TNF protein co-treated with CSF2 protein] results in increased expression of CD1A protein]23164666

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI12833155  15723809  
GO:0030883endogenous lipid antigen binding-IBA21873635  
GO:0030884exogenous lipid antigen binding-IBA21873635  
GO:0071723lipopeptide binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001916positive regulation of T cell mediated cytotoxicity-IBA21873635  
GO:0002250adaptive immune response-IEA-  
GO:0006955immune response-IBA21873635  
GO:0006955immune response-NAS2447586  
GO:0048006antigen processing and presentation, endogenous lipid antigen via MHC class Ib-IBA21873635  
GO:0048007antigen processing and presentation, exogenous lipid antigen via MHC class Ib-IBA21873635  
GO:0050776regulation of immune response-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-NAS2447586  
GO:0009986cell surface-IBA21873635  
GO:0010008endosome membrane-IEA-  
GO:0045121membrane raft-IEA-  
KEGG ID KEGG Term
hsa04640Hematopoietic cell lineage
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-198933Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22261033Cigarette smoke induction of osteopontin (SPP1) mediates T(H)17 inflammation in human and experimental emphysema. (2012 Jan 18)Shan MSci Transl Med
17144589[A case of pulmonary Langerhans cell histiocytosis discovered by CT mass screening and followed by bronchoalveolar lavage]. (2006 Nov)Watanabe HNihon Kokyuki Gakkai Zasshi
28352790A confusing case report of pulmonary langerhans cell histiocytosis and literature review. (2016)Li YOpen Med (Wars)
11402847[Histopathological aspects of Langerhans cell histiocytosis. With emphasis on the pulmonary form]. (2001 May)Harms DPathologe
25172546Effect of smoking on immunity in human chronic periodontitis. (2014 Dec)Souto GRImmunobiology
26546473Smoking habits and clinical patterns can alter the inflammatory infiltrate in oral lichenoid lesions. (2016 Jan)Alrashdan MSOral Surg Oral Med Oral Pathol Oral Radiol
11732289[Pulmonary Langerhans cell histiocytosis--clinicopathologic analysis of 7 cases]. (2001)Elzbieta RPneumonol Alergol Pol
17925605Monocyte-derived dendritic cells of patients with coronary artery disease show an increased expression of costimulatory molecules CD40, CD80 and CD86 in vitro. (2007 Nov)Dopheide JFCoron Artery Dis
27816338[Adult Langerhans cell histiocytosis]. (2017 Jan)de Menthon MPresse Med
28123731Bone Langerhans cell histiocytosis with pulmonary involvement in an adult non-smoker: A case report and brief review of the literature. (2017 Jan)Shen JMol Clin Oncol
15468972Pulmonary Langerhans cell histiocytosis associated with lingual carcinoma. (2004 Aug)Tsuji TIntern Med
14531308[A case of pulmonary Langerhans' cell histiocytosis]. (2003 Sep)Sakai KNihon Kokyuki Gakkai Zasshi
17303795Cigarette smoking alters bronchial mucosal immunity in asthma. (2007 May 1)Tsoumakidou MAm J Respir Crit Care Med
8164153Langerhans cell density in normal human oral mucosa and skin: relationship to age, smoking and alcohol consumption. (1994 Feb)Cruchley ATJ Oral Pathol Med
20307269Selective accumulation of langerhans-type dendritic cells in small airways of patients with COPD. (2010 Mar 22)Van Pottelberge GRRespir Res
29083024Pulmonary Langerhans' cell histiocytosis in adults. (2017)Radzikowska EAdv Respir Med
27692140Bronchoalveolar lavage for the diagnosis of Pulmonary Langerhans cell histiocytosis. (2016 Oct)Lommatzsch MRespir Med
28877978How I manage pulmonary Langerhans cell histiocytosis. (2017 Sep 30)Lorillon GEur Respir Rev
28689173Current understanding and management of pulmonary Langerhans cell histiocytosis. (2017 Oct)Vassallo RThorax
25351656Establishment of a Langerhans cell histiocytosis lesion cell line with dermal dendritic cell characteristics. (2015 Jan)Murakami IOncol Rep
16502866[A case of Langerhans cell histiocytosis which resolved only on smoking cessation]. (2006 Jan)Noma SNihon Kokyuki Gakkai Zasshi
19035226[Clinical features of adult pulmonary Langerhans' cell histiocytosis]. (2008 Jul)Ye QZhonghua Jie He He Hu Xi Za Zhi
29023924A decreased peritumoral CD1a+ cell number predicts a worse prognosis in oral squamous cell carcinoma. (2018 May)Jardim JFHistopathology
18203971Function-associated surface molecules on airway dendritic cells in cigarette smokers. (2008 Jun)Bratke KAm J Respir Cell Mol Biol
29250688Pulmonary Langerhans cell histiocytosis in a 26-year-old female: still a diagnostic challenge. (2017)Ianosi ESRom J Morphol Embryol
17536561Pulmonary langerhans cell histiocytosis (histiocytosis X) on bronchoalveolar lavage: a report of 2 cases. (2007 May-Jun)Zeppa PActa Cytol
11587096Pulmonary Langerhans cell Histiocytosis. (2001 Oct)Harari SSarcoidosis Vasc Diffuse Lung Dis
20715667Pulmonary langerhans cell histiocytosis diagnosed in a cervical lymph node: a case report. (2010 Jul-Aug)Scuderi RTActa Cytol
21054228Effect of smoking on Langerhans and dendritic cells in patients with chronic gingivitis. (2011 Apr)Souto GRJ Periodontol
29404095A Case of Langerhans Cell Histiocytosis with Atypical Radiological Presentation. (2015 Jul)Turk MTurk Thorac J
15566009[A case of pulmonary Langerhans' cell histiocytosis with liver involvement]. (2004 Oct)Nagai SNihon Kokyuki Gakkai Zasshi
9419104Laryngeal melanosis: report of four cases and literature review. (1997 Dec)Gonzalez-Vela MCOtolaryngol Head Neck Surg
15330806Desquamative interstitial pneumonia, respiratory bronchiolitis and their relationship to smoking. (2004 Sep)Craig PJHistopathology
25973117Pulmonary Langerhans cell histiocytosis with cervical lymph node involvement, and coexistence with pulmonary tuberculosis and right pneumothorax: a case report and review of literature. (2015)Gao LInt J Clin Exp Pathol
24162113Utility of bronchoscopy in pulmonary Langerhans cell histiocytosis. (2013 Oct)Baqir MJ Bronchology Interv Pulmonol
20819500Quantitative differentiation of dendritic cells in lung tissues of smokers with and without chronic obstructive pulmonary disease. (2010 Jun)Su YWChin Med J (Engl)
8735863Increased numbers of dendritic cells in the bronchial mucosa of atopic asthmatic patients: downregulation by inhaled corticosteroids. (1996 May)Moller GMClin Exp Allergy
16050471[A case of pulmonary langerhans cell histiocytosis presenting disappearance of coalescing air wall cysts after smoking cessation]. (2005 Jul)Okubo FNihon Kokyuki Gakkai Zasshi
25899682Pulmonary Langerhans cell histiocytosis: a comprehensive analysis of 40 patients and literature review. (2015 Jun)Elia DEur J Intern Med
9989877Lymphocytes and dendritic cells in the normal uterine cervix. An immunohistochemical study. (1998 Dec)Poppe WAEur J Obstet Gynecol Reprod Biol
16778410Langerhans cell sarcoma arising from Langerhans cell histiocytosis: a case report. (2006 Jun)Lee JSJ Korean Med Sci
21485154[Pulmonary Langerhans cell histiocytosis in a non-smoking Japanese woman]. (2011 Mar)Tadokoro ANihon Kokyuki Gakkai Zasshi
25433492Effectiveness of cladribine therapy in patients with pulmonary Langerhans cell histiocytosis. (2014 Nov 30)Grobost VOrphanet J Rare Dis