Gene: SART1

9092
Ara1|HAF|HOMS1|SART1259|SNRNP110|Snu66
SART1, U4/U6.U5 tri-snRNP-associated protein 1
protein-coding
11q13.1
Ensembl:ENSG00000175467 MIM:605941 Vega:OTTHUMG00000166771 UniprotKB:O43290
NC_000011.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.095e-1 (AD)  1.723e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PAF10.931
ADRM10.929
SAFB0.927
FAM50A0.926
GPS20.917
XAB20.911
SRSF40.911
PRPF60.911
SUPT5H0.909
EIF3B0.908

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.732
OR4F5-0.718
MTRNR2L9-0.298
MTRNR2L6-0.287
MTRNR2L10-0.259
OR4F16-0.242
TTLL10-AS1-0.241
SCNN1B-0.206
MTRNR2L3-0.203
TTLL10-0.202

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of SART1 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of SART1 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of SART1 mRNA"18648102
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of SART1 mRNA"21346803
D000082AcetaminophenAcetaminophen affects the expression of SART1 mRNA17562736
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SART1 mRNA16483693
D001151ArsenicArsenic affects the methylation of SART1 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SART1 mRNA20498004
C006780bisphenol Abisphenol A results in increased expression of SART1 mRNA12075121|2518105
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SART1 gene20938992
D003042CocaineCocaine affects the expression of SART1 mRNA20187946
D016572CyclosporineCyclosporine results in increased expression of SART1 mRNA25562108
D003976DiazinonDiazinon affects the expression of SART1 mRNA22546817
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SART1 mRNA17361019|2126653
D002945CisplatinCisplatin results in decreased expression of SART1 mRNA27392435
D004026DieldrinDieldrin affects the expression of SART1 mRNA22546817
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of SART1 protein23301498
D000431EthanolEthanol results in increased expression of SART1 mRNA19167417
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of SART1 mRNA29097150
D005485FlutamideFlutamide results in increased expression of SART1 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SART1 gene20938992
D015759Ionomycinpyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SART1 mRNA]15477007
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SART1 mRNA15477007
D007657Ketone BodiesKetone Bodies results in increased expression of SART1 mRNA16807920
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SART1 gene20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SART1 mRNA26011545
C022838nickel chloridenickel chloride affects the expression of SART1 mRNA22546817
D010936Plant ExtractsPlant Extracts results in increased expression of SART1 mRNA23557933
C020972pyrrolidine dithiocarbamic acidpyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SART1 mRNA]15477007
D011794QuercetinQuercetin results in decreased expression of SART1 mRNA15309432
D012643SeleniumSelenium results in increased expression of SART1 mRNA19244175
D018038Sodium SeleniteSodium Selenite results in increased expression of SART1 mRNA18175754
D013629TamoxifenTamoxifen results in decreased expression of SART1 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SART1 mRNA21570461
D013755Tetradecanoylphorbol Acetatepyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SART1 mRNA]15477007
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SART1 mRNA15477007
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of SART1 mRNA28065790
D014635Valproic AcidValproic Acid affects the expression of SART1 mRNA17292431|1796380
C025643vinclozolinvinclozolin results in increased expression of SART1 mRNA23869203

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  22681889  
GO:0005515protein binding-IPI15620657  17000644  20467437  22365833  25092792  
GO ID GO Term Qualifier Evidence PubMed
GO:0000387spliceosomal snRNP assembly-TAS16687569  
GO:0000398mRNA splicing, via spliceosome-IC11991638  
GO:0000398mRNA splicing, via spliceosome-IDA28781166  
GO:0000398mRNA splicing, via spliceosome-TAS-  
GO:0000481maturation of 5S rRNA-IBA21873635  
GO:0045292mRNA cis splicing, via spliceosome-IBA21873635  
GO:0045585positive regulation of cytotoxic T cell differentiation-IDA10209962  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA28781166  
GO:0005654nucleoplasm-IDA16687569  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-TAS9856836  
GO:0005794Golgi apparatus-IDA-  
GO:0005829cytosol-TAS10929426  
GO:0015030Cajal body-IDA16687569  
GO:0016607nuclear speck-IDA-  
GO:0046540U4/U6 x U5 tri-snRNP complex-IBA21873635  
GO:0071005U2-type precatalytic spliceosome-IDA28781166  
GO:0071013catalytic step 2 spliceosome-IDA11991638  
KEGG ID KEGG Term
hsa03040Spliceosome
Reactome ID Reactome Term Evidence
R-HSA-72163mRNA Splicing - Major PathwayTAS
R-HSA-72172mRNA SplicingTAS
R-HSA-72203Processing of Capped Intron-Containing Pre-mRNATAS
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21695249Identification of novel SNPs in glioblastoma using targeted resequencing. (2011)Keller APLoS One