Gene: USP2

9099
UBP41|USP9
ubiquitin specific peptidase 2
protein-coding
11q23.3
Ensembl:ENSG00000036672 MIM:604725 Vega:OTTHUMG00000166200 UniprotKB:O75604
NG_029825.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.853e-1 (AD)  2.289e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg26077811chr11:119232263USP22.000e-13Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GTF3C10.868
ZFYVE280.867
NAGPA0.864
MEN10.861
URGCP0.86
DBN10.858
NCLN0.858
CABIN10.858
SIN3B0.856
DAGLB0.856

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.508
OR4F29-0.467
TFPI2-0.449
KLF17-0.42
CD48-0.417
KLRB1-0.389
AGTR1-0.387
C9orf153-0.386
GZMA-0.371
CD8B-0.37

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of USP2 mRNA"26377693
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of USP2 mRNA"21354444
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of USP2 mRNA19933214
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of USP2 mRNA"20056577|2729130
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of USP2 mRNA"28433925
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of USP2 mRNA"21346803
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of USP2 mRNA]"19467301
C0261373-hydroxyacetanilide3-hydroxyacetanilide results in decreased expression of USP2 mRNA18544908
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of USP2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of USP2 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of USP2 mRNA17562736
D000082AcetaminophenAcetaminophen results in decreased expression of USP2 mRNA18544908
D020106AcrylamideAcrylamide results in decreased expression of USP2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of USP2 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of USP2 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of USP2 mRNA21641981
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of USP2 mRNA19770486
D000452AldrinAldrin results in decreased expression of USP2 mRNA18579281
D000638AmiodaroneAmiodarone results in increased expression of USP2 mRNA19774075
D000643Ammonium ChlorideAmmonium Chloride affects the expression of USP2 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of USP2 mRNA24449571
C015001arsenitearsenite results in increased methylation of USP2 promoter23974009
D001280AtrazineAtrazine results in increased expression of USP2 mRNA22378314
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of USP2 mRNA26377693
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of USP2 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of USP2 mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of USP2 mRNA26377693
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of USP2 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of USP2 mRNA20106945
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of USP2 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of USP2 mRNA19770486|2156981
C004961beta-hydroxyisovaleric acidbeta-hydroxyisovaleric acid results in increased expression of USP2 mRNA24124592
C006780bisphenol Abisphenol A results in decreased expression of USP2 mRNA26063408
C006780bisphenol A"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of USP2 mRNA"28433925
C006780bisphenol Abisphenol A affects the expression of USP2 mRNA25181051
D002101Cacodylic AcidCacodylic Acid results in increased expression of USP2 mRNA17720352
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of USP2 mRNA20061341
D002118Calcium[[USP2 gene mutant form results in increased expression of PDZD3 protein] which results in increased activity of TRPV6 protein] which results in increased uptake of Calcium26756164
D002136Calcium, Dietary"[[USP2 gene mutant form results in increased expression of PDZD3 protein] which results in increased activity of TRPV6 protein] which results in increased uptake of Calcium, Dietary"26756164
D002185CannabidiolCannabidiol results in decreased expression of USP2 mRNA21542829
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of USP2 mRNA27339419
D002737ChloropreneChloroprene results in increased expression of USP2 mRNA23125180
D004390ChlorpyrifosChlorpyrifos results in increased expression of USP2 mRNA20350560
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of USP2 mRNA20938992
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of USP2 mRNA27858113
C031180chrysenechrysene results in increased expression of USP2 mRNA26377693
D002922CiguatoxinsCiguatoxins affects the expression of USP2 mRNA18353800
C018021cobaltous chloridecobaltous chloride results in decreased expression of USP2 mRNA24386269
D003300CopperCopper results in decreased expression of USP2 mRNA17205981
D019327Copper SulfateCopper Sulfate results in decreased expression of USP2 mRNA18579281
D016572CyclosporineCyclosporine results in decreased expression of USP2 mRNA20106945
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of USP2 mRNA23640034
D003907DexamethasoneDexamethasone results in increased expression of USP2 mRNA22733784
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of USP2 mRNA28962523
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of USP2 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of USP2 mRNA27392435
C000944dicrotophosdicrotophos results in increased expression of USP2 mRNA28302478
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of USP2 mRNA]"19467301
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of USP2 mRNA28433925
D004041Dietary FatsDietary Fats results in increased expression of USP2 mRNA19467301
D004041Dietary Fats[Quercetin co-treated with Dietary Fats] affects the expression of USP2 mRNA23359794
D019422Dietary Sucrose[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of USP2 mRNA28433925
D004051Diethylhexyl Phthalate"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of USP2 mRNA"28433925
C014476diethyl maleatediethyl maleate results in decreased expression of USP2 mRNA21161181
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of USP2 mRNA19638242
C118739entinostatentinostat results in increased expression of USP2 mRNA27188386
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of USP2 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of USP2 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of USP2 mRNA17942748
C024565ethylene dichlorideethylene dichloride results in decreased expression of USP2 mRNA28189721
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of USP2 mRNA20938992
C069837fullerene C60fullerene C60 affects the expression of USP2 mRNA19167457
C010176halofuginonehalofuginone results in decreased expression of USP2 mRNA17180598
D006997Hypochlorous AcidHypochlorous Acid results in decreased expression of USP2 mRNA19376150
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of USP2 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of USP2 mRNA27392435
D007649KetamineKetamine results in increased expression of USP2 mRNA20080153
D007854LeadLead affects the expression of USP2 mRNA28903495
C045463leflunomideleflunomide results in increased expression of USP2 mRNA24136188
D064704LevofloxacinLevofloxacin results in increased expression of USP2 mRNA24136188
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of USP2 mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of USP2 mRNA26378955
D008627Mercuric ChlorideMercuric Chloride results in increased expression of USP2 mRNA16507785
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of USP2 mRNA20938992
D008727MethotrexateMethotrexate affects the expression of USP2 mRNA18502557
C500085muraglitazarmuraglitazar results in increased expression of USP2 mRNA21515302
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of USP2 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of USP2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of USP2 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of USP2 mRNA"25554681|2562005
C461488N-benzylpiperazineN-benzylpiperazine results in decreased expression of USP2 mRNA26821219
D009532NickelNickel results in decreased expression of USP2 mRNA24768652
C029938nickel sulfatenickel sulfate results in decreased expression of USP2 mRNA22714537
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of USP2 mRNA17616710
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of USP2 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of USP2 mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of USP2 mRNA19270015|1948288
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of USP2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of USP2 mRNA26272509
C006253pirinixic acidpirinixic acid affects the expression of USP2 mRNA17950772|1844570
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of USP2 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of USP2 mRNA23811191
C006253pirinixic acid[PPARA protein affects the susceptibility to pirinixic acid] which affects the expression of USP2 mRNA21318169
D011192Potassium DichromatePotassium Dichromate results in increased expression of USP2 mRNA23608068
D011441PropylthiouracilPropylthiouracil results in decreased expression of USP2 mRNA24780913
C031280pyrazolepyrazole results in decreased expression of USP2 mRNA17945193
D011794QuercetinQuercetin results in decreased expression of USP2 mRNA20596804
D011794Quercetin[Quercetin co-treated with Dietary Fats] affects the expression of USP2 mRNA23359794
C059514resveratrolresveratrol results in increased expression of USP2 mRNA25905778
D015474IsotretinoinIsotretinoin results in decreased expression of USP2 mRNA20436886
D012312RitodrineRitodrine results in increased expression of USP2 mRNA23370008
C089730rosiglitazonerosiglitazone results in increased expression of USP2 mRNA21515302
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of USP2 mRNA21427059
C541923sandostatinLARsandostatinLAR results in decreased expression of USP2 mRNA17210224
D017632Asbestos, Serpentine"Asbestos, Serpentine results in decreased expression of USP2 mRNA"24160326
C009250sevofluranesevoflurane affects the expression of USP2 mRNA15967596
C009277sodium arsenatesodium arsenate results in decreased expression of USP2 mRNA21795629
C009277sodium arsenatesodium arsenate results in increased expression of USP2 mRNA21795629
C017947sodium arsenitesodium arsenite affects the methylation of USP2 gene28589171
C017947sodium arsenitesodium arsenite results in decreased expression of USP2 mRNA22714537
C017947sodium arsenitesodium arsenite results in increased expression of USP2 mRNA17879257
D013311StreptozocinStreptozocin results in increased expression of USP2 mRNA25905778
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of USP2 mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of USP2 mRNA26378955
C016766sulforafansulforafan results in decreased expression of USP2 mRNA26833863
D0150852,4,5-Trichlorophenoxyacetic Acid"2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of USP2 mRNA"18579281
D013629TamoxifenTamoxifen affects the expression of USP2 mRNA17555576|2093736
D013629TamoxifenTamoxifen results in increased expression of USP2 mRNA25123088
C004648testosterone enanthatetestosterone enanthate affects the expression of USP2 mRNA17440010
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of USP2 mRNA28300664
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of USP2 mRNA21570461|2637764
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of USP2 mRNA"28433925
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of USP2 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to USP2 promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of USP2 mRNA19465110|1977048
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of USP2 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of USP2 mRNA19490992|2121527
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of USP2 mRNA"26179874
C057693troglitazonetroglitazone results in increased expression of USP2 mRNA21515302
C406224valdecoxibvaldecoxib results in decreased expression of USP2 mRNA24136188
D014635Valproic AcidValproic Acid results in decreased expression of USP2 mRNA24935251
D014635Valproic AcidValproic Acid results in increased expression of USP2 mRNA23179753|2915479
D014635Valproic AcidValproic Acid affects the expression of USP2 mRNA17963808
D014635Valproic AcidValproic Acid results in increased expression of USP2 mRNA21427059
D001335Vehicle EmissionsVehicle Emissions affects the methylation of USP2 gene25560391
D014874Water Pollutants, Chemical"Water Pollutants, Chemical affects the expression of USP2 mRNA"24525044

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004197cysteine-type endopeptidase activity-TAS9827704  
GO:0004843thiol-dependent ubiquitin-specific protease activity-IDA17290220  
GO:0004843thiol-dependent ubiquitin-specific protease activity-IMP19917254  
GO:0005515protein binding-IPI16189514  17290220  19838211  22024150  25416956  
GO:0030332cyclin binding-IPI19917254  
GO:0031625ubiquitin protein ligase binding-IPI17290220  
GO:0036459thiol-dependent ubiquitinyl hydrolase activity-TAS-  
GO:0042802identical protein binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IMP17290220  
GO:0006511ubiquitin-dependent protein catabolic process-IEA-  
GO:0007049cell cycle-IEA-  
GO:0007517muscle organ development-IEA-  
GO:0016579protein deubiquitination-IDA17290220  19838211  19917254  
GO:0016579protein deubiquitination-TAS-  
GO:0032922circadian regulation of gene expression-ISS-  
GO:0043153entrainment of circadian clock by photoperiod-ISS-  
GO:0045475locomotor rhythm-ISS-  
GO:0045931positive regulation of mitotic cell cycle-IMP17290220  
GO:0048512circadian behavior-ISS-  
GO:0050821protein stabilization-IDA17290220  
GO:0050821protein stabilization-IMP19838211  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IBA21873635  
GO:0005813centrosome-IEA-  
GO:0005938cell cortex-IEA-  
GO:0016020membrane-IEA-  
GO:0048471perinuclear region of cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5357786TNFR1-induced proapoptotic signalingTAS
R-HSA-5357905Regulation of TNFR1 signalingTAS
R-HSA-5357956TNFR1-induced NFkappaB signaling pathwayTAS
R-HSA-5633007Regulation of TP53 ActivityTAS
R-HSA-5688426DeubiquitinationTAS
R-HSA-5689880Ub-specific processing proteasesTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6804757Regulation of TP53 DegradationTAS
R-HSA-6806003Regulation of TP53 Expression and DegradationTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-73887Death Receptor SignallingTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-75893TNF signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20552680Positive symptoms of psychosis correlate with expression of ubiquitin proteasome genes in peripheral blood. (2010 Oct 5)Bousman CAAm J Med Genet B Neuropsychiatr Genet