Gene: CD1C

911
BDCA1|CD1|CD1A|R7
CD1c molecule
protein-coding
1q23.1
Ensembl:ENSG00000158481 MIM:188340 Vega:OTTHUMG00000017514 UniprotKB:P29017
NC_000001.11
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.396e-1 (AD)  9.679e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ATP2A30.497
OSR20.489
CD280.477
VCAM10.475
UGT2A10.471
GATA60.462
IRF60.454
BNC20.454
FOXD20.453
C1QTNF70.45

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC22A9-0.247
PDZD9-0.245
CRIP3-0.242
TP53TG3D-0.241
RHCG-0.237
EFNA5-0.234
PTCHD1-0.234
SPTBN5-0.232
COLQ-0.231
C20orf203-0.231

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CD1C mRNA24449571
C064925gadodiamidegadodiamide results in increased expression of CD1C mRNA20959327
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of CD1C mRNA17183730
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CD1C mRNA25613284
D009532NickelNickel results in increased expression of CD1C mRNA25583101
C029938nickel sulfatenickel sulfate results in increased expression of CD1C mRNA16780908
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CD1C mRNA25613284
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of CD1C mRNA17183730
D014810Vitamin EVitamin E results in increased expression of CD1C mRNA19244175
D015215Zidovudine[Zidovudine co-treated with IFNA1 protein] results in decreased expression of CD1C mRNA20370541

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0030883endogenous lipid antigen binding-IBA21873635  
GO:0030883endogenous lipid antigen binding-IDA21167756  
GO:0030884exogenous lipid antigen binding-IBA21873635  
GO:0030884exogenous lipid antigen binding-IDA21167756  
GO:0051861glycolipid binding-IDA21167756  
GO:0071723lipopeptide binding-IBA21873635  
GO:0071723lipopeptide binding-IDA21167756  
GO ID GO Term Qualifier Evidence PubMed
GO:0001916positive regulation of T cell mediated cytotoxicity-IBA21873635  
GO:0002250adaptive immune response-IEA-  
GO:0002286T cell activation involved in immune response-IDA21167756  
GO:0006955immune response-IBA21873635  
GO:0048006antigen processing and presentation, endogenous lipid antigen via MHC class Ib-IBA21873635  
GO:0048007antigen processing and presentation, exogenous lipid antigen via MHC class Ib-IBA21873635  
GO:0050776regulation of immune response-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005764lysosome-IEA-  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS1702817  
GO:0009986cell surface-IBA21873635  
GO:0010008endosome membrane-IEA-  
KEGG ID KEGG Term
hsa04640Hematopoietic cell lineage
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-198933Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
11587096Pulmonary Langerhans cell Histiocytosis. (2001 Oct)Harari SSarcoidosis Vasc Diffuse Lung Dis
21338429Peripheral blood dendritic cell subtypes are significantly elevated in subjects with asthma. (2011 May)Spears MClin Exp Allergy