Gene: MTMR4

9110
FYVE-DSP2|ZFYVE11
myotubularin related protein 4
protein-coding
17q22
Ensembl:ENSG00000108389 MIM:603559 Vega:OTTHUMG00000179079 UniprotKB:Q9NYA4
NC_000017.11
SNP Mapped
1   ANCO-SNPs
CD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.490e-2 (AD)  1.868e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs116087723chr17:58507645 (GRCh38.p7)C>Tcocaine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg04610235chr17:56592440MTMR44.580e-9Alcohol consumption der day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARHGEF70.968
HERC10.965
KLHL420.965
RNMT0.96
KAT70.957
ATP2A20.956
RALGPS10.956
ATG2B0.954
DOCK30.954
GPRASP10.953

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.524
OR4F29-0.469
CSAG1-0.415
RAB13-0.41
TFPI2-0.408
MYL3-0.408
HEY2-0.406
ASB4-0.403
COPZ2-0.402
MTRNR2L10-0.392

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of MTMR4 mRNA"19167446
D000082AcetaminophenAcetaminophen results in decreased expression of MTMR4 mRNA21420995|2906747
D000082AcetaminophenAcetaminophen affects the expression of MTMR4 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of MTMR4 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of MTMR4 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of MTMR4 gene27153756
C547126AZM551248AZM551248 results in decreased expression of MTMR4 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MTMR4 mRNA22316170
D004958EstradiolEstradiol results in decreased expression of MTMR4 mRNA19693291
C006780bisphenol Abisphenol A results in increased expression of MTMR4 mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of MTMR4 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of MTMR4 mRNA20147733
C026690cerous chloridecerous chloride results in increased expression of MTMR4 mRNA23573234
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of MTMR4 mRNA20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of MTMR4 gene20938992
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of MTMR4 mRNA28472532
C039671ciglitazone[ciglitazone binds to PPARG protein alternative form] which results in increased expression of MTMR4 mRNA16197558
C018021cobaltous chloridecobaltous chloride results in decreased expression of MTMR4 mRNA19376846
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of MTMR4 mRNA20971185
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of MTMR4 mRNA"19167446
D016572CyclosporineCyclosporine results in decreased expression of MTMR4 mRNA20106945
D016572CyclosporineCyclosporine results in decreased expression of MTMR4 mRNA19770486
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of MTMR4 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of MTMR4 mRNA27594783
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of MTMR4 mRNA23649840
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of MTMR4 mRNA20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of MTMR4 gene20938992
D005557FormaldehydeFormaldehyde results in decreased expression of MTMR4 mRNA23649840
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of MTMR4 mRNA17183730
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of MTMR4 mRNA21179406
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MTMR4 mRNA25613284
C051890irinotecanirinotecan affects the expression of MTMR4 mRNA20097248
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of MTMR4 mRNA27392435
C045463leflunomideleflunomide results in decreased expression of MTMR4 mRNA28988120
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of MTMR4 mRNA"24972896
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of MTMR4 mRNA20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of MTMR4 gene20938992
C013598methoxyacetic acidmethoxyacetic acid affects the expression of MTMR4 mRNA20864626
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of MTMR4 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of MTMR4 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MTMR4 mRNA"25620056
C051752nefazodonenefazodone results in increased expression of MTMR4 mRNA24136188
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of MTMR4 mRNA20971185
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MTMR4 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of MTMR4 mRNA18301758
D011794QuercetinQuercetin results in decreased expression of MTMR4 mRNA21632981
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of MTMR4 mRNA23806026
D012822Silicon DioxideSilicon Dioxide results in decreased expression of MTMR4 mRNA19073995
C017947sodium arsenitesodium arsenite results in decreased expression of MTMR4 mRNA28595984
D012999SomanSoman results in decreased expression of MTMR4 mRNA19281266
D013739TestosteroneTestosterone results in decreased expression of MTMR4 mRNA19693291
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MTMR4 mRNA25613284
D014212TretinoinTretinoin results in increased expression of MTMR4 mRNA16169686
D017974Uranium CompoundsUranium Compounds results in decreased expression of MTMR4 mRNA19654044
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of MTMR4 mRNA17183730
D014635Valproic AcidValproic Acid affects the expression of MTMR4 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of MTMR4 mRNA28001369
D014635Valproic AcidValproic Acid results in decreased methylation of MTMR4 gene29154799
D014635Valproic AcidValproic Acid affects the expression of MTMR4 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions affects the methylation of MTMR4 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004438phosphatidylinositol-3-phosphatase activity-TAS-  
GO:0004722protein serine/threonine phosphatase activity-TAS-  
GO:0004725protein tyrosine phosphatase activity-IEA-  
GO:0005515protein binding-IPI20061380  
GO:0019903protein phosphatase binding-IPI16787938  
GO:0046872metal ion binding-IEA-  
GO:0052629phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006470protein dephosphorylation-TAS9736772  
GO:0006661phosphatidylinositol biosynthetic process-TAS-  
GO:0007179transforming growth factor beta receptor signaling pathway-IEA-  
GO:0014894response to denervation involved in regulation of muscle adaptation-IEA-  
GO:0030512negative regulation of transforming growth factor beta receptor signaling pathway-TAS-  
GO:0035335peptidyl-tyrosine dephosphorylation-IEA-  
GO:0060304regulation of phosphatidylinositol dephosphorylation-IDA16787938  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-HDA22664934  
GO:0005768endosome-IDA16787938  
GO:0005829cytosol-TAS-  
GO:0031901early endosome membrane-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1483255PI MetabolismTAS
R-HSA-1483257Phospholipid metabolismTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1660516Synthesis of PIPs at the early endosome membraneTAS
R-HSA-1660517Synthesis of PIPs at the late endosome membraneTAS
R-HSA-170834Signaling by TGF-beta Receptor ComplexTAS
R-HSA-2173788Downregulation of TGF-beta receptor signalingTAS
R-HSA-2173789TGF-beta receptor signaling activates SMADsTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-9006936Signaling by TGF-beta family membersTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal