Gene: MTA1

9112
-
metastasis associated 1
protein-coding
14q32.33
Ensembl:ENSG00000182979 MIM:603526 Vega:OTTHUMG00000150362 UniprotKB:Q13330
NG_029515.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.622e-1 (AD)  3.333e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg18182566chr14:105888161MTA15.000e-8Maternal smoking in pregnancy27040690
cg18182566chr14:105888161MTA18.880e-9Maternal smoking in pregnancy27040690
cg21517792chr14:105885531MTA12.030e-9Smoking28686328
cg18182566chr14:105888161MTA12.550e-8Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GGA10.933
PTPN230.927
CSNK1E0.916
TBC1D170.912
TMEM2590.91
GAK0.908
KHSRP0.908
ATN10.908
DVL30.905
POLRMT0.905

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.776
OR4F29-0.73
ODAM-0.26
AGTR1-0.244
OR6C74-0.238
HBD-0.227
C9orf153-0.209
IAPP-0.204
CPA3-0.199
AMPD1-0.199

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of MTA1 mRNA"19114083
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of MTA1 mRNA"18648102
D000082AcetaminophenAcetaminophen affects the expression of MTA1 mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of MTA1 mRNA28959563
D000393Air Pollutants[Air Pollutants results in increased abundance of Soot] which results in decreased methylation of MTA1 gene28843141
C030419andrographolideandrographolide results in decreased expression of MTA1 mRNA28651835
C030419andrographolideandrographolide results in decreased expression of MTA1 protein28651835
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of MTA1 mRNA24449571
D001151ArsenicArsenic affects the methylation of MTA1 gene25304211
C006632arsenic trioxidearsenic trioxide results in decreased expression of MTA1 mRNA12478894|2045855
D001241AspirinAspirin results in increased expression of MTA1 mRNA15456535
D001280AtrazineAtrazine results in increased expression of MTA1 mRNA22378314
C028559bathocuproine sulfonate[pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of MTA1 mRNA15477007
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of MTA1 gene25435355
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of MTA1 mRNA26496021
C006780bisphenol Abisphenol A affects the methylation of MTA1 promoter27334623
C006780bisphenol Abisphenol A results in decreased methylation of MTA1 promoter27312807
C006780bisphenol Abisphenol A affects the expression of MTA1 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of MTA1 mRNA26496021
C584509C646 compoundC646 compound results in decreased expression of MTA1 mRNA26191083
D002101Cacodylic AcidCacodylic Acid results in increased expression of MTA1 mRNA16122865
D002104CadmiumCadmium results in decreased expression of MTA1 mRNA24284285
C028031cadmium acetatecadmium acetate results in increased expression of MTA1 mRNA18155341
D0157622-Chloroadenosine2-Chloroadenosine results in decreased expression of MTA1 mRNA15601553
C018021cobaltous chloridecobaltous chloride results in decreased expression of MTA1 mRNA19320972
D019327Copper SulfateCopper Sulfate results in decreased expression of MTA1 mRNA19549813
D017373Cyproterone Acetate[Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to MTA1 protein modified form]28751236
C000944dicrotophosdicrotophos results in increased expression of MTA1 mRNA28302478
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of MTA1 mRNA20360939
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of MTA1 mRNA"23811387
D006997Hypochlorous AcidHypochlorous Acid results in decreased expression of MTA1 mRNA19376150
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MTA1 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MTA1 mRNA25961927
D007854LeadLead affects the splicing of MTA1 mRNA28903495
D008694MethamphetamineMethamphetamine results in increased methylation of MTA1 promoter26307267
C013598methoxyacetic acidmethoxyacetic acid results in decreased expression of MTA1 mRNA17401724
C013598methoxyacetic acidmethoxyacetic acid results in decreased expression of MTA1 protein17401724
C005219methyl cellosolvemethyl cellosolve results in decreased expression of MTA1 mRNA19643169
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of MTA1 mRNA"20188158
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of MTA1 mRNA24810058
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of MTA1 protein"27044752
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"CSF3 protein inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of MTA1 protein]"27044752
D015735MifepristoneMifepristone results in decreased expression of MTA1 mRNA17584828
D009285NaphthoquinonesNaphthoquinones results in increased expression of MTA1 mRNA23811387
C014153pirimiphos methylpirimiphos methyl results in increased expression of MTA1 mRNA27845199
D011374ProgesteroneProgesterone results in increased expression of MTA1 mRNA16888808
C020972pyrrolidine dithiocarbamic acid[pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of MTA1 mRNA15477007
D011794QuercetinQuercetin results in increased expression of MTA1 mRNA21632981
C059514resveratrolMTA1 protein inhibits the reaction [resveratrol results in increased acetylation of TP53 protein]19810103
C059514resveratrolresveratrol results in decreased expression of MTA1 protein19810103
C059514resveratrol[resveratrol results in decreased expression of MTA1 protein] inhibits the reaction [MTA1 protein binds to HDAC1 protein]19810103
C059514resveratrol[[resveratrol results in decreased expression of MTA1 protein] inhibits the reaction [MTA1 protein binds to HDAC1 protein]] which results in increased acetylation of and results in increased activity of TP53 protein19810103
C059514resveratrol[resveratrol results in decreased expression of MTA1 protein] which results in decreased expression of BCL2 protein19810103
C059514resveratrol[resveratrol results in decreased expression of MTA1 protein] which results in increased expression of BAX protein19810103
D012715Sesame OilSesame Oil results in decreased expression of MTA1 mRNA29191790
D053260Soot[Air Pollutants results in increased abundance of Soot] which results in decreased methylation of MTA1 gene28843141
C061133tamibarotenetamibarotene results in decreased expression of MTA1 mRNA15498508
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MTA1 mRNA21570461|2405805
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MTA1 mRNA25613284
D013849ThimerosalThimerosal results in decreased expression of MTA1 mRNA27188386
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of MTA1 mRNA28111298
D014212TretinoinTretinoin results in decreased expression of MTA1 mRNA15498508
D014635Valproic AcidValproic Acid affects the expression of MTA1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of MTA1 mRNA23179753|2800136
D014635Valproic AcidValproic Acid results in increased methylation of MTA1 gene29154799
D014635Valproic AcidValproic Acid affects the expression of MTA1 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of MTA1 gene25560391
C025643vinclozolinvinclozolin affects the expression of MTA1 mRNA19015723
C025643vinclozolinvinclozolin results in decreased expression of MTA1 mRNA18042343|2303416
D014800VitalliumVitallium analog results in decreased expression of MTA1 mRNA23825117
C088658zoledronic acidzoledronic acid results in decreased expression of MTA1 protein28871336

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA21965678  24413532  
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding-ISS-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000989transcription factor activity, transcription factor binding-IBA21873635  
GO:0001046core promoter sequence-specific DNA binding-IBA21873635  
GO:0001103RNA polymerase II repressing transcription factor binding-IBA21873635  
GO:0001103RNA polymerase II repressing transcription factor binding-IPI22926524  
GO:0003682chromatin binding-IEA-  
GO:0003713transcription coactivator activity-IBA21873635  
GO:0003713transcription coactivator activity-IMP21965678  
GO:0003714transcription corepressor activity-IBA21873635  
GO:0003714transcription corepressor activity-IMP21965678  
GO:0004407histone deacetylase activity-TAS-  
GO:0005515protein binding-IPI16511565  18451879  19805145  20651739  21258344  21555589  
21965678  23752268  24413532  24970816  25416956  25609649  
26028330  26496610  27705803  
GO:0008270zinc ion binding-IEA-  
GO:0042826histone deacetylase binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IBA21873635  
GO:0006302double-strand break repair-IBA21873635  
GO:0006302double-strand break repair-IMP19805145  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO:0007165signal transduction-TAS8083195  
GO:0010212response to ionizing radiation-IBA21873635  
GO:0010212response to ionizing radiation-IDA19805145  
GO:0016575histone deacetylation-IBA21873635  
GO:0016575histone deacetylation-IEA-  
GO:0032922circadian regulation of gene expression-ISS-  
GO:0040029regulation of gene expression, epigenetic-IMP24413532  
GO:0043153entrainment of circadian clock by photoperiod-ISS-  
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process-IMP19805145  
GO:0045475locomotor rhythm-ISS-  
GO:1902499positive regulation of protein autoubiquitination-IDA19805145  
GO:1903507negative regulation of nucleic acid-templated transcription-IEA-  
GO:1903508positive regulation of nucleic acid-templated transcription-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA21965678  24413532  24970816  
GO:0005635nuclear envelope-IDA24970816  
GO:0005654nucleoplasm-IBA21873635  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IDA24970816  
GO:0005829cytosol-IDA-  
GO:0005874microtubule-IDA24970816  
GO:0016581NuRD complex-IBA21873635  
GO:0016581NuRD complex-IDA22926524  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-1257604PIP3 activates AKT signalingIEA
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-212165Epigenetic regulation of gene expressionIEA
R-HSA-2990846SUMOylationTAS
R-HSA-3108232SUMO E3 ligases SUMOylate target proteinsTAS
R-HSA-3214815HDACs deacetylate histonesTAS
R-HSA-3232118SUMOylation of transcription factorsTAS
R-HSA-3247509Chromatin modifying enzymesTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-427389ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expressionIEA
R-HSA-4839726Chromatin organizationTAS
R-HSA-5250913Positive epigenetic regulation of rRNA expressionIEA
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6807070PTEN RegulationTAS
R-HSA-6807070PTEN RegulationIEA
R-HSA-73762RNA Polymerase I Transcription InitiationTAS
R-HSA-73854RNA Polymerase I Promoter ClearanceTAS
R-HSA-73864RNA Polymerase I TranscriptionTAS
R-HSA-74160Gene expression (Transcription)IEA
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8943724Regulation of PTEN gene transcriptionTAS
R-HSA-8943724Regulation of PTEN gene transcriptionIEA
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-9006925Intracellular signaling by second messengersIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27035126Correlation between insulinlike growth factor binding protein 3 and metastasisassociated gene 1 protein in esophageal squamous cell carcinoma. (2016 May)Yang HMol Med Rep
21892752MTA1 expression correlates significantly with cigarette smoke in non-small cell lung cancer. (2011 Oct)Xu LVirchows Arch
20935042Relation between prognosis and expression of metastasis-associated protein 1 in stage I non-small cell lung cancer. (2011 Feb)Yu YInteract Cardiovasc Thorac Surg