Gene: LATS1

9113
WARTS|wts
large tumor suppressor kinase 1
protein-coding
6q25.1
Ensembl:ENSG00000131023 MIM:603473 Vega:OTTHUMG00000016437 UniprotKB:O95835
NC_000006.12
PubMed
0   ANCO-SNPs
ND
1   
8.108e-1 (AD)  1.366e-1 (ND)   (Frontal_Cortex)
5.754e-1 (AD)  4.838e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PKN20.894
MED130.889
MAP3K20.885
ARID20.875
HOOK30.872
SMCHD10.868
LRRC580.867
BTBD70.866
AFF40.863
UBR50.862

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.546
OR4F29-0.508
SPRR2D-0.223
SPRR2A-0.214
LCN1-0.211
TGM3-0.189
SULT2B1-0.188
NANOGNB-0.187
KRT78-0.179
TMPRSS11B-0.176

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of LATS1 mRNA21298039
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of LATS1 mRNA24449571
D001151ArsenicArsenic results in increased phosphorylation of LATS1 protein23942117
D001152Arsenicals[AS3MT protein results in increased abundance of Arsenicals metabolite] which affects the susceptibility to LATS1 gene mutant form21447609
C006780bisphenol Abisphenol A affects the expression of LATS1 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of LATS1 mRNA21786754
C006780bisphenol Abisphenol A results in increased methylation of LATS1 gene28505145
D019327Copper SulfateCopper Sulfate results in increased expression of LATS1 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of LATS1 mRNA25562108
C014347decitabinedecitabine affects the methylation of LATS1 promoter17049657
C014347decitabine[decitabine affects the methylation of LATS1 promoter] which affects the expression of LATS1 mRNA17049657|1704965
C000944dicrotophosdicrotophos results in increased expression of LATS1 mRNA28302478
C024629dimethyl phthalatedimethyl phthalate affects the expression of LATS1 mRNA26924002
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of LATS1 mRNA26846883
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of LATS1 mRNA18951874
C544151jinfukangjinfukang results in decreased expression of LATS1 mRNA27392435
C045463leflunomideleflunomide results in increased expression of LATS1 mRNA28988120
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of LATS1 mRNA"26251327
C028577monobutyl phthalatemonobutyl phthalate affects the expression of LATS1 mRNA20864626
C517284monomethyl phthalatemonomethyl phthalate affects the expression of LATS1 mRNA26924002
C000621033napabucasinnapabucasin results in decreased expression of LATS1 mRNA25605917
D010416PentachlorophenolPentachlorophenol results in decreased expression of LATS1 mRNA23892564
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of LATS1 mRNA25895662
D012834SilverSilver results in decreased expression of LATS1 mRNA27131904
D014635Valproic AcidValproic Acid results in decreased expression of LATS1 mRNA28001369
D014635Valproic AcidValproic Acid affects the expression of LATS1 mRNA17963808
C025643vinclozolinvinclozolin results in decreased expression of LATS1 mRNA23034163
D019287Zinc SulfateZinc Sulfate results in increased expression of LATS1 mRNA27504894

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000287magnesium ion binding-IDA10518011  
GO:0004674protein serine/threonine kinase activity-IBA21873635  
GO:0004674protein serine/threonine kinase activity-IDA10518011  20412773  
GO:0004674protein serine/threonine kinase activity-TAS-  
GO:0005515protein binding-IPI9988268  10831611  15220930  18158288  19739119  19927127  
20303269  20412773  22078877  22863277  24012335  24255178  
24362629  24366813  25026211  25218637  25283809  25438054  
25751139  28087714  28169360  
GO:0005524ATP binding-IDA10518011  
GO:0019901protein kinase binding-IPI19927127  
GO:0030331estrogen receptor binding-IPI28068668  
GO ID GO Term Qualifier Evidence PubMed
GO:0000082G1/S transition of mitotic cell cycle-IBA21873635  
GO:0000086G2/M transition of mitotic cell cycle-IDA15122335  
GO:0000819sister chromatid segregation-IDA15122335  
GO:0001827inner cell mass cell fate commitment-IEA-  
GO:0001828inner cell mass cellular morphogenesis-IEA-  
GO:0006468protein phosphorylation-IDA10518011  
GO:0009755hormone-mediated signaling pathway-ISS-  
GO:0018105peptidyl-serine phosphorylation-IBA21873635  
GO:0030216keratinocyte differentiation-IEA-  
GO:0030833regulation of actin filament polymerization-IDA15220930  
GO:0033138positive regulation of peptidyl-serine phosphorylation-IDA20412773  
GO:0033146regulation of intracellular estrogen receptor signaling pathway-IMP28068668  
GO:0034613cellular protein localization-IEA-  
GO:0035329hippo signaling-IBA21873635  
GO:0035329hippo signaling-IDA20412773  
GO:0035329hippo signaling-TAS-  
GO:0035556intracellular signal transduction-IBA21873635  
GO:0043065positive regulation of apoptotic process-IBA21873635  
GO:0043254regulation of protein complex assembly-IMP20412773  
GO:0045736negative regulation of cyclin-dependent protein serine/threonine kinase activity-IDA9988268  
GO:0046620regulation of organ growth-IBA21873635  
GO:0051220cytoplasmic sequestering of protein-IMP20412773  
GO:0051301cell division-IEA-  
GO:0060644mammary gland epithelial cell differentiation-IMP28068668  
GO:0090090negative regulation of canonical Wnt signaling pathway-IMP20412773  
GO:2000058regulation of ubiquitin-dependent protein catabolic process-IMP28068668  
GO ID GO Term Qualifier Evidence PubMed
GO:0000922spindle pole-IBA21873635  
GO:0000922spindle pole-IDA10518011  
GO:0005815microtubule organizing center-IEA-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-2028269Signaling by HippoTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22966299Hypermethylation of the large tumor suppressor genes in Japanese lung cancer. (2010 Mar)Sasaki HOncol Lett