Gene: INA

9118
NEF5|NF-66|TXBP-1
internexin neuronal intermediate filament protein alpha
protein-coding
10q24.33
Ensembl:ENSG00000148798 MIM:605338 Vega:OTTHUMG00000018986 UniprotKB:Q16352
NG_012318.1
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.572e-1 (AD)  8.067e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NEFL0.984
SULT4A10.98
NSF0.979
SNAP910.977
RTN10.975
VSNL10.975
MAP7D20.974
ATP1B10.973
STMN20.972
CDK5R10.972

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.527
RAI14-0.516
REST-0.508
CNN2-0.506
CSAG1-0.492
TFPI2-0.49
HEY2-0.487
RUNX3-0.487
OR4F29-0.484
ARHGEF5-0.481

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0326681-nitropyrene1-nitropyrene results in increased expression of INA mRNA19041380
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of INA mRNA"19114083
C0112692,5-hexanedione"2,5-hexanedione results in decreased expression of INA protein"19033394
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of INA mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of INA mRNA]17585979
D000393Air PollutantsAir Pollutants analog results in increased expression of INA mRNA21757418
D000447AldehydesAldehydes results in increased expression of INA mRNA25014914
D000643Ammonium ChlorideAmmonium Chloride affects the expression of INA mRNA16483693
D000643Ammonium ChlorideAmmonium Chloride results in decreased expression of INA protein16483693
D001104ArbutinArbutin results in decreased expression of INA mRNA17103032
C015001arsenitearsenite results in increased methylation of INA promoter23974009
D001280AtrazineAtrazine results in decreased expression of INA mRNA25929836
D004958EstradiolEstradiol results in increased expression of INA mRNA23019147
C006780bisphenol Abisphenol A results in decreased expression of INA mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of INA mRNA28628672
C013418bromfenacoumbromfenacoum results in decreased expression of INA protein28903499
C018475butyraldehydebutyraldehyde results in increased expression of INA mRNA26079696
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of INA mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of INA mRNA]17585979
D003042Cocaine[Cocaine co-treated with FOS protein mutant form] results in increased expression of INA mRNA18355967
D003042CocaineCocaine results in decreased expression of INA mRNA18355967
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of INA mRNA15467011
D003471CuprizoneCuprizone results in decreased expression of INA mRNA26577399
C017160cypermethrincypermethrin results in increased expression of INA protein21561882
C017160cypermethrinMinocycline inhibits the reaction [cypermethrin results in increased expression of INA protein]21561882
D003561CytarabineCytarabine results in increased expression of INA mRNA21198554
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of INA mRNA28628672
C042577diallyl trisulfidediallyl trisulfide results in increased expression of INA protein19550292
D002945CisplatinCisplatin results in increased phosphorylation of INA protein22006019
D004041Dietary FatsDietary Fats results in increased expression of INA mRNA25016146
C024629dimethyl phthalatedimethyl phthalate affects the expression of INA mRNA26924002
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of INA protein23301498
D005038EthylnitrosoureaEthylnitrosourea results in increased expression of INA mRNA15954086
D005839GentamicinsGentamicins results in decreased expression of INA mRNA22061828
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of INA protein21179406
C503753Indolinone AIndolinone A results in increased phosphorylation of INA protein15712243
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of INA mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of INA mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of INA mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of INA mRNA24796395|2683047
D007649KetamineKetamine results in increased expression of INA protein18504422
D008130LomustineINA affects the susceptibility to [Procarbazine co-treated with Lomustine co-treated with Vincristine]21246521
D008713MethimazoleMethimazole results in decreased expression of INA mRNA17403546
D008767Methylmercury Compounds[Methylmercury Compounds co-treated with Polychlorinated Biphenyls] results in increased expression of INA mRNA20020106
D052998MicrocystinsMicrocystins results in increased expression of INA mRNA22430071
D052998MicrocystinsMicrocystins results in increased expression of INA protein22430071
D008911MinocyclineMinocycline inhibits the reaction [cypermethrin results in increased expression of INA protein]21561882
D009532NickelNickel results in increased expression of INA mRNA25583101
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"PON1 gene polymorphism affects the susceptibility to [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate affects the expression of INA mRNA]"21673326
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of INA mRNA"21673326
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"PON1 protein affects the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of INA mRNA]"21673326
C046012pentanalpentanal results in increased expression of INA mRNA26079696
C494474perchlorateperchlorate results in decreased expression of INA mRNA17403546
D010936Plant ExtractsPlant Extracts results in decreased expression of INA mRNA23557933
D011078Polychlorinated Biphenyls[Methylmercury Compounds co-treated with Polychlorinated Biphenyls] results in increased expression of INA mRNA20020106
D011344ProcarbazineINA affects the susceptibility to [Procarbazine co-treated with Lomustine co-treated with Vincristine]21246521
C005556propionaldehydepropionaldehyde results in increased expression of INA mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of INA mRNA17403546
D012524SarinSarin results in decreased expression of INA protein28973502
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of INA mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of INA mRNA25351596
D012999SomanSoman results in increased expression of INA mRNA19281266
C016766sulforafanINA protein binds to sulforafan21838287
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of INA mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of INA mRNA25613284
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased expression of INA protein"25852303
D013974ThyroxineThyroxine results in increased expression of INA mRNA17403546
C024746tobacco tartobacco tar results in decreased expression of INA mRNA19559774
D014212TretinoinTretinoin results in decreased expression of INA mRNA21934132
D014212TretinoinTretinoin results in increased phosphorylation of INA protein26498558
D014212TretinoinTretinoin results in decreased expression of INA mRNA16604517
D014212TretinoinTretinoin results in decreased expression of INA mRNA24977338
D014415TunicamycinTunicamycin results in decreased expression of INA mRNA22378314
D014635Valproic AcidValproic Acid affects the expression of INA mRNA25979313|2607246
D014635Valproic AcidValproic Acid results in increased expression of INA mRNA23179753|2438349
D014635Valproic AcidValproic Acid affects the expression of INA mRNA26072468
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of INA gene25560391
C025643vinclozolinvinclozolin affects the expression of INA mRNA19015723
D014750VincristineINA affects the susceptibility to [Procarbazine co-treated with Lomustine co-treated with Vincristine]21246521
C111237vorinostatvorinostat results in decreased expression of INA mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005200structural constituent of cytoskeleton-TAS7769995  
GO ID GO Term Qualifier Evidence PubMed
GO:0021762substantia nigra development-HEP22926577  
GO:0030154cell differentiation-IEA-  
GO:0060052neurofilament cytoskeleton organization-IEA-  
GO:1990830cellular response to leukemia inhibitory factor-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-HDA22664934  
GO:0005654nucleoplasm-IDA-  
GO:0005883neurofilament-IEA-  
GO:0031965nuclear membrane-IDA-  
GO:0036464cytoplasmic ribonucleoprotein granule-IDA15121898  
GO:0043209myelin sheath-IEA-  
GO:0045111intermediate filament cytoskeleton-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
10900673[Intensified after-care--a method for improving occupational reintegration after myocardial infarct and/or bypass operation]. (2000 May)Karoff MZ Kardiol