Gene info: ID 912

Gene: CD1D

GENE ID: 912

Synonyms: CD1A|R3|R3G1

Description: CD1d molecule

Gene type: protein-coding

Location: 1q23.1

dbXrefs: Ensembl:ENSG00000158473 MIM:188410 Vega:OTTHUMG00000022436 UniprotKB:P15813

RefSeq: NC_000001.11

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 4

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 3.210e-1 (AD) 8.120e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
TLR8	0.876
CD300LF	0.842
SIRPB2	0.842
ARL11	0.834
TLR5	0.832
FPR2	0.827
DAPP1	0.821
CD226	0.816
NABP1	0.813
GPR65	0.812

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
KCNIP3	-0.421
WNT7A	-0.415
NEUROD6	-0.414
MARCH4	-0.397
RTN4R	-0.389
EXTL1	-0.386
HAS1	-0.383
PVALB	-0.382
CPLX3	-0.382
KIT	-0.382

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB04661	Cis-tetracosenoyl sulfatide	Small Molecule	-	Experimental	Target

ID	Drug Name	Action	PubMed
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of CD1D mRNA"	23146750
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of CD1D mRNA"	23146750
D000082	Acetaminophen	Acetaminophen results in decreased expression of CD1D mRNA	29067470
D000068816	Adapalene	Adapalene results in increased expression of CD1D protein	17518990
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of CD1D mRNA	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of CD1D gene	27153756
C068073	Am 580	Am 580 results in increased expression of CD1D mRNA	16982809\|1739248
C068073	Am 580	Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of CD1D mRNA]	17392484
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of CD1D mRNA	24449571
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of CD1D mRNA	15761015
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of CD1D mRNA	22316170
D004958	Estradiol	Estradiol results in decreased expression of CD1D mRNA	20106945
C006780	bisphenol A	bisphenol A results in increased expression of CD1D mRNA	25181051
D002220	Carbamazepine	Carbamazepine affects the expression of CD1D mRNA	25979313
D016572	Cyclosporine	Cyclosporine results in decreased expression of CD1D mRNA	20106945
D003609	Dactinomycin	Dactinomycin inhibits the reaction [Tretinoin results in increased expression of CD1D mRNA]	17392484
D017313	Fenretinide	Fenretinide results in decreased expression of CD1D mRNA	28973697
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of CD1D mRNA	22802445
D008727	Methotrexate	Methotrexate results in increased expression of CD1D mRNA	17400583
D009532	Nickel	Nickel results in increased expression of CD1D mRNA	24768652\|2558310
C084904	Ro 41-5253	Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of CD1D mRNA]	17392484
C084904	Ro 41-5253	Ro 41-5253 inhibits the reaction [Tretinoin results in increased expression of CD1D mRNA]	17392484
C089730	rosiglitazone	rosiglitazone results in increased expression of CD1D mRNA	16982809
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of CD1D mRNA	23806026
C017947	sodium arsenite	sodium arsenite results in increased expression of CD1D mRNA	28595984
D014212	Tretinoin	Dactinomycin inhibits the reaction [Tretinoin results in increased expression of CD1D mRNA]	17392484
D014212	Tretinoin	Ro 41-5253 inhibits the reaction [Tretinoin results in increased expression of CD1D mRNA]	17392484
D014212	Tretinoin	Tretinoin promotes the reaction [RARA protein binds to CD1D promoter]	17392484
D014212	Tretinoin	Tretinoin promotes the reaction [RARG protein binds to CD1D promoter]	17392484
D014212	Tretinoin	Tretinoin promotes the reaction [RXRA protein binds to CD1D promoter]	17392484
D014212	Tretinoin	Tretinoin results in increased expression of CD1D mRNA	16054129\|1739248
D014212	Tretinoin	Tretinoin results in increased expression of CD1D mRNA	17392484
D014212	Tretinoin	Tretinoin results in increased expression of CD1D mRNA	17392484
C012589	trichostatin A	trichostatin A results in increased expression of CD1D mRNA	24935251
D017974	Uranium Compounds	Uranium Compounds results in increased expression of CD1D mRNA	19654044
D014635	Valproic Acid	Valproic Acid results in increased expression of CD1D mRNA	24935251\|2915479
D024483	Vitamin K 3	Vitamin K 3 affects the expression of CD1D mRNA	20829426

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0030881	beta-2-microglobulin binding	-	TAS	14500461
GO:0030882	lipid antigen binding	-	IDA	19124746
GO:0030883	endogenous lipid antigen binding	-	IBA	21873635
GO:0030884	exogenous lipid antigen binding	-	IBA	21873635
GO:0030884	exogenous lipid antigen binding	-	IDA	10523605
GO:0042393	histone binding	-	IPI	20363964
GO:0050839	cell adhesion molecule binding	-	IPI	19124746
GO:0071723	lipopeptide binding	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001916	positive regulation of T cell mediated cytotoxicity	-	IBA	21873635
GO:0006955	immune response	-	IBA	21873635
GO:0016032	viral process	-	IEA	-
GO:0016045	detection of bacterium	-	TAS	14500461
GO:0034113	heterotypic cell-cell adhesion	-	TAS	19124746
GO:0042102	positive regulation of T cell proliferation	-	IDA	19124746
GO:0045058	T cell selection	-	TAS	14500461
GO:0045087	innate immune response	-	IEA	-
GO:0045089	positive regulation of innate immune response	-	TAS	14500461
GO:0048006	antigen processing and presentation, endogenous lipid antigen via MHC class Ib	-	IBA	21873635
GO:0048006	antigen processing and presentation, endogenous lipid antigen via MHC class Ib	-	IDA	10523605
GO:0048007	antigen processing and presentation, exogenous lipid antigen via MHC class Ib	-	IBA	21873635
GO:0050776	regulation of immune response	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005737	cytoplasm	-	IDA	19124746
GO:0005765	lysosomal membrane	-	IEA	-
GO:0005783	endoplasmic reticulum	-	IDA	-
GO:0005789	endoplasmic reticulum membrane	-	IEA	-
GO:0005886	plasma membrane	-	IBA	21873635
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	TAS	11315191
GO:0009986	cell surface	-	IBA	21873635
GO:0009986	cell surface	-	IDA	19124746
GO:0010008	endosome membrane	-	IEA	-
GO:0016323	basolateral plasma membrane	-	IEA	-

KEGG ID	KEGG Term
hsa04640	Hematopoietic cell lineage
hsa05146	Amoebiasis

Reactome ID	Reactome Term	Evidence
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-198933	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25399514	Protein S exacerbates alcoholic hepatitis by stimulating liver natural killer T cells. (2015 Jan)	Chelakkot-Govindalayathil AL	J Thromb Haemost
21684213	Cigarette smoke alters the invariant natural killer T cell function and may inhibit anti-tumor responses. (2011 Sep)	Hogan AE	Clin Immunol
28620964	Does gene expression in laryngeal subsites differ between patients with laryngopharyngeal reflux and controls? (2018 Feb)	Wood JM	Clin Otolaryngol
23638007	Colonic inflammation in mice is improved by cigarette smoke through iNKT cells recruitment. (2013)	Montbarbon M	PLoS One