Gene: UAP1L1

91373
-
UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
protein-coding
9q34.3
Ensembl:ENSG00000197355 Vega:OTTHUMG00000020962 UniprotKB:Q3KQV9
NC_000009.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.071e-1 (AD)  7.914e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs17065341chr9:137084167 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SFSWAP0.84
SLC12A90.84
LZTS20.839
TSEN540.835
AKT20.833
POMT20.829
METTL170.823
UCKL10.821
CEP1640.82
WDR590.819

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.47
OR4F29-0.438
OR4F16-0.257
FER1L6-0.235
MTRNR2L9-0.231
UNC45B-0.227
TTLL10-AS1-0.219
IBSP-0.214
HMHB1-0.214
CALCR-0.211

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of UAP1L1 mRNA"20453058
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of UAP1L1 mRNA"25510870
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of UAP1L1 mRNA"19095052
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of UAP1L1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of UAP1L1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of UAP1L1 mRNA"25510870
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of UAP1L1 mRNA"21346803
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of UAP1L1 mRNA"25510870
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of UAP1L1 mRNA"21346803
C5850042-monochloropropanediol2-monochloropropanediol results in increased expression of UAP1L1 mRNA28522335
D000082AcetaminophenAcetaminophen results in decreased expression of UAP1L1 mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of UAP1L1 mRNA17562736
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of UAP1L1 mRNA28522335
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of UAP1L1 mRNA"18687144
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of UAP1L1 mRNA22228805
D001622BetaineBetaine inhibits the reaction [Copper deficiency affects the expression of UAP1L1 protein]25150618
C006780bisphenol Abisphenol A affects the expression of UAP1L1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of UAP1L1 mRNA27685785|2927551
C006780bisphenol Abisphenol A results in increased expression of UAP1L1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of UAP1L1 gene28505145
C584509C646 compoundC646 compound results in decreased expression of UAP1L1 mRNA26191083
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of UAP1L1 mRNA25270620
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of UAP1L1 mRNA20938992
D002994ClofibrateClofibrate results in increased expression of UAP1L1 mRNA25270620
D003300CopperBetaine inhibits the reaction [Copper deficiency affects the expression of UAP1L1 protein]25150618
D003300CopperCopper deficiency affects the expression of UAP1L1 protein25150618
D016572CyclosporineCyclosporine results in decreased expression of UAP1L1 mRNA27989131
D016572CyclosporineCyclosporine results in decreased methylation of UAP1L1 promoter27989131
D016572CyclosporineCyclosporine results in increased expression of UAP1L1 mRNA25562108
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of UAP1L1 mRNA27392435
C000944dicrotophosdicrotophos results in increased expression of UAP1L1 mRNA28302478
D004041Dietary FatsDietary Fats results in increased expression of UAP1L1 mRNA18042831|2260994
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of UAP1L1 mRNA24535843
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of UAP1L1 mRNA24535843
C118739entinostatentinostat results in increased expression of UAP1L1 mRNA27188386
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of UAP1L1 mRNA23649840
C540355fenamidonefenamidone results in increased expression of UAP1L1 mRNA27029645
D018120FinasterideFinasteride results in increased expression of UAP1L1 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of UAP1L1 mRNA20938992
D005557FormaldehydeFormaldehyde results in increased expression of UAP1L1 mRNA23649840
D006046GoldGold analog results in decreased expression of UAP1L1 protein24780912
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of UAP1L1 mRNA20044591
C492448ICG 001ICG 001 results in decreased expression of UAP1L1 mRNA26191083
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of UAP1L1 mRNA27392435
C544151jinfukangjinfukang results in increased expression of UAP1L1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of UAP1L1 mRNA24796395
D048628KetolidesKetolides analog results in increased expression of UAP1L1 mRNA24967691
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of UAP1L1 mRNA20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of UAP1L1 mRNA23649840
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of UAP1L1 mRNA24810058
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate affects the expression of UAP1L1 mRNA21195148
C028577monobutyl phthalatemonobutyl phthalate affects the expression of UAP1L1 mRNA21195148
C510784ormosil[ormosil binds to Polyethylene Glycols] which results in increased expression of UAP1L1 mRNA24888373
D000073878Palm OilPalm Oil results in increased expression of UAP1L1 mRNA18042831
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of UAP1L1 mRNA"25510870
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in increased expression of UAP1L1 mRNA19095052
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of UAP1L1 mRNA24535843
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in increased expression of UAP1L1 mRNA20813756
C006253pirinixic acidpirinixic acid results in increased expression of UAP1L1 mRNA18301758|2081375
D011092Polyethylene Glycols[ormosil binds to Polyethylene Glycols] which results in increased expression of UAP1L1 mRNA24888373
D011374ProgesteroneProgesterone results in increased expression of UAP1L1 mRNA19690047
C513428pyrachlostrobinpyrachlostrobin results in increased expression of UAP1L1 mRNA27029645
D011794QuercetinQuercetin results in increased expression of UAP1L1 mRNA21632981
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of UAP1L1 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of UAP1L1 mRNA25351596
C016104sodium bichromatesodium bichromate affects the expression of UAP1L1 mRNA22110744
D012999SomanSoman results in increased expression of UAP1L1 mRNA19281266
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of UAP1L1 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of UAP1L1 mRNA26377647|2892240
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of UAP1L1 mRNA19770486|2629044
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of UAP1L1 mRNA22808131
D014212TretinoinTretinoin results in decreased expression of UAP1L1 mRNA23830798
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of UAP1L1 mRNA"26743178
C057693troglitazonetroglitazone results in increased expression of UAP1L1 mRNA28973697
D014520UrethaneUrethane results in decreased expression of UAP1L1 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of UAP1L1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of UAP1L1 mRNA23179753|2800136
D014635Valproic AcidValproic Acid results in increased methylation of UAP1L1 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003977UDP-N-acetylglucosamine diphosphorylase activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006048UDP-N-acetylglucosamine biosynthetic process-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
hsa00520Amino sugar and nucleotide sugar metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal