Gene info: ID 914

Gene: CD2

GENE ID: 914

Synonyms: LFA-2|SRBC|T11

Description: CD2 molecule

Gene type: protein-coding

Location: 1p13.1

dbXrefs: Ensembl:ENSG00000116824 MIM:186990 Vega:OTTHUMG00000022750 UniprotKB:P06729

RefSeq: NG_050908.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 6

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 7.495e-1 (AD) 3.247e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
LCK	0.866
TBX21	0.858
GZMA	0.845
CD3G	0.841
LY9	0.828
SLAMF7	0.817
IL2RB	0.817
CTSW	0.815
CD96	0.809
PYHIN1	0.802

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CYP46A1	-0.506
CA7	-0.493
B3GALT1	-0.482
LGI1	-0.482
BDH1	-0.48
CDS1	-0.479
KIAA0319	-0.479
EFNA5	-0.478
TMEM221	-0.478
OGDHL	-0.475

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00092	Alefacept	BiotechDrug	222535-22-0	Approved\|Investigational\|Withdrawn	Target
DB06371	Siplizumab	BiotechDrug	288392-69-8	Investigational	Target

ID	Drug Name	Action	PubMed
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in decreased expression of CD2 mRNA"	18648102
D000082	Acetaminophen	Acetaminophen results in increased expression of CD2 mRNA	26690555
D000082	Acetaminophen	[Dietary Carbohydrates co-treated with Acetaminophen] results in decreased expression of CD2 mRNA	17093179
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of CD2 gene	27153756
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of CD2 mRNA	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of CD2 mRNA	24449571
D001151	Arsenic	Arsenic results in increased methylation of CD2 gene	27838757
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of CD2 mRNA	21569818
C006780	bisphenol A	bisphenol A results in decreased methylation of CD2 promoter	27312807
C006780	bisphenol A	bisphenol A results in decreased expression of CD2 mRNA	25181051
D002101	Cacodylic Acid	Cacodylic Acid results in increased expression of CD2 mRNA	16122865
D002737	Chloroprene	Chloroprene results in decreased expression of CD2 mRNA	23125180
D002994	Clofibrate	Clofibrate results in increased expression of CD2 mRNA	17585979
D003520	Cyclophosphamide	Cyclophosphamide results in decreased expression of CD2 mRNA	21041162
D003907	Dexamethasone	Dexamethasone results in decreased expression of CD2 mRNA	21041162
D004040	Dietary Carbohydrates	[Dietary Carbohydrates co-treated with Acetaminophen] results in decreased expression of CD2 mRNA	17093179
D004041	Dietary Fats	Dietary Fats results in increased expression of CD2 mRNA	25016146
D005419	Flavonoids	Flavonoids results in increased expression of CD2 mRNA	18035473
D005557	Formaldehyde	Formaldehyde results in increased expression of CD2 mRNA	23649840
D005839	Gentamicins	Gentamicins results in increased expression of CD2 mRNA	22061828
D006418	Heme	Heme metabolite results in increased expression of CD2 mRNA	19191707
C014026	hexamethylene bisacetamide	hexamethylene bisacetamide results in decreased expression of CD2 mRNA	26941288
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of CD2 mRNA	22802445
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of CD2 mRNA	26941288
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of CD2 mRNA"	24972896
D008727	Methotrexate	Methotrexate results in decreased expression of CD2 mRNA	17400583
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of CD2 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of CD2 mRNA"	25554681
D009532	Nickel	Nickel results in increased expression of CD2 mRNA	25583101
C006253	pirinixic acid	pirinixic acid results in increased expression of CD2 mRNA	20813756
D059808	Polyphenols	Polyphenols results in decreased expression of CD2 mRNA	16293270
D015474	Isotretinoin	Isotretinoin results in increased expression of CD2 mRNA	20436886
D018038	Sodium Selenite	Sodium Selenite results in increased expression of CD2 mRNA	18175754
D016559	Tacrolimus	Tacrolimus inhibits the reaction [CD2 protein results in increased expression of IL2 protein]	1705513
C009495	titanium dioxide	titanium dioxide results in increased expression of CD2 mRNA	23557971
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of CD2 mRNA	22363418
D014118	Toxins, Biological	"Toxins, Biological affects the expression of CD2 mRNA"	19682533
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of CD2 mRNA	16141432
C111237	vorinostat	vorinostat results in increased expression of CD2 mRNA	26941288

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005102	signaling receptor binding	-	IPI	17344209
GO:0005515	protein binding	-	IPI	1970422 7544493 9677430 9741631 9843987 9857189 10380930 10404223 11971877 12356317 12426371 15105431 16000308 17020880 23663663
GO:0038023	signaling receptor activity	-	NAS	7544493
GO:0042803	protein homodimerization activity	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001766	membrane raft polarization	-	TAS	11376005 11591762
GO:0006915	apoptotic process	-	TAS	9270771 10575274
GO:0007166	cell surface receptor signaling pathway	-	TAS	10575274
GO:0030101	natural killer cell activation	-	NAS	12714509
GO:0030887	positive regulation of myeloid dendritic cell activation	-	NAS	12714509
GO:0032760	positive regulation of tumor necrosis factor production	-	IDA	19109405
GO:0034113	heterotypic cell-cell adhesion	-	IDA	15345303
GO:0042110	T cell activation	-	TAS	2471997
GO:0045580	regulation of T cell differentiation	-	NAS	11544295
GO:0050900	leukocyte migration	-	TAS	-
GO:0098609	cell-cell adhesion	-	NAS	7544493
GO:1902715	positive regulation of interferon-gamma secretion	-	IDA	19109405
GO:2000484	positive regulation of interleukin-8 secretion	-	IMP	19109405

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	IEA	-
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	NAS	7544493
GO:0005911	cell-cell junction	-	IEA	-
GO:0009897	external side of plasma membrane	-	IDA	21460847
GO:0009898	cytoplasmic side of plasma membrane	-	IEA	-
GO:0009986	cell surface	-	IDA	15345303
GO:0046658	anchored component of plasma membrane	-	IEA	-

KEGG ID	KEGG Term
hsa04514	Cell adhesion molecules (CAMs)
hsa04640	Hematopoietic cell lineage

Reactome ID	Reactome Term	Evidence
R-HSA-109582	Hemostasis	TAS
R-HSA-202733	Cell surface interactions at the vascular wall	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
1585942	T-cell alveolitis in lung lavage of asbestos-exposed subjects. (1992)	Sprince NL	Am J Ind Med
10069570	Upregulated expression of VLA proteins and CD29 in peripheral blood lymphocytes of chronic alcoholics without ethanol-related diseases. (1999 Feb)	Sacanella E	Alcohol Clin Exp Res
23288628	Genetics of rheumatoid arthritis - a comprehensive review. (2013 Oct)	Kurko J	Clin Rev Allergy Immunol
1976725	T-lymphocyte subsets in occupationally exposed persons. (1990 Oct)	Tuschl H	Int J Radiat Biol
7709007	Alveolar lavage fluid (ALF) of normal volunteer subjects: cytologic, immunocytochemical, and biochemical reference values. (1995 Feb)	Sutinen S	Respir Med
21745561	Cadmium inhibits motility factor-dependent migration of human trophoblast cells. (2011 Dec)	Alvarez MM	Toxicol In Vitro